Insights into Klebsiella pneumoniae type VI secretion system transcriptional regulation
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/35352 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ. Brasil. |
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Barbosa, Victor Augusto AraújoLery, Leticia Miranda Santos2019-09-05T13:54:46Z2019-09-05T13:54:46Z2019BARBOSA, Victor Augusto Araújo; LEVY, Leticia Miranda Santos. Insights into Klebsiella pneumoniae type VI secretion system transcriptional regulation. BMC Genomics, v. 20, n. 506, p. 1-12, 2019.1471-2164https://www.arca.fiocruz.br/handle/icict/3535210.1186/s12864-019-5885-9engBMCKlebsiella pneumoniaeSistema de secreção tipo VIRegulador transcricionalAnálise do genoma bacterianoType VI secretion systemT6SSKlebsiella pneumoniaeTranscriptional regulatorBacterial genome analysisInsights into Klebsiella pneumoniae type VI secretion system transcriptional regulationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ. Brasil.Klebsiella pneumoniae (KP) is an opportunistic pathogen that mainly causes respiratory and urinary tract infections. The frequent occurrence of simultaneously virulent and multiple drug-resistant isolates led WHO to include this species in the list of top priorities for research and development of therapeutic alternatives. The comprehensive knowledge of the molecular mechanisms underlying KP virulence may lead to the proposal of more efficient and specific drugs. One of its virulence factors is the Type VI Secretion System (T6SS), which contributes to bacterial competition, cell invasion and in vivo colonisation. Despite the few studies showing the involvement of T6SS in KP pathogenesis, little is known concerning the regulation of its expression. The understanding of regulatory mechanisms may give more clues about the function of the system and the possibilities of future interference in this process. This work aimed to standardise the annotation of T6SS genes in KP strains and identify mechanisms of their transcriptional regulation through computational predictions.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/35352/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALLeticiaSLevy_VictorBarbosa_IOC_2019.pdfLeticiaSLevy_VictorBarbosa_IOC_2019.pdfapplication/pdf4019376https://www.arca.fiocruz.br/bitstream/icict/35352/2/LeticiaSLevy_VictorBarbosa_IOC_2019.pdfc24447aa8118e406749803256e556945MD52TEXTLeticiaSLevy_VictorBarbosa_IOC_2019.pdf.txtLeticiaSLevy_VictorBarbosa_IOC_2019.pdf.txtExtracted texttext/plain52951https://www.arca.fiocruz.br/bitstream/icict/35352/3/LeticiaSLevy_VictorBarbosa_IOC_2019.pdf.txtd55ac17a170e3021baaef65c5c3d873eMD53icict/353522019-09-06 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dc.title.pt_BR.fl_str_mv |
Insights into Klebsiella pneumoniae type VI secretion system transcriptional regulation |
title |
Insights into Klebsiella pneumoniae type VI secretion system transcriptional regulation |
spellingShingle |
Insights into Klebsiella pneumoniae type VI secretion system transcriptional regulation Barbosa, Victor Augusto Araújo Klebsiella pneumoniae Sistema de secreção tipo VI Regulador transcricional Análise do genoma bacteriano Type VI secretion system T6SS Klebsiella pneumoniae Transcriptional regulator Bacterial genome analysis |
title_short |
Insights into Klebsiella pneumoniae type VI secretion system transcriptional regulation |
title_full |
Insights into Klebsiella pneumoniae type VI secretion system transcriptional regulation |
title_fullStr |
Insights into Klebsiella pneumoniae type VI secretion system transcriptional regulation |
title_full_unstemmed |
Insights into Klebsiella pneumoniae type VI secretion system transcriptional regulation |
title_sort |
Insights into Klebsiella pneumoniae type VI secretion system transcriptional regulation |
author |
Barbosa, Victor Augusto Araújo |
author_facet |
Barbosa, Victor Augusto Araújo Lery, Leticia Miranda Santos |
author_role |
author |
author2 |
Lery, Leticia Miranda Santos |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Barbosa, Victor Augusto Araújo Lery, Leticia Miranda Santos |
dc.subject.other.pt_BR.fl_str_mv |
Klebsiella pneumoniae Sistema de secreção tipo VI Regulador transcricional Análise do genoma bacteriano |
topic |
Klebsiella pneumoniae Sistema de secreção tipo VI Regulador transcricional Análise do genoma bacteriano Type VI secretion system T6SS Klebsiella pneumoniae Transcriptional regulator Bacterial genome analysis |
dc.subject.en.pt_BR.fl_str_mv |
Type VI secretion system T6SS Klebsiella pneumoniae Transcriptional regulator Bacterial genome analysis |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ. Brasil. |
publishDate |
2019 |
dc.date.accessioned.fl_str_mv |
2019-09-05T13:54:46Z |
dc.date.available.fl_str_mv |
2019-09-05T13:54:46Z |
dc.date.issued.fl_str_mv |
2019 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
BARBOSA, Victor Augusto Araújo; LEVY, Leticia Miranda Santos. Insights into Klebsiella pneumoniae type VI secretion system transcriptional regulation. BMC Genomics, v. 20, n. 506, p. 1-12, 2019. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/35352 |
dc.identifier.issn.pt_BR.fl_str_mv |
1471-2164 |
dc.identifier.doi.none.fl_str_mv |
10.1186/s12864-019-5885-9 |
identifier_str_mv |
BARBOSA, Victor Augusto Araújo; LEVY, Leticia Miranda Santos. Insights into Klebsiella pneumoniae type VI secretion system transcriptional regulation. BMC Genomics, v. 20, n. 506, p. 1-12, 2019. 1471-2164 10.1186/s12864-019-5885-9 |
url |
https://www.arca.fiocruz.br/handle/icict/35352 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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BMC |
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