Implication of Apoptosis for the Pathogenesis of Trypanosoma cruzi Infection

Detalhes bibliográficos
Autor(a) principal: Ricardo, Debora Decote
Data de Publicação: 2017
Outros Autores: Nunes, Marise P., Morrot, Alexandre, Lima, Célio G. Freire de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/20040
Resumo: Universidade Federal Rural do Rio de Janeiro. Instituto de Veterinária. Seropédica, RJ, Brasil.
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spelling Ricardo, Debora DecoteNunes, Marise P.Morrot, AlexandreLima, Célio G. Freire de2017-07-11T15:37:08Z2017-07-11T15:37:08Z2017RICARDO, Débora Decote; et al. Impllication of Apoptosis for the Pathogenesis of Trypanosma cruzii infection. Frontiers in Immunology, v.8, Article 518, 5p, May 2017.1664-3224https://www.arca.fiocruz.br/handle/icict/2004010.3389/fimmu.2017.00518engFrontiers MediaTrypanosoma cruziApoptoseImunomodulaçãoInfecçãoMacrófagosTrypanosoma cruziApoptosisimmunomodulationinfectionmacrophagesImplication of Apoptosis for the Pathogenesis of Trypanosoma cruzi Infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal Rural do Rio de Janeiro. Instituto de Veterinária. Seropédica, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Apoptosis is induced during the course of immune response to different infectious agents, and the ultimate fate is the recognition and uptake of apoptotic bodies by neighboring cells or by professional phagocytes. Apoptotic cells expose specific ligands to a set of conserved receptors expressed on macrophage cellular surface, which are the main cells involved in the clearance of the dying cells. These scavenger receptors, besides triggering the production of anti-inflammatory factors, also block the production of inflammatory mediators by phagocytes. Experimental infection of mice with the parasite Trypanosoma cruzi shows many pathological changes that parallels the evolution of human infection. Leukocytes undergoing intense apoptotic death are observed during the immune response to T. cruzi in the mouse model of the disease. T. cruzi replicate intensely and secrete molecules with immunomodulatory activities that interfere with T cell-mediated immune responses and secretion of pro-inflammatory cytokine secretion. This mechanism of immune evasion allows the infection to be established in the vertebrate host. Under inflammatory conditions, efferocytosis of apoptotic bodies generates an immune-regulatory phenotype in phagocytes, which is conducive to intracellular pathogen replication. However, the relevance of cellular apoptosis in the pathology of Chagas' disease requires further studies. 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dc.title.pt_BR.fl_str_mv Implication of Apoptosis for the Pathogenesis of Trypanosoma cruzi Infection
title Implication of Apoptosis for the Pathogenesis of Trypanosoma cruzi Infection
spellingShingle Implication of Apoptosis for the Pathogenesis of Trypanosoma cruzi Infection
Ricardo, Debora Decote
Trypanosoma cruzi
Apoptose
Imunomodulação
Infecção
Macrófagos
Trypanosoma cruzi
Apoptosis
immunomodulation
infection
macrophages
title_short Implication of Apoptosis for the Pathogenesis of Trypanosoma cruzi Infection
title_full Implication of Apoptosis for the Pathogenesis of Trypanosoma cruzi Infection
title_fullStr Implication of Apoptosis for the Pathogenesis of Trypanosoma cruzi Infection
title_full_unstemmed Implication of Apoptosis for the Pathogenesis of Trypanosoma cruzi Infection
title_sort Implication of Apoptosis for the Pathogenesis of Trypanosoma cruzi Infection
author Ricardo, Debora Decote
author_facet Ricardo, Debora Decote
Nunes, Marise P.
Morrot, Alexandre
Lima, Célio G. Freire de
author_role author
author2 Nunes, Marise P.
Morrot, Alexandre
Lima, Célio G. Freire de
author2_role author
author
author
dc.contributor.author.fl_str_mv Ricardo, Debora Decote
Nunes, Marise P.
Morrot, Alexandre
Lima, Célio G. Freire de
dc.subject.other.pt_BR.fl_str_mv Trypanosoma cruzi
Apoptose
Imunomodulação
Infecção
Macrófagos
topic Trypanosoma cruzi
Apoptose
Imunomodulação
Infecção
Macrófagos
Trypanosoma cruzi
Apoptosis
immunomodulation
infection
macrophages
dc.subject.en.pt_BR.fl_str_mv Trypanosoma cruzi
Apoptosis
immunomodulation
infection
macrophages
description Universidade Federal Rural do Rio de Janeiro. Instituto de Veterinária. Seropédica, RJ, Brasil.
publishDate 2017
dc.date.accessioned.fl_str_mv 2017-07-11T15:37:08Z
dc.date.available.fl_str_mv 2017-07-11T15:37:08Z
dc.date.issued.fl_str_mv 2017
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv RICARDO, Débora Decote; et al. Impllication of Apoptosis for the Pathogenesis of Trypanosma cruzii infection. Frontiers in Immunology, v.8, Article 518, 5p, May 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/20040
dc.identifier.issn.pt_BR.fl_str_mv 1664-3224
dc.identifier.doi.none.fl_str_mv 10.3389/fimmu.2017.00518
identifier_str_mv RICARDO, Débora Decote; et al. Impllication of Apoptosis for the Pathogenesis of Trypanosma cruzii infection. Frontiers in Immunology, v.8, Article 518, 5p, May 2017.
1664-3224
10.3389/fimmu.2017.00518
url https://www.arca.fiocruz.br/handle/icict/20040
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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instacron:FIOCRUZ
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