Therapeutic response to thalidomide in Melkersson-Rosenthal syndrome: a case report.

Detalhes bibliográficos
Autor(a) principal: Medeiros Junior, Manoel
Data de Publicação: 2002
Outros Autores: Araujo, Maria Ilma, Guimarães, Newton Sales, Freitas, Luiz Antonio Rodrigues de, Silva, Tânia Maria Correia, Carvalho Filho, Edgar Marcelino
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7896
Resumo: Hospital Universitário Professor Edgard Santos. Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil
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spelling Medeiros Junior, ManoelAraujo, Maria IlmaGuimarães, Newton SalesFreitas, Luiz Antonio Rodrigues deSilva, Tânia Maria CorreiaCarvalho Filho, Edgar Marcelino2014-07-09T19:06:09Z2014-07-09T19:06:09Z2002MEDEIROS JUNIOR, M. et al. Therapeutic response to thalidomide in Melkersson-Rosenthal syndrome: a case report. Annals of Allergy, Asthma and Immunology, v. 88, n. 4, p. 421-424, 2002.1081-1206https://www.arca.fiocruz.br/handle/icict/7896engElsevierTherapeutic response to thalidomide in Melkersson-Rosenthal syndrome: a case report.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHospital Universitário Professor Edgard Santos. Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, BrasilHospital Universitário Professor Edgard Santos. Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Division of Dermatology. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil / Escola Baiana de Medicina e Saúde Pública. Salvador, BA, BrasilBACKGROUND: Melkersson-Rosenthal syndrome (MRS) is a rare disorder of unknown etiology characterized by a triad of symptoms: recurrent orofacial swelling, relapsing facial palsy. and a fissured tongue. A differential diagnosis must be made with other granulomatous diseases, such as sarcoidosis and oral Crohn disease; however, the histologic findings of noncaseating, sarcoidal granulomas support the diagnosis of MRS. RESULTS: Many therapeutic modalities have been described for this disease. In this case report, we present a patient with MRS that was treated with thalidomide because of the identification of tumor necrosis factor a in the lesion by immunohistochemical analysis. This is the first reported detection of tumor necrosis factor a in an MRS lesion, as well the first reported use of thalidomide to treat this clinical conditionImunossupressores/uso terapêuticoSíndrome de Melkersson-Rosenthal/quimioterapiaTalidomida/uso terapêuticoFator de Necrose Tumoral alfa/antagonistas & inibidoresAdolescenteAnti-Inflamatórios/administração & dosagemAnti-Inflamatórios/uso terapêuticoBiópsiaDexametasona/administração & dosagemDexametasona/uso terapêuticoQuimioterapia CombinadaHumanosQuimioterapia CombinadaLábio/químicaMasculinoSíndrome de Melkersson-Rosenthal/metabolismoIndução de RemissãoTalidomida/administração & dosagemFator de Necrose Tumoral alfa/análiseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALMedeiros Jr M Therapeutic response....pdfMedeiros Jr M Therapeutic response....pdfapplication/pdf610333https://www.arca.fiocruz.br/bitstream/icict/7896/1/Medeiros%20Jr%20M%20Therapeutic%20response....pdf7a33b63590164610f977dfb34b8c92e4MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7896/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTMedeiros Jr M Therapeutic response....pdf.txtMedeiros Jr M Therapeutic response....pdf.txtExtracted texttext/plain14203https://www.arca.fiocruz.br/bitstream/icict/7896/3/Medeiros%20Jr%20M%20Therapeutic%20response....pdf.txtd9e3024bf924343cc0b68ab6dfced7b5MD53icict/78962023-03-15 14:33:16.394oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:16Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Therapeutic response to thalidomide in Melkersson-Rosenthal syndrome: a case report.
title Therapeutic response to thalidomide in Melkersson-Rosenthal syndrome: a case report.
spellingShingle Therapeutic response to thalidomide in Melkersson-Rosenthal syndrome: a case report.
