Intralesional infiltration versus parenteral use of meglumine antimoniate for treatment of cutaneous leishmaniasis: A cost-effectiveness analysis
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
DOI: | 10.1371/journal.pntd.0007856 |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/42919 |
Resumo: | Fundação Oswaldo Cruz. Instituto René Rachou. Clínica e Políticas Públicas em Doenças Infecto-Parasitárias. Belo Horizonte, MG, Brazil |
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Brito, Nayara CastelanoAssis, Tália Santana Machado deRabello, Ana Lúcia TelesCota, Gláucia Fernandes2020-08-24T17:02:28Z2020-08-24T17:02:28Z2020BRITO, Nayara Castelano et al. Intralesional infiltration versus parenteral use of meglumine antimoniate for treatment of cutaneous leishmaniasis: A cost-effectiveness analysis. PLoS Negl Trop Dis, v. 13, n. 12, e0007856, 2020. https://doi.org/10.1371/journal.pntd.00078561935-2727https://www.arca.fiocruz.br/handle/icict/4291910.1371/journal.pntd.0007856engPublic Library of ScienceIntralesional infiltration versus parenteral use of meglumine antimoniate for treatment of cutaneous leishmaniasis: A cost-effectiveness analysisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto René Rachou. Clínica e Políticas Públicas em Doenças Infecto-Parasitárias. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Clínica e Políticas Públicas em Doenças Infecto-Parasitárias. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Clínica e Políticas Públicas em Doenças Infecto-Parasitárias. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Clínica e Políticas Públicas em Doenças Infecto-Parasitárias. Belo Horizonte, MG, BrazilCutaneous leishmaniasis (LC) is a complex and variable disease in terms of epidemiology, aetiology, pathology and clinical characteristics. The mainstay of treatment is still pentavalent antimony (Sbv) compounds administered systemically, despite their recognized toxicity. The advantages of antimony intralesional (IL) infiltration are the use of lower doses of Sbv and, therefore, less toxic effects. The objective of this study was to estimate the cost-effectiveness ratio of intralesional meglumine antimoniate therapy (IL-MA) compared with endovenous meglumine antimoniate therapy (EV-MA) for the treatment of CL in the context of the Brazilian National Health System (SUS). An analytical decision model (decision tree) was developed using TreeAge Pro 2018 software. Data from the open-label, uncontrolled phase II clinical trial evaluating IL-MA were used as a reference for posology, efficacy, and adverse event rates (AE). The same premises for the intravenous approach (EV-MA) were extracted from systematic literature reviews. Macro and micro calculations of spending were included in the analysis. The IL-MA and EV-MA strategies had a total cost per patient cured of US$330.81 and US$494.16, respectively. The intralesional approach was dominant, meaning it was more economic and effective than was endovenous therapy. The incremental cost-effectiveness ratio showed that IL-MA could result in savings of US$864.37 for each additional patient cured, confirming that the IL-MA strategy is cost effective in the context of the Brazilian public health scenario.Cost-effectiveness analysisTherapeutic drug monitoringBrazilAdverse eventsDrug therapyDrug administrationLeishmaniasisAntimonyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/42919/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALIntralesional infiltration versus parenteral.pdfIntralesional infiltration versus parenteral.pdfapplication/pdf786665https://www.arca.fiocruz.br/bitstream/icict/42919/2/Intralesional%20infiltration%20versus%20parenteral.pdfcb3694d50135d28b8d2f316a0fb96206MD52TEXTIntralesional infiltration versus parenteral.pdf.txtIntralesional 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dc.title.pt_BR.fl_str_mv |
Intralesional infiltration versus parenteral use of meglumine antimoniate for treatment of cutaneous leishmaniasis: A cost-effectiveness analysis |
title |
Intralesional infiltration versus parenteral use of meglumine antimoniate for treatment of cutaneous leishmaniasis: A cost-effectiveness analysis |
spellingShingle |
Intralesional infiltration versus parenteral use of meglumine antimoniate for treatment of cutaneous leishmaniasis: A cost-effectiveness analysis Brito, Nayara Castelano Cost-effectiveness analysis Therapeutic drug monitoring Brazil Adverse events Drug therapy Drug administration Leishmaniasis Antimony |
title_short |
Intralesional infiltration versus parenteral use of meglumine antimoniate for treatment of cutaneous leishmaniasis: A cost-effectiveness analysis |
title_full |
Intralesional infiltration versus parenteral use of meglumine antimoniate for treatment of cutaneous leishmaniasis: A cost-effectiveness analysis |
title_fullStr |
Intralesional infiltration versus parenteral use of meglumine antimoniate for treatment of cutaneous leishmaniasis: A cost-effectiveness analysis |
title_full_unstemmed |
Intralesional infiltration versus parenteral use of meglumine antimoniate for treatment of cutaneous leishmaniasis: A cost-effectiveness analysis |
title_sort |
Intralesional infiltration versus parenteral use of meglumine antimoniate for treatment of cutaneous leishmaniasis: A cost-effectiveness analysis |
author |
Brito, Nayara Castelano |
author_facet |
Brito, Nayara Castelano Assis, Tália Santana Machado de Rabello, Ana Lúcia Teles Cota, Gláucia Fernandes |
author_role |
author |
author2 |
Assis, Tália Santana Machado de Rabello, Ana Lúcia Teles Cota, Gláucia Fernandes |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Brito, Nayara Castelano Assis, Tália Santana Machado de Rabello, Ana Lúcia Teles Cota, Gláucia Fernandes |
dc.subject.en.pt_BR.fl_str_mv |
Cost-effectiveness analysis Therapeutic drug monitoring Brazil Adverse events Drug therapy Drug administration Leishmaniasis Antimony |
topic |
Cost-effectiveness analysis Therapeutic drug monitoring Brazil Adverse events Drug therapy Drug administration Leishmaniasis Antimony |
description |
Fundação Oswaldo Cruz. Instituto René Rachou. Clínica e Políticas Públicas em Doenças Infecto-Parasitárias. Belo Horizonte, MG, Brazil |
publishDate |
2020 |
dc.date.accessioned.fl_str_mv |
2020-08-24T17:02:28Z |
dc.date.available.fl_str_mv |
2020-08-24T17:02:28Z |
dc.date.issued.fl_str_mv |
2020 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
BRITO, Nayara Castelano et al. Intralesional infiltration versus parenteral use of meglumine antimoniate for treatment of cutaneous leishmaniasis: A cost-effectiveness analysis. PLoS Negl Trop Dis, v. 13, n. 12, e0007856, 2020. https://doi.org/10.1371/journal.pntd.0007856 |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/42919 |
dc.identifier.issn.pt_BR.fl_str_mv |
1935-2727 |
dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pntd.0007856 |
identifier_str_mv |
BRITO, Nayara Castelano et al. Intralesional infiltration versus parenteral use of meglumine antimoniate for treatment of cutaneous leishmaniasis: A cost-effectiveness analysis. PLoS Negl Trop Dis, v. 13, n. 12, e0007856, 2020. https://doi.org/10.1371/journal.pntd.0007856 1935-2727 10.1371/journal.pntd.0007856 |
url |
https://www.arca.fiocruz.br/handle/icict/42919 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Public Library of Science |
publisher.none.fl_str_mv |
Public Library of Science |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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Fundação Oswaldo Cruz (FIOCRUZ) |
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FIOCRUZ |
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FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
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