Schistosoma mansoni Tegument (Smteg) Induces IL-10 and Modulates Experimental Airway Inflammation
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/19495 |
Resumo: | Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Laboratório de Imunologia de Doenças Infecciosas. Belo Horizonte, MG, Brazil |
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Marinho, Fábio Antônio VitarelliAlves, Clarice CarvalhoSouza, Sara Camila deSilva, Cintia Maria Gonçalves daCassali, Geovanni DantasOliveira, Sergio CostaPacifico, Lucila Grossi GonçalvesFonseca, Cristina Toscano2017-06-22T17:45:00Z2017-06-22T17:45:00Z2016MARINHO, Fábio Vitarelli, et al. Schistosoma mansoni Tegument (Smteg) Induces IL-10 and Modulates Experimental Airway Inflammation. PLoS ONE, v. 11, n. 7, art. e0160118.1932-6203https://www.arca.fiocruz.br/handle/icict/1949510.1371/journal.pone.0160118engPublic Library of ScienceEsquistosomoseinflamaçãoInflammationMouse modelsAsthmaCytokinesEosinophilsCollagensInflammatory diseasesSchistosoma mansoniSchistosoma mansoni Tegument (Smteg) Induces IL-10 and Modulates Experimental Airway Inflammationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Laboratório de Imunologia de Doenças Infecciosas. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biologia e Imunologia Parasitária. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biologia e Imunologia Parasitária. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biologia e Imunologia Parasitária. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Departamento de Patologia. Laboratório de Patologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Laboratório de Imunologia de Doenças Infecciosas. Belo Horizonte, MG, Brazil/Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biologia e Imunologia Parasitária Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biologia e Imunologia Parasitária Belo Horizonte, MG, Brazil/Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais . Salvador, BA, BrazilBackground: Previous studies have demonstrated that S. mansoni infection and inoculation of the parasite eggs and antigens are able to modulate airways inflammation induced by OVA in mice. This modulation was associated to an enhanced production of interleukin-10 and to an increased number of regulatory T cells. The S. mansoni schistosomulum is the first stage to come into contact with the host immune system and its tegument represents the host-parasite interface. The schistosomula tegument (Smteg) has never been studied in the context of modulation of inflammatory disorders, although immune evasion mechanisms take place in this phase of infection to guarantee the persistence of the parasite in the host. Methodology and Principal Findings: The aim of this study was to evaluate the Smteg ability to modulate inflammation in an experimental airway inflammation model induced by OVA and to characterize the immune factors involved in this modulation. To achieve the objective, BALB/c mice were sensitized with ovalbumin (OVA) and then challenged with OVA aerosol after Smteg intraperitoneal inoculation. Protein extravasation and inflammatory cells were assessed in bronchoalveolar lavage and IgE levels were measured in serum. Additionally, lungs were excised for histopathological analyses, cytokine measurement and characterization of the cell populations. Inoculation with Smteg led to a reduction in the protein levels in bronchoalveolar lavage (BAL) and eosinophils in both BAL and lung tissue. In the lung tissue there was a reduction in inflammatory cells and collagen deposition as well as in IL-5, IL-13, IL-25 and CCL11 levels. Additionally, a decrease in specific anti-OVA IgE levels was observed. The reduction observed in these inflammatory parameters was associated with increased levels of IL-10 in lung tissues. Furthermore, Smteg/asthma mice showed high percentage of CD11b+F4/80+IL-10+ and CD11c+CD11b+IL-10+ cells in lungs. Conclusion: Taken together, these findings demonstrate that S. mansoni schistosomula tegument can modulates experimental airway inflammation.