Variation of cytokine patterns related to therapeutic response in diffuse cutaneous leishmaniasis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 1996 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/8386 |
Resumo: | Texto completo: acesso restrito. p.188–194 |
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1932 |
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Bomfim, GlóriaNascimento, Cristiane SantosCosta, JacksonCarvalho Filho, Edgar Marcelino deBarral-Netto, ManoelBarral, Aldina Maria PradoBomfim, GlóriaNascimento, Cristiane SantosCosta, JacksonCarvalho Filho, Edgar Marcelino deBarral-Netto, ManoelBarral, Aldina Maria Prado2013-02-06T13:47:54Z19960014-4894http://www.repositorio.ufba.br/ri/handle/ri/8386v. 84, n. 2Texto completo: acesso restrito. p.188–194Diffuse cutaneous leishmaniasis is a rare entity characterized by disseminated cutaneous nodules associated with specific anergy to leishmanial antigens. A low but not absent IFN-γ expression by cells present in cutaneous lesions has been documented during the active phase of diffuse cutaneous leishmaniasis. In this study we confirm this observation, and extend it by showing a similar pattern in peripheral blood mononuclear cells and the variation of mRNA cytokine expression pattern during different stages of the disease. During active disease, patients did not express mRNA for IFN-γ, while expressing mRNA for IL-2, IL-4, and IL-10. In contrast, an expression of IFN-γ and low IL-10 was observed after treatment-induced transient healing of cutaneous lesions. In three patients we have been able to analyze a third PBMC sample obtained after clinical relapse, documenting in all of them decreased IFN-γ expression with no expression of IL-10. Although there was an association between the appearance of IFN-γ expression and clinical improvement, with marked expression of IFN-γ mRNA and decreased expression of mRNA for IL-10 after treatment, this was not sufficient to prevent relapse in these patients. Therefore, it is possible that factors other than the cytokines characteristic of the Th1 and Th2 balance are implicated in the inability of diffuse cutaneous leishmaniasis patients to mount an anti-Leishmaniaimmune response causing clinical improvement.Submitted by Suelen Reis (suelen_suzane@hotmail.com) on 2013-02-04T16:53:54Z No. of bitstreams: 1 Bomfim.pdf: 147739 bytes, checksum: 7a9c7f1812f8d06b2f66ec0e831c8fdf (MD5)Approved for entry into archive by Fatima Cleômenis Botelho Maria (botelho@ufba.br) on 2013-02-06T13:47:54Z (GMT) No. of bitstreams: 1 Bomfim.pdf: 147739 bytes, checksum: 7a9c7f1812f8d06b2f66ec0e831c8fdf (MD5)Made available in DSpace on 2013-02-06T13:47:54Z (GMT). No. of bitstreams: 1 Bomfim.pdf: 147739 bytes, checksum: 7a9c7f1812f8d06b2f66ec0e831c8fdf (MD5) Previous issue date: 1996http://dx.doi.org/10.1006/expr.1996.0104reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAleishmaniasiscytokinestherapycutaneous leishmaniasisDCLdiffuse cutaneous leishmaniasisIFN-γinterferon-gammaILinterleukinPBMCperipheral blood mononuclear cellsDEPCPCRdiethylpyrocarbonatepolymerase chain reactionVariation of cytokine patterns related to therapeutic response in diffuse cutaneous leishmaniasisExperimental Parasitologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINALBomfim.pdfBomfim.pdfapplication/pdf147739https://repositorio.ufba.br/bitstream/ri/8386/1/Bomfim.pdf7a9c7f1812f8d06b2f66ec0e831c8fdfMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/8386/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52ri/83862022-08-08 13:17:38.858oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:17:38Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Variation of cytokine patterns related to therapeutic response in diffuse cutaneous leishmaniasis |
| dc.title.alternative.pt_BR.fl_str_mv |
Experimental Parasitology |
| title |
Variation of cytokine patterns related to therapeutic response in diffuse cutaneous leishmaniasis |
| spellingShingle |
Variation of cytokine patterns related to therapeutic response in diffuse cutaneous leishmaniasis Bomfim, Glória leishmaniasis cytokines therapy cutaneous leishmaniasis DCL diffuse cutaneous leishmaniasis IFN-γ interferon-gamma IL interleukin PBMC peripheral blood mononuclear cells DEPC PCR diethylpyrocarbonate polymerase chain reaction |
| title_short |
Variation of cytokine patterns related to therapeutic response in diffuse cutaneous leishmaniasis |
| title_full |
Variation of cytokine patterns related to therapeutic response in diffuse cutaneous leishmaniasis |
| title_fullStr |
Variation of cytokine patterns related to therapeutic response in diffuse cutaneous leishmaniasis |
| title_full_unstemmed |
Variation of cytokine patterns related to therapeutic response in diffuse cutaneous leishmaniasis |
| title_sort |
Variation of cytokine patterns related to therapeutic response in diffuse cutaneous leishmaniasis |
| author |
Bomfim, Glória |
| author_facet |
Bomfim, Glória Nascimento, Cristiane Santos Costa, Jackson Carvalho Filho, Edgar Marcelino de Barral-Netto, Manoel Barral, Aldina Maria Prado |
| author_role |
author |
| author2 |
Nascimento, Cristiane Santos Costa, Jackson Carvalho Filho, Edgar Marcelino de Barral-Netto, Manoel Barral, Aldina Maria Prado |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Bomfim, Glória Nascimento, Cristiane Santos Costa, Jackson Carvalho Filho, Edgar Marcelino de Barral-Netto, Manoel Barral, Aldina Maria Prado Bomfim, Glória Nascimento, Cristiane Santos Costa, Jackson Carvalho Filho, Edgar Marcelino de Barral-Netto, Manoel Barral, Aldina Maria Prado |
| dc.subject.por.fl_str_mv |
leishmaniasis cytokines therapy cutaneous leishmaniasis DCL diffuse cutaneous leishmaniasis IFN-γ interferon-gamma IL interleukin PBMC peripheral blood mononuclear cells DEPC PCR diethylpyrocarbonate polymerase chain reaction |
| topic |
leishmaniasis cytokines therapy cutaneous leishmaniasis DCL diffuse cutaneous leishmaniasis IFN-γ interferon-gamma IL interleukin PBMC peripheral blood mononuclear cells DEPC PCR diethylpyrocarbonate polymerase chain reaction |
| description |
Texto completo: acesso restrito. p.188–194 |
| publishDate |
1996 |
| dc.date.issued.fl_str_mv |
1996 |
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2013-02-06T13:47:54Z |
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info:eu-repo/semantics/publishedVersion |
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http://www.repositorio.ufba.br/ri/handle/ri/8386 |
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0014-4894 |
| dc.identifier.number.pt_BR.fl_str_mv |
v. 84, n. 2 |
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0014-4894 v. 84, n. 2 |
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http://www.repositorio.ufba.br/ri/handle/ri/8386 |
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eng |
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