Host factors associated to false negative and indeterminate results in an interferon‐γ release assay in patients with active tuberculosis

Detalhes bibliográficos
Autor(a) principal: Santos, J.A.
Data de Publicação: 2020
Outros Autores: Duarte, R., Nunes, C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/7616
Resumo: Information on host factors that contribute to false negative and indeterminate results in interferon-γ release assays (IGRA) are critical to improve the usefulness of these tests in the fight against tuberculosis (TB) epidemics. The aim of this study was to estimate and compare the sensitivity of an IGRA and the tuberculin skin test (TST), independently and as a combined approach, in patients with TB and to identify risk factors associated with false negative and indeterminate IGRA results.
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spelling Host factors associated to false negative and indeterminate results in an interferon‐γ release assay in patients with active tuberculosisInterferon-gamma ReleaseTestsLatent TuberculosisPreventive MedicinePublic HealthTuberculin TestTuberculosisInfecções RespiratóriasInformation on host factors that contribute to false negative and indeterminate results in interferon-γ release assays (IGRA) are critical to improve the usefulness of these tests in the fight against tuberculosis (TB) epidemics. The aim of this study was to estimate and compare the sensitivity of an IGRA and the tuberculin skin test (TST), independently and as a combined approach, in patients with TB and to identify risk factors associated with false negative and indeterminate IGRA results.Fundação para a Ciência e Tecnologia provided financial support to conduct this research [Grant: PTDC/SAU-PUB/31346/2017] but had no involvement in the researchitself.Elsevier/ Sociedade Portuguesa de PneumologiaRepositório Científico do Instituto Nacional de SaúdeSantos, J.A.Duarte, R.Nunes, C.2021-03-31T16:37:36Z2020-12-132020-12-13T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/7616engPulmonology. Nov-Dec 2020;26(6):353-362. doi: 10.1016/j.pulmoe.2019.11.001. Epub 2019 Dec 13.2531-043710.1016/j.pulmoe.2019.11.001info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:42:06Zoai:repositorio.insa.pt:10400.18/7616Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:42:14.767543Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Host factors associated to false negative and indeterminate results in an interferon‐γ release assay in patients with active tuberculosis
title Host factors associated to false negative and indeterminate results in an interferon‐γ release assay in patients with active tuberculosis
spellingShingle Host factors associated to false negative and indeterminate results in an interferon‐γ release assay in patients with active tuberculosis
Santos, J.A.
Interferon-gamma Release
Tests
Latent Tuberculosis
Preventive Medicine
Public Health
Tuberculin Test
Tuberculosis
Infecções Respiratórias
title_short Host factors associated to false negative and indeterminate results in an interferon‐γ release assay in patients with active tuberculosis
title_full Host factors associated to false negative and indeterminate results in an interferon‐γ release assay in patients with active tuberculosis
title_fullStr Host factors associated to false negative and indeterminate results in an interferon‐γ release assay in patients with active tuberculosis
title_full_unstemmed Host factors associated to false negative and indeterminate results in an interferon‐γ release assay in patients with active tuberculosis
title_sort Host factors associated to false negative and indeterminate results in an interferon‐γ release assay in patients with active tuberculosis
author Santos, J.A.
author_facet Santos, J.A.
Duarte, R.
Nunes, C.
author_role author
author2 Duarte, R.
Nunes, C.
author2_role author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Santos, J.A.
Duarte, R.
Nunes, C.
dc.subject.por.fl_str_mv Interferon-gamma Release
Tests
Latent Tuberculosis
Preventive Medicine
Public Health
Tuberculin Test
Tuberculosis
Infecções Respiratórias
topic Interferon-gamma Release
Tests
Latent Tuberculosis
Preventive Medicine
Public Health
Tuberculin Test
Tuberculosis
Infecções Respiratórias
description Information on host factors that contribute to false negative and indeterminate results in interferon-γ release assays (IGRA) are critical to improve the usefulness of these tests in the fight against tuberculosis (TB) epidemics. The aim of this study was to estimate and compare the sensitivity of an IGRA and the tuberculin skin test (TST), independently and as a combined approach, in patients with TB and to identify risk factors associated with false negative and indeterminate IGRA results.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-13
2020-12-13T00:00:00Z
2021-03-31T16:37:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/7616
url http://hdl.handle.net/10400.18/7616
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pulmonology. Nov-Dec 2020;26(6):353-362. doi: 10.1016/j.pulmoe.2019.11.001. Epub 2019 Dec 13.
2531-0437
10.1016/j.pulmoe.2019.11.001
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier/ Sociedade Portuguesa de Pneumologia
publisher.none.fl_str_mv Elsevier/ Sociedade Portuguesa de Pneumologia
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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