Tempol, an intracellular antioxidant, inhibits tissue factor expression, attenuates dendritic cell function, and is partially protective in a murine model of cerebral malaria

Francischetti, Ivo M. B; Gordon, Emile; Bizzarro, Bruna; Gera, Nidhi; Andrade, Bruno de Bezerril; Oliveira, Fabiano; Ma, Dongying; Assumpção, Teresa Cristina França; Ribeiro, José M. C; Pena, Mirna; Qi, Chen-Feng; Diouf, Ababacar; Moretz, Samuel E; Long, Carole A; Ackerman, Hans C; Pierce, Susan K; Nunes, Anderson Sá; Waisberg, Michael

Tempol, an intracellular antioxidant, inhibits tissue factor expression, attenuates dendritic cell function, and is partially protective in a murine model of cerebral malaria

Detalhes bibliográficos
Autor(a) principal:	Francischetti, Ivo M. B
Data de Publicação:	2014
Outros Autores:	Gordon, Emile, Bizzarro, Bruna, Gera, Nidhi, Andrade, Bruno de Bezerril, Oliveira, Fabiano, Ma, Dongying, Assumpção, Teresa Cristina França, Ribeiro, José M. C, Pena, Mirna, Qi, Chen-Feng, Diouf, Ababacar, Moretz, Samuel E, Long, Carole A, Ackerman, Hans C, Pierce, Susan K, Nunes, Anderson Sá, Waisberg, Michael
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/24911
Resumo:	ANDRADE, Bruno Bezerril. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.

