Attenuated nephritis in inducible nitric oxide synthase knockout C57BL/6 mice and pulmonary hemorrhage in CB17 SCID and recombination activating gene 1 knockout C57BL/6 mice infected with Leptospira interrogans.

Bandeira, Maurício; Santos, Cleiton Silva; Azevedo, Everton Cruz de; Soares, Luciane Marieta; Macedo, Júlio Oliveira; Marchi, Samyra; Silva, Caroline Luane Rabelo da; Chagas Júnior, Adenizar Delgado das; McBride, Alan John Alexander; McBride, Flávia Weykamp da Cruz; Reis, Mitermayer Galvão dos; Athanazio, Daniel Abensur

Attenuated nephritis in inducible nitric oxide synthase knockout C57BL/6 mice and pulmonary hemorrhage in CB17 SCID and recombination activating gene 1 knockout C57BL/6 mice infected with Leptospira interrogans.

Detalhes bibliográficos
Autor(a) principal:	Bandeira, Maurício
Data de Publicação:	2011
Outros Autores:	Santos, Cleiton Silva, Azevedo, Everton Cruz de, Soares, Luciane Marieta, Macedo, Júlio Oliveira, Marchi, Samyra, Silva, Caroline Luane Rabelo da, Chagas Júnior, Adenizar Delgado das, McBride, Alan John Alexander, McBride, Flávia Weykamp da Cruz, Reis, Mitermayer Galvão dos, Athanazio, Daniel Abensur
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/7497
Resumo:	Universidade Federal da Bahia. Salvador, BA, Brasil

