NK Cell Responses in Zika Virus Infection Are Biased towards Cytokine-Mediated Effector Functions
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/50070 |
Resumo: | European Union Horizon 2020 ZIKAlliance Program (grant agreement 734548) and by the Coordination of Superior Level Staff Improvement-Brazil (CAPES Finance Code 001). C.M. received a Ph.D. fellowship from the French Ministry of Education; L.L.G. received a grant from the French Society for Cytometry; and M.F.R.G. is a research fellow of the National Council for Scientific and Technological Development (CNPq) and Foundation for the Development of Private Higher Education from Brazil. |
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Maucourant, ChristopherQueiroz, Gabriel Andrade NonatoCorneau, AurelienGois, Luana LeandroKheddar, Aida MeghraouiTarantino, NadineBandeira, Antonio CarlosSamri, AssiaBlanc, CatherineYssel, HansGrassi, Maria Fernanda RiosVieillard, Vincent2021-11-26T11:32:56Z2021-11-26T11:32:56Z2021MAUCOURANT, Christopher et al. NK Cell Responses in Zika Virus Infection Are Biased towards Cytokine-Mediated Effector Functions. Journal of Immunology, v. 207, p. 1333 1343, 2021.0022-1767https://www.arca.fiocruz.br/handle/icict/5007010.4049/jimmunol.2001180European Union Horizon 2020 ZIKAlliance Program (grant agreement 734548) and by the Coordination of Superior Level Staff Improvement-Brazil (CAPES Finance Code 001). C.M. received a Ph.D. fellowship from the French Ministry of Education; L.L.G. received a grant from the French Society for Cytometry; and M.F.R.G. is a research fellow of the National Council for Scientific and Technological Development (CNPq) and Foundation for the Development of Private Higher Education from Brazil.Sorbonne Universite. Inserm. Centre d’Immunologie et des Maladies Infectieuses. Paris, France.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Univ Paris. Faculté de Medecine Pierre et Marie Curie. Plateforme de Cytometrie. Site Pitie-Salpêtriere. Paris, France.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Sorbonne Universite. Inserm. Centre d’Immunologie et des Maladies Infectieuses. Paris, France.Sorbonne Universite. Inserm. Centre d’Immunologie et des Maladies Infectieuses. Paris, France.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Secretaria de Saúde da Bahia. Salvador, BA, Brasil.Sorbonne Universite. Inserm. Centre d’Immunologie et des Maladies Infectieuses. Paris, France.Univ Paris. Faculté de Medecine Pierre et Marie Curie. Plateforme de Cytometrie. Site Pitie-Salpêtriere. Paris, France.Sorbonne Universite. Inserm. Centre d’Immunologie et des Maladies Infectieuses. Paris, France.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Sorbonne Universite. Inserm. Centre d’Immunologie et des Maladies Infectieuses. Paris, France.Zika virus (ZIKV) is a mosquito-borne flavivirus that has emerged as a global concern because of its impact on human health. ZIKV infection during pregnancy can cause microcephaly and other severe brain defects in the developing fetus and there have been reports of the occurrence of Guillain-Barr e syndrome in areas affected by ZIKV. NK cells are activated during acute viral infections and their activity contributes to a first line of defense because of their ability to rapidly recognize and kill virus-infected cells. To provide insight into NK cell function