Medeiros Junior, Manoel
Imunossupressores/uso terapêutico
Síndrome de Melkersson-Rosenthal/quimioterapia
Talidomida/uso terapêutico
Fator de Necrose Tumoral alfa/antagonistas & inibidores
Adolescente
Anti-Inflamatórios/administração & dosagem
Anti-Inflamatórios/uso terapêutico
Biópsia
Dexametasona/administração & dosagem
Dexametasona/uso terapêutico
Quimioterapia Combinada
Humanos
Quimioterapia Combinada
Lábio/química
Masculino
Síndrome de Melkersson-Rosenthal/metabolismo
Indução de Remissão
Talidomida/administração & dosagem
Fator de Necrose Tumoral alfa/análise
title_short Therapeutic response to thalidomide in Melkersson-Rosenthal syndrome: a case report.
title_full Therapeutic response to thalidomide in Melkersson-Rosenthal syndrome: a case report.
title_fullStr Therapeutic response to thalidomide in Melkersson-Rosenthal syndrome: a case report.
title_full_unstemmed Therapeutic response to thalidomide in Melkersson-Rosenthal syndrome: a case report.
title_sort Therapeutic response to thalidomide in Melkersson-Rosenthal syndrome: a case report.
author Medeiros Junior, Manoel
author_facet Medeiros Junior, Manoel
Araujo, Maria Ilma
Guimarães, Newton Sales
Freitas, Luiz Antonio Rodrigues de
Silva, Tânia Maria Correia
Carvalho Filho, Edgar Marcelino
author_role author
author2 Araujo, Maria Ilma
Guimarães, Newton Sales
Freitas, Luiz Antonio Rodrigues de
Silva, Tânia Maria Correia
Carvalho Filho, Edgar Marcelino
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Medeiros Junior, Manoel
Araujo, Maria Ilma
Guimarães, Newton Sales
Freitas, Luiz Antonio Rodrigues de
Silva, Tânia Maria Correia
Carvalho Filho, Edgar Marcelino
dc.subject.decs.pt_BR.fl_str_mv Imunossupressores/uso terapêutico
Síndrome de Melkersson-Rosenthal/quimioterapia
Talidomida/uso terapêutico
Fator de Necrose Tumoral alfa/antagonistas & inibidores
Adolescente
Anti-Inflamatórios/administração & dosagem
Anti-Inflamatórios/uso terapêutico
Biópsia
Dexametasona/administração & dosagem
Dexametasona/uso terapêutico
Quimioterapia Combinada
Humanos
Quimioterapia Combinada
Lábio/química
Masculino
Síndrome de Melkersson-Rosenthal/metabolismo
Indução de Remissão
Talidomida/administração & dosagem
Fator de Necrose Tumoral alfa/análise
topic Imunossupressores/uso terapêutico
Síndrome de Melkersson-Rosenthal/quimioterapia
Talidomida/uso terapêutico
Fator de Necrose Tumoral alfa/antagonistas & inibidores
Adolescente
Anti-Inflamatórios/administração & dosagem
Anti-Inflamatórios/uso terapêutico
Biópsia
Dexametasona/administração & dosagem
Dexametasona/uso terapêutico
Quimioterapia Combinada
Humanos
Quimioterapia Combinada
Lábio/química
Masculino
Síndrome de Melkersson-Rosenthal/metabolismo
Indução de Remissão
Talidomida/administração & dosagem
Fator de Necrose Tumoral alfa/análise
description Hospital Universitário Professor Edgard Santos. Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil
publishDate 2002
dc.date.issued.fl_str_mv 2002
dc.date.accessioned.fl_str_mv 2014-07-09T19:06:09Z
dc.date.available.fl_str_mv 2014-07-09T19:06:09Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MEDEIROS JUNIOR, M. et al. Therapeutic response to thalidomide in Melkersson-Rosenthal syndrome: a case report. Annals of Allergy, Asthma and Immunology, v. 88, n. 4, p. 421-424, 2002.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7896
dc.identifier.issn.none.fl_str_mv 1081-1206
identifier_str_mv MEDEIROS JUNIOR, M. et al. Therapeutic response to thalidomide in Melkersson-Rosenthal syndrome: a case report. Annals of Allergy, Asthma and Immunology, v. 88, n. 4, p. 421-424, 2002.
1081-1206
url https://www.arca.fiocruz.br/handle/icict/7896
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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