Enhanced Expression of Hedgehog Pathway Proteins in Oral Epithelial Dysplasia
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/18073 |
Resumo: | National Council for Scientific and Technological Development (CNPq, Brazil). Foundation to Support Research in the State of Bahia (FAPESB, Bahia, Brazil) |
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Dias, Rosane BorgesValverde, Ludmila de FaroSales, Caroline Brandi SchlaepferGuimarães, Vanessa Sousa NazaréCabral, Márcia GrilloXavier, Flávia Caló de AquinoSantos, Jean Nunes dosRamos, Eduardo Antônio GonçalvesRocha, Clarissa Araújo Gurgel2017-03-17T16:54:02Z2017-03-17T16:54:02Z2016DIAS, R. B. et al. Enhanced Expression of Hedgehog Pathway Proteins in Oral Epithelial Dysplasia. Applied Immunohistochemistry & Molecular Morphology, v. 24, p. 595–602, 2016.1541-2016https://www.arca.fiocruz.br/handle/icict/1807310.1097/PAI.0000000000000225National Council for Scientific and Technological Development (CNPq, Brazil). Foundation to Support Research in the State of Bahia (FAPESB, Bahia, Brazil)Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilFederal University of Rio de Janeiro. School of Dentistry. Department of Pathology and Oral Diagnosis. Rio de Janeiro, RJ, BrazilFederal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, BrazilFederal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, BrazilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, BrazilThe aim of this study was to characterize the profile of the proteins involved in the Hedgehog signaling pathway to aid in the understanding of the pathogenesis of oral epithelial dysplasia (OED). The proteins SHH, PTCH1, HHIP, SUFU, GLI1, and cyclin D1 were evaluated by immunohistochemistry in 25 cases of OED, 4 of non-neoplasic oral mucosa, 8 of inflammatory fibrous hyperplasia and 5 of hyperkeratosis. SHH proteins were predominant in OED cases. Although PTCH1 protein was observed in all cases, this molecule was more highly expressed in OED. The inhibitor protein SUFU was present in OED and HHIP protein was overexpressed in OED. GLI1 proteins were predominantly found in the nuclei of epithelial cells in OED. Basal and suprabasal cells in the epithelial lining were positive for cyclin D1 only in OED. In conclusion, comparative analysis of the proteins involved in the Hedgehog pathway suggests that enhanced expression of these proteins can play an important role in the biological behavior of OED.engLippincott, Williams & WilkinsDisplasia epitelial oralProteínas HedgehogLesão pré-malignaOral epithelial dysplasiaHedgehog proteinsPremalignant lesionEnhanced Expression of Hedgehog Pathway Proteins in Oral Epithelial Dysplasiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/18073/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALDias RB Enhanced....pdfDias RB Enhanced....pdfapplication/pdf443668https://www.arca.fiocruz.br/bitstream/icict/18073/2/Dias%20RB%20Enhanced....pdf2e650998b99a17d38ac6e02573e73502MD52TEXTDias RB 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14:33:28.988oai:www.arca.fiocruz.br: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ório 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| dc.title.pt_BR.fl_str_mv |
Enhanced Expression of Hedgehog Pathway Proteins in Oral Epithelial Dysplasia |
| title |
Enhanced Expression of Hedgehog Pathway Proteins in Oral Epithelial Dysplasia |
| spellingShingle |
Enhanced Expression of Hedgehog Pathway Proteins in Oral Epithelial Dysplasia Dias, Rosane Borges Displasia epitelial oral Proteínas Hedgehog Lesão pré-maligna Oral epithelial dysplasia Hedgehog proteins Premalignant lesion |
| title_short |
Enhanced Expression of Hedgehog Pathway Proteins in Oral Epithelial Dysplasia |
| title_full |
Enhanced Expression of Hedgehog Pathway Proteins in Oral Epithelial Dysplasia |
| title_fullStr |
Enhanced Expression of Hedgehog Pathway Proteins in Oral Epithelial Dysplasia |
| title_full_unstemmed |
Enhanced Expression of Hedgehog Pathway Proteins in Oral Epithelial Dysplasia |
| title_sort |
Enhanced Expression of Hedgehog Pathway Proteins in Oral Epithelial Dysplasia |
| author |
Dias, Rosane Borges |
| author_facet |
Dias, Rosane Borges Valverde, Ludmila de Faro Sales, Caroline Brandi Schlaepfer Guimarães, Vanessa Sousa Nazaré Cabral, Márcia Grillo Xavier, Flávia Caló de Aquino Santos, Jean Nunes dos Ramos, Eduardo Antônio Gonçalves Rocha, Clarissa Araújo Gurgel |
| author_role |
author |
| author2 |
Valverde, Ludmila de Faro Sales, Caroline Brandi Schlaepfer Guimarães, Vanessa Sousa Nazaré Cabral, Márcia Grillo Xavier, Flávia Caló de Aquino Santos, Jean Nunes dos Ramos, Eduardo Antônio Gonçalves Rocha, Clarissa Araújo Gurgel |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Dias, Rosane Borges Valverde, Ludmila de Faro Sales, Caroline Brandi Schlaepfer Guimarães, Vanessa Sousa Nazaré Cabral, Márcia Grillo Xavier, Flávia Caló de Aquino Santos, Jean Nunes dos Ramos, Eduardo Antônio Gonçalves Rocha, Clarissa Araújo Gurgel |
| dc.subject.other.pt_BR.fl_str_mv |
Displasia epitelial oral Proteínas Hedgehog Lesão pré-maligna |
| topic |
Displasia epitelial oral Proteínas Hedgehog Lesão pré-maligna Oral epithelial dysplasia Hedgehog proteins Premalignant lesion |
| dc.subject.en.pt_BR.fl_str_mv |
Oral epithelial dysplasia Hedgehog proteins Premalignant lesion |
| description |
National Council for Scientific and Technological Development (CNPq, Brazil). Foundation to Support Research in the State of Bahia (FAPESB, Bahia, Brazil) |
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2016 |
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2016 |
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2017-03-17T16:54:02Z |
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2017-03-17T16:54:02Z |
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DIAS, R. B. et al. Enhanced Expression of Hedgehog Pathway Proteins in Oral Epithelial Dysplasia. Applied Immunohistochemistry & Molecular Morphology, v. 24, p. 595–602, 2016. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/18073 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1541-2016 |
| dc.identifier.doi.none.fl_str_mv |
10.1097/PAI.0000000000000225 |
| identifier_str_mv |
DIAS, R. B. et al. Enhanced Expression of Hedgehog Pathway Proteins in Oral Epithelial Dysplasia. Applied Immunohistochemistry & Molecular Morphology, v. 24, p. 595–602, 2016. 1541-2016 10.1097/PAI.0000000000000225 |
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Lippincott, Williams & Wilkins |
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