NK Cell Responses in Zika Virus Infection Are Biased towards Cytokine-Mediated Effector Functions

Detalhes bibliográficos
Autor(a) principal: Maucourant, Christopher
Data de Publicação: 2021
Outros Autores: Queiroz, Gabriel Andrade Nonato, Corneau, Aurelien, Gois, Luana Leandro, Kheddar, Aida Meghraoui, Tarantino, Nadine, Bandeira, Antonio Carlos, Samri, Assia, Blanc, Catherine, Yssel, Hans, Grassi, Maria Fernanda Rios, Vieillard, Vincent
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/50070
Resumo: European Union Horizon 2020 ZIKAlliance Program (grant agreement 734548) and by the Coordination of Superior Level Staff Improvement-Brazil (CAPES Finance Code 001). C.M. received a Ph.D. fellowship from the French Ministry of Education; L.L.G. received a grant from the French Society for Cytometry; and M.F.R.G. is a research fellow of the National Council for Scientific and Technological Development (CNPq) and Foundation for the Development of Private Higher Education from Brazil.
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spelling Maucourant, ChristopherQueiroz, Gabriel Andrade NonatoCorneau, AurelienGois, Luana LeandroKheddar, Aida MeghraouiTarantino, NadineBandeira, Antonio CarlosSamri, AssiaBlanc, CatherineYssel, HansGrassi, Maria Fernanda RiosVieillard, Vincent2021-11-26T11:32:56Z2021-11-26T11:32:56Z2021MAUCOURANT, Christopher et al. NK Cell Responses in Zika Virus Infection Are Biased towards Cytokine-Mediated Effector Functions. Journal of Immunology, v. 207, p. 1333 1343, 2021.0022-1767https://www.arca.fiocruz.br/handle/icict/5007010.4049/jimmunol.2001180European Union Horizon 2020 ZIKAlliance Program (grant agreement 734548) and by the Coordination of Superior Level Staff Improvement-Brazil (CAPES Finance Code 001). C.M. received a Ph.D. fellowship from the French Ministry of Education; L.L.G. received a grant from the French Society for Cytometry; and M.F.R.G. is a research fellow of the National Council for Scientific and Technological Development (CNPq) and Foundation for the Development of Private Higher Education from Brazil.Sorbonne Universite. Inserm. Centre d’Immunologie et des Maladies Infectieuses. Paris, France.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Univ Paris. Faculté de Medecine Pierre et Marie Curie. Plateforme de Cytometrie. Site Pitie-Salpêtriere. Paris, France.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Sorbonne Universite. Inserm. Centre d’Immunologie et des Maladies Infectieuses. Paris, France.Sorbonne Universite. Inserm. Centre d’Immunologie et des Maladies Infectieuses. Paris, France.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Secretaria de Saúde da Bahia. Salvador, BA, Brasil.Sorbonne Universite. Inserm. Centre d’Immunologie et des Maladies Infectieuses. Paris, France.Univ Paris. Faculté de Medecine Pierre et Marie Curie. Plateforme de Cytometrie. Site Pitie-Salpêtriere. Paris, France.Sorbonne Universite. Inserm. Centre d’Immunologie et des Maladies Infectieuses. Paris, France.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Sorbonne Universite. Inserm. Centre d’Immunologie et des Maladies Infectieuses. Paris, France.Zika virus (ZIKV) is a mosquito-borne flavivirus that has emerged as a global concern because of its impact on human health. ZIKV infection during pregnancy can cause microcephaly and other severe brain defects in the developing fetus and there have been reports of the occurrence of Guillain-Barr e syndrome in areas affected by ZIKV. NK cells are activated during acute viral infections and their activity contributes to a first line of defense because of their ability to rapidly recognize and kill virus-infected cells. To provide insight into NK cell function during ZIKV infection, we have profiled, using mass cytometry, the NK cell receptor-ligand repertoire in a cohort of acute ZIKV-infected female patients. Freshly isolated NK cells from these patients contained distinct, activated, and terminally differentiated, subsets expressing higher levels of CD57, NKG2C, and KIR3DL1 as compared with those from healthy donors. Moreover, KIR3DL1+ NK cells from these patients produced high levels of IFN-g and TNF-a, in the absence of direct cytotoxicity, in response to in vitro stimulation with autologous, ZIKV-infected, monocyte-derived dendritic cells. In ZIKV-infected patients, overproduction of IFN-g correlated with STAT-5 activation (r 5 0.6643; p 5 0.0085) and was mediated following the recognition of MHC class 1 related chain A and chain B molecules expressed by ZIKV-infected monocyte-derived dendritic cells, in synergy with IL-12 production by the latter cells. Together, these findings suggest that NK cells contribute to the generation of an efficacious adaptive anti-ZIKV immune response that could potentially affect the outcome of the disease and/or the development of persistent symptoms.engAmerican Association of ImmunologistsZika virusInfecção por Zika virusMicrocefaliaFlavivirusCélulas DendríticasZika virusZika Virus InfectionMicrocephalyFlavavirusDendritic CellsNK Cell Responses in Zika Virus Infection Are Biased towards Cytokine-Mediated Effector Functionsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/50070/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALMaucourant, Christopher NK cell responses... .pdfMaucourant, Christopher NK cell responses... 