HIV-1-Host Interaction in Gut-Associated Lymphoid Tissue (GALT): Effects on Local Environment and Comorbidities.

Detalhes bibliográficos
Autor(a) principal: Moretti, Sonia
Data de Publicação: 2023
Outros Autores: Schietroma, Ivan, Sberna, Giuseppe, Maggiorella, Maria Teresa, Sernicola, Leonardo, Farcomeni, Stefania, Giovanetti, Marta, Ciccozzi, Massimo, Borsetti, Alessandra
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/60687
Resumo: National HIV/AIDS Research Center. Istituto Superiore di Sanità. Rome, Italy
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spelling Moretti, SoniaSchietroma, IvanSberna, GiuseppeMaggiorella, Maria TeresaSernicola, LeonardoFarcomeni, StefaniaGiovanetti, MartaCiccozzi, MassimoBorsetti, Alessandra2023-10-04T15:49:08Z2023-10-04T15:49:08Z2023MORETTI, Sonia et al. HIV-1-Host Interaction in Gut-Associated Lymphoid Tissue (GALT): Effects on Local Environment and Comorbidities. International Journal of Molecular Sciences, v. 24, n. 15, 12193, 2023. doi: 10.3390/ijms241512193.1422-0067https://www.arca.fiocruz.br/handle/icict/60687engMDPIHIV-1-Host Interaction in Gut-Associated Lymphoid Tissue (GALT): Effects on Local Environment and Comorbidities.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleNational HIV/AIDS Research Center. Istituto Superiore di Sanità. Rome, ItalyNational HIV/AIDS Research Center. Istituto Superiore di Sanità. Rome, ItalyNational HIV/AIDS Research Center. Istituto Superiore di Sanità. Rome, ItalyNational HIV/AIDS Research Center. Istituto Superiore di Sanità. Rome, ItalyNational HIV/AIDS Research Center. Istituto Superiore di Sanità. Rome, ItalyNational HIV/AIDS Research Center. Istituto Superiore di Sanità. Rome, ItalyFundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil/Sciences and Technologies for Sustainable Development and One Health. University Campus Bio-Medico of Rome. Rome, ItalyUnit of Medical Statistics and Molecular Epidemiology. University Campus Bio-Medico of Rome. Rome, ItalyNational HIV/AIDS Research Center. Istituto Superiore di Sanità. Rome, ItalyHIV-1 replication in the gastrointestinal (GI) tract causes severe CD4+ T-cell depletion and disruption of the protective epithelial barrier in the intestinal mucosa, causing microbial translocation, the main driver of inflammation and immune activation, even in people living with HIV (PLWH) taking antiretroviral drug therapy. The higher levels of HIV DNA in the gut compared to the blood highlight the importance of the gut as a viral reservoir. CD4+ T-cell subsets in the gut differ in phenotypic characteristics and differentiation status from the ones in other tissues or in peripheral blood, and little is still known about the mechanisms by which the persistence of HIV is maintained at this anatomical site. This review aims to describe the interaction with key subsets of CD4+ T cells in the intestinal mucosa targeted by HIV-1 and the role of gut microbiome and its metabolites in HIV-associated systemic inflammation and immune activation that are crucial in the pathogenesis of HIV infection and related comorbidities.GALTHIV-1 pathogenesisHIV-1 reservoirTfhTh17Tregcomorbiditiesgut dysbiosisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/60687/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALHIV-1–Host Interaction in Gut-Associated Lymphoid Tissue (GALT)_ Effects on Local Environment and Comorbidities.pdfHIV-1–Host Interaction in Gut-Associated Lymphoid Tissue (GALT)_ Effects on Local Environment and Comorbidities.pdfapplication/pdf1125450https://www.arca.fiocruz.br/bitstream/icict/60687/2/HIV-1%e2%80%93Host%20Interaction%20in%20Gut-Associated%20Lymphoid%20Tissue%20%28GALT%29_%20Effects%20on%20Local%20Environment%20and%20Comorbidities.pdfe47625010efad8f9b0ffeb16e9800cc1MD52icict/606872023-10-04 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dc.title.en_US.fl_str_mv HIV-1-Host Interaction in Gut-Associated Lymphoid Tissue (GALT): Effects on Local Environment and Comorbidities.