Metadados do item

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spelling	Francischetti, Ivo M. BGordon, EmileBizzarro, BrunaGera, NidhiAndrade, Bruno de BezerrilOliveira, FabianoMa, DongyingAssumpção, Teresa Cristina FrançaRibeiro, José M. CPena, MirnaQi, Chen-FengDiouf, AbabacarMoretz, Samuel ELong, Carole AAckerman, Hans CPierce, Susan KNunes, Anderson SáWaisberg, Michael2018-02-22T13:29:59Z2018-02-22T13:29:59Z2014FRANCISCHETTI, I. M. B. et al. Tempol, an intracellular antioxidant, inhibits tissue factor expression, attenuates dendritic cell function, and is partially protective in a murine model of cerebral malaria. PLoS One, v. 9, n. 2, e87140, 2014.1932-6203https://www.arca.fiocruz.br/handle/icict/2491110.1371/journal.pone.0087140ANDRADE, Bruno Bezerril. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.Research Program of the Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health.National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Malaria and Vector Research. Rockville, MD, USANational Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Immunogenetics. Rockville, MD, USAUniversity of São Paulo. Institute of Biomedical Sciences. Laboratory of Experimental Immunology. Department of Immunology. São Paulo, SP, BrazilNational Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Immunogenetics. Rockville, MD, USANational Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Bethesda, MD, USANational Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Malaria and Vector Research. Rockville, MD, USANational Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Malaria and Vector Research. Rockville, MD, USANational Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Malaria and Vector Research. Rockville, MD, USANational Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Malaria and Vector Research. Rockville, MD, USANational Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Immunogenetics. Rockville, MD, USANational Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Immunogenetics. Rockville, MD, USANational Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Malaria and Vector Research. Rockville, MD, USANational Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Malaria and Vector Research. Rockville, MD, USANational Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Malaria and Vector Research. Rockville, MD, USANational Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Malaria and Vector Research. Rockville, MD, USANational Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Immunogenetics. Rockville, MD, USAUniversity of São Paulo. Institute of Biomedical Sciences. Laboratory of Experimental Immunology. Department of Immunology. São Paulo, SP, BrazilNational Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Immunogenetics. Rockville, MD, USA / University of Virginia. Department of Pathology. Charlottesville, Virginia, USAThe role of intracellular radical oxygen species (ROS) in pathogenesis of cerebral malaria (CM) remains incompletely understood. Methods and Findings: We undertook testing Tempol—a superoxide dismutase (SOD) mimetic and pleiotropic intracellular antioxidant—in cells relevant to malaria pathogenesis in the context of coagulation and inflammation. Tempol was also tested in a murine model of CM induced by Plasmodium berghei Anka infection. Tempol was found to prevent transcription and functional expression of procoagulant tissue factor in endothelial cells (ECs) stimulated by lipopolysaccharide (LPS). This effect was accompanied by inhibition of IL-6, IL-8, and monocyte chemoattractant protein (MCP-1) production. Tempol also attenuated platelet aggregation and human promyelocytic leukemia HL60 cells oxidative burst. In dendritic cells, Tempol inhibited LPS-induced production of TNF-a, IL-6, and IL-12p70, downregulated expression of co-stimulatory molecules, and prevented antigen-dependent lymphocyte proliferation. Notably, Tempol (20 mg/kg) partially increased the survival of mice with CM. Mechanistically, treated mice had lowered plasma levels of MCP-1, suggesting that Tempol downmodulates EC function and vascular inflammation. Tempol also diminished blood brain barrier permeability associated with CM when started at day 4 post infection but not at day 1, suggesting that ROS production is tightly regulated. Other antioxidants— such as a-phenyl N-tertiary-butyl nitrone (PBN; a spin trap), MnTe-2-PyP and MnTBAP (Mn-phorphyrin), Mitoquinone (MitoQ) and Mitotempo (mitochondrial antioxidants), M30 (an iron chelator), and epigallocatechin gallate (EGCG; polyphenol from green tea) did not improve survival. By contrast, these compounds (except PBN) inhibited Plasmodium falciparum growth in culture with different IC50s. Knockout mice for SOD1 or phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (gp91phox–/–) or mice treated with inhibitors of SOD (diethyldithiocarbamate) or NADPH oxidase (diphenyleneiodonium) did not show protection or exacerbation for CM. Conclusion: Results with Tempol suggest that intracellular ROS contribute, in part, to CM pathogenesis. Therapeutic targeting of intracellular ROS in CM is discussed.engPublic Library of ScienceMalaria cerebralCélulas dendríticasReação em cadeia da polimerase em tempo realAntioxidantesPlasmodium FalciparumMalaria cerebralDendritic CellsReal-Time Polymerase Chain ReactionAntioxidantsPlasmodium FalciparumTempol, an intracellular antioxidant, inhibits tissue factor expression, attenuates dendritic cell function, and is partially protective in a murine model of cerebral malariainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/24911/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALFrancischetti I MB Tempol, an intracellular antioxidant.....pdfFrancischetti I MB Tempol, an intracellular antioxidant.....pdfapplication/pdf1419415https://www.arca.fiocruz.br/bitstream/icict/24911/2/Francischetti%20I%20MB%20Tempol%2c%20an%20intracellular%20antioxidant.....pdfcb1fb31e6b27562042411511da3639c4MD52TEXTFrancischetti I MB Tempol, an intracellular antioxidant.....pdf.txtFrancischetti I MB Tempol, an intracellular antioxidant.....pdf.txtExtracted texttext/plain104471https://www.arca.fiocruz.br/bitstream/icict/24911/3/Francischetti%20I%20MB%20Tempol%2c%20an%20intracellular%20antioxidant.....pdf.txtd3e0646dcca5b174461789e217179863MD53icict/249112023-03-15 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dc.title.pt_BR.fl_str_mv	Tempol, an intracellular antioxidant, inhibits tissue factor expression, attenuates dendritic cell function, and is partially protective in a murine model of cerebral malaria
