Evaluation of the effect of supervised anti-malarial treatment on recurrences of Plasmodium vivax malaria
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/48413 |
Resumo: | Universidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Manaus, AM, Brasil / Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil / Faculdade Metropolitana de Manaus. Manaus, AM, Brasil. |
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Dinelly, Kelry Mazurega OliveiraVitor-Silva, SheilaBrito-Sousa, Jose DiegoSampaio, Vanderson SouzaSilva, Milena Gabriela OliveiraSiqueira, André MachadoPeterka, CássioRodovalho, SheilaOmena, Aretha GomesMonteiro, Wuelton MarceloLacerda, Marcus Vinícius GuimarãesMelo, Gisely Cardoso2021-07-29T21:37:49Z2021-07-29T21:37:49Z2021DINELLY, Kelry Mazurega Oliveira et al. Evaluation of the effect of supervised anti-malarial treatment on recurrences of Plasmodium vivax malaria. Malaria journal, v. 20, n. 1, p. 1-6, 20211475-2875https://www.arca.fiocruz.br/handle/icict/4841310.1186/s12936-021-03793-0engBMCEvaluation of the effect of supervised anti-malarial treatment on recurrences of Plasmodium vivax malariainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Manaus, AM, Brasil / Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil / Faculdade Metropolitana de Manaus. Manaus, AM, Brasil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil / Universidade Federal do Amazonas. Escola de Enfermagem de Manaus. Manaus, AM, Brasil.Universidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Manaus, AM, Brasil / Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil.Universidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Manaus, AM, Brasil / Fundação de Vigilância em Saúde do Amazonas. Manaus, AM, Brasil.Universidade Federal do Amazonas. Escola de Enfermagem de Manaus. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Manaus, AM, Brasil.Universidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Manaus, AM, Brasil / Organização Pan Americana da Saúde. Brasília, DF, Brasil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil.Universidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Manaus, AM, Brasil / Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Leônidas & Maria Deane. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Manaus, AM, Brasil / Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil.Universidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Manaus, AM, Brasil / Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil.Background: Relapses in vivax malaria have posed great challenges for malaria control, and they also account for a great proportion of reported cases. Knowing the real effectiveness of a 7-day primaquine (PQ) scheme is crucial in order to evaluate not only the cost-effectiveness of implementing new anti-hypnozoite drugs, but also how health education strategies can guarantee better compliance and be reinforced. This study aimed to evaluate the effect of daily treatment with chloroquine and PQ supervised by health workers versus prescription without supervision. Methods: The outcome was the passive detection of new positive thick blood smears up to 180 days, based on the official data records from the National Malaria Control Programme. The recurrences seen in the real life were, therefore, used as a surrogate for true relapses. Results: Patients under supervised treatment had a lower risk of recurrence up to day 180 when compared to the unsupervised treatment (17.9% vs. 36.1%; p = 0.027). Conclusions: The lack of supervision in the non-supervised group (which followed standard of care in the real life) enabled proper comparison, as consent itself would have lead to greater compliance in this group. Future studies should scale such an analysis to different settings in the Brazilian Amazon.MalariaPlasmodium vivaxRecurrenceSupervised treatmentUnsupervised treatmentinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/48413/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALEvaluation_Andre_Siqueira_etal_INI_2021.pdfEvaluation_Andre_Siqueira_etal_INI_2021.pdfapplication/pdf813486https://www.arca.fiocruz.br/bitstream/icict/48413/2/Evaluation_Andre_Siqueira_etal_INI_2021.pdf54e10d840b81ea7de534bed0dd360eccMD52TEXTEvaluation_Andre_Siqueira_etal_INI_2021.pdf.txtEvaluation_Andre_Siqueira_etal_INI_2021.pdf.txtExtracted texttext/plain25967https://www.arca.fiocruz.br/bitstream/icict/48413/3/Evaluation_Andre_Siqueira_etal_INI_2021.pdf.txt7fd95c34316f263a69657dc56e4de2f5MD53icict/484132021-07-30 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| dc.title.pt_BR.fl_str_mv |
Evaluation of the effect of supervised anti-malarial treatment on recurrences of Plasmodium vivax malaria |
| title |
Evaluation of the effect of supervised anti-malarial treatment on recurrences of Plasmodium vivax malaria |
| spellingShingle |
Evaluation of the effect of supervised anti-malarial treatment on recurrences of Plasmodium vivax malaria Dinelly, Kelry Mazurega Oliveira Malaria Plasmodium vivax Recurrence Supervised treatment Unsupervised treatment |
| title_short |
Evaluation of the effect of supervised anti-malarial treatment on recurrences of Plasmodium vivax malaria |
| title_full |
Evaluation of the effect of supervised anti-malarial treatment on recurrences of Plasmodium vivax malaria |
| title_fullStr |
Evaluation of the effect of supervised anti-malarial treatment on recurrences of Plasmodium vivax malaria |
| title_full_unstemmed |
Evaluation of the effect of supervised anti-malarial treatment on recurrences of Plasmodium vivax malaria |
| title_sort |
Evaluation of the effect of supervised anti-malarial treatment on recurrences of Plasmodium vivax malaria |
| author |
Dinelly, Kelry Mazurega Oliveira |
| author_facet |
Dinelly, Kelry Mazurega Oliveira Vitor-Silva, Sheila Brito-Sousa, Jose Diego Sampaio, Vanderson Souza Silva, Milena Gabriela Oliveira Siqueira, André Machado Peterka, Cássio Rodovalho, Sheila Omena, Aretha Gomes Monteiro, Wuelton Marcelo Lacerda, Marcus Vinícius Guimarães Melo, Gisely Cardoso |
| author_role |
author |
| author2 |
Vitor-Silva, Sheila Brito-Sousa, Jose Diego Sampaio, Vanderson Souza Silva, Milena Gabriela Oliveira Siqueira, André Machado Peterka, Cássio Rodovalho, Sheila Omena, Aretha Gomes Monteiro, Wuelton Marcelo Lacerda, Marcus Vinícius Guimarães Melo, Gisely Cardoso |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Dinelly, Kelry Mazurega Oliveira Vitor-Silva, Sheila Brito-Sousa, Jose Diego Sampaio, Vanderson Souza Silva, Milena Gabriela Oliveira Siqueira, André Machado Peterka, Cássio Rodovalho, Sheila Omena, Aretha Gomes Monteiro, Wuelton Marcelo Lacerda, Marcus Vinícius Guimarães Melo, Gisely Cardoso |
| dc.subject.en.pt_BR.fl_str_mv |
Malaria Plasmodium vivax Recurrence Supervised treatment Unsupervised treatment |
| topic |
Malaria Plasmodium vivax Recurrence Supervised treatment Unsupervised treatment |
| description |
Universidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Manaus, AM, Brasil / Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil / Faculdade Metropolitana de Manaus. Manaus, AM, Brasil. |
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2021 |
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2021-07-29T21:37:49Z |
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2021-07-29T21:37:49Z |
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2021 |
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DINELLY, Kelry Mazurega Oliveira et al. Evaluation of the effect of supervised anti-malarial treatment on recurrences of Plasmodium vivax malaria. Malaria journal, v. 20, n. 1, p. 1-6, 2021 |
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https://www.arca.fiocruz.br/handle/icict/48413 |
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1475-2875 |
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10.1186/s12936-021-03793-0 |
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DINELLY, Kelry Mazurega Oliveira et al. Evaluation of the effect of supervised anti-malarial treatment on recurrences of Plasmodium vivax malaria. Malaria journal, v. 20, n. 1, p. 1-6, 2021 1475-2875 10.1186/s12936-021-03793-0 |
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