title HIV-1-Host Interaction in Gut-Associated Lymphoid Tissue (GALT): Effects on Local Environment and Comorbidities.
spellingShingle HIV-1-Host Interaction in Gut-Associated Lymphoid Tissue (GALT): Effects on Local Environment and Comorbidities.
Moretti, Sonia
GALT
HIV-1 pathogenesis
HIV-1 reservoir
Tfh
Th17
Treg
comorbidities
gut dysbiosis
title_short HIV-1-Host Interaction in Gut-Associated Lymphoid Tissue (GALT): Effects on Local Environment and Comorbidities.
title_full HIV-1-Host Interaction in Gut-Associated Lymphoid Tissue (GALT): Effects on Local Environment and Comorbidities.
title_fullStr HIV-1-Host Interaction in Gut-Associated Lymphoid Tissue (GALT): Effects on Local Environment and Comorbidities.
title_full_unstemmed HIV-1-Host Interaction in Gut-Associated Lymphoid Tissue (GALT): Effects on Local Environment and Comorbidities.
title_sort HIV-1-Host Interaction in Gut-Associated Lymphoid Tissue (GALT): Effects on Local Environment and Comorbidities.
author Moretti, Sonia
author_facet Moretti, Sonia
Schietroma, Ivan
Sberna, Giuseppe
Maggiorella, Maria Teresa
Sernicola, Leonardo
Farcomeni, Stefania
Giovanetti, Marta
Ciccozzi, Massimo
Borsetti, Alessandra
author_role author
author2 Schietroma, Ivan
Sberna, Giuseppe
Maggiorella, Maria Teresa
Sernicola, Leonardo
Farcomeni, Stefania
Giovanetti, Marta
Ciccozzi, Massimo
Borsetti, Alessandra
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Moretti, Sonia
Schietroma, Ivan
Sberna, Giuseppe
Maggiorella, Maria Teresa
Sernicola, Leonardo
Farcomeni, Stefania
Giovanetti, Marta
Ciccozzi, Massimo
Borsetti, Alessandra
dc.subject.en.en_US.fl_str_mv GALT
HIV-1 pathogenesis
HIV-1 reservoir
Tfh
Th17
Treg
comorbidities
gut dysbiosis
topic GALT
HIV-1 pathogenesis
HIV-1 reservoir
Tfh
Th17
Treg
comorbidities
gut dysbiosis
description National HIV/AIDS Research Center. Istituto Superiore di Sanità. Rome, Italy
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-10-04T15:49:08Z
dc.date.available.fl_str_mv 2023-10-04T15:49:08Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MORETTI, Sonia et al. HIV-1-Host Interaction in Gut-Associated Lymphoid Tissue (GALT): Effects on Local Environment and Comorbidities. International Journal of Molecular Sciences, v. 24, n. 15, 12193, 2023. doi: 10.3390/ijms241512193.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/60687
dc.identifier.issn.en_US.fl_str_mv 1422-0067
identifier_str_mv MORETTI, Sonia et al. HIV-1-Host Interaction in Gut-Associated Lymphoid Tissue (GALT): Effects on Local Environment and Comorbidities. International Journal of Molecular Sciences, v. 24, n. 15, 12193, 2023. doi: 10.3390/ijms241512193.
1422-0067
url https://www.arca.fiocruz.br/handle/icict/60687
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/60687/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/60687/2/HIV-1%e2%80%93Host%20Interaction%20in%20Gut-Associated%20Lymphoid%20Tissue%20%28GALT%29_%20Effects%20on%20Local%20Environment%20and%20Comorbidities.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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