during ZIKV infection, we have profiled, using mass cytometry, the NK cell receptor-ligand repertoire in a cohort of acute ZIKV-infected female patients. Freshly isolated NK cells from these patients contained distinct, activated, and terminally differentiated, subsets expressing higher levels of CD57, NKG2C, and KIR3DL1 as compared with those from healthy donors. Moreover, KIR3DL1+ NK cells from these patients produced high levels of IFN-g and TNF-a, in the absence of direct cytotoxicity, in response to in vitro stimulation with autologous, ZIKV-infected, monocyte-derived dendritic cells. In ZIKV-infected patients, overproduction of IFN-g correlated with STAT-5 activation (r 5 0.6643; p 5 0.0085) and was mediated following the recognition of MHC class 1 related chain A and chain B molecules expressed by ZIKV-infected monocyte-derived dendritic cells, in synergy with IL-12 production by the latter cells. Together, these findings suggest that NK cells contribute to the generation of an efficacious adaptive anti-ZIKV immune response that could potentially affect the outcome of the disease and/or the development of persistent symptoms.engAmerican Association of ImmunologistsZika virusInfecção por Zika virusMicrocefaliaFlavivirusCélulas DendríticasZika virusZika Virus InfectionMicrocephalyFlavavirusDendritic CellsNK Cell Responses in Zika Virus Infection Are Biased towards Cytokine-Mediated Effector Functionsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/50070/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALMaucourant, Christopher NK cell responses... .pdfMaucourant, Christopher NK cell responses... 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14:34:30.882oai:www.arca.fiocruz.br:icict/50070Q0VTU8ODTyBOw4NPIEVYQ0xVU0lWQSBERSBESVJFSVRPUyBBVVRPUkFJUw0KDQpBbmEgTWFyaWEgRmlzY2luYSBTYW1wYWlvLCBDUEY6IDA2NS40MzEuMDM1LTE1LCB2aW5jdWxhZG8gYSBDUHFHTSAtIENlbnRybyBkZSBQZXNxdWlzYXMgR29uw6dhbG8gTW9uaXoKCkFvIGFjZWl0YXIgb3MgVEVSTU9TIGUgQ09OREnDh8OVRVMgZGVzdGEgQ0VTU8ODTywgbyBBVVRPUiBlL291IFRJVFVMQVIgZGUgZGlyZWl0b3MKYXV0b3JhaXMgc29icmUgYSBPQlJBIGRlIHF1ZSB0cmF0YSBlc3RlIGRvY3VtZW50bzoKCigxKSBDRURFIGUgVFJBTlNGRVJFLCB0b3RhbCBlIGdyYXR1aXRhbWVudGUsIMOgIEZJT0NSVVogLSBGVU5EQcOHw4NPIE9TV0FMRE8gQ1JVWiwgZW0KY2Fyw6F0ZXIgcGVybWFuZW50ZSwgaXJyZXZvZ8OhdmVsIGUgTsODTyBFWENMVVNJVk8sIHRvZG9zIG9zIGRpcmVpdG9zIHBhdHJpbW9uaWFpcyBOw4NPCkNPTUVSQ0lBSVMgZGUgdXRpbGl6YcOnw6NvIGRhIE9CUkEgYXJ0w61zdGljYSBlL291IGNpZW50w61maWNhIGluZGljYWRhIGFjaW1hLCBpbmNsdXNpdmUgb3MgZGlyZWl0b3MKZGUgdm96IGUgaW1hZ2VtIHZpbmN1bGFkb3Mgw6AgT0JSQSwgZHVyYW50ZSB0b2RvIG8gcHJhem8gZGUgZHVyYcOnw6NvIGRvcyBkaXJlaXRvcyBhdXRvcmFpcywgZW0KcXVhbHF1ZXIgaWRpb21hIGUgZW0gdG9kb3Mgb3MgcGHDrXNlczsKCigyKSBBQ0VJVEEgcXVlIGEgY2Vzc8OjbyB0b3RhbCBuw6NvIGV4Y2x1c2l2YSwgcGVybWFuZW50ZSBlIGlycmV2b2fDoXZlbCBkb3MgZGlyZWl0b3MgYXV0b3JhaXMKcGF0cmltb25pYWlzIG7Do28gY29tZXJjaWFpcyBkZSB1dGlsaXphw6fDo28gZGUgcXVlIHRyYXRhIGVzdGUgZG9jdW1lbnRvIGluY2x1aSwgZXhlbXBsaWZpY2F0aXZhbWVudGUsCm9zIGRpcmVpdG9zIGRlIGRpc3BvbmliaWxpemHDp8OjbyBlIGNvbXVuaWNhw6fDo28gcMO6YmxpY2EgZGEgT0JSQSwgZW0gcXVhbHF1ZXIgbWVpbyBvdSB2ZcOtY3VsbywKaW5jbHVzaXZlIGVtIFJlcG9zaXTDs3Jpb3MgRGlnaXRhaXMsIGJlbSBjb21vIG9zIGRpcmVpdG9zIGRlIHJlcHJvZHXDp8OjbywgZXhpYmnDp8OjbywgZXhlY3XDp8OjbywKZGVjbGFtYcOnw6NvLCByZWNpdGHDp8OjbywgZXhwb3Npw6fDo28sIGFycXVpdmFtZW50bywgaW5jbHVzw6NvIGVtIGJhbmNvIGRlIGRhZG9zLCBwcmVzZXJ2YcOnw6NvLCBkaWZ1c8OjbywKZGlzdHJpYnVpw6fDo28sIGRpdnVsZ2HDp8OjbywgZW1wcsOpc3RpbW8sIHRyYWR1w6fDo28sIGR1YmxhZ2VtLCBsZWdlbmRhZ2VtLCBpbmNsdXPDo28gZW0gbm92YXMgb2JyYXMgb3UKY29sZXTDom5lYXMsIHJldXRpbGl6YcOnw6NvLCBlZGnDp8OjbywgcHJvZHXDp8OjbyBkZSBtYXRlcmlhbCBkaWTDoXRpY28gZSBjdXJzb3Mgb3UgcXVhbHF1ZXIgZm9ybWEgZGUKdXRpbGl6YcOnw6NvIG7Do28gY29tZXJjaWFsOwoKKDMpIFJFQ09OSEVDRSBxdWUgYSBjZXNzw6NvIGFxdWkgZXNwZWNpZmljYWRhIGNvbmNlZGUgw6AgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETwpDUlVaIG8gZGlyZWl0byBkZSBhdXRvcml6YXIgcXVhbHF1ZXIgcGVzc29hIOKAkyBmw61zaWNhIG91IGp1csOtZGljYSwgcMO6YmxpY2Egb3UgcHJpdmFkYSwgbmFjaW9uYWwgb3UKZXN0cmFuZ2VpcmEg4oCTIGEgYWNlc3NhciBlIHV0aWxpemFyIGFtcGxhbWVudGUgYSBPQlJBLCBzZW0gZXhjbHVzaXZpZGFkZSwgcGFyYSBxdWFpc3F1ZXIKZmluYWxpZGFkZXMgbsOjbyBjb21lcmNpYWlzOwoKKDQpIERFQ0xBUkEgcXVlIGEgb2JyYSDDqSBjcmlhw6fDo28gb3JpZ2luYWwgZSBxdWUgw6kgbyB0aXR1bGFyIGRvcyBkaXJlaXRvcyBhcXVpIGNlZGlkb3MgZSBhdXRvcml6YWRvcywKcmVzcG9uc2FiaWxpemFuZG8tc2UgaW50ZWdyYWxtZW50ZSBwZWxvIGNvbnRlw7pkbyBlIG91dHJvcyBlbGVtZW50b3MgcXVlIGZhemVtIHBhcnRlIGRhIE9CUkEsCmluY2x1c2l2ZSBvcyBkaXJlaXRvcyBkZSB2b3ogZSBpbWFnZW0gdmluY3VsYWRvcyDDoCBPQlJBLCBvYnJpZ2FuZG8tc2UgYSBpbmRlbml6YXIgdGVyY2Vpcm9zIHBvcgpkYW5vcywgYmVtIGNvbW8gaW5kZW5pemFyIGUgcmVzc2FyY2lyIGEgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaIGRlCmV2ZW50dWFpcyBkZXNwZXNhcyBxdWUgdmllcmVtIGEgc3Vwb3J0YXIsIGVtIHJhesOjbyBkZSBxdWFscXVlciBvZmVuc2EgYSBkaXJlaXRvcyBhdXRvcmFpcyBvdQpkaXJlaXRvcyBkZSB2b3ogb3UgaW1hZ2VtLCBwcmluY2lwYWxtZW50ZSBubyBxdWUgZGl6IHJlc3BlaXRvIGEgcGzDoWdpbyBlIHZpb2xhw6fDtWVzIGRlIGRpcmVpdG9zOwoKKDUpIEFGSVJNQSBxdWUgY29uaGVjZSBhIFBvbMOtdGljYSBJbnN0aXR1Y2lvbmFsIGRlIEFjZXNzbyBBYmVydG8gZGEgRklPQ1JVWiAtIEZVTkRBw4fDg08KT1NXQUxETyBDUlVaIGUgYXMgZGlyZXRyaXplcyBwYXJhIG8gZnVuY2lvbmFtZW50byBkbyByZXBvc2l0w7NyaW8gaW5zdGl0dWNpb25hbCBBUkNBLgoKQSBQb2zDrXRpY2EgSW5zdGl0dWNpb25hbCBkZSBBY2Vzc28gQWJlcnRvIGRhIEZJT0NSVVogLSBGVU5EQcOHw4NPIE9TV0FMRE8gQ1JVWiByZXNlcnZhCmV4Y2x1c2l2YW1lbnRlIGFvIEFVVE9SIG9zIGRpcmVpdG9zIG1vcmFpcyBlIG9zIHVzb3MgY29tZXJjaWFpcyBzb2JyZSBhcyBvYnJhcyBkZSBzdWEgYXV0b3JpYQplL291IHRpdHVsYXJpZGFkZSwgc2VuZG8gb3MgdGVyY2Vpcm9zIHVzdcOhcmlvcyByZXNwb25zw6F2ZWlzIHBlbGEgYXRyaWJ1acOnw6NvIGRlIGF1dG9yaWEgZSBtYW51dGVuw6fDo28KZGEgaW50ZWdyaWRhZGUgZGEgT0JSQSBlbSBxdWFscXVlciB1dGlsaXphw6fDo28uCgpBIFBvbMOtdGljYSBJbnN0aXR1Y2lvbmFsIGRlIEFjZXNzbyBBYmVydG8gZGEgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaCnJlc3BlaXRhIG9zIGNvbnRyYXRvcyBlIGFjb3Jkb3MgcHJlZXhpc3RlbnRlcyBkb3MgQXV0b3JlcyBjb20gdGVyY2Vpcm9zLCBjYWJlbmRvIGFvcyBBdXRvcmVzCmluZm9ybWFyIMOgIEluc3RpdHVpw6fDo28gYXMgY29uZGnDp8O1ZXMgZSBvdXRyYXMgcmVzdHJpw6fDtWVzIGltcG9zdGFzIHBvciBlc3RlcyBpbnN0cnVtZW50b3MuCg==Repositório 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dc.title.pt_BR.fl_str_mv |
NK Cell Responses in Zika Virus Infection Are Biased towards Cytokine-Mediated Effector Functions |
title |
NK Cell Responses in Zika Virus Infection Are Biased towards Cytokine-Mediated Effector Functions |
spellingShingle |
NK Cell Responses in Zika Virus Infection Are Biased towards Cytokine-Mediated Effector Functions Maucourant, Christopher Zika virus Infecção por Zika virus Microcefalia Flavivirus Células Dendríticas Zika virus Zika Virus Infection Microcephaly Flavavirus Dendritic Cells |
title_short |
NK Cell Responses in Zika Virus Infection Are Biased towards Cytokine-Mediated Effector Functions |
title_full |
NK Cell Responses in Zika Virus Infection Are Biased towards Cytokine-Mediated Effector Functions |
