Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/17788 |
Resumo: | Biotechnology and Biological Sciences Research Council |
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Phelan, Jody EColl, FrancescBergval, IndraAnthony, Richard MWarren, RobSampson, Samantha LGey van Pittius, Nicolaas CGlynn, Judith RCrampin, Amelia CAlves, AdrianaBessa, Theolis Costa BarbosaCampino, SusanaDheda, KeertanGrandjean, LouisHasan, RuminaHasan, ZahraMiranda, AnabelaMoore, DavidPanaiotov, StefanPerdigao, JoaoPortugal, IsabelSheen, PatriciaSousa, Erivelton de OliveiraStreicher, Elizabeth Mvan Helden, Paul DViveiros, MiguelHibberd, Martin LPain, ArnabMcNerney, RuthClark, Taane G2017-02-10T16:54:31Z2017-02-10T16:54:31Z2016PHELAN, J. E. et al. Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages. BMC Genomics, v. 17, p. 151, 2016.1471-2164https://www.arca.fiocruz.br/handle/icict/1778810.1186/s12864-016-2467-yBiotechnology and Biological Sciences Research CouncilLondon School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Diseases Department of Pathogen. Molecular Biology. KeppelLondon School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Diseases Department of Pathogen. Molecular Biology. KeppelRoyal Tropical Institute. KIT Biomedical Research. Amsterdam, NetherlandsRoyal Tropical Institute. KIT Biomedical Research. Amsterdam, NetherlandsStellenbosch University. Faculty of Medicine and Health Sciences. Department of Science and Technology and National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, and Medical Research Council Centre for Molecular and Cellular Biology. Division of Molecular Biology and Human Genetics. Tygerberg, South Africa.Stellenbosch University. Faculty of Medicine and Health Sciences. Department of Science and Technology and National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, and Medical Research Council Centre for Molecular and Cellular Biology. Division of Molecular Biology and Human Genetics. Tygerberg, South Africa.Stellenbosch University. Faculty of Medicine and Health Sciences. Department of Science and Technology and National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, and Medical Research Council Centre for Molecular and Cellular Biology. Division of Molecular Biology and Human Genetics. Tygerberg, South Africa.London School of Hygiene & Tropical Medicine. Faculty of Epidemiology and Population Health. London, UKLondon School of Hygiene & Tropical Medicine. Faculty of Epidemiology and Population Health. London, UK / Karonga Prevention Study. Lilongwe, Malawi.National Mycobacterium Reference Laboratory. Porto, PortugalFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilLondon School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Diseases Department of Pathogen. Molecular Biology. KeppelUniversity of Cape Town. Department of Medicine, Lung Infection and Immunity Unit. Division of Pulmonology & UCT Lung Institute. Cape Town, Western Cape, South Africa / University of Cape Town. Institute of Infectious Diseases and Molecular Medicine. Cape Town, Western Cape, South AfricaLondon School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Diseases Department of Pathogen. Molecular Biology. Keppel / Universidad Peruana Cayetano Heredia. Facultad de Ciencias y Filosofía. Laboratorio de Enfermedades Infecciosas. Laboratorios de Investigación y Desarrollo. Lima, PeruThe Aga Khan University, Stadium Road. Department of Pathology and Laboratory Medicine. Karachi, PakistanThe Aga Khan University, Stadium Road. Department of Pathology and Laboratory Medicine. Karachi, PakistanNational Mycobacterium Reference Laboratory. Porto, PortugalLondon School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Diseases Department of Pathogen. Molecular Biology. KeppelNational Center of Infectious and Parasitic Diseases. Sofia, BulgariaNational Center of Infectious and Parasitic Diseases. Sofia, BulgariaUniversidade de Lisboa. Lisbon, PortugalUniversidad Peruana Cayetano Heredia. Facultad de Ciencias y Filosofía. Laboratorio de Enfermedades Infecciosas. Laboratorios de Investigación y Desarrollo. Lima, PeruFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilLondon School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Diseases Department of Pathogen. Molecular Biology. KeppelLondon School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Diseases Department of Pathogen. Molecular Biology. Keppel / London School of Hygiene & Tropical Medicine. Faculty of Epidemiology and Population Health. London, UKApproximately 10% of the Mycobacterium tuberculosis genome is made up of two families of genes that are poorly characterized due to their high GC content and highly repetitive nature. The PE and PPE families are typified by their highly conserved N-terminal domains that incorporate proline-glutamate (PE) and proline-proline-glutamate (PPE) signature motifs. They are hypothesised to be important virulence factors involved with host-pathogen interactions, but their high genetic variability and complexity of analysis means they are typically disregarded in genome studies.engBioMed CentralMycobacterium tuberculosisGenoma, BacterianoGenomicaEvolução, MolecularDNA, BacterianaAnálise