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spelling Phelan, Jody EColl, FrancescBergval, IndraAnthony, Richard MWