Platelet-monocyte interaction amplifies thromboinflammation through tissue factor signaling in COVID-19
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/52589 |
Resumo: | Inova Fiocruz. Fundação de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). |
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Hottz, Eugenio D.Gonçalves, Remy MartinsPalhinha, LohannaQuintanilha, Isaclaudia G. AzevedoCampos, Mariana M. deSacramento, Carolina Q.Temerozo, Jairo R.Soares, Vinicius CardosoGomes Dias, Suelen S.Teixeira, LíviaCastro, ÍcaroRighy, CάssiaSouza, Thiago Moreno L.Kurtz, PedroAndrade, Bruno B.Nakaya, Helder I.Monteiro, Robson Q.Bozza, Fernando A.Bozza, Patrícia T.2022-05-09T15:47:15Z2022-05-09T15:47:15Z2022HOTTZ, Eugenio D. et al. Platelet-monocyte interaction amplifies thromboinflammation through tissue factor signaling in COVID-19. Blood Advances, p. 1-54, 2022.2473-9529https://www.arca.fiocruz.br/handle/icict/5258910.1182/bloodadvances.2021006680Inova Fiocruz. Fundação de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia, Rio de Janeiro, RJ, Brasil / Universidade Federal de Juiz de Fora. Departamento de Bioquímica. Laboratório de Imunotrombose. Juiz de Fora, MG, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia, Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia, Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia, Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia, Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia, Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia, Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa do Timo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia, Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Imunologia e inflamação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia, Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia, Rio de Janeiro, RJ, Brasil.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Departamento de Análises Clínicas e Toxicológicas. São Paulo, SP, Brasil.Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia, Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil.Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil / Instituto D'Or de Pesquisa e Ensino. Rio de Janeiro, RJ, Brasil.Iniciativa de Pesquisa Translacional e Epidemiológica da Rede de Organizações Multinacionais (MONSTER). Salvador, BA, Brasil. / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Departamento de Análises Clínicas e Toxicológicas. São Paulo, SP, Brasil / Hospital Israelita Albert Einstein. São Paulo, SP, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, Brasil.Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Instituto D'Or de Pesquisa e Ensino. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia, Rio de Janeiro, RJ, Brasil.Accumulating evidence into the pathogenesis of COVID-19 highlight a hypercoagulability state with high risk of life-threatening thromboembolic complications. However, the mechanisms of hypercoagulability and their link to hyperinflammation remain poorly understood. Here we investigate functions and mechanisms of platelet activation and platelet-monocyte interactions in inflammatory amplification during SARS-CoV2 infection. We used a combination of immunophenotyping, single cell analysis, functional assays and pharmacological approaches to gain insights on mechanisms. Critically ill COVID-19 patients exhibited increased platelet-monocyte aggregates formation. We identified a subset of inflammatory monocytes presenting high CD16 and low HLA-DR expression as the subset mainly interacting with platelets during severe COVID-19. Single cell RNAseq analysis indicated enhanced fibrinogen receptor Mac-1 in monocytes from severe COVID-19 patients. Monocytes from severe COVID-19 patients displayed increased platelet binding and hyperresponsiveness to P-selectin and fibrinogen with respect to TFN-α and IL-1β secretion. Platelets were able to orchestrate monocyte responses driving TF expression, inflammatory activation and inflammatory cytokines secretion in SARS-CoV-2 infection. Platelet-monocyte interactions ex-vivo and in SARS-CoV-2 infection model in vitro reciprocally activated monocytes and platelets, inducing the heightened secretion of a wide panel of inflammatory mediators. We identified platelet adhesion as a primary signaling mechanism inducing mediator secretion and TF expression, while TF signaling played major roles in amplifying inflammation by inducing proinflammatory cytokines, especially TNF-α and IL-1β. Our data identify platelet-induced TF expression and activity at the crossroad of coagulation and inflammation in severe COVID-19.engAmerican Society of HematologyCOVID-19TromboinflamaçãoCOVID-19Interação plaqueta-monócito87 sinalização do fator tecidualAmplificação inflamatóriaThromboinflammationCOVID-19Platelet-monocyte interaction87 tissue factor signalingInflammatory amplificationTromboinflamaciónCOVID-19interacción plaquetas-monocitos87 señalización del factor tisularamplificación inflamatoriaThromboinflammationInteraction plaquettes-monocytes87 signalisation du facteur tissulaireamplification inflammatoireCOVID-19TromboplastinaPlatelet-monocyte interaction amplifies thromboinflammation through tissue factor signaling in COVID-19info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/52589/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALHottz, Eugenio D. - Platelet-monocyte.pdfHottz, Eugenio D. - Platelet-monocyte.pdfapplication/pdf4028758https://www.arca.fiocruz.br/bitstream/icict/52589/2/Hottz%2c%20Eugenio%20D.%20-%20Platelet-monocyte.pdf6889617b7acd14a9eff90ba09e59a662MD52icict/525892023-03-15 14:34:34.747oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:34Repositório Institucional da FIOCRUZ (ARCA) - 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| dc.title.pt_BR.fl_str_mv |