title	Tempol, an intracellular antioxidant, inhibits tissue factor expression, attenuates dendritic cell function, and is partially protective in a murine model of cerebral malaria
spellingShingle	Tempol, an intracellular antioxidant, inhibits tissue factor expression, attenuates dendritic cell function, and is partially protective in a murine model of cerebral malaria Francischetti, Ivo M. B Malaria cerebral Células dendríticas Reação em cadeia da polimerase em tempo real Antioxidantes Plasmodium Falciparum Malaria cerebral Dendritic Cells Real-Time Polymerase Chain Reaction Antioxidants Plasmodium Falciparum
title_short	Tempol, an intracellular antioxidant, inhibits tissue factor expression, attenuates dendritic cell function, and is partially protective in a murine model of cerebral malaria
title_full	Tempol, an intracellular antioxidant, inhibits tissue factor expression, attenuates dendritic cell function, and is partially protective in a murine model of cerebral malaria
title_fullStr	Tempol, an intracellular antioxidant, inhibits tissue factor expression, attenuates dendritic cell function, and is partially protective in a murine model of cerebral malaria
title_full_unstemmed	Tempol, an intracellular antioxidant, inhibits tissue factor expression, attenuates dendritic cell function, and is partially protective in a murine model of cerebral malaria
title_sort	Tempol, an intracellular antioxidant, inhibits tissue factor expression, attenuates dendritic cell function, and is partially protective in a murine model of cerebral malaria
author	Francischetti, Ivo M. B
author_facet	Francischetti, Ivo M. B Gordon, Emile Bizzarro, Bruna Gera, Nidhi Andrade, Bruno de Bezerril Oliveira, Fabiano Ma, Dongying Assumpção, Teresa Cristina França Ribeiro, José M. C Pena, Mirna Qi, Chen-Feng Diouf, Ababacar Moretz, Samuel E Long, Carole A Ackerman, Hans C Pierce, Susan K Nunes, Anderson Sá Waisberg, Michael
author_role	author
author2	Gordon, Emile Bizzarro, Bruna Gera, Nidhi Andrade, Bruno de Bezerril Oliveira, Fabiano Ma, Dongying Assumpção, Teresa Cristina França Ribeiro, José M. C Pena, Mirna Qi, Chen-Feng Diouf, Ababacar Moretz, Samuel E Long, Carole A Ackerman, Hans C Pierce, Susan K Nunes, Anderson Sá Waisberg, Michael
author2_role	author author author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Francischetti, Ivo M. B Gordon, Emile Bizzarro, Bruna Gera, Nidhi Andrade, Bruno de Bezerril Oliveira, Fabiano Ma, Dongying Assumpção, Teresa Cristina França Ribeiro, José M. C Pena, Mirna Qi, Chen-Feng Diouf, Ababacar Moretz, Samuel E Long, Carole A Ackerman, Hans C Pierce, Susan K Nunes, Anderson Sá Waisberg, Michael
dc.subject.other.pt_BR.fl_str_mv	Malaria cerebral Células dendríticas Reação em cadeia da polimerase em tempo real Antioxidantes Plasmodium Falciparum
topic	Malaria cerebral Células dendríticas Reação em cadeia da polimerase em tempo real Antioxidantes Plasmodium Falciparum Malaria cerebral Dendritic Cells Real-Time Polymerase Chain Reaction Antioxidants Plasmodium Falciparum
dc.subject.en.pt_BR.fl_str_mv	Malaria cerebral Dendritic Cells Real-Time Polymerase Chain Reaction Antioxidants Plasmodium Falciparum
description	ANDRADE, Bruno Bezerril. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate	2014
dc.date.issued.fl_str_mv	2014
dc.date.accessioned.fl_str_mv	2018-02-22T13:29:59Z
dc.date.available.fl_str_mv	2018-02-22T13:29:59Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	FRANCISCHETTI, I. M. B. et al. Tempol, an intracellular antioxidant, inhibits tissue factor expression, attenuates dendritic cell function, and is partially protective in a murine model of cerebral malaria. PLoS One, v. 9, n. 2, e87140, 2014.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/24911
dc.identifier.issn.pt_BR.fl_str_mv	1932-6203
dc.identifier.doi.none.fl_str_mv	10.1371/journal.pone.0087140
identifier_str_mv	FRANCISCHETTI, I. M. B. et al. Tempol, an intracellular antioxidant, inhibits tissue factor expression, attenuates dendritic cell function, and is partially protective in a murine model of cerebral malaria. PLoS One, v. 9, n. 2, e87140, 2014. 1932-6203 10.1371/journal.pone.0087140
url	https://www.arca.fiocruz.br/handle/icict/24911
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Public Library of Science
publisher.none.fl_str_mv	Public Library of Science
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/24911/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/24911/2/Francischetti%20I%20MB%20Tempol%2c%20an%20intracellular%20antioxidant.....pdf https://www.arca.fiocruz.br/bitstream/icict/24911/3/Francischetti%20I%20MB%20Tempol%2c%20an%20intracellular%20antioxidant.....pdf.txt
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repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
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Tempol, an intracellular antioxidant, inhibits tissue factor expression, attenuates dendritic cell function, and is partially protective in a murine model of cerebral malaria

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