Brazilian Network for HIV Drug Resistance Surveillance: a survey of individuals recently diagnosed with HIV
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2009 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/20606 |
Resumo: | Ministério da Saúde. Programa Brasileiro DST/AIDS. Brasília, DF, Brasil. |
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Inocencio, Lilian A.Pereira, Anderson A.Sucupira, Maria Cecilia A.Fernandez, José Carlos C.Jorge, Célia P.Fink, Helena T.Diaz, Ricardo S.Becker, Irina M.Suffert, .Theodoro A.Arruda, Monica B.Macedo, OlindaSimão, Mariangela B. G.Tanuri, Amilcar2017-08-15T12:08:28Z2017-08-15T12:08:28Z2009INOCENCIO. Lilian A. et al. Brazilian Network for HIV Drug Resistance Surveillance: a survey of individuals recently diagnosed with HIV. Journal of the International AIDS Survey, v.12, n.20, 6p, Sept. 2009.1758-2652https://www.arca.fiocruz.br/handle/icict/2060610.1186/1758-2652-12-20engBioMed CentralAIDSAntiretroviraisDiagnósticoTratamentoMedicamentosAIDSAntiretroviral TherapyDrugsDiagnosisBrazilian Network for HIV Drug Resistance Surveillance: a survey of individuals recently diagnosed with HIVinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMinistério da Saúde. Programa Brasileiro DST/AIDS. Brasília, DF, Brasil.Ministério da Saúde. Programa Brasileiro DST/AIDS. Brasília, DF, Brasil.Universidade Federal de São Paulo. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia. Rio de Janeiro, RJ. Brasil.Universidade Federal da Bahia. Laboratório de Biologia Molecular. Salvador, BA, BrasilMinistério da Saúde. Prograna Brasileiro DST/AIDS. Brasília, DF, Brasil.Laboratório de Saúde Pública. Brasília, DF, BrasilUniversidade Federal de São Paulo. São Paulo, SP, Brasil.Laboratório de Saúde Pública. Porto Alegre, RS, Brasil.Prefeitura de Porto Alegre. Centro de Saúde do Porto. Porto Alegre, RS, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biociências. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Instituto de Biociências. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, BrasilMinistério da Saúde. Programa Brasileiro DST/AIDS. Brasília, DF, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biociências. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, BrasilUse of antiretrovirals is widespread in Brazil, where more than 200,000 individuals are under treatment. Although general prevalence of primary antiretroviral resistance in Brazil is low, systematic sampling in large metropolitan areas has not being performed.The HIV Threshold Survey methodology (HIV-THS, WHO) was utilized, targeting Brazil's four major regions and selecting the six most populated state capitals: Sao Paulo, Rio de Janeiro, Salvador, Porto Alegre, Brasilia and Belem. We were able to sequence samples from 210 individuals with recent HIV diagnosis, 17 of them (8.1%) carrying HIV isolates with primary antiretroviral resistance mutations. Five, nine and four isolates showed mutations related to resistance to nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (PIs), respectively. Using HIV-THS, we could find an intermediate level of transmitted resistance (5% to 15%) in Belem/Brasilia, Sao Paulo and Rio de Janeiro. Lower level of transmitted resistance (<5%) were observed in the other areas. Despite the extensive antiretroviral exposure and high rates of virologic antiretroviral failure in Brazil, the general prevalence of primary resistance is still low. However, an intermediate level of primary resistance was found in the four major Brazilian cities, confirming the critical need to start larger sampling surveys to better define the risk factors associated with transmission of resistant HIV.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/20606/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALBrazilian network for HIV drug resistance aurveillance.pdfBrazilian network for HIV drug resistance aurveillance.pdfapplication/pdf218869https://www.arca.fiocruz.br/bitstream/icict/20606/2/Brazilian%20network%20for%20HIV%20drug%20resistance%20aurveillance.pdfabf9bc78a1058cbfeb86f9e02e20118aMD52TEXTBrazilian network for HIV drug resistance aurveillance.pdf.txtBrazilian network for HIV drug resistance aurveillance.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Brazilian Network for HIV Drug Resistance Surveillance: a survey of individuals recently diagnosed with HIV |
