Vg1 gd T cells regulate type-1/type-2 immune responses and participate in the resistance to infection and development of heart inflammation in Trypanosoma cruzi-infected BALB/c mice.

Detalhes bibliográficos
Autor(a) principal: Nomizo, Auro
Data de Publicação: 2006
Outros Autores: Cardillo, Fabíola, Postol, Edilberto, Pontes-de-Carvalho, Lain Carlos, Mengele Junior, José Orivaldo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/8304
Resumo: University of São Paulo. Department of Clinical Analysis, Toxicology and Bromatology. FCFRP. Ribeirão Preto, SP, Brasil
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spelling Nomizo, AuroCardillo, FabíolaPostol, EdilbertoPontes-de-Carvalho, Lain CarlosMengele Junior, José Orivaldo2014-09-04T16:51:59Z2014-09-04T16:51:59Z2006NOMIZO, A. et al. Vg1 gd T cells regulate type-1/type-2 immune responses and participate in the resistance to infection and development of heart inflammation in Trypanosoma cruzi-infected BALB/c mice. Microbes and Infection, v. 8, n. 3, p. 880-888, 2006.1286-4579https://www.arca.fiocruz.br/handle/icict/830410.1016/j.micinf.2005.10.012engElsevier SASVg1 gd T cells regulate type-1/type-2 immune responses and participate in the resistance to infection and development of heart inflammation in Trypanosoma cruzi-infected BALB/c mice.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity of São Paulo. Department of Clinical Analysis, Toxicology and Bromatology. FCFRP. Ribeirão Preto, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilUniversity of São Paulo. Institute for Biomedical Sciences IV. Department of Immunology. São Paulo, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilMany different cell populations or lineages participate in the resistance to Trypanosoma cruzi infection. gammadelta T cells may also take part in a network of interactions that lead to control of T. cruzi infection with minimal tissue damage by controlling alphabeta T cell activation, as was previously suggested. However, the gammadelta T cell population is not homogeneous and its functions might vary, depending on T cell receptor usage or distinct stimulatory conditions. In this study, we show that the in vivo depletion of V gamma 1-bearing gammadelta T cells, prior to the infection of BALB/c mice with the Y strain of T. cruzi, induces an increased susceptibility to the infection with lower amounts of IFN-gamma being produced by conventional CD4+ or CD8+ T cells. In addition, the production of IL-4 by spleen T cells in V gamma 1-depleted mice was increased and the production of IL-10 remained unchanged. Since V gamma 1(+) gammadelta T cell depletion diminished the conversion of naive to memory/activated CD4 T cells and the production of IFN-gamma during the acute infection, these cells appear to function as helper cells for conventional CD4+ Th1 cells. Depletion of V gamma 1(+) cells also reduced the infection-induced inflammatory infiltrate in the heart and skeletal muscle. More importantly, V gamma 1(+) cells were required for up-regulation of CD40L in CD4+ and CD8+ T cells during infection. These results show that a subset of gammadelta T cells (V gamma 1(+)), which is an important component of the innate immune response, up-regulates the type 1 arm of the adaptative immune response, during T. cruzi infection.Trypanosoma cruziSusceptibilityCD40LIFN-gIL-4Gd T cellsDoença de Chagas/imunologiaCardiopatias/imunologiaInflamação/imunologiaReceptores de Antígenos de Linfócitos T gama-delta/metabolismoSubpopulações de Linfócitos T/imunologiaAnimaisAnticorpos Monoclonais/farmacologiaLigante de CD40/metabolismoInterferon gama/metabolismoCamundongosCamundongos Endogâmicos BALB CCamundongos NusMúsculo Esquelético/metabolismoBaço/citologiaSubpopulações de Linfócitos T/efeitos de drogasRegulação para Cimainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8304/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALNomizo A Vg1 gd T cells regulate......pdfNomizo A Vg1 gd T cells regulate......pdfapplication/pdf627769https://www.arca.fiocruz.br/bitstream/icict/8304/2/Nomizo%20A%20Vg1%20gd%20T%20cells%20regulate......pdf92918c4b307fdc95f4a92d6956008285MD52TEXTNomizo A Vg1 gd T cells regulate......pdf.txtNomizo A Vg1 gd T cells regulate......pdf.txtExtracted texttext/plain35670https://www.arca.fiocruz.br/bitstream/icict/8304/3/Nomizo%20A%20Vg1%20gd%20T%20cells%20regulate......pdf.txt3154f6fb14817056046837c5115cbebaMD53icict/83042023-03-15 14:33:21.252oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:21Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Vg1 gd T cells regulate type-1/type-2 immune responses and participate in the resistance to infection and development of heart inflammation in Trypanosoma cruzi-infected BALB/c mice.
title Vg1 gd T cells regulate type-1/type-2 immune responses and participate in the resistance to infection and development of heart inflammation in Trypanosoma cruzi-infected BALB/c mice.
spellingShingle Vg1 gd T cells regulate type-1/type-2 immune responses and participate in the resistance to infection and development of heart inflammation in Trypanosoma cruzi-infected BALB/c mice.
