Paraprobiotics and Postbiotics of Lactobacillus delbrueckii CIDCA 133 Mitigate 5-FU-Induced Intestinal Inflammation

Detalhes bibliográficos
Autor(a) principal: Batista, Viviane Lima
Data de Publicação: 2022
Outros Autores: Jesus, Luís Cláudio Lima De, Tavares, Laísa Macedo, Barroso, Fernanda Lima Alvarenga, Fernandes, Lucas Jorge da Silva, Freitas, Andria dos Santos, Americo, Monique Ferrary, Drumond, Mariana Martins, Mancha-Agresti, Pamela, Ferreira, Enio, Laguna, Juliana Guimarães, Alcantara, Luiz Carlos Júnior, Azevedo, Vasco
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/56360
Resumo: Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Belo Horizonte, MG, Brasil.
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spelling Batista, Viviane LimaJesus, Luís Cláudio Lima DeTavares, Laísa MacedoBarroso, Fernanda Lima AlvarengaFernandes, Lucas Jorge da SilvaFreitas, Andria dos SantosAmerico, Monique FerraryDrumond, Mariana MartinsMancha-Agresti, PamelaFerreira, EnioLaguna, Juliana GuimarãesAlcantara, Luiz Carlos JúniorAzevedo, Vasco2023-01-07T14:23:59Z2023-01-07T14:23:59Z2022BATISTA, Viviane Lima et al. Paraprobiotics and Postbiotics of Lactobacillus delbrueckii CIDCA 133 Mitigate 5-FU-Induced Intestinal Inflammation. Microorganisms, v. 10, 1418, p. 1-18, July 2022.2076-2607https://www.arca.fiocruz.br/handle/icict/5636010.3390/ microorganisms10071418engMDPIMucositeQuimioterapiaDanos intestinaisBactérias mortas pelo calorSobrenadante livre de célulasImunomodulaçãoMarcador de barreira epitelialMucositisChemotherapyIntestinal damageHeat-killed bacteriaCell-free supernatantImmunomodulationEpithelial barrier markersParaprobiotics and Postbiotics of Lactobacillus delbrueckii CIDCA 133 Mitigate 5-FU-Induced Intestinal Inflammationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Belo Horizonte, MG, Brasil.Centro Federal de Educação Tecnológica de Minas Gerais. Departamento de Ciências Biológicas. Belo Horizonte, MG, Brasil.Centro Federal de Educação Tecnológica de Minas Gerais. Departamento de Ciências Biológicas. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Departamento de Patologia Geral. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Belo Horizonte, MG, Brasil.Intestinal mucositis is a commonly reported side effect in oncology practice. Probiotics are considered an excellent alternative therapeutic approach to this debilitating condition; however, there are safety questions regarding the viable consumption of probiotics in clinical practice due to the risks of systemic infections, especially in immune-compromised patients. The use of heat-killed or cell-free supernatants derived from probiotic strains has been evaluated to minimize these adverse effects. Thus, this work evaluated the anti-inflammatory properties of paraprobiotics (heat-killed) and postbiotics (cell-free supernatant) of the probiotic Lactobacillus delbrueckii CIDCA 133 strain in a mouse model of 5-Fluorouracil drug-induced mucositis. Administration of paraprobiotics and postbiotics reduced the neutrophil cells infiltrating into the small intestinal mucosa and ameliorated the intestinal epithelium architecture damaged by 5-FU. These ameliorative effects were associated with a downregulation of inflammatory markers (Tlr2, Nfkb1, Il12, Il17a, Il1b, Tnf ), and upregulation of immunoregulatory Il10 cytokine and the epithelial barrier markers Ocln, Cldn1, 2, 5, Hp and Muc2. Thus, heat-killed L. delbrueckii CIDCA 133 and supernatants derived from this strain were shown to be effective in reducing 5-FU-induced inflammatory damage, demonstrating them to be an alternative approach to the problems arising from the use of live beneficial microorganisms in clinical practice.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/56360/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALVivianeLBatista_LuizCJuniorAlcantara_etal_IOC_2022.pdfVivianeLBatista_LuizCJuniorAlcantara_etal_IOC_2022.pdfapplication/pdf3579772https://www.arca.fiocruz.br/bitstream/icict/56360/2/VivianeLBatista_LuizCJuniorAlcantara_etal_IOC_2022.pdf4ae27d72234a3c1f9de499716bb1e833MD52icict/563602023-09-04 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dc.title.en_US.fl_str_mv Paraprobiotics and Postbiotics of Lactobacillus delbrueckii CIDCA 133 Mitigate 5-FU-Induced Intestinal Inflammation
