Advances in Development of New Treatment for Leishmaniasis.

Detalhes bibliográficos
Autor(a) principal: Menezes, Juliana Perrone Bezerra de
Data de Publicação: 2015
Outros Autores: Guedes, Carlos Eduardo Sampaio, Petersen, Antonio Luis de Oliveira Almeida, Fraga, Deborah Bittencourt Mothé, Veras, Patrícia Sampaio Tavares
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/13251
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biointervenção. Salvador, BA, Brasil
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spelling Menezes, Juliana Perrone Bezerra deGuedes, Carlos Eduardo SampaioPetersen, Antonio Luis de Oliveira AlmeidaFraga, Deborah Bittencourt MothéVeras, Patrícia Sampaio Tavares2016-03-23T12:31:49Z2016-03-23T12:31:49Z2015MENEZES, J. P. B et al. Advances in Development of New Treatment for Leishmaniasis. BioMed Research International, 815023, 2015.2314-6141https://www.arca.fiocruz.br/handle/icict/13251dx.doi.org/10.1155/2015/815023engHindawi Publishing CorporationAdvances in Development of New Treatment for Leishmaniasis.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biointervenção. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biointervenção. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biointervenção. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biointervenção. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biointervenção. Salvador, BA, BrasilLeishmaniasis is a neglected infectious disease caused by several different species of protozoan parasites of the genus Leishmania. Current strategies to control this disease are mainly based on chemotherapy.Despite being available for the last 70 years, leishmanial chemotherapy has lack of efficiency, since its route of administration is difficult and it can cause serious side effects, which results in the emergence of resistant cases.The medical-scientific community is facing difficulties to overcome these problems with new suitable and efficient drugs, as well as the identification of new drug targets. The availability of the complete genome sequence of Leishmania has given the scientific community the possibility of large-scale analysis, which may lead to better understanding of parasite biology and consequent identification of novel drug targets. In this review we focus on how high-throughput analysis is helping us and other groups to identify novel targets for chemotherapeutic interventions.We further discuss recent data produced by our group regarding the use of the high-throughput techniques and how this helped us to identify and assess the potential of new identified targets.Leishmania/genéticaLeishmaniose/quimioterapiaTerapia de Alvo MolecularSistemas de Liberação de MedicamentosHumanosLeishmania/efeitos de drogasLeishmania/patogenicidadeLeishmaniose/parasitologiaLeishmaniose/fisiopatologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/13251/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMenezes JPB Advances in ....pdfMenezes JPB Advances in 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dc.title.pt_BR.fl_str_mv Advances in Development of New Treatment for Leishmaniasis.
title Advances in Development of New Treatment for Leishmaniasis.
spellingShingle Advances in Development of New Treatment for Leishmaniasis.
Menezes, Juliana Perrone Bezerra de
Leishmania/genética
Leishmaniose/quimioterapia
Terapia de Alvo Molecular
Sistemas de Liberação de Medicamentos
Humanos
Leishmania/efeitos de drogas
Leishmania/patogenicidade
Leishmaniose/parasitologia
Leishmaniose/fisiopatologia
title_short Advances in Development of New Treatment for Leishmaniasis.
title_full Advances in Development of New Treatment for Leishmaniasis.
title_fullStr Advances in Development of New Treatment for Leishmaniasis.
title_full_unstemmed Advances in Development of New Treatment for Leishmaniasis.
title_sort Advances in Development of New Treatment for Leishmaniasis.
author Menezes, Juliana Perrone Bezerra de
author_facet Menezes, Juliana Perrone Bezerra de
Guedes, Carlos Eduardo Sampaio
Petersen, Antonio Luis de Oliveira Almeida
Fraga, Deborah Bittencourt Mothé
Veras, Patrícia Sampaio Tavares
author_role author
author2 Guedes, Carlos Eduardo Sampaio
Petersen, Antonio Luis de Oliveira Almeida
Fraga, Deborah Bittencourt Mothé
Veras, Patrícia Sampaio Tavares
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Menezes, Juliana Perrone Bezerra de
Guedes, Carlos Eduardo Sampaio
Petersen, Antonio Luis de Oliveira Almeida
Fraga, Deborah Bittencourt Mothé
Veras, Patrícia Sampaio Tavares
dc.subject.decs.pt_BR.fl_str_mv Leishmania/genética
Leishmaniose/quimioterapia
Terapia de Alvo Molecular
Sistemas de Liberação de Medicamentos
Humanos
Leishmania/efeitos de drogas
Leishmania/patogenicidade
Leishmaniose/parasitologia
Leishmaniose/fisiopatologia
topic Leishmania/genética
Leishmaniose/quimioterapia
Terapia de Alvo Molecular
Sistemas de Liberação de Medicamentos
Humanos
Leishmania/efeitos de drogas
Leishmania/patogenicidade
Leishmaniose/parasitologia
Leishmaniose/fisiopatologia
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biointervenção. Salvador, BA, Brasil
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-03-23T12:31:49Z
dc.date.available.fl_str_mv 2016-03-23T12:31:49Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MENEZES, J. P. B et al. Advances in Development of New Treatment for Leishmaniasis. BioMed Research International, 815023, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/13251
dc.identifier.issn.none.fl_str_mv 2314-6141
dc.identifier.doi.none.fl_str_mv dx.doi.org/10.1155/2015/815023
identifier_str_mv MENEZES, J. P. B et al. Advances in Development of New Treatment for Leishmaniasis. BioMed Research International, 815023, 2015.
2314-6141
dx.doi.org/10.1155/2015/815023
url https://www.arca.fiocruz.br/handle/icict/13251
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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