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dc.title.pt_BR.fl_str_mv NK Cell Responses in Zika Virus Infection Are Biased towards Cytokine-Mediated Effector Functions
title NK Cell Responses in Zika Virus Infection Are Biased towards Cytokine-Mediated Effector Functions
spellingShingle NK Cell Responses in Zika Virus Infection Are Biased towards Cytokine-Mediated Effector Functions
Maucourant, Christopher
Zika virus
Infecção por Zika virus
Microcefalia
Flavivirus
Células Dendríticas
Zika virus
Zika Virus Infection
Microcephaly
Flavavirus
Dendritic Cells
title_short NK Cell Responses in Zika Virus Infection Are Biased towards Cytokine-Mediated Effector Functions
title_full NK Cell Responses in Zika Virus Infection Are Biased towards Cytokine-Mediated Effector Functions
title_fullStr NK Cell Responses in Zika Virus Infection Are Biased towards Cytokine-Mediated Effector Functions
title_full_unstemmed NK Cell Responses in Zika Virus Infection Are Biased towards Cytokine-Mediated Effector Functions
title_sort NK Cell Responses in Zika Virus Infection Are Biased towards Cytokine-Mediated Effector Functions
author Maucourant, Christopher
author_facet Maucourant, Christopher
Queiroz, Gabriel Andrade Nonato
Corneau, Aurelien
Gois, Luana Leandro
Kheddar, Aida Meghraoui
Tarantino, Nadine
Bandeira, Antonio Carlos
Samri, Assia
Blanc, Catherine
Yssel, Hans
Grassi, Maria Fernanda Rios
Vieillard, Vincent
author_role author
author2 Queiroz, Gabriel Andrade Nonato
Corneau, Aurelien
Gois, Luana Leandro
Kheddar, Aida Meghraoui
Tarantino, Nadine
Bandeira, Antonio Carlos
Samri, Assia
Blanc, Catherine
Yssel, Hans
Grassi, Maria Fernanda Rios
Vieillard, Vincent
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Maucourant, Christopher
Queiroz, Gabriel Andrade Nonato
Corneau, Aurelien
Gois, Luana Leandro
Kheddar, Aida Meghraoui
Tarantino, Nadine
Bandeira, Antonio Carlos
Samri, Assia
Blanc, Catherine
Yssel, Hans
Grassi, Maria Fernanda Rios
Vieillard, Vincent
dc.subject.other.pt_BR.fl_str_mv Zika virus
Infecção por Zika virus
Microcefalia
Flavivirus
Células Dendríticas
topic Zika virus
Infecção por Zika virus
Microcefalia
Flavivirus
Células Dendríticas
Zika virus
Zika Virus Infection
Microcephaly
Flavavirus
Dendritic Cells
dc.subject.en.pt_BR.fl_str_mv Zika virus
Zika Virus Infection
Microcephaly
Flavavirus
Dendritic Cells
description European Union Horizon 2020 ZIKAlliance Program (grant agreement 734548) and by the Coordination of Superior Level Staff Improvement-Brazil (CAPES Finance Code 001). C.M. received a Ph.D. fellowship from the French Ministry of Education; L.L.G. received a grant from the French Society for Cytometry; and M.F.R.G. is a research fellow of the National Council for Scientific and Technological Development (CNPq) and Foundation for the Development of Private Higher Education from Brazil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-11-26T11:32:56Z
dc.date.available.fl_str_mv 2021-11-26T11:32:56Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MAUCOURANT, Christopher et al. NK Cell Responses in Zika Virus Infection Are Biased towards Cytokine-Mediated Effector Functions. Journal of Immunology, v. 207, p. 1333 1343, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/50070
dc.identifier.issn.pt_BR.fl_str_mv 0022-1767
dc.identifier.doi.none.fl_str_mv 10.4049/jimmunol.2001180
identifier_str_mv MAUCOURANT, Christopher et al. NK Cell Responses in Zika Virus Infection Are Biased towards Cytokine-Mediated Effector Functions. Journal of Immunology, v. 207, p. 1333 1343, 2021.
0022-1767
10.4049/jimmunol.2001180
url https://www.arca.fiocruz.br/handle/icict/50070
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Association of Immunologists
publisher.none.fl_str_mv American Association of Immunologists
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/50070/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/50070/2/Maucourant%2c%20Christopher%20NK%20cell%20responses...%20.pdf
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