title_fullStr |
NK Cell Responses in Zika Virus Infection Are Biased towards Cytokine-Mediated Effector Functions |
title_full_unstemmed |
NK Cell Responses in Zika Virus Infection Are Biased towards Cytokine-Mediated Effector Functions |
title_sort |
NK Cell Responses in Zika Virus Infection Are Biased towards Cytokine-Mediated Effector Functions |
author |
Maucourant, Christopher |
author_facet |
Maucourant, Christopher Queiroz, Gabriel Andrade Nonato Corneau, Aurelien Gois, Luana Leandro Kheddar, Aida Meghraoui Tarantino, Nadine Bandeira, Antonio Carlos Samri, Assia Blanc, Catherine Yssel, Hans Grassi, Maria Fernanda Rios Vieillard, Vincent |
author_role |
author |
author2 |
Queiroz, Gabriel Andrade Nonato Corneau, Aurelien Gois, Luana Leandro Kheddar, Aida Meghraoui Tarantino, Nadine Bandeira, Antonio Carlos Samri, Assia Blanc, Catherine Yssel, Hans Grassi, Maria Fernanda Rios Vieillard, Vincent |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Maucourant, Christopher Queiroz, Gabriel Andrade Nonato Corneau, Aurelien Gois, Luana Leandro Kheddar, Aida Meghraoui Tarantino, Nadine Bandeira, Antonio Carlos Samri, Assia Blanc, Catherine Yssel, Hans Grassi, Maria Fernanda Rios Vieillard, Vincent |
dc.subject.other.pt_BR.fl_str_mv |
Zika virus Infecção por Zika virus Microcefalia Flavivirus Células Dendríticas |
topic |
Zika virus Infecção por Zika virus Microcefalia Flavivirus Células Dendríticas Zika virus Zika Virus Infection Microcephaly Flavavirus Dendritic Cells |
dc.subject.en.pt_BR.fl_str_mv |
Zika virus Zika Virus Infection Microcephaly Flavavirus Dendritic Cells |
description |
European Union Horizon 2020 ZIKAlliance Program (grant agreement 734548) and by the Coordination of Superior Level Staff Improvement-Brazil (CAPES Finance Code 001). C.M. received a Ph.D. fellowship from the French Ministry of Education; L.L.G. received a grant from the French Society for Cytometry; and M.F.R.G. is a research fellow of the National Council for Scientific and Technological Development (CNPq) and Foundation for the Development of Private Higher Education from Brazil. |
publishDate |
2021 |
dc.date.accessioned.fl_str_mv |
2021-11-26T11:32:56Z |
dc.date.available.fl_str_mv |
2021-11-26T11:32:56Z |
dc.date.issued.fl_str_mv |
2021 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
MAUCOURANT, Christopher et al. NK Cell Responses in Zika Virus Infection Are Biased towards Cytokine-Mediated Effector Functions. Journal of Immunology, v. 207, p. 1333 1343, 2021. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/50070 |
dc.identifier.issn.pt_BR.fl_str_mv |
0022-1767 |
dc.identifier.doi.none.fl_str_mv |
10.4049/jimmunol.2001180 |
identifier_str_mv |
MAUCOURANT, Christopher et al. NK Cell Responses in Zika Virus Infection Are Biased towards Cytokine-Mediated Effector Functions. Journal of Immunology, v. 207, p. 1333 1343, 2021. 0022-1767 10.4049/jimmunol.2001180 |
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https://www.arca.fiocruz.br/handle/icict/50070 |
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eng |
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eng |
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American Association of Immunologists |
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American Association of Immunologists |
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