The Role of Neuregulin 1 in Schizophrenia: A Bioinformatics Approach

Detalhes bibliográficos
Autor(a) principal: Dias, Álvaro Machado
Data de Publicação: 2009
Outros Autores: Coutinho, Vinícius Maracaja, Queiroz, Artur Trancoso Lopo de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/27512
Resumo: Queiroz, Artur Trancoso Lopo. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento.
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spelling Dias, Álvaro MachadoCoutinho, Vinícius MaracajaQueiroz, Artur Trancoso Lopo de2018-07-12T17:06:08Z2018-07-12T17:06:08Z2009DIAS, Álvaro Machado; COUTINHO, Vinícius Maracaja; QUEIROZ, Artur Trancoso Lopo de. The Role of Neuregulin 1 in Schizophrenia: A Bioinformatics Approach. Nature Precedings, p. 1-8, 2009.1756-0357https://www.arca.fiocruz.br/handle/icict/27512Queiroz, Artur Trancoso Lopo. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento.University of São Paulo. Institute of Psychology. Deptartment of Neuroscience and Behavior. São Paulo, SP, Brazil.University of São Paulo. Department of Biochemistry. São Paulo, SP, Brazil.University of São Paulo. Department of Bioscience. São Paulo, SP, Brazil.Abstract. Context: Notwithstanding the great number of studies on the etiology and pathophysiology of schizophrenia, both issues remain far from being fully understood. Schizophrenia seems to be related to several biochemical abnormalities, which point to a multi-factor etiology and pathophysiology, as well as to the perspective that several etiologically diverse disorders might coexist within this nosographic entity. On the other hand, identical twins reveal a high concordance for schizophrenia. From that standpoint, the perspective that structurally-related proteins may play an important and yet non-deterministic role seems attractive. Among these proteins, it is suggestive that Neuregulin 1 exerts a pivotal role. Objective: This paper aims to uncover the most prominent relations that Neuregulin 1 establishes with schizophrenia. Method: Several bioinformatical methods are used in order to present: 1. A visual representation of Neuregulin 1’s main molecular pathways, associated with a discussion about their importance to schizophrenia research; 2. A new heatmap of Neuregulin 1 and its receptor’s expression in brain tissues most relevant to the understanding of schizophrenia, created after the development of new R programming scripts (described elsewhere), which facilitate the analysis of gene expression profiles in public datasets; 3. A conceptual map of the literature retrieved using the keywords ‘Neuregulin 1 and human’ in PubMed, followed by a discussion of the most relevant sub-topics. Results: Neuregulin 1 polymorphisms affect several brain tissues and contribute to the etiology and pathophysiology of schizophrenia. Suggestively, Neuregulin 1 partially bridges the 'molecular gap' that schizophrenia establishes in relation to bipolar disorder and Alzheimer disease, which involves genes that affect several brain networks, at the same time that they are highly dependent on noxious environmental variables to be triggered.engEsquizofreniaBioinformáticaPsiquiatria MolecularGenéticaSchizophreniaBioinformaticsMolecular PsychiatryGeneticsThe Role of Neuregulin 1 in Schizophrenia: A Bioinformatics Approachinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/27512/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALDias AL The Role of Neuregulin 1 in Schizophrenia....pdfDias AL The Role of Neuregulin 1 in 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dc.title.pt_BR.fl_str_mv The Role of Neuregulin 1 in Schizophrenia: A Bioinformatics Approach
title The Role of Neuregulin 1 in Schizophrenia: A Bioinformatics Approach
spellingShingle The Role of Neuregulin 1 in Schizophrenia: A Bioinformatics Approach
Dias, Álvaro Machado
Esquizofrenia
Bioinformática
Psiquiatria Molecular
Genética
Schizophrenia
Bioinformatics
Molecular Psychiatry
Genetics
title_short The Role of Neuregulin 1 in Schizophrenia: A Bioinformatics Approach
title_full The Role of Neuregulin 1 in Schizophrenia: A Bioinformatics Approach
title_fullStr The Role of Neuregulin 1 in Schizophrenia: A Bioinformatics Approach
title_full_unstemmed The Role of Neuregulin 1 in Schizophrenia: A Bioinformatics Approach
title_sort The Role of Neuregulin 1 in Schizophrenia: A Bioinformatics Approach
author Dias, Álvaro Machado
author_facet Dias, Álvaro Machado
Coutinho, Vinícius Maracaja
Queiroz, Artur Trancoso Lopo de
author_role author
author2 Coutinho, Vinícius Maracaja
Queiroz, Artur Trancoso Lopo de
author2_role author
author
dc.contributor.author.fl_str_mv Dias, Álvaro Machado
Coutinho, Vinícius Maracaja
Queiroz, Artur Trancoso Lopo de
dc.subject.other.pt_BR.fl_str_mv Esquizofrenia
Bioinformática
Psiquiatria Molecular
Genética
topic Esquizofrenia
Bioinformática
Psiquiatria Molecular
Genética
Schizophrenia
Bioinformatics
Molecular Psychiatry
Genetics
dc.subject.en.pt_BR.fl_str_mv Schizophrenia
Bioinformatics
Molecular Psychiatry
Genetics
description Queiroz, Artur Trancoso Lopo. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento.
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2018-07-12T17:06:08Z
dc.date.available.fl_str_mv 2018-07-12T17:06:08Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv DIAS, Álvaro Machado; COUTINHO, Vinícius Maracaja; QUEIROZ, Artur Trancoso Lopo de. The Role of Neuregulin 1 in Schizophrenia: A Bioinformatics Approach. Nature Precedings, p. 1-8, 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/27512
dc.identifier.issn.pt_BR.fl_str_mv 1756-0357
identifier_str_mv DIAS, Álvaro Machado; COUTINHO, Vinícius Maracaja; QUEIROZ, Artur Trancoso Lopo de. The Role of Neuregulin 1 in Schizophrenia: A Bioinformatics Approach. Nature Precedings, p. 1-8, 2009.
1756-0357
url https://www.arca.fiocruz.br/handle/icict/27512
dc.language.iso.fl_str_mv eng
language eng
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