Metadados do item

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spelling	Bandeira, MaurícioSantos, Cleiton SilvaAzevedo, Everton Cruz deSoares, Luciane MarietaMacedo, Júlio OliveiraMarchi, SamyraSilva, Caroline Luane Rabelo daChagas Júnior, Adenizar Delgado dasMcBride, Alan John AlexanderMcBride, Flávia Weykamp da CruzReis, Mitermayer Galvão dosAthanazio, Daniel Abensur2014-04-04T18:55:38Z2014-04-04T18:55:38Z2011BANDEIRA, M. et al. Attenuated nephritis in inducible nitric oxide synthase knockout C57BL/6 mice and pulmonary hemorrhage in CB17 SCID and recombination activating gene 1 knockout C57BL/6 mice infected with Leptospira interrogans. Infection and Immunity, v. 79, n. 7, p. 2936–2940, 2011.1098-5522https://www.arca.fiocruz.br/handle/icict/749710.1128/IAI.05099-11engAmerican Society for MicrobiologyAttenuated nephritis in inducible nitric oxide synthase knockout C57BL/6 mice and pulmonary hemorrhage in CB17 SCID and recombination activating gene 1 knockout C57BL/6 mice infected with Leptospira interrogans.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilThe aims of this study were to investigate the frequency of pulmonary hemorrhage (PH) in mice unable to produce functional B and T lymphocytes and to explore the effect of an inducible nitric oxide synthase gene (Inos) knockout (KO) on the frequency/severity of interstitial nephritis in vivo. We studied the outcome of infection by the virulent Leptospira interrogans serovar Copenhageni strain Cop. The animals used were Inos KO mice, recombination activating gene 1 (Rag1) KO mice, CB17 severe combined immunodeficiency (SCID) mice, and the respective wild-type (WT) C57BL/6 and BALB/c controls. The Inos KO and WT mice survived with no clinical symptoms of leptospirosis. The frequency and severity of nephritis was significantly lower in the Inos KO mice. All of the Rag1 KO and SCID animals died of acute leptospirosis, whereas all of the WT mice survived. PH was observed in 57 and 94% of Rag1 KO mice and in 83 and 100% of SCID mice, using inoculum doses of 107 and 106 leptospires, respectively. There was no evidence of PH in the WT controls. In conclusion, the loss of the Inos gene had a negligible effect on the outcome of leptospiral infection, although we observed a reduced susceptibility for interstitial nephritis in this group. Of note, the absence of functional B- and T-cell lymphocytes did not preclude the occurrence of PH. These data provide evidence that PH in leptospirosis may not be related only to autoimmune mechanisms.Genes RAG-1Hemorragia/imunologiaLeptospira interrogansLeptospirose/imunologiaPneumopatias/imunologiaNefrite Intersticial/imunologiaÓxido Nítrico Sintase Tipo II/genéticaAnimaisLinfócitos B/imunologiaLeptospirose/microbiologiaCamundongosCamundongos Endogâmicos BALB CCamundongos KnockoutÓxido Nítrico Sintase Tipo II/metabolismoLinfócitos T/imunologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALBandeira M. Attenuated Nephritis.pdfBandeira M. Attenuated Nephritis.pdfapplication/pdf519655https://www.arca.fiocruz.br/bitstream/icict/7497/1/Bandeira%20M.%20Attenuated%20Nephritis.pdf59e2e45aae2e4574fb5462f38c779546MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7497/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTBandeira M. 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dc.title.pt_BR.fl_str_mv	Attenuated nephritis in inducible nitric oxide synthase knockout C57BL/6 mice and pulmonary hemorrhage in CB17 SCID and recombination activating gene 1 knockout C57BL/6 mice infected with Leptospira interrogans.
title	Attenuated nephritis in inducible nitric oxide synthase knockout C57BL/6 mice and pulmonary hemorrhage in CB17 SCID and recombination activating gene 1 knockout C57BL/6 mice infected with Leptospira interrogans.
spellingShingle	Attenuated nephritis in inducible nitric oxide synthase knockout C57BL/6 mice and pulmonary hemorrhage in CB17 SCID and recombination activating gene 1 knockout C57BL/6 mice infected with Leptospira interrogans. Bandeira, Maurício Genes RAG-1 Hemorragia/imunologia Leptospira interrogans Leptospirose/imunologia Pneumopatias/imunologia Nefrite Intersticial/imunologia Óxido Nítrico Sintase Tipo II/genética Animais Linfócitos B/imunologia Leptospirose/microbiologia Camundongos Camundongos Endogâmicos BALB C Camundongos Knockout Óxido Nítrico Sintase Tipo II/metabolismo Linfócitos T/imunologia
title_short	Attenuated nephritis in inducible nitric oxide synthase knockout C57BL/6 mice and pulmonary hemorrhage in CB17 SCID and recombination activating gene 1 knockout C57BL/6 mice infected with Leptospira interrogans.
title_full	Attenuated nephritis in inducible nitric oxide synthase knockout C57BL/6 mice and pulmonary hemorrhage in CB17 SCID and recombination activating gene 1 knockout C57BL/6 mice infected with Leptospira interrogans.
title_fullStr	Attenuated nephritis in inducible nitric oxide synthase knockout C57BL/6 mice and pulmonary hemorrhage in CB17 SCID and recombination activating gene 1 knockout C57BL/6 mice infected with Leptospira interrogans.
title_full_unstemmed	Attenuated nephritis in inducible nitric oxide synthase knockout C57BL/6 mice and pulmonary hemorrhage in CB17 SCID and recombination activating gene 1 knockout C57BL/6 mice infected with Leptospira interrogans.
title_sort	Attenuated nephritis in inducible nitric oxide synthase knockout C57BL/6 mice and pulmonary hemorrhage in CB17 SCID and recombination activating gene 1 knockout C57BL/6 mice infected with Leptospira interrogans.
author	Bandeira, Maurício
author_facet	Bandeira, Maurício Santos, Cleiton Silva Azevedo, Everton Cruz de Soares, Luciane Marieta Macedo, Júlio Oliveira Marchi, Samyra Silva, Caroline Luane Rabelo da Chagas Júnior, Adenizar Delgado das McBride, Alan John Alexander McBride, Flávia Weykamp da Cruz Reis, Mitermayer Galvão dos Athanazio, Daniel Abensur
author_role	author
author2	Santos, Cleiton Silva Azevedo, Everton Cruz de Soares, Luciane Marieta Macedo, Júlio Oliveira Marchi, Samyra Silva, Caroline Luane Rabelo da Chagas Júnior, Adenizar Delgado das McBride, Alan John Alexander McBride, Flávia Weykamp da Cruz Reis, Mitermayer Galvão dos Athanazio, Daniel Abensur
author2_role	author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Bandeira, Maurício Santos, Cleiton Silva Azevedo, Everton Cruz de Soares, Luciane Marieta Macedo, Júlio Oliveira Marchi, Samyra Silva, Caroline Luane Rabelo da Chagas Júnior, Adenizar Delgado das McBride, Alan John Alexander McBride, Flávia Weykamp da Cruz Reis, Mitermayer Galvão dos Athanazio, Daniel Abensur
dc.subject.decs.pt_BR.fl_str_mv	Genes RAG-1 Hemorragia/imunologia Leptospira interrogans Leptospirose/imunologia Pneumopatias/imunologia Nefrite Intersticial/imunologia Óxido Nítrico Sintase Tipo II/genética Animais Linfócitos B/imunologia Leptospirose/microbiologia Camundongos Camundongos Endogâmicos BALB C Camundongos Knockout Óxido Nítrico Sintase Tipo II/metabolismo Linfócitos T/imunologia
topic	Genes RAG-1 Hemorragia/imunologia Leptospira interrogans Leptospirose/imunologia Pneumopatias/imunologia Nefrite Intersticial/imunologia Óxido Nítrico Sintase Tipo II/genética Animais Linfócitos B/imunologia Leptospirose/microbiologia Camundongos Camundongos Endogâmicos BALB C Camundongos Knockout Óxido Nítrico Sintase Tipo II/metabolismo Linfócitos T/imunologia
description	Universidade Federal da Bahia. Salvador, BA, Brasil
publishDate	2011
dc.date.issued.fl_str_mv	2011
dc.date.accessioned.fl_str_mv	2014-04-04T18:55:38Z
dc.date.available.fl_str_mv	2014-04-04T18:55:38Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	BANDEIRA, M. et al. Attenuated nephritis in inducible nitric oxide synthase knockout C57BL/6 mice and pulmonary hemorrhage in CB17 SCID and recombination activating gene 1 knockout C57BL/6 mice infected with Leptospira interrogans. Infection and Immunity, v. 79, n. 7, p. 2936–2940, 2011.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/7497
dc.identifier.issn.none.fl_str_mv	1098-5522
dc.identifier.doi.none.fl_str_mv	10.1128/IAI.05099-11
identifier_str_mv	BANDEIRA, M. et al. Attenuated nephritis in inducible nitric oxide synthase knockout C57BL/6 mice and pulmonary hemorrhage in CB17 SCID and recombination activating gene 1 knockout C57BL/6 mice infected with Leptospira interrogans. Infection and Immunity, v. 79, n. 7, p. 2936–2940, 2011. 1098-5522 10.1128/IAI.05099-11
url	https://www.arca.fiocruz.br/handle/icict/7497
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	American Society for Microbiology
publisher.none.fl_str_mv	American Society for Microbiology
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
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Attenuated nephritis in inducible nitric oxide synthase knockout C57BL/6 mice and pulmonary hemorrhage in CB17 SCID and recombination activating gene 1 knockout C57BL/6 mice infected with Leptospira interrogans.

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