Exercise–Linked Irisin: Consequences on Mental and Cardiovascular Health in Type 2 Diabetes

Detalhes bibliográficos
Autor(a) principal: Sousa, Ricardo Augusto Leoni de
Data de Publicação: 2021
Outros Autores: Caria, Alex Cleber Improta, Souza, Bruno Solano de Freitas
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/46875
Resumo: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior-Brazil (CAPES)—Finance Code 001.
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spelling Sousa, Ricardo Augusto Leoni deCaria, Alex Cleber ImprotaSouza, Bruno Solano de Freitas2021-04-24T13:35:48Z2021-04-24T13:35:48Z2021SOUSA, Ricardo Augusto Leoni de; CARIA, Alex Cleber Improta; SOUZA, Bruno Solano de Freitas. Exercise–Linked Irisin: Consequences on Mental and Cardiovascular Health in Type 2 Diabetes. International Journal of Molecular Sciences, v. 22, p. 1-15, 2021.1661-6596https://www.arca.fiocruz.br/handle/icict/4687510.3390/ijms22042199Coordenação de Aperfeiçoamento de Pessoal de Nível Superior-Brazil (CAPES)—Finance Code 001.Multicenter Post Graduation Program in Physiological Sciences, Brazilian Society of PhysiologyFederal University of the Valleys of Jequitinhonha and Mucuri. Diamantina, MG, Brazil / Federal University of the Valleys of Jequitinhonha and Mucuri. Neuroscience and Exercise Study Group. Diamantina, MG, Brazil.Federal University of Bahia. Faculty of Medicine. Post-Graduate Program in Medicine and Health. Salvador, BA, Brazil / Brazilian Society of Cardiology. Department of Physical Education in Cardiology. Salvador, BA , Brazil / São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil.São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Type 2 diabetes mellitus (T2DM) is a metabolic disorder associated with insulin resistance and hyperglycemia. Chronic exposure to a T2DM microenvironment with hyperglycemia, hyperinsulinemia, oxidative stress and increased levels of proinflammatory mediators, has negative consequences to the cardiovascular system and mental health. Therefore, atherosclerotic cardiovascular diseases (CVD) and mental health issues have been strongly associated with T2DM. Lifestyle modifications, including physical exercise training, are necessary to prevent T2DM development and its associated complications. It is widely known that the regular practice of exercise provides several physiological benefits to subjects with T2DM, such as managing glycemic and blood pressure levels. Different types of exercise, from aerobic to resistance training, are effective to improve mental health and cognitive function in T2DM. Irisin is a myokine produced in response to exercise, which has been pointed as a relevant mechanism of action to explain the benefits of exercise on cardiovascular and mental health in T2DM patients. Here, we review emerging clinical and experimental evidence about exercise-linked irisin consequences to cardiovascular and mental health in T2DM.engMDPIExercício físicoResistência a insulinaDiabetes Mellitus Tipo 2CogniçãoComplicaçõesHiperglicemiaPhysical activityInsulin resistanceInflammationCognitive declineMemoryDementiaExercise–Linked Irisin: Consequences on Mental and Cardiovascular Health in Type 2 Diabetesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/46875/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALSousa, Ricardo Augusto Leoni Exercise-Linked....pdfSousa, Ricardo Augusto Leoni Exercise-Linked....pdfapplication/pdf1848926https://www.arca.fiocruz.br/bitstream/icict/46875/2/Sousa%2c%20Ricardo%20Augusto%20Leoni%20Exercise-Linked....pdf762ce3fcac918d3ec107ff65ef92a4b5MD52TEXTSousa, Ricardo Augusto Leoni Exercise-Linked....pdf.txtSousa, Ricardo Augusto Leoni Exercise-Linked....pdf.txtExtracted texttext/plain76714https://www.arca.fiocruz.br/bitstream/icict/46875/3/Sousa%2c%20Ricardo%20Augusto%20Leoni%20Exercise-Linked....pdf.txtac0c925ad35c2f7b26e5e43101aa5ee5MD53icict/468752023-03-15 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dc.title.pt_BR.fl_str_mv Exercise–Linked Irisin: Consequences on Mental and Cardiovascular Health in Type 2 Diabetes
title Exercise–Linked Irisin: Consequences on Mental and Cardiovascular Health in Type 2 Diabetes
spellingShingle Exercise–Linked Irisin: Consequences on Mental and Cardiovascular Health in Type 2 Diabetes
Sousa, Ricardo Augusto Leoni de
Exercício físico
Resistência a insulina
Diabetes Mellitus Tipo 2
Cognição
Complicações
Hiperglicemia
Physical activity
Insulin resistance
Inflammation
Cognitive decline
Memory
Dementia
title_short Exercise–Linked Irisin: Consequences on Mental and Cardiovascular Health in Type 2 Diabetes
title_full Exercise–Linked Irisin: Consequences on Mental and Cardiovascular Health in Type 2 Diabetes
title_fullStr Exercise–Linked Irisin: Consequences on Mental and Cardiovascular Health in Type 2 Diabetes
title_full_unstemmed Exercise–Linked Irisin: Consequences on Mental and Cardiovascular Health in Type 2 Diabetes
title_sort Exercise–Linked Irisin: Consequences on Mental and Cardiovascular Health in Type 2 Diabetes
author Sousa, Ricardo Augusto Leoni de
author_facet Sousa, Ricardo Augusto Leoni de
Caria, Alex Cleber Improta
Souza, Bruno Solano de Freitas
author_role author
author2 Caria, Alex Cleber Improta
Souza, Bruno Solano de Freitas
author2_role author
author
dc.contributor.author.fl_str_mv Sousa, Ricardo Augusto Leoni de
Caria, Alex Cleber Improta
Souza, Bruno Solano de Freitas
dc.subject.other.pt_BR.fl_str_mv Exercício físico
Resistência a insulina
Diabetes Mellitus Tipo 2
Cognição
Complicações
Hiperglicemia
topic Exercício físico
Resistência a insulina
Diabetes Mellitus Tipo 2
Cognição
Complicações
Hiperglicemia
Physical activity
Insulin resistance
Inflammation
Cognitive decline
Memory
Dementia
dc.subject.en.pt_BR.fl_str_mv Physical activity
Insulin resistance
Inflammation
Cognitive decline
Memory
Dementia
description Coordenação de Aperfeiçoamento de Pessoal de Nível Superior-Brazil (CAPES)—Finance Code 001.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-04-24T13:35:48Z
dc.date.available.fl_str_mv 2021-04-24T13:35:48Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SOUSA, Ricardo Augusto Leoni de; CARIA, Alex Cleber Improta; SOUZA, Bruno Solano de Freitas. Exercise–Linked Irisin: Consequences on Mental and Cardiovascular Health in Type 2 Diabetes. International Journal of Molecular Sciences, v. 22, p. 1-15, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/46875
dc.identifier.issn.pt_BR.fl_str_mv 1661-6596
dc.identifier.doi.none.fl_str_mv 10.3390/ijms22042199
identifier_str_mv SOUSA, Ricardo Augusto Leoni de; CARIA, Alex Cleber Improta; SOUZA, Bruno Solano de Freitas. Exercise–Linked Irisin: Consequences on Mental and Cardiovascular Health in Type 2 Diabetes. International Journal of Molecular Sciences, v. 22, p. 1-15, 2021.
1661-6596
10.3390/ijms22042199
url https://www.arca.fiocruz.br/handle/icict/46875
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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