HIV-1 genetic diversity and antiretroviral drug resistance among individuals from Roraima state, northern Brazil

Detalhes bibliográficos
Autor(a) principal: Corado, André de Lima Guerra
Data de Publicação: 2017
Outros Autores: Bello, Gonzalo, Leão, Renato Augusto Carvalho, Granja, Fabiana, Naveca, Felipe Gomes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/23462
Resumo: Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brasil.
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spelling Corado, André de Lima GuerraBello, GonzaloLeão, Renato Augusto CarvalhoGranja, FabianaNaveca, Felipe Gomes2017-11-30T11:45:30Z2017-11-30T11:45:30Z2017CORADO, André de Lima Guerra; et al. HIV-1 genetic diversity and antiretroviral drug resistance among individuals from Roraima state, northern Brazil. Plos One, v.12, n.3, e0173894, 11p, Mar. 2017.1932-6203https://www.arca.fiocruz.br/handle/icict/2346210.1371/journal.pone.0173894engPublic Library of ScienceHIV-1Diversidade genéticaResistência a medicamentosAntiretroviraisRoraimaHIV-1Genetic Diversityantiretroviral drug resistanceRoraimaBrazilHIV-1 genetic diversity and antiretroviral drug resistance among individuals from Roraima state, northern Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil.Laboratório Central de Saúde Pública de Roraima. Boa Vista, RR, Brasil.Universidade Federal de Roraima. Laboratório de Biologia Molecular. Boa Vista, RR, Brasil.Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brasil.The HIV-1 epidemic in Brazil has spread towards the Northern country region, but little is known about HIV-1 subtypes and prevalence of HIV strains with resistance mutations to antiretrovirals in some of the Northern states. HIV-1 protease (PR) and reverse transcriptase (RT) sequences were obtained from 73 treatment-naive and -experienced subjects followed between 2013 and 2014 at a public health reference unit from Roraima, the northernmost Brazilian state. The most prevalent HIV-1 clade observed in the study population was the subtype B (91%), followed by subtype C (9%). Among 12 HIV-1 strains from treatment-naïve patients, only one had a transmitted drug resistance mutation for NNRTI. Among 59 treatment-experienced patients, 12 (20%) harbored HIV-1 strains with acquired drug resistance mutations (ADRM) that reduce the susceptibility to two classes of antiretroviral drugs (NRTI and NNRTI or NRTI and PI), and five (8%) harbored HIV-1 strains with ADRM that reduced susceptibility to only one class of antiretroviral drugs (NNRTI or PI). No patients harboring HIV strains with reduced susceptibility to all three classes of antiretroviral drugs were detected. A substantial fraction of treatment-experienced patients with (63%) and without (70%) ADRM had undetectable plasma viral loads (<40 copies/ml) at the time of sampling. Among treatment-experienced with plasma viral loads above 2,000 copies/ml, 44% displayed no ADRM. This data showed that the HIV-1 epidemic in Roraima displayed a much lower level of genetic diversity and a lower prevalence of ADRM than that described in other Brazilian states.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/23462/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALgonzalo_bello_etal_IOC_2017.pdfgonzalo_bello_etal_IOC_2017.pdfapplication/pdf1244840https://www.arca.fiocruz.br/bitstream/icict/23462/2/gonzalo_bello_etal_IOC_2017.pdf6363785d7fa23fba31140f355761e995MD52TEXTgonzalo_bello_etal_IOC_2017.pdf.txtgonzalo_bello_etal_IOC_2017.pdf.txtExtracted texttext/plain37456https://www.arca.fiocruz.br/bitstream/icict/23462/3/gonzalo_bello_etal_IOC_2017.pdf.txt0b99b8cdf2bce26977596580931faa7fMD53icict/234622018-08-15 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dc.title.pt_BR.fl_str_mv HIV-1 genetic diversity and antiretroviral drug resistance among individuals from Roraima state, northern Brazil
title HIV-1 genetic diversity and antiretroviral drug resistance among individuals from Roraima state, northern Brazil
spellingShingle HIV-1 genetic diversity and antiretroviral drug resistance among individuals from Roraima state, northern Brazil
Corado, André de Lima Guerra
HIV-1
Diversidade genética
Resistência a medicamentos
Antiretrovirais
Roraima
HIV-1
Genetic Diversity
antiretroviral drug resistance
Roraima
Brazil
title_short HIV-1 genetic diversity and antiretroviral drug resistance among individuals from Roraima state, northern Brazil
title_full HIV-1 genetic diversity and antiretroviral drug resistance among individuals from Roraima state, northern Brazil
title_fullStr HIV-1 genetic diversity and antiretroviral drug resistance among individuals from Roraima state, northern Brazil
title_full_unstemmed HIV-1 genetic diversity and antiretroviral drug resistance among individuals from Roraima state, northern Brazil
title_sort HIV-1 genetic diversity and antiretroviral drug resistance among individuals from Roraima state, northern Brazil
author Corado, André de Lima Guerra
author_facet Corado, André de Lima Guerra
Bello, Gonzalo
Leão, Renato Augusto Carvalho
Granja, Fabiana
Naveca, Felipe Gomes
author_role author
author2 Bello, Gonzalo
Leão, Renato Augusto Carvalho
Granja, Fabiana
Naveca, Felipe Gomes
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Corado, André de Lima Guerra
Bello, Gonzalo
Leão, Renato Augusto Carvalho
Granja, Fabiana
Naveca, Felipe Gomes
dc.subject.other.pt_BR.fl_str_mv HIV-1
Diversidade genética
Resistência a medicamentos
Antiretrovirais
Roraima
topic HIV-1
Diversidade genética
Resistência a medicamentos
Antiretrovirais
Roraima
HIV-1
Genetic Diversity
antiretroviral drug resistance
Roraima
Brazil
dc.subject.en.pt_BR.fl_str_mv HIV-1
Genetic Diversity
antiretroviral drug resistance
Roraima
Brazil
description Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brasil.
publishDate 2017
dc.date.accessioned.fl_str_mv 2017-11-30T11:45:30Z
dc.date.available.fl_str_mv 2017-11-30T11:45:30Z
dc.date.issued.fl_str_mv 2017
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CORADO, André de Lima Guerra; et al. HIV-1 genetic diversity and antiretroviral drug resistance among individuals from Roraima state, northern Brazil. Plos One, v.12, n.3, e0173894, 11p, Mar. 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/23462
dc.identifier.issn.pt_BR.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0173894
identifier_str_mv CORADO, André de Lima Guerra; et al. HIV-1 genetic diversity and antiretroviral drug resistance among individuals from Roraima state, northern Brazil. Plos One, v.12, n.3, e0173894, 11p, Mar. 2017.
1932-6203
10.1371/journal.pone.0173894
url https://www.arca.fiocruz.br/handle/icict/23462
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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