Insights into Klebsiella pneumoniae type VI secretion system transcriptional regulation

Detalhes bibliográficos
Autor(a) principal: Barbosa, Victor Augusto Araújo
Data de Publicação: 2019
Outros Autores: Lery, Leticia Miranda Santos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/35352
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ. Brasil.
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spelling Barbosa, Victor Augusto AraújoLery, Leticia Miranda Santos2019-09-05T13:54:46Z2019-09-05T13:54:46Z2019BARBOSA, Victor Augusto Araújo; LEVY, Leticia Miranda Santos. Insights into Klebsiella pneumoniae type VI secretion system transcriptional regulation. BMC Genomics, v. 20, n. 506, p. 1-12, 2019.1471-2164https://www.arca.fiocruz.br/handle/icict/3535210.1186/s12864-019-5885-9engBMCKlebsiella pneumoniaeSistema de secreção tipo VIRegulador transcricionalAnálise do genoma bacterianoType VI secretion systemT6SSKlebsiella pneumoniaeTranscriptional regulatorBacterial genome analysisInsights into Klebsiella pneumoniae type VI secretion system transcriptional regulationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ. Brasil.Klebsiella pneumoniae (KP) is an opportunistic pathogen that mainly causes respiratory and urinary tract infections. The frequent occurrence of simultaneously virulent and multiple drug-resistant isolates led WHO to include this species in the list of top priorities for research and development of therapeutic alternatives. The comprehensive knowledge of the molecular mechanisms underlying KP virulence may lead to the proposal of more efficient and specific drugs. One of its virulence factors is the Type VI Secretion System (T6SS), which contributes to bacterial competition, cell invasion and in vivo colonisation. Despite the few studies showing the involvement of T6SS in KP pathogenesis, little is known concerning the regulation of its expression. The understanding of regulatory mechanisms may give more clues about the function of the system and the possibilities of future interference in this process. This work aimed to standardise the annotation of T6SS genes in KP strains and identify mechanisms of their transcriptional regulation through computational predictions.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/35352/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALLeticiaSLevy_VictorBarbosa_IOC_2019.pdfLeticiaSLevy_VictorBarbosa_IOC_2019.pdfapplication/pdf4019376https://www.arca.fiocruz.br/bitstream/icict/35352/2/LeticiaSLevy_VictorBarbosa_IOC_2019.pdfc24447aa8118e406749803256e556945MD52TEXTLeticiaSLevy_VictorBarbosa_IOC_2019.pdf.txtLeticiaSLevy_VictorBarbosa_IOC_2019.pdf.txtExtracted texttext/plain52951https://www.arca.fiocruz.br/bitstream/icict/35352/3/LeticiaSLevy_VictorBarbosa_IOC_2019.pdf.txtd55ac17a170e3021baaef65c5c3d873eMD53icict/353522019-09-06 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dc.title.pt_BR.fl_str_mv Insights into Klebsiella pneumoniae type VI secretion system transcriptional regulation
title Insights into Klebsiella pneumoniae type VI secretion system transcriptional regulation
spellingShingle Insights into Klebsiella pneumoniae type VI secretion system transcriptional regulation
Barbosa, Victor Augusto Araújo
Klebsiella pneumoniae
Sistema de secreção tipo VI
Regulador transcricional
Análise do genoma bacteriano
Type VI secretion system
T6SS
Klebsiella pneumoniae
Transcriptional regulator
Bacterial genome analysis
title_short Insights into Klebsiella pneumoniae type VI secretion system transcriptional regulation
title_full Insights into Klebsiella pneumoniae type VI secretion system transcriptional regulation
title_fullStr Insights into Klebsiella pneumoniae type VI secretion system transcriptional regulation
title_full_unstemmed Insights into Klebsiella pneumoniae type VI secretion system transcriptional regulation
title_sort Insights into Klebsiella pneumoniae type VI secretion system transcriptional regulation
author Barbosa, Victor Augusto Araújo
author_facet Barbosa, Victor Augusto Araújo
Lery, Leticia Miranda Santos
author_role author
author2 Lery, Leticia Miranda Santos
author2_role author
dc.contributor.author.fl_str_mv Barbosa, Victor Augusto Araújo
Lery, Leticia Miranda Santos
dc.subject.other.pt_BR.fl_str_mv Klebsiella pneumoniae
Sistema de secreção tipo VI
Regulador transcricional
Análise do genoma bacteriano
topic Klebsiella pneumoniae
Sistema de secreção tipo VI
Regulador transcricional
Análise do genoma bacteriano
Type VI secretion system
T6SS
Klebsiella pneumoniae
Transcriptional regulator
Bacterial genome analysis
dc.subject.en.pt_BR.fl_str_mv Type VI secretion system
T6SS
Klebsiella pneumoniae
Transcriptional regulator
Bacterial genome analysis
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ. Brasil.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-09-05T13:54:46Z
dc.date.available.fl_str_mv 2019-09-05T13:54:46Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BARBOSA, Victor Augusto Araújo; LEVY, Leticia Miranda Santos. Insights into Klebsiella pneumoniae type VI secretion system transcriptional regulation. BMC Genomics, v. 20, n. 506, p. 1-12, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/35352
dc.identifier.issn.pt_BR.fl_str_mv 1471-2164
dc.identifier.doi.none.fl_str_mv 10.1186/s12864-019-5885-9
identifier_str_mv BARBOSA, Victor Augusto Araújo; LEVY, Leticia Miranda Santos. Insights into Klebsiella pneumoniae type VI secretion system transcriptional regulation. BMC Genomics, v. 20, n. 506, p. 1-12, 2019.
1471-2164
10.1186/s12864-019-5885-9
url https://www.arca.fiocruz.br/handle/icict/35352
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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