Frequency of indeterminate results from an interferon-gamma release assay among HIV-infected individuals

Detalhes bibliográficos
Autor(a) principal: Oliveira, Sandra Maria do Valle Leone de
Data de Publicação: 2017
Outros Autores: Trajman, Anete, Paniago, Anamaria Mello Miranda, Motta-Castro, Ana Rita Coimbra, Ruffino-Netto, Antonio, Maciel, Ethel Leonor Noia, Croda, Julio, Bonecini-Almeida, Maria da Gloria
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31621
Resumo: Universidade Federal de Mato Grosso do Sul. Faculdade de Medicina. Programa de Pós-Graduação em Doenças Infecciosas e Parasitárias. Campo Grande, MS, Brasil / Fundação Oswaldo Cruz. Campo Grande, MS, Brasil.
id CRUZ_98fec784d9b5dbd0f8e6c30908289f83
oai_identifier_str oai:www.arca.fiocruz.br:icict/31621
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Oliveira, Sandra Maria do Valle Leone deTrajman, AnetePaniago, Anamaria Mello MirandaMotta-Castro, Ana Rita CoimbraRuffino-Netto, AntonioMaciel, Ethel Leonor NoiaCroda, JulioBonecini-Almeida, Maria da Gloria2019-02-13T22:49:04Z2019-02-13T22:49:04Z2017OLIVEIRA,Sandra Maria do Valle Leone de et al. Frequency of indeterminate results from an interferon-gamma release assay among HIV-infected individuals. Jornal Brasileiro de Pneumologia, v. 43, n. 3, p. 215-218, 2017.1806-3713https://www.arca.fiocruz.br/handle/icict/3162110.1590/S1806-375620160000001251806-3756engSociedade Brasileira de Pneumologia e TisiologiaFrequency of indeterminate results from an interferon-gamma release assay among HIV-infected individualsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Mato Grosso do Sul. Faculdade de Medicina. Programa de Pós-Graduação em Doenças Infecciosas e Parasitárias. Campo Grande, MS, Brasil / Fundação Oswaldo Cruz. Campo Grande, MS, Brasil.McGill University. Montreal Chest Institute. Montreal, QC, Canada / Universidade do Estado do Rio de Janeiro. Instituto de Medicina Social. Rio de Janeiro, RJ, Brasil.Universidade Federal de Mato Grosso do Sul. Faculdade de Medicina. Programa de Pós-Graduação em Doenças Infecciosas e Parasitárias. Campo Grande, MS, Brasil.Universidade Federal de Mato Grosso do Sul. Faculdade de Medicina. Programa de Pós-Graduação em Doenças Infecciosas e Parasitárias. Campo Grande, MS, Brasil / Fundação Oswaldo Cruz. Campo Grande, MS, Brasil.Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto, SP, Brasil.Universidade Federal do Espírito Santo. Laboratório de Epidemiologia. Vitória, ES, Brasil.Fundação Oswaldo Cruz. Campo Grande, MS, Brasil / Universidade Federal da Grande Dourados. Faculdade de Medicina. Campo Grande, MS, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Imunologia e Imunogenética em Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.Objective: To evaluate the frequency of and factors associated with indeterminate interferon-gamma release assay (IGRA) results in people living with HIV/AIDS (PLWHA). Methods: We tested 81 PLWHA in the central-west region of Brazil, using the tuberculin skin test and an IGRA. Information on sociodemographic and clinical variables was gathered through the use of questionnaires and from medical records. The association of those variables with indeterminate results was analyzed by calculating the adjusted ORs in a multivariate logistic regression model. Concordance was evaluated by determining the kappa statistic. Results: Among the 81 patients evaluated, the tuberculin skin test results were positive in 18 (22.2%) of the patients, and the IGRA results were positive in 10 (12.3%), with a kappa of 0.62. The IGRA results were indeterminate in 22 (27.1%) of the patients (95% CI: 17.8-38.1%). The odds of obtaining indeterminate results were significantly higher in smokers (adjusted OR = 6.0; 95% CI: 1.4-26.7) and in samples stored for less than 35 days (adjusted OR = 14.0; 95% CI: 3.1-64.2). Patients with advanced immunosuppression (CD4+ T-cell count < 200 cells/mm3) were at a higher risk for indeterminate results (OR adjusted for smoking and inadequate duration of sample storage = 4.7; 95% CI: 0.91-24.0), although the difference was not significant. Conclusions: The high prevalence of indeterminate results can be a major limitation for the routine use of IGRAs in PLWHA. The need to repeat the test increases its costs and should be taken into account in cost-effectiveness studies. The processing of samples can significantly alter the results.Interferon-gamma release testsInterferon-gammaTuberculosisHIVLatent tuberculosisTuberculin testinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31621/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_Oliveira_Sandra_etal_INI_2017.pdfve_Oliveira_Sandra_etal_INI_2017.pdfapplication/pdf262117https://www.arca.fiocruz.br/bitstream/icict/31621/2/ve_Oliveira_Sandra_etal_INI_2017.pdfa129af2070b49f1ad80b5fe5f1c33a15MD52TEXTve_Oliveira_Sandra_etal_INI_2017.pdf.txtve_Oliveira_Sandra_etal_INI_2017.pdf.txtExtracted texttext/plain18639https://www.arca.fiocruz.br/bitstream/icict/31621/3/ve_Oliveira_Sandra_etal_INI_2017.pdf.txte00d9a7340c59ea706f73a24920c3bc2MD53icict/316212019-02-14 02:03:05.2oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-02-14T04:03:05Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Frequency of indeterminate results from an interferon-gamma release assay among HIV-infected individuals
title Frequency of indeterminate results from an interferon-gamma release assay among HIV-infected individuals
spellingShingle Frequency of indeterminate results from an interferon-gamma release assay among HIV-infected individuals
Oliveira, Sandra Maria do Valle Leone de
Interferon-gamma release tests
Interferon-gamma
Tuberculosis
HIV
Latent tuberculosis
Tuberculin test
title_short Frequency of indeterminate results from an interferon-gamma release assay among HIV-infected individuals
title_full Frequency of indeterminate results from an interferon-gamma release assay among HIV-infected individuals
title_fullStr Frequency of indeterminate results from an interferon-gamma release assay among HIV-infected individuals
title_full_unstemmed Frequency of indeterminate results from an interferon-gamma release assay among HIV-infected individuals
title_sort Frequency of indeterminate results from an interferon-gamma release assay among HIV-infected individuals
author Oliveira, Sandra Maria do Valle Leone de
author_facet Oliveira, Sandra Maria do Valle Leone de
Trajman, Anete
Paniago, Anamaria Mello Miranda
Motta-Castro, Ana Rita Coimbra
Ruffino-Netto, Antonio
Maciel, Ethel Leonor Noia
Croda, Julio
Bonecini-Almeida, Maria da Gloria
author_role author
author2 Trajman, Anete
Paniago, Anamaria Mello Miranda
Motta-Castro, Ana Rita Coimbra
Ruffino-Netto, Antonio
Maciel, Ethel Leonor Noia
Croda, Julio
Bonecini-Almeida, Maria da Gloria
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira, Sandra Maria do Valle Leone de
Trajman, Anete
Paniago, Anamaria Mello Miranda
Motta-Castro, Ana Rita Coimbra
Ruffino-Netto, Antonio
Maciel, Ethel Leonor Noia
Croda, Julio
Bonecini-Almeida, Maria da Gloria
dc.subject.en.pt_BR.fl_str_mv Interferon-gamma release tests
Interferon-gamma
Tuberculosis
HIV
Latent tuberculosis
Tuberculin test
topic Interferon-gamma release tests
Interferon-gamma
Tuberculosis
HIV
Latent tuberculosis
Tuberculin test
description Universidade Federal de Mato Grosso do Sul. Faculdade de Medicina. Programa de Pós-Graduação em Doenças Infecciosas e Parasitárias. Campo Grande, MS, Brasil / Fundação Oswaldo Cruz. Campo Grande, MS, Brasil.
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2019-02-13T22:49:04Z
dc.date.available.fl_str_mv 2019-02-13T22:49:04Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv OLIVEIRA,Sandra Maria do Valle Leone de et al. Frequency of indeterminate results from an interferon-gamma release assay among HIV-infected individuals. Jornal Brasileiro de Pneumologia, v. 43, n. 3, p. 215-218, 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31621
dc.identifier.issn.pt_BR.fl_str_mv 1806-3713
dc.identifier.doi.none.fl_str_mv 10.1590/S1806-37562016000000125
dc.identifier.eissn.none.fl_str_mv 1806-3756
identifier_str_mv OLIVEIRA,Sandra Maria do Valle Leone de et al. Frequency of indeterminate results from an interferon-gamma release assay among HIV-infected individuals. Jornal Brasileiro de Pneumologia, v. 43, n. 3, p. 215-218, 2017.
1806-3713
10.1590/S1806-37562016000000125
1806-3756
url https://www.arca.fiocruz.br/handle/icict/31621
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedade Brasileira de Pneumologia e Tisiologia
publisher.none.fl_str_mv Sociedade Brasileira de Pneumologia e Tisiologia
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/31621/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/31621/2/ve_Oliveira_Sandra_etal_INI_2017.pdf
https://www.arca.fiocruz.br/bitstream/icict/31621/3/ve_Oliveira_Sandra_etal_INI_2017.pdf.txt
bitstream.checksum.fl_str_mv 5a560609d32a3863062d77ff32785d58
a129af2070b49f1ad80b5fe5f1c33a15
e00d9a7340c59ea706f73a24920c3bc2
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1813009099398316032

Registros relacionados