Platelet-monocyte interaction amplifies thromboinflammation through tissue factor signaling in COVID-19 |
| title |
Platelet-monocyte interaction amplifies thromboinflammation through tissue factor signaling in COVID-19 |
| spellingShingle |
Platelet-monocyte interaction amplifies thromboinflammation through tissue factor signaling in COVID-19 Hottz, Eugenio D. COVID-19 Tromboinflamação COVID-19 Interação plaqueta-monócito 87 sinalização do fator tecidual Amplificação inflamatória Thromboinflammation COVID-19 Platelet-monocyte interaction 87 tissue factor signaling Inflammatory amplification Tromboinflamación COVID-19 interacción plaquetas-monocitos 87 señalización del factor tisular amplificación inflamatoria Thromboinflammation Interaction plaquettes-monocytes 87 signalisation du facteur tissulaire amplification inflammatoire COVID-19 Tromboplastina |
| title_short |
Platelet-monocyte interaction amplifies thromboinflammation through tissue factor signaling in COVID-19 |
| title_full |
Platelet-monocyte interaction amplifies thromboinflammation through tissue factor signaling in COVID-19 |
| title_fullStr |
Platelet-monocyte interaction amplifies thromboinflammation through tissue factor signaling in COVID-19 |
| title_full_unstemmed |
Platelet-monocyte interaction amplifies thromboinflammation through tissue factor signaling in COVID-19 |
| title_sort |
Platelet-monocyte interaction amplifies thromboinflammation through tissue factor signaling in COVID-19 |
| author |
Hottz, Eugenio D. |
| author_facet |
Hottz, Eugenio D. Gonçalves, Remy Martins Palhinha, Lohanna Quintanilha, Isaclaudia G. Azevedo Campos, Mariana M. de Sacramento, Carolina Q. Temerozo, Jairo R. Soares, Vinicius Cardoso Gomes Dias, Suelen S. Teixeira, Lívia Castro, Ícaro Righy, Cάssia Souza, Thiago Moreno L. Kurtz, Pedro Andrade, Bruno B. Nakaya, Helder I. Monteiro, Robson Q. Bozza, Fernando A. Bozza, Patrícia T. |
| author_role |
author |
| author2 |
Gonçalves, Remy Martins Palhinha, Lohanna Quintanilha, Isaclaudia G. Azevedo Campos, Mariana M. de Sacramento, Carolina Q. Temerozo, Jairo R. Soares, Vinicius Cardoso Gomes Dias, Suelen S. Teixeira, Lívia Castro, Ícaro Righy, Cάssia Souza, Thiago Moreno L. Kurtz, Pedro Andrade, Bruno B. Nakaya, Helder I. Monteiro, Robson Q. Bozza, Fernando A. Bozza, Patrícia T. |
| author2_role |
author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Hottz, Eugenio D. Gonçalves, Remy Martins Palhinha, Lohanna Quintanilha, Isaclaudia G. Azevedo Campos, Mariana M. de Sacramento, Carolina Q. Temerozo, Jairo R. Soares, Vinicius Cardoso Gomes Dias, Suelen S. Teixeira, Lívia Castro, Ícaro Righy, Cάssia Souza, Thiago Moreno L. Kurtz, Pedro Andrade, Bruno B. Nakaya, Helder I. Monteiro, Robson Q. Bozza, Fernando A. Bozza, Patrícia T. |
| dc.subject.mesh.pt_BR.fl_str_mv |
COVID-19 |
| topic |
COVID-19 Tromboinflamação COVID-19 Interação plaqueta-monócito 87 sinalização do fator tecidual Amplificação inflamatória Thromboinflammation COVID-19 Platelet-monocyte interaction 87 tissue factor signaling Inflammatory amplification Tromboinflamación COVID-19 interacción plaquetas-monocitos 87 señalización del factor tisular amplificación inflamatoria Thromboinflammation Interaction plaquettes-monocytes 87 signalisation du facteur tissulaire amplification inflammatoire COVID-19 Tromboplastina |
| dc.subject.other.pt_BR.fl_str_mv |
Tromboinflamação COVID-19 Interação plaqueta-monócito 87 sinalização do fator tecidual Amplificação inflamatória |
| dc.subject.en.pt_BR.fl_str_mv |
Thromboinflammation COVID-19 Platelet-monocyte interaction 87 tissue factor signaling Inflammatory amplification |
| dc.subject.es.pt_BR.fl_str_mv |
Tromboinflamación COVID-19 interacción plaquetas-monocitos 87 señalización del factor tisular amplificación inflamatoria |
| dc.subject.fr.pt_BR.fl_str_mv |
Thromboinflammation Interaction plaquettes-monocytes 87 signalisation du facteur tissulaire amplification inflammatoire |
| dc.subject.decs.pt_BR.fl_str_mv |
COVID-19 Tromboplastina |
| description |
Inova Fiocruz. Fundação de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). |
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2022 |
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2022-05-09T15:47:15Z |
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2022-05-09T15:47:15Z |
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2022 |
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info:eu-repo/semantics/publishedVersion |
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HOTTZ, Eugenio D. et al. Platelet-monocyte interaction amplifies thromboinflammation through tissue factor signaling in COVID-19. Blood Advances, p. 1-54, 2022. |
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https://www.arca.fiocruz.br/handle/icict/52589 |
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2473-9529 |
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10.1182/bloodadvances.2021006680 |
| identifier_str_mv |
HOTTZ, Eugenio D. et al. Platelet-monocyte interaction amplifies thromboinflammation through tissue factor signaling in COVID-19. Blood Advances, p. 1-54, 2022. 2473-9529 10.1182/bloodadvances.2021006680 |
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https://www.arca.fiocruz.br/handle/icict/52589 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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American Society of Hematology |
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American Society of Hematology |
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