Variation of cytokine patterns related to therapeutic response in diffuse cutaneous leishmaniasis.

Detalhes bibliográficos
Autor(a) principal: Arruda, Maria da Gloria Bomfim
Data de Publicação: 1996
Outros Autores: Nascimento, Cristiane Santos, Costa, Jackson Mauricio Lopes, Carvalho Filho, Edgar Marcelino, Barral Netto, Manoel, Barral, Aldina Maria Prado
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/9492
Resumo: Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil.
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spelling Arruda, Maria da Gloria BomfimNascimento, Cristiane SantosCosta, Jackson Mauricio LopesCarvalho Filho, Edgar MarcelinoBarral Netto, ManoelBarral, Aldina Maria Prado2015-02-11T18:02:08Z2015-02-11T18:02:08Z1996ARRUDA, Maria da Gloria Bomfim et al. Variation of cytokine patterns related to therapeutic response in diffuse cutaneous leishmaniasis. Experimental Parasitology, v. 84, n. 2, p. 188-194, 1996.0014-4894https://www.arca.fiocruz.br/handle/icict/9492engElsevierVariation of cytokine patterns related to therapeutic response in diffuse cutaneous leishmaniasis.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil.Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal do Maranhão. Faculdade de Medicina. Departamento de Doenças Infecciosas e Parasitárias. São Luis, MA, Brasil.Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil.Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil.Diffuse cutaneous leishmaniasis is a rare entity characterized by disseminated cutaneous nodules associated with specific anergy to leishmanial antigens. A low but not absent IFN-gamma expression by cells present in cutaneous lesions has been documented during the active phase of diffuse cutaneous leishmaniasis. In this study we confirm this observation, and extend it by showing a similar pattern in peripheral blood mononuclear cells and the variation of mRNA cytokine expression pattern during different stages of the disease. During active disease, patients did not express mRNA for IFN-gamma, while expressing mRNA for IL-2, IL-4, and IL-10. In contrast, an expression of IFN-gamma and low IL-10 was observed after treatment-induced transient healing of cutaneous lesions. In three patients we have been able to analyze a third PBMC sample obtained after clinical relapse, documenting in all of them decreased IFN-gamma expression with no expression of IL-10. Although there was an association between the appearance of IFN-gamma expression and clinical improvement, with marked expression of IFN-gamma mRNA and decreased expression of mRNA for IL-10 after treatment, this was not sufficient to prevent relapse in these patients. Therefore, it is possible that factors other than the cytokines characteristic of the Th1 and Th2 balance are implicated in the inability of diffuse cutaneous leishmaniasis patients to mount an anti-Leishmania immune response causing clinical improvement.LeishmaniasisCytokinesTherapyCutaneous leishmaniasisDCLDiffuse cutaneous leishmaniasisInterferon gama/biossínteseInterleucinas/biossínteseLeishmaniose Tegumentar Difusa/imunologiaAdolescenteAdultoAntiprotozoários/uso terapêuticoCriançaFemininoHumanosEnsaio de Imunoadsorção EnzimáticaLeishmaniose Tegumentar Difusa/quimioterapiaMasculinoReação em Cadeia da PolimeraseRNA Mensageiro/genéticaRNA Mensageiro/metabolismoRecidivainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALBomfim G Variation....pdfBomfim G Variation....pdfapplication/pdf147739https://www.arca.fiocruz.br/bitstream/icict/9492/2/Bomfim%20G%20Variation....pdf7a9c7f1812f8d06b2f66ec0e831c8fdfMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/9492/3/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD53TEXTBomfim G Variation....pdf.txtBomfim G Variation....pdf.txtExtracted texttext/plain25878https://www.arca.fiocruz.br/bitstream/icict/9492/4/Bomfim%20G%20Variation....pdf.txt6f68e032b46cc5c87d4289ed01ac86ccMD54icict/94922023-03-15 14:33:10.004oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:10Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Variation of cytokine patterns related to therapeutic response in diffuse cutaneous leishmaniasis.
title Variation of cytokine patterns related to therapeutic response in diffuse cutaneous leishmaniasis.
spellingShingle Variation of cytokine patterns related to therapeutic response in diffuse cutaneous leishmaniasis.