title Paraprobiotics and Postbiotics of Lactobacillus delbrueckii CIDCA 133 Mitigate 5-FU-Induced Intestinal Inflammation
spellingShingle Paraprobiotics and Postbiotics of Lactobacillus delbrueckii CIDCA 133 Mitigate 5-FU-Induced Intestinal Inflammation
Batista, Viviane Lima
Mucosite
Quimioterapia
Danos intestinais
Bactérias mortas pelo calor
Sobrenadante livre de células
Imunomodulação
Marcador de barreira epitelial
Mucositis
Chemotherapy
Intestinal damage
Heat-killed bacteria
Cell-free supernatant
Immunomodulation
Epithelial barrier markers
title_short Paraprobiotics and Postbiotics of Lactobacillus delbrueckii CIDCA 133 Mitigate 5-FU-Induced Intestinal Inflammation
title_full Paraprobiotics and Postbiotics of Lactobacillus delbrueckii CIDCA 133 Mitigate 5-FU-Induced Intestinal Inflammation
title_fullStr Paraprobiotics and Postbiotics of Lactobacillus delbrueckii CIDCA 133 Mitigate 5-FU-Induced Intestinal Inflammation
title_full_unstemmed Paraprobiotics and Postbiotics of Lactobacillus delbrueckii CIDCA 133 Mitigate 5-FU-Induced Intestinal Inflammation
title_sort Paraprobiotics and Postbiotics of Lactobacillus delbrueckii CIDCA 133 Mitigate 5-FU-Induced Intestinal Inflammation
author Batista, Viviane Lima
author_facet Batista, Viviane Lima
Jesus, Luís Cláudio Lima De
Tavares, Laísa Macedo
Barroso, Fernanda Lima Alvarenga
Fernandes, Lucas Jorge da Silva
Freitas, Andria dos Santos
Americo, Monique Ferrary
Drumond, Mariana Martins
Mancha-Agresti, Pamela
Ferreira, Enio
Laguna, Juliana Guimarães
Alcantara, Luiz Carlos Júnior
Azevedo, Vasco
author_role author
author2 Jesus, Luís Cláudio Lima De
Tavares, Laísa Macedo
Barroso, Fernanda Lima Alvarenga
Fernandes, Lucas Jorge da Silva
Freitas, Andria dos Santos
Americo, Monique Ferrary
Drumond, Mariana Martins
Mancha-Agresti, Pamela
Ferreira, Enio
Laguna, Juliana Guimarães
Alcantara, Luiz Carlos Júnior
Azevedo, Vasco
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Batista, Viviane Lima
Jesus, Luís Cláudio Lima De
Tavares, Laísa Macedo
Barroso, Fernanda Lima Alvarenga
Fernandes, Lucas Jorge da Silva
Freitas, Andria dos Santos
Americo, Monique Ferrary
Drumond, Mariana Martins
Mancha-Agresti, Pamela
Ferreira, Enio
Laguna, Juliana Guimarães
Alcantara, Luiz Carlos Júnior
Azevedo, Vasco
dc.subject.other.en_US.fl_str_mv Mucosite
Quimioterapia
Danos intestinais
Bactérias mortas pelo calor
Sobrenadante livre de células
Imunomodulação
Marcador de barreira epitelial
topic Mucosite
Quimioterapia
Danos intestinais
Bactérias mortas pelo calor
Sobrenadante livre de células
Imunomodulação
Marcador de barreira epitelial
Mucositis
Chemotherapy
Intestinal damage
Heat-killed bacteria
Cell-free supernatant
Immunomodulation
Epithelial barrier markers
dc.subject.en.en_US.fl_str_mv Mucositis
Chemotherapy
Intestinal damage
Heat-killed bacteria
Cell-free supernatant
Immunomodulation
Epithelial barrier markers
description Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Belo Horizonte, MG, Brasil.
publishDate 2022
dc.date.issued.fl_str_mv 2022
dc.date.accessioned.fl_str_mv 2023-01-07T14:23:59Z
dc.date.available.fl_str_mv 2023-01-07T14:23:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BATISTA, Viviane Lima et al. Paraprobiotics and Postbiotics of Lactobacillus delbrueckii CIDCA 133 Mitigate 5-FU-Induced Intestinal Inflammation. Microorganisms, v. 10, 1418, p. 1-18, July 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/56360
dc.identifier.issn.en_US.fl_str_mv 2076-2607
dc.identifier.doi.none.fl_str_mv 10.3390/ microorganisms10071418
identifier_str_mv BATISTA, Viviane Lima et al. Paraprobiotics and Postbiotics of Lactobacillus delbrueckii CIDCA 133 Mitigate 5-FU-Induced Intestinal Inflammation. Microorganisms, v. 10, 1418, p. 1-18, July 2022.
2076-2607
10.3390/ microorganisms10071418
url https://www.arca.fiocruz.br/handle/icict/56360
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/56360/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/56360/2/VivianeLBatista_LuizCJuniorAlcantara_etal_IOC_2022.pdf
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