Clinical features, fungal load, coinfections, histological skin changes, and itraconazole treatment response of cats with sporotrichosis caused by Sporothrix brasiliensis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/27723 |
Resumo: | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. |
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Souza, Elaine Waite deBorba, Cintia de MoraesPereira, Sandro AntonioGremião, Isabella Dib FerreiraLangohr, Ingeborg MariaOliveira, Manoel Marques EvangelistaOliveira, Raquel de Vasconcellos Carvalhaes deCunha, Camila Rocha deZancopé-Oliveira, Rosely MariaMiranda, Luisa Helena Monteiro deMenezes, Rodrigo Caldas2018-07-30T18:13:40Z2018-07-30T18:13:40Z2018SOUZA, Elaine Waite de et al. Clinical features, fungal load, coinfections, histological skin changes, and itraconazole treatment response of cats with sporotrichosis caused by Sporothrix brasiliensis. Scientific Reports, v. 8, p. 1-10, 2018.2045-2322https://www.arca.fiocruz.br/handle/icict/2772310.1038/s41598-018-27447-5engClinical features, fungal load, coinfections, histological skin changes, and itraconazole treatment response of cats with sporotrichosis caused by Sporothrix brasiliensisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.School of Veterinary Medicine. Louisiana State University, Baton Rouge. Los Angeles, USA.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Zoonotic sporotrichosis caused by the fungus Sporothrix brasiliensis is usually severe in cats. This study investigated the associations between clinical features, fungal load, coinfections, histological skin changes, and response to itraconazole in cats with sporotrichosis caused by S. brasiliensis. Fifty-two cats with skin lesions and a definitive diagnosis of sporotrichosis were treated with itraconazole for a maximum period of 36 weeks. The animals were submitted to clinical examination and two subsequent collections of samples from the same skin lesion for fungal diagnosis and histopathology, as well as serology for feline immunodeficiency (FIV) and leukaemia (FeLV) viruses. Thirty-seven (71%) cats were clinically cured. Nasal mucosa lesions and respiratory signs were associated with treatment failure. Cats coinfected with FIV/FeLV (n = 12) had a lower neutrophil count in the lesion. A high fungal load in skin lesions was linked to young age and treatment failure, as well as to a longer time of wound healing, poorly formed granulomas and fewer neutrophils, macrophages and lymphocytes in these lesions. These results indicate that itraconazole is effective, but nasal mucosal involvement, respiratory signs and high fungal loads in skin lesions are predictors of treatment failure that will assist in the development of better treatment protocols for cats.CatsSporothrix brasiliensisSporotrichosisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83100https://www.arca.fiocruz.br/bitstream/icict/27723/1/license.txte0c0e718db411cbd1e3f91252b389ec2MD51ORIGINALSouza_et_al-2018-Scientific_Reports.pdfSouza_et_al-2018-Scientific_Reports.pdfapplication/pdf1890404https://www.arca.fiocruz.br/bitstream/icict/27723/2/Souza_et_al-2018-Scientific_Reports.pdfd0fc4182b13d4a922bcba16273624d7eMD52TEXTSouza_et_al-2018-Scientific_Reports.pdf.txtSouza_et_al-2018-Scientific_Reports.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Clinical features, fungal load, coinfections, histological skin changes, and itraconazole treatment response of cats with sporotrichosis caused by Sporothrix brasiliensis |
| title |
Clinical features, fungal load, coinfections, histological skin changes, and itraconazole treatment response of cats with sporotrichosis caused by Sporothrix brasiliensis |
| spellingShingle |
Clinical features, fungal load, coinfections, histological skin changes, and itraconazole treatment response of cats with sporotrichosis caused by Sporothrix brasiliensis Souza, Elaine Waite de Cats Sporothrix brasiliensis Sporotrichosis |
| title_short |
Clinical features, fungal load, coinfections, histological skin changes, and itraconazole treatment response of cats with sporotrichosis caused by Sporothrix brasiliensis |
| title_full |
Clinical features, fungal load, coinfections, histological skin changes, and itraconazole treatment response of cats with sporotrichosis caused by Sporothrix brasiliensis |
| title_fullStr |
Clinical features, fungal load, coinfections, histological skin changes, and itraconazole treatment response of cats with sporotrichosis caused by Sporothrix brasiliensis |
| title_full_unstemmed |
Clinical features, fungal load, coinfections, histological skin changes, and itraconazole treatment response of cats with sporotrichosis caused by Sporothrix brasiliensis |
| title_sort |
Clinical features, fungal load, coinfections, histological skin changes, and itraconazole treatment response of cats with sporotrichosis caused by Sporothrix brasiliensis |
| author |
Souza, Elaine Waite de |
| author_facet |
Souza, Elaine Waite de Borba, Cintia de Moraes Pereira, Sandro Antonio Gremião, Isabella Dib Ferreira Langohr, Ingeborg Maria Oliveira, Manoel Marques Evangelista Oliveira, Raquel de Vasconcellos Carvalhaes de Cunha, Camila Rocha de Zancopé-Oliveira, Rosely Maria Miranda, Luisa Helena Monteiro de Menezes, Rodrigo Caldas |
| author_role |
author |
| author2 |
Borba, Cintia de Moraes Pereira, Sandro Antonio Gremião, Isabella Dib Ferreira Langohr, Ingeborg Maria Oliveira, Manoel Marques Evangelista Oliveira, Raquel de Vasconcellos Carvalhaes de Cunha, Camila Rocha de Zancopé-Oliveira, Rosely Maria Miranda, Luisa Helena Monteiro de Menezes, Rodrigo Caldas |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Souza, Elaine Waite de Borba, Cintia de Moraes Pereira, Sandro Antonio Gremião, Isabella Dib Ferreira Langohr, Ingeborg Maria Oliveira, Manoel Marques Evangelista Oliveira, Raquel de Vasconcellos Carvalhaes de Cunha, Camila Rocha de Zancopé-Oliveira, Rosely Maria Miranda, Luisa Helena Monteiro de Menezes, Rodrigo Caldas |
| dc.subject.en.pt_BR.fl_str_mv |
Cats Sporothrix brasiliensis Sporotrichosis |
| topic |
Cats Sporothrix brasiliensis Sporotrichosis |
| description |
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. |
| publishDate |
2018 |
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2018-07-30T18:13:40Z |
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2018-07-30T18:13:40Z |
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2018 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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SOUZA, Elaine Waite de et al. Clinical features, fungal load, coinfections, histological skin changes, and itraconazole treatment response of cats with sporotrichosis caused by Sporothrix brasiliensis. Scientific Reports, v. 8, p. 1-10, 2018. |
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https://www.arca.fiocruz.br/handle/icict/27723 |
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2045-2322 |
| dc.identifier.doi.none.fl_str_mv |
10.1038/s41598-018-27447-5 |
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SOUZA, Elaine Waite de et al. Clinical features, fungal load, coinfections, histological skin changes, and itraconazole treatment response of cats with sporotrichosis caused by Sporothrix brasiliensis. Scientific Reports, v. 8, p. 1-10, 2018. 2045-2322 10.1038/s41598-018-27447-5 |
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