Schistosoma mansoni antigens modulate the allergic response in a murine model of ovalbumin-induced airway inflammation

Detalhes bibliográficos
Autor(a) principal: Cardoso, Luciana Santos
Data de Publicação: 2010
Outros Autores: Oliveira, Sergio Costa, Góes, Alfredo Miranda de, Oliveira, Ricardo Riccio, Pacífico, Lucila Grossi Gonçalves, Marinho, Fábio Antônio Vitarelli, Fonseca, Cristina Toscano, Cardoso, Fernanda Caldas, Carvalho Filho, Edgar Marcelino, Araujo, Maria Ilma Andrade Santos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/27505
Resumo: Oliveira, Ricardo Riccio; Carvalho Filho, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
id CRUZ_d8db2bb9ccea87a9d5cefcde4289a7e5
oai_identifier_str oai:www.arca.fiocruz.br:icict/27505
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Cardoso, Luciana SantosOliveira, Sergio CostaGóes, Alfredo Miranda deOliveira, Ricardo RiccioPacífico, Lucila Grossi GonçalvesMarinho, Fábio Antônio VitarelliFonseca, Cristina ToscanoCardoso, Fernanda CaldasCarvalho Filho, Edgar MarcelinoAraujo, Maria Ilma Andrade Santos2018-07-12T13:53:30Z2018-07-12T13:53:30Z2010Schistosoma mansoni antigens modulate the allergic response in a murine model of ovalbumin-induced airway inflammation0009-9104https://www.arca.fiocruz.br/handle/icict/2750510.1111/j.1365-2249.2009.04084.xOliveira, Ricardo Riccio; Carvalho Filho, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.Brazilian National Research Council (CNPq). M. I. A., S. C. O. and E. M. C. are investigators supported by CNPq.Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal University de Minas Gerais. Departamento de Imunologia e Bioquímica. Belo Horizonte, MG, BrasilUniversidade Federal University de Minas Gerais. Departamento de Imunologia e Bioquímica. Belo Horizonte, MG, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal University de Minas Gerais. Departamento de Imunologia e Bioquímica. Belo Horizonte, MG, BrasilUniversidade Federal University de Minas Gerais. Departamento de Imunologia e Bioquímica. Belo Horizonte, MG, BrasilUniversidade Federal University de Minas Gerais. Departamento de Imunologia e Bioquímica. Belo Horizonte, MG, BrasilUniversidade Federal University de Minas Gerais. Departamento de Imunologia e Bioquímica. Belo Horizonte, MG, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, BrasilSchistosoma mansoni infection has been associated with protection against allergies. The mechanisms underlying this association may involve regulatory cells and cytokines. We evaluated the immune response induced by the S. mansoni antigens Sm22.6, PIII and Sm29 in a murine model of ovalbumin (OVA)-induced airway inflammation. BALB/c mice were sensitized with subcutaneously injected OVA-alum and challenged with aerolized OVA. Mice were given three doses of the different S. mansoni antigens. Lung histopathology, cellularity of bronchoalveolar lavage (BAL) and eosinophil peroxidase activity in lung were evaluated. Immunoglobulin (Ig)E levels in serum and cytokines in BAL were also measured. Additionally, we evaluated the frequency of CD4+forkhead box P3 (FoxP3)+ T cells in cultures stimulated with OVA and the expression of interleukin (IL)-10 by these cells. The number of total cells and eosinophils in BAL and the levels of OVA-specific IgE were reduced in the immunized mice. Also, the levels of IL-4 and IL-5 in the BAL of mice immunized with PIII and Sm22.6 were decreased, while the levels of IL-10 were higher in mice immunized with Sm22.6 compared to the non-immunized mice. The frequency of CD4+FoxP3+ T cells was higher in the groups of mice who received Sm22.6, Sm29 and PIII, being the expression of IL-10 by these cells only higher in mice immunized with Sm22.6. We concluded that the S. mansoni antigens used in this study are able to down-modulate allergic inflammatory mediators in a murine model of airway inflammation and that the CD4+FoxP3+ T cells, even in the absence of IL-10 expression, might play an important role in this process.engWileyAlergiaAsmaVacinasSchistosoma mansoniAllergyAsthmaVaccinesSchistosoma mansoniSchistosoma mansoni antigens modulate the allergic response in a murine model of ovalbumin-induced airway inflammationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/27505/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCardoso LS Schistosoma mansoni ... ovalbumin-induced.....pdfCardoso LS Schistosoma mansoni ... ovalbumin-induced.....pdfapplication/pdf466426https://www.arca.fiocruz.br/bitstream/icict/27505/2/Cardoso%20LS%20Schistosoma%20mansoni%20...%20ovalbumin-induced.....pdf69fc480793bf9c7c7fe0e9bf761648faMD52TEXTCardoso LS Schistosoma mansoni ... ovalbumin-induced.....pdf.txtCardoso LS Schistosoma mansoni ... ovalbumin-induced.....pdf.txtExtracted texttext/plain42798https://www.arca.fiocruz.br/bitstream/icict/27505/3/Cardoso%20LS%20Schistosoma%20mansoni%20...%20ovalbumin-induced.....pdf.txtf85a8e1a98ba6267c894deba595a9ff6MD53icict/275052023-03-15 14:34:14.179oai:www.arca.fiocruz.br:icict/27505Q0VTU8ODTyBOw4NPIEVYQ0xVU0lWQSBERSBESVJFSVRPUyBBVVRPUkFJUwoKQW8gYWNlaXRhciBvcyBURVJNT1MgZSBDT05EScOHw5VFUyBkZXN0YSBDRVNTw4NPLCBvIEFVVE9SIGUvb3UgVElUVUxBUiBkZSBkaXJlaXRvcwphdXRvcmFpcyBzb2JyZSBhIE9CUkEgZGUgcXVlIHRyYXRhIGVzdGUgZG9jdW1lbnRvOgoKKDEpIENFREUgZSBUUkFOU0ZFUkUsIHRvdGFsIGUgZ3JhdHVpdGFtZW50ZSwgw6AgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaLCBlbQpjYXLDoXRlciBwZXJtYW5lbnRlLCBpcnJldm9nw6F2ZWwgZSBOw4NPIEVYQ0xVU0lWTywgdG9kb3Mgb3MgZGlyZWl0b3MgcGF0cmltb25pYWlzIE7Dg08KQ09NRVJDSUFJUyBkZSB1dGlsaXphw6fDo28gZGEgT0JSQSBhcnTDrXN0aWNhIGUvb3UgY2llbnTDrWZpY2EgaW5kaWNhZGEgYWNpbWEsIGluY2x1c2l2ZSBvcyBkaXJlaXRvcwpkZSB2b3ogZSBpbWFnZW0gdmluY3VsYWRvcyDDoCBPQlJBLCBkdXJhbnRlIHRvZG8gbyBwcmF6byBkZSBkdXJhw6fDo28gZG9zIGRpcmVpdG9zIGF1dG9yYWlzLCBlbQpxdWFscXVlciBpZGlvbWEgZSBlbSB0b2RvcyBvcyBwYcOtc2VzOwoKKDIpIEFDRUlUQSBxdWUgYSBjZXNzw6NvIHRvdGFsIG7Do28gZXhjbHVzaXZhLCBwZXJtYW5lbnRlIGUgaXJyZXZvZ8OhdmVsIGRvcyBkaXJlaXRvcyBhdXRvcmFpcwpwYXRyaW1vbmlhaXMgbsOjbyBjb21lcmNpYWlzIGRlIHV0aWxpemHDp8OjbyBkZSBxdWUgdHJhdGEgZXN0ZSBkb2N1bWVudG8gaW5jbHVpLCBleGVtcGxpZmljYXRpdmFtZW50ZSwKb3MgZGlyZWl0b3MgZGUgZGlzcG9uaWJpbGl6YcOnw6NvIGUgY29tdW5pY2HDp8OjbyBww7pibGljYSBkYSBPQlJBLCBlbSBxdWFscXVlciBtZWlvIG91IHZlw61jdWxvLAppbmNsdXNpdmUgZW0gUmVwb3NpdMOzcmlvcyBEaWdpdGFpcywgYmVtIGNvbW8gb3MgZGlyZWl0b3MgZGUgcmVwcm9kdcOnw6NvLCBleGliacOnw6NvLCBleGVjdcOnw6NvLApkZWNsYW1hw6fDo28sIHJlY2l0YcOnw6NvLCBleHBvc2nDp8OjbywgYXJxdWl2YW1lbnRvLCBpbmNsdXPDo28gZW0gYmFuY28gZGUgZGFkb3MsIHByZXNlcnZhw6fDo28sIGRpZnVzw6NvLApkaXN0cmlidWnDp8OjbywgZGl2dWxnYcOnw6NvLCBlbXByw6lzdGltbywgdHJhZHXDp8OjbywgZHVibGFnZW0sIGxlZ2VuZGFnZW0sIGluY2x1c8OjbyBlbSBub3ZhcyBvYnJhcyBvdQpjb2xldMOibmVhcywgcmV1dGlsaXphw6fDo28sIGVkacOnw6NvLCBwcm9kdcOnw6NvIGRlIG1hdGVyaWFsIGRpZMOhdGljbyBlIGN1cnNvcyBvdSBxdWFscXVlciBmb3JtYSBkZQp1dGlsaXphw6fDo28gbsOjbyBjb21lcmNpYWw7CgooMykgUkVDT05IRUNFIHF1ZSBhIGNlc3PDo28gYXF1aSBlc3BlY2lmaWNhZGEgY29uY2VkZSDDoCBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPCkNSVVogbyBkaXJlaXRvIGRlIGF1dG9yaXphciBxdWFscXVlciBwZXNzb2Eg4oCTIGbDrXNpY2Egb3UganVyw61kaWNhLCBww7pibGljYSBvdSBwcml2YWRhLCBuYWNpb25hbCBvdQplc3RyYW5nZWlyYSDigJMgYSBhY2Vzc2FyIGUgdXRpbGl6YXIgYW1wbGFtZW50ZSBhIE9CUkEsIHNlbSBleGNsdXNpdmlkYWRlLCBwYXJhIHF1YWlzcXVlcgpmaW5hbGlkYWRlcyBuw6NvIGNvbWVyY2lhaXM7CgooNCkgREVDTEFSQSBxdWUgYSBvYnJhIMOpIGNyaWHDp8OjbyBvcmlnaW5hbCBlIHF1ZSDDqSBvIHRpdHVsYXIgZG9zIGRpcmVpdG9zIGFxdWkgY2VkaWRvcyBlIGF1dG9yaXphZG9zLApyZXNwb25zYWJpbGl6YW5kby1zZSBpbnRlZ3JhbG1lbnRlIHBlbG8gY29udGXDumRvIGUgb3V0cm9zIGVsZW1lbnRvcyBxdWUgZmF6ZW0gcGFydGUgZGEgT0JSQSwKaW5jbHVzaXZlIG9zIGRpcmVpdG9zIGRlIHZveiBlIGltYWdlbSB2aW5jdWxhZG9zIMOgIE9CUkEsIG9icmlnYW5kby1zZSBhIGluZGVuaXphciB0ZXJjZWlyb3MgcG9yCmRhbm9zLCBiZW0gY29tbyBpbmRlbml6YXIgZSByZXNzYXJjaXIgYSBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVogZGUKZXZlbnR1YWlzIGRlc3Blc2FzIHF1ZSB2aWVyZW0gYSBzdXBvcnRhciwgZW0gcmF6w6NvIGRlIHF1YWxxdWVyIG9mZW5zYSBhIGRpcmVpdG9zIGF1dG9yYWlzIG91CmRpcmVpdG9zIGRlIHZveiBvdSBpbWFnZW0sIHByaW5jaXBhbG1lbnRlIG5vIHF1ZSBkaXogcmVzcGVpdG8gYSBwbMOhZ2lvIGUgdmlvbGHDp8O1ZXMgZGUgZGlyZWl0b3M7CgooNSkgQUZJUk1BIHF1ZSBjb25oZWNlIGEgUG9sw610aWNhIEluc3RpdHVjaW9uYWwgZGUgQWNlc3NvIEFiZXJ0byBkYSBGSU9DUlVaIC0gRlVOREHDh8ODTwpPU1dBTERPIENSVVogZSBhcyBkaXJldHJpemVzIHBhcmEgbyBmdW5jaW9uYW1lbnRvIGRvIHJlcG9zaXTDs3JpbyBpbnN0aXR1Y2lvbmFsIEFSQ0EuCgpBIFBvbMOtdGljYSBJbnN0aXR1Y2lvbmFsIGRlIEFjZXNzbyBBYmVydG8gZGEgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaIHJlc2VydmEKZXhjbHVzaXZhbWVudGUgYW8gQVVUT1Igb3MgZGlyZWl0b3MgbW9yYWlzIGUgb3MgdXNvcyBjb21lcmNpYWlzIHNvYnJlIGFzIG9icmFzIGRlIHN1YSBhdXRvcmlhCmUvb3UgdGl0dWxhcmlkYWRlLCBzZW5kbyBvcyB0ZXJjZWlyb3MgdXN1w6FyaW9zIHJlc3BvbnPDoXZlaXMgcGVsYSBhdHJpYnVpw6fDo28gZGUgYXV0b3JpYSBlIG1hbnV0ZW7Dp8OjbwpkYSBpbnRlZ3JpZGFkZSBkYSBPQlJBIGVtIHF1YWxxdWVyIHV0aWxpemHDp8Ojby4KCkEgUG9sw610aWNhIEluc3RpdHVjaW9uYWwgZGUgQWNlc3NvIEFiZXJ0byBkYSBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVoKcmVzcGVpdGEgb3MgY29udHJhdG9zIGUgYWNvcmRvcyBwcmVleGlzdGVudGVzIGRvcyBBdXRvcmVzIGNvbSB0ZXJjZWlyb3MsIGNhYmVuZG8gYW9zIEF1dG9yZXMKaW5mb3JtYXIgw6AgSW5zdGl0dWnDp8OjbyBhcyBjb25kacOnw7VlcyBlIG91dHJhcyByZXN0cmnDp8O1ZXMgaW1wb3N0YXMgcG9yIGVzdGVzIGluc3RydW1lbnRvcy4KRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:14Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Schistosoma mansoni antigens modulate the allergic response in a murine model of ovalbumin-induced airway inflammation
title Schistosoma mansoni antigens modulate the allergic response in a murine model of ovalbumin-induced airway inflammation
spellingShingle Schistosoma mansoni antigens modulate the allergic response in a murine model of ovalbumin-induced airway inflammation
Cardoso, Luciana Santos
Alergia
Asma
Vacinas