Nomizo, Auro
Trypanosoma cruzi
Susceptibility
CD40L
IFN-g
IL-4
Gd T cells
Doença de Chagas/imunologia
Cardiopatias/imunologia
Inflamação/imunologia
Receptores de Antígenos de Linfócitos T gama-delta/metabolismo
Subpopulações de Linfócitos T/imunologia
Animais
Anticorpos Monoclonais/farmacologia
Ligante de CD40/metabolismo
Interferon gama/metabolismo
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Nus
Músculo Esquelético/metabolismo
Baço/citologia
Subpopulações de Linfócitos T/efeitos de drogas
Regulação para Cima
title_short Vg1 gd T cells regulate type-1/type-2 immune responses and participate in the resistance to infection and development of heart inflammation in Trypanosoma cruzi-infected BALB/c mice.
title_full Vg1 gd T cells regulate type-1/type-2 immune responses and participate in the resistance to infection and development of heart inflammation in Trypanosoma cruzi-infected BALB/c mice.
title_fullStr Vg1 gd T cells regulate type-1/type-2 immune responses and participate in the resistance to infection and development of heart inflammation in Trypanosoma cruzi-infected BALB/c mice.
title_full_unstemmed Vg1 gd T cells regulate type-1/type-2 immune responses and participate in the resistance to infection and development of heart inflammation in Trypanosoma cruzi-infected BALB/c mice.
title_sort Vg1 gd T cells regulate type-1/type-2 immune responses and participate in the resistance to infection and development of heart inflammation in Trypanosoma cruzi-infected BALB/c mice.
author Nomizo, Auro
author_facet Nomizo, Auro
Cardillo, Fabíola
Postol, Edilberto
Pontes-de-Carvalho, Lain Carlos
Mengele Junior, José Orivaldo
author_role author
author2 Cardillo, Fabíola
Postol, Edilberto
Pontes-de-Carvalho, Lain Carlos
Mengele Junior, José Orivaldo
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Nomizo, Auro
Cardillo, Fabíola
Postol, Edilberto
Pontes-de-Carvalho, Lain Carlos
Mengele Junior, José Orivaldo
dc.subject.en.pt_BR.fl_str_mv Trypanosoma cruzi
Susceptibility
CD40L
IFN-g
IL-4
Gd T cells
topic Trypanosoma cruzi
Susceptibility
CD40L
IFN-g
IL-4
Gd T cells
Doença de Chagas/imunologia
Cardiopatias/imunologia
Inflamação/imunologia
Receptores de Antígenos de Linfócitos T gama-delta/metabolismo
Subpopulações de Linfócitos T/imunologia
Animais
Anticorpos Monoclonais/farmacologia
Ligante de CD40/metabolismo
Interferon gama/metabolismo
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Nus
Músculo Esquelético/metabolismo
Baço/citologia
Subpopulações de Linfócitos T/efeitos de drogas
Regulação para Cima
dc.subject.decs.pt_BR.fl_str_mv Doença de Chagas/imunologia
Cardiopatias/imunologia
Inflamação/imunologia
Receptores de Antígenos de Linfócitos T gama-delta/metabolismo
Subpopulações de Linfócitos T/imunologia
Animais
Anticorpos Monoclonais/farmacologia
Ligante de CD40/metabolismo
Interferon gama/metabolismo
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Nus
Músculo Esquelético/metabolismo
Baço/citologia
Subpopulações de Linfócitos T/efeitos de drogas
Regulação para Cima
description University of São Paulo. Department of Clinical Analysis, Toxicology and Bromatology. FCFRP. Ribeirão Preto, SP, Brasil
publishDate 2006
dc.date.issued.fl_str_mv 2006
dc.date.accessioned.fl_str_mv 2014-09-04T16:51:59Z
dc.date.available.fl_str_mv 2014-09-04T16:51:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv NOMIZO, A. et al. Vg1 gd T cells regulate type-1/type-2 immune responses and participate in the resistance to infection and development of heart inflammation in Trypanosoma cruzi-infected BALB/c mice. Microbes and Infection, v. 8, n. 3, p. 880-888, 2006.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/8304
dc.identifier.issn.none.fl_str_mv 1286-4579
dc.identifier.doi.none.fl_str_mv 10.1016/j.micinf.2005.10.012
identifier_str_mv NOMIZO, A. et al. Vg1 gd T cells regulate type-1/type-2 immune responses and participate in the resistance to infection and development of heart inflammation in Trypanosoma cruzi-infected BALB/c mice. Microbes and Infection, v. 8, n. 3, p. 880-888, 2006.
1286-4579
10.1016/j.micinf.2005.10.012
url https://www.arca.fiocruz.br/handle/icict/8304
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier SAS
publisher.none.fl_str_mv Elsevier SAS
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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