Arruda, Maria da Gloria Bomfim
Leishmaniasis
Cytokines
Therapy
Cutaneous leishmaniasis
DCL
Diffuse cutaneous leishmaniasis
Interferon gama/biossíntese
Interleucinas/biossíntese
Leishmaniose Tegumentar Difusa/imunologia
Adolescente
Adulto
Antiprotozoários/uso terapêutico
Criança
Feminino
Humanos
Ensaio de Imunoadsorção Enzimática
Leishmaniose Tegumentar Difusa/quimioterapia
Masculino
Reação em Cadeia da Polimerase
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Recidiva
title_short Variation of cytokine patterns related to therapeutic response in diffuse cutaneous leishmaniasis.
title_full Variation of cytokine patterns related to therapeutic response in diffuse cutaneous leishmaniasis.
title_fullStr Variation of cytokine patterns related to therapeutic response in diffuse cutaneous leishmaniasis.
title_full_unstemmed Variation of cytokine patterns related to therapeutic response in diffuse cutaneous leishmaniasis.
title_sort Variation of cytokine patterns related to therapeutic response in diffuse cutaneous leishmaniasis.
author Arruda, Maria da Gloria Bomfim
author_facet Arruda, Maria da Gloria Bomfim
Nascimento, Cristiane Santos
Costa, Jackson Mauricio Lopes
Carvalho Filho, Edgar Marcelino
Barral Netto, Manoel
Barral, Aldina Maria Prado
author_role author
author2 Nascimento, Cristiane Santos
Costa, Jackson Mauricio Lopes
Carvalho Filho, Edgar Marcelino
Barral Netto, Manoel
Barral, Aldina Maria Prado
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Arruda, Maria da Gloria Bomfim
Nascimento, Cristiane Santos
Costa, Jackson Mauricio Lopes
Carvalho Filho, Edgar Marcelino
Barral Netto, Manoel
Barral, Aldina Maria Prado
dc.subject.en.pt_BR.fl_str_mv Leishmaniasis
Cytokines
Therapy
Cutaneous leishmaniasis
DCL
Diffuse cutaneous leishmaniasis
topic Leishmaniasis
Cytokines
Therapy
Cutaneous leishmaniasis
DCL
Diffuse cutaneous leishmaniasis
Interferon gama/biossíntese
Interleucinas/biossíntese
Leishmaniose Tegumentar Difusa/imunologia
Adolescente
Adulto
Antiprotozoários/uso terapêutico
Criança
Feminino
Humanos
Ensaio de Imunoadsorção Enzimática
Leishmaniose Tegumentar Difusa/quimioterapia
Masculino
Reação em Cadeia da Polimerase
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Recidiva
dc.subject.decs.pt_BR.fl_str_mv Interferon gama/biossíntese
Interleucinas/biossíntese
Leishmaniose Tegumentar Difusa/imunologia
Adolescente
Adulto
Antiprotozoários/uso terapêutico
Criança
Feminino
Humanos
Ensaio de Imunoadsorção Enzimática
Leishmaniose Tegumentar Difusa/quimioterapia
Masculino
Reação em Cadeia da Polimerase
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Recidiva
description Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil.
publishDate 1996
dc.date.issued.fl_str_mv 1996
dc.date.accessioned.fl_str_mv 2015-02-11T18:02:08Z
dc.date.available.fl_str_mv 2015-02-11T18:02:08Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ARRUDA, Maria da Gloria Bomfim et al. Variation of cytokine patterns related to therapeutic response in diffuse cutaneous leishmaniasis. Experimental Parasitology, v. 84, n. 2, p. 188-194, 1996.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/9492
dc.identifier.issn.none.fl_str_mv 0014-4894
identifier_str_mv ARRUDA, Maria da Gloria Bomfim et al. Variation of cytokine patterns related to therapeutic response in diffuse cutaneous leishmaniasis. Experimental Parasitology, v. 84, n. 2, p. 188-194, 1996.
0014-4894
url https://www.arca.fiocruz.br/handle/icict/9492
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
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