de Seqüência, DNAGenes, BacterianaMycobacterium tuberculosisGenome, BacterialGenomicsEvolution, MolecularDNA, BacterialSequence Analysis, DNAGenes, BacterianoRecombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineagesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/17788/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPhelan JE Recombination....pdfPhelan JE Recombination....pdfapplication/pdf1687871https://www.arca.fiocruz.br/bitstream/icict/17788/2/Phelan%20JE%20Recombination....pdf78e155dbcd0ba496984f07b0276651e6MD52TEXTPhelan JE Recombination....pdf.txtPhelan JE Recombination....pdf.txtExtracted texttext/plain60230https://www.arca.fiocruz.br/bitstream/icict/17788/3/Phelan%20JE%20Recombination....pdf.txt40af49aec3e0ce93f9a695df6d75ff81MD53icict/177882023-03-15 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dc.title.pt_BR.fl_str_mv |
Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages |
title |
Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages |
spellingShingle |
Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages Phelan, Jody E Mycobacterium tuberculosis Genoma, Bacteriano Genomica Evolução, Molecular DNA, Bacteriana Análise de Seqüência, DNA Genes, Bacteriana Mycobacterium tuberculosis Genome, Bacterial Genomics Evolution, Molecular DNA, Bacterial Sequence Analysis, DNA Genes, Bacteriano |
title_short |
Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages |
title_full |
Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages |
title_fullStr |
Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages |
title_full_unstemmed |
Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages |
title_sort |
Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages |
author |
Phelan, Jody E |
author_facet |
Phelan, Jody E Coll, Francesc Bergval, Indra Anthony, Richard M Warren, Rob Sampson, Samantha L Gey van Pittius, Nicolaas C Glynn, Judith R Crampin, Amelia C Alves, Adriana Bessa, Theolis Costa Barbosa Campino, Susana Dheda, Keertan Grandjean, Louis Hasan, Rumina Hasan, Zahra Miranda, Anabela Moore, David Panaiotov, Stefan Perdigao, Joao Portugal, Isabel Sheen, Patricia Sousa, Erivelton de Oliveira Streicher, Elizabeth M van Helden, Paul D Viveiros, Miguel Hibberd, Martin L Pain, Arnab McNerney, Ruth Clark, Taane G |
author_role |
author |
author2 |
Coll, Francesc Bergval, Indra Anthony, Richard M Warren, Rob Sampson, Samantha L Gey van Pittius, Nicolaas C Glynn, Judith R Crampin, Amelia C Alves, Adriana Bessa, Theolis Costa Barbosa Campino, Susana Dheda, Keertan Grandjean, Louis Hasan, Rumina Hasan, Zahra Miranda, Anabela Moore, David Panaiotov, Stefan Perdigao, Joao Portugal, Isabel Sheen, Patricia Sousa, Erivelton de Oliveira Streicher, Elizabeth M van Helden, Paul D Viveiros, Miguel Hibberd, Martin L Pain, Arnab McNerney, Ruth Clark, Taane G |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Phelan, Jody E Coll, Francesc Bergval, Indra Anthony, Richard M Warren, Rob Sampson, Samantha L Gey van Pittius, Nicolaas C Glynn, Judith R Crampin, Amelia C Alves, Adriana Bessa, Theolis Costa Barbosa Campino, Susana Dheda, Keertan Grandjean, Louis Hasan, Rumina Hasan, Zahra Miranda, Anabela Moore, David Panaiotov, Stefan Perdigao, Joao Portugal, Isabel Sheen, Patricia Sousa, Erivelton de Oliveira Streicher, Elizabeth M van Helden, Paul D Viveiros, Miguel Hibberd, Martin L Pain, Arnab McNerney, Ruth Clark, Taane G |
dc.subject.other.pt_BR.fl_str_mv |
Mycobacterium tuberculosis Genoma, Bacteriano Genomica Evolução, Molecular DNA, Bacteriana Análise de Seqüência, DNA Genes, Bacteriana |
topic |
Mycobacterium tuberculosis Genoma, Bacteriano Genomica Evolução, Molecular DNA, Bacteriana Análise de Seqüência, DNA Genes, Bacteriana Mycobacterium tuberculosis Genome, Bacterial Genomics Evolution, Molecular DNA, Bacterial Sequence Analysis, DNA Genes, Bacteriano |
dc.subject.en.pt_BR.fl_str_mv |
Mycobacterium tuberculosis Genome, Bacterial Genomics Evolution, Molecular DNA, Bacterial Sequence Analysis, DNA Genes, Bacteriano |
description |
Biotechnology and Biological Sciences Research Council |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2017-02-10T16:54:31Z |
dc.date.available.fl_str_mv |
2017-02-10T16:54:31Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
PHELAN, J. E. et al. Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages. BMC Genomics, v. 17, p. 151, 2016. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/17788 |
dc.identifier.issn.pt_BR.fl_str_mv |
1471-2164 |
dc.identifier.doi.none.fl_str_mv |
10.1186/s12864-016-2467-y |
identifier_str_mv |
PHELAN, J. E. et al. Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages. BMC Genomics, v. 17, p. 151, 2016. 1471-2164 10.1186/s12864-016-2467-y |
url |
https://www.arca.fiocruz.br/handle/icict/17788 |
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eng |
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eng |
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openAccess |
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BioMed Central |
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BioMed Central |
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