| title |
Brazilian Network for HIV Drug Resistance Surveillance: a survey of individuals recently diagnosed with HIV |
| spellingShingle |
Brazilian Network for HIV Drug Resistance Surveillance: a survey of individuals recently diagnosed with HIV Inocencio, Lilian A. AIDS Antiretrovirais Diagnóstico Tratamento Medicamentos AIDS Antiretroviral Therapy Drugs Diagnosis |
| title_short |
Brazilian Network for HIV Drug Resistance Surveillance: a survey of individuals recently diagnosed with HIV |
| title_full |
Brazilian Network for HIV Drug Resistance Surveillance: a survey of individuals recently diagnosed with HIV |
| title_fullStr |
Brazilian Network for HIV Drug Resistance Surveillance: a survey of individuals recently diagnosed with HIV |
| title_full_unstemmed |
Brazilian Network for HIV Drug Resistance Surveillance: a survey of individuals recently diagnosed with HIV |
| title_sort |
Brazilian Network for HIV Drug Resistance Surveillance: a survey of individuals recently diagnosed with HIV |
| author |
Inocencio, Lilian A. |
| author_facet |
Inocencio, Lilian A. Pereira, Anderson A. Sucupira, Maria Cecilia A. Fernandez, José Carlos C. Jorge, Célia P. Fink, Helena T. Diaz, Ricardo S. Becker, Irina M. Suffert, .Theodoro A. Arruda, Monica B. Macedo, Olinda Simão, Mariangela B. G. Tanuri, Amilcar |
| author_role |
author |
| author2 |
Pereira, Anderson A. Sucupira, Maria Cecilia A. Fernandez, José Carlos C. Jorge, Célia P. Fink, Helena T. Diaz, Ricardo S. Becker, Irina M. Suffert, .Theodoro A. Arruda, Monica B. Macedo, Olinda Simão, Mariangela B. G. Tanuri, Amilcar |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Inocencio, Lilian A. Pereira, Anderson A. Sucupira, Maria Cecilia A. Fernandez, José Carlos C. Jorge, Célia P. Fink, Helena T. Diaz, Ricardo S. Becker, Irina M. Suffert, .Theodoro A. Arruda, Monica B. Macedo, Olinda Simão, Mariangela B. G. Tanuri, Amilcar |
| dc.subject.other.pt_BR.fl_str_mv |
AIDS Antiretrovirais Diagnóstico Tratamento Medicamentos |
| topic |
AIDS Antiretrovirais Diagnóstico Tratamento Medicamentos AIDS Antiretroviral Therapy Drugs Diagnosis |
| dc.subject.en.pt_BR.fl_str_mv |
AIDS Antiretroviral Therapy Drugs Diagnosis |
| description |
Ministério da Saúde. Programa Brasileiro DST/AIDS. Brasília, DF, Brasil. |
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2009 |
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2009 |
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2017-08-15T12:08:28Z |
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2017-08-15T12:08:28Z |
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INOCENCIO. Lilian A. et al. Brazilian Network for HIV Drug Resistance Surveillance: a survey of individuals recently diagnosed with HIV. Journal of the International AIDS Survey, v.12, n.20, 6p, Sept. 2009. |
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https://www.arca.fiocruz.br/handle/icict/20606 |
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1758-2652 |
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10.1186/1758-2652-12-20 |
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INOCENCIO. Lilian A. et al. Brazilian Network for HIV Drug Resistance Surveillance: a survey of individuals recently diagnosed with HIV. Journal of the International AIDS Survey, v.12, n.20, 6p, Sept. 2009. 1758-2652 10.1186/1758-2652-12-20 |
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