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/19495/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALve_Marinho_Fabio_Schistosoma mansoni Tegument_CPqRR_2016 .pdfve_Marinho_Fabio_Schistosoma mansoni Tegument_CPqRR_2016 .pdfapplication/pdf880332https://www.arca.fiocruz.br/bitstream/icict/19495/2/ve_Marinho_Fabio_Schistosoma%20mansoni%20Tegument_CPqRR_2016%20.pdf92aa2eaf28ad18662156035fa4527548MD52TEXTve_Marinho_Fabio_Schistosoma mansoni Tegument_CPqRR_2016 .pdf.txtve_Marinho_Fabio_Schistosoma mansoni Tegument_CPqRR_2016 .pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Schistosoma mansoni Tegument (Smteg) Induces IL-10 and Modulates Experimental Airway Inflammation |
| title |
Schistosoma mansoni Tegument (Smteg) Induces IL-10 and Modulates Experimental Airway Inflammation |
| spellingShingle |
Schistosoma mansoni Tegument (Smteg) Induces IL-10 and Modulates Experimental Airway Inflammation Marinho, Fábio Antônio Vitarelli Esquistosomose inflamação Inflammation Mouse models Asthma Cytokines Eosinophils Collagens Inflammatory diseases Schistosoma mansoni |
| title_short |
Schistosoma mansoni Tegument (Smteg) Induces IL-10 and Modulates Experimental Airway Inflammation |
| title_full |
Schistosoma mansoni Tegument (Smteg) Induces IL-10 and Modulates Experimental Airway Inflammation |
| title_fullStr |
Schistosoma mansoni Tegument (Smteg) Induces IL-10 and Modulates Experimental Airway Inflammation |
| title_full_unstemmed |
Schistosoma mansoni Tegument (Smteg) Induces IL-10 and Modulates Experimental Airway Inflammation |
| title_sort |
Schistosoma mansoni Tegument (Smteg) Induces IL-10 and Modulates Experimental Airway Inflammation |
| author |
Marinho, Fábio Antônio Vitarelli |
| author_facet |
Marinho, Fábio Antônio Vitarelli Alves, Clarice Carvalho Souza, Sara Camila de Silva, Cintia Maria Gonçalves da Cassali, Geovanni Dantas Oliveira, Sergio Costa Pacifico, Lucila Grossi Gonçalves Fonseca, Cristina Toscano |
| author_role |
author |
| author2 |
Alves, Clarice Carvalho Souza, Sara Camila de Silva, Cintia Maria Gonçalves da Cassali, Geovanni Dantas Oliveira, Sergio Costa Pacifico, Lucila Grossi Gonçalves Fonseca, Cristina Toscano |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Marinho, Fábio Antônio Vitarelli Alves, Clarice Carvalho Souza, Sara Camila de Silva, Cintia Maria Gonçalves da Cassali, Geovanni Dantas Oliveira, Sergio Costa Pacifico, Lucila Grossi Gonçalves Fonseca, Cristina Toscano |
| dc.subject.other.pt_BR.fl_str_mv |
Esquistosomose inflamação |
| topic |
Esquistosomose inflamação Inflammation Mouse models Asthma Cytokines Eosinophils Collagens Inflammatory diseases Schistosoma mansoni |
| dc.subject.en.pt_BR.fl_str_mv |
Inflammation Mouse models Asthma Cytokines Eosinophils Collagens Inflammatory diseases Schistosoma mansoni |
| description |
Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Laboratório de Imunologia de Doenças Infecciosas. Belo Horizonte, MG, Brazil |
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2016 |
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2016 |
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2017-06-22T17:45:00Z |
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2017-06-22T17:45:00Z |
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MARINHO, Fábio Vitarelli, et al. Schistosoma mansoni Tegument (Smteg) Induces IL-10 and Modulates Experimental Airway Inflammation. PLoS ONE, v. 11, n. 7, art. e0160118. |
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https://www.arca.fiocruz.br/handle/icict/19495 |
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1932-6203 |
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10.1371/journal.pone.0160118 |
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MARINHO, Fábio Vitarelli, et al. Schistosoma mansoni Tegument (Smteg) Induces IL-10 and Modulates Experimental Airway Inflammation. PLoS ONE, v. 11, n. 7, art. e0160118. 1932-6203 10.1371/journal.pone.0160118 |
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