Schistosoma mansoni
Allergy
Asthma
Vaccines
Schistosoma mansoni
title_short Schistosoma mansoni antigens modulate the allergic response in a murine model of ovalbumin-induced airway inflammation
title_full Schistosoma mansoni antigens modulate the allergic response in a murine model of ovalbumin-induced airway inflammation
title_fullStr Schistosoma mansoni antigens modulate the allergic response in a murine model of ovalbumin-induced airway inflammation
title_full_unstemmed Schistosoma mansoni antigens modulate the allergic response in a murine model of ovalbumin-induced airway inflammation
title_sort Schistosoma mansoni antigens modulate the allergic response in a murine model of ovalbumin-induced airway inflammation
author Cardoso, Luciana Santos
author_facet Cardoso, Luciana Santos
Oliveira, Sergio Costa
Góes, Alfredo Miranda de
Oliveira, Ricardo Riccio
Pacífico, Lucila Grossi Gonçalves
Marinho, Fábio Antônio Vitarelli
Fonseca, Cristina Toscano
Cardoso, Fernanda Caldas
Carvalho Filho, Edgar Marcelino
Araujo, Maria Ilma Andrade Santos
author_role author
author2 Oliveira, Sergio Costa
Góes, Alfredo Miranda de
Oliveira, Ricardo Riccio
Pacífico, Lucila Grossi Gonçalves
Marinho, Fábio Antônio Vitarelli
Fonseca, Cristina Toscano
Cardoso, Fernanda Caldas
Carvalho Filho, Edgar Marcelino
Araujo, Maria Ilma Andrade Santos
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cardoso, Luciana Santos
Oliveira, Sergio Costa
Góes, Alfredo Miranda de
Oliveira, Ricardo Riccio
Pacífico, Lucila Grossi Gonçalves
Marinho, Fábio Antônio Vitarelli
Fonseca, Cristina Toscano
Cardoso, Fernanda Caldas
Carvalho Filho, Edgar Marcelino
Araujo, Maria Ilma Andrade Santos
dc.subject.other.pt_BR.fl_str_mv Alergia
Asma
Vacinas
Schistosoma mansoni
topic Alergia
Asma
Vacinas
Schistosoma mansoni
Allergy
Asthma
Vaccines
Schistosoma mansoni
dc.subject.en.pt_BR.fl_str_mv Allergy
Asthma
Vaccines
Schistosoma mansoni
description Oliveira, Ricardo Riccio; Carvalho Filho, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2018-07-12T13:53:30Z
dc.date.available.fl_str_mv 2018-07-12T13:53:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv Schistosoma mansoni antigens modulate the allergic response in a murine model of ovalbumin-induced airway inflammation
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/27505
dc.identifier.issn.pt_BR.fl_str_mv 0009-9104
dc.identifier.doi.none.fl_str_mv 10.1111/j.1365-2249.2009.04084.x
identifier_str_mv Schistosoma mansoni antigens modulate the allergic response in a murine model of ovalbumin-induced airway inflammation
0009-9104
10.1111/j.1365-2249.2009.04084.x
url https://www.arca.fiocruz.br/handle/icict/27505
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/27505/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/27505/2/Cardoso%20LS%20Schistosoma%20mansoni%20...%20ovalbumin-induced.....pdf
https://www.arca.fiocruz.br/bitstream/icict/27505/3/Cardoso%20LS%20Schistosoma%20mansoni%20...%20ovalbumin-induced.....pdf.txt
bitstream.checksum.fl_str_mv 5a560609d32a3863062d77ff32785d58
69fc480793bf9c7c7fe0e9bf761648fa
f85a8e1a98ba6267c894deba595a9ff6
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1813008984276205568

Registros relacionados