An updated map of Trypanosoma cruzi histone post-translational modifications

Detalhes bibliográficos
Autor(a) principal: Almeida, Rafael Fogaça de
Data de Publicação: 2021
Outros Autores: Fernandes, Matheus, Godoy, Lyris Martins Franco de
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/46835
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
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spelling Almeida, Rafael Fogaça deFernandes, MatheusGodoy, Lyris Martins Franco de2021-04-22T14:09:15Z2021-04-22T14:09:15Z2021ALMEIDA, Rafael Fogaça de et al. An updated map of Trypanosoma cruzi histone post-translational modifications. Scientific Data, v.8 n. 93, p. 1–10, 2021.2052-4463https://www.arca.fiocruz.br/handle/icict/4683510.1038/s41597-021-00818-wporNature ResearchEpigenômicaTrypanosoma cruziHistonesEpigenomicsEpigenómicaHistoneÉpigénomiqueHistonasEpigenéticaAn updated map of Trypanosoma cruzi histone post-translational modificationsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.In humans and other eukaryotes, histone post-translational modifcations (hPTMs) play an essential role in the epigenetic control of gene expression. In trypanosomatid parasites, conversely, gene regulation occurs mainly atthe post-transcriptional level. However, our group has recently shown that hPTMs are abundant and varied in Trypanosoma cruzi,the etiological agent of Chagas Disease, signaling for possible conserved epigenetic functions. Here, we applied an optimized mass spectrometry-based proteomic workfow to provide a high-confdence comprehensive map of hPTMs, distributed in all canonical, variant and linker histones of T. cruzi. Our work expands the number of known T. cruzi hPTMs by almost 2-fold, representing the largest dataset of hPTMs available to any trypanosomatid to date, and can be used as a basis for functional studies on the dynamic regulation of chromatin by epigenetic mechanisms and the selection of candidates forthe development of epigenetic drugs against trypanosomatids.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/46835/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINALs41597-021-00818ok.pdfs41597-021-00818ok.pdfapplication/pdf4207904https://www.arca.fiocruz.br/bitstream/icict/46835/2/s41597-021-00818ok.pdf4271742cec35015e4b194c3e260cfb18MD52TEXTs41597-021-00818ok.pdf.txts41597-021-00818ok.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv An updated map of Trypanosoma cruzi histone post-translational modifications
title An updated map of Trypanosoma cruzi histone post-translational modifications
spellingShingle An updated map of Trypanosoma cruzi histone post-translational modifications
Almeida, Rafael Fogaça de
Epigenômica
Trypanosoma cruzi
Histones
Epigenomics
Epigenómica
Histone
Épigénomique
Histonas
Epigenética
title_short An updated map of Trypanosoma cruzi histone post-translational modifications
title_full An updated map of Trypanosoma cruzi histone post-translational modifications
title_fullStr An updated map of Trypanosoma cruzi histone post-translational modifications
title_full_unstemmed An updated map of Trypanosoma cruzi histone post-translational modifications
title_sort An updated map of Trypanosoma cruzi histone post-translational modifications
author Almeida, Rafael Fogaça de
author_facet Almeida, Rafael Fogaça de
Fernandes, Matheus
Godoy, Lyris Martins Franco de
author_role author
author2 Fernandes, Matheus
Godoy, Lyris Martins Franco de
author2_role author
author
dc.contributor.author.fl_str_mv Almeida, Rafael Fogaça de
Fernandes, Matheus
Godoy, Lyris Martins Franco de
dc.subject.other.pt_BR.fl_str_mv Epigenômica
Trypanosoma cruzi
topic Epigenômica
Trypanosoma cruzi
Histones
Epigenomics
Epigenómica
Histone
Épigénomique
Histonas
Epigenética
dc.subject.en.pt_BR.fl_str_mv Histones
Epigenomics
dc.subject.es.pt_BR.fl_str_mv Epigenómica
dc.subject.fr.pt_BR.fl_str_mv Histone
Épigénomique
dc.subject.decs.pt_BR.fl_str_mv Histonas
Epigenética
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-04-22T14:09:15Z
dc.date.available.fl_str_mv 2021-04-22T14:09:15Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ALMEIDA, Rafael Fogaça de et al. An updated map of Trypanosoma cruzi histone post-translational modifications. Scientific Data, v.8 n. 93, p. 1–10, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/46835
dc.identifier.issn.pt_BR.fl_str_mv 2052-4463
dc.identifier.doi.none.fl_str_mv 10.1038/s41597-021-00818-w
identifier_str_mv ALMEIDA, Rafael Fogaça de et al. An updated map of Trypanosoma cruzi histone post-translational modifications. Scientific Data, v.8 n. 93, p. 1–10, 2021.
2052-4463
10.1038/s41597-021-00818-w
url https://www.arca.fiocruz.br/handle/icict/46835
dc.language.iso.fl_str_mv por
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
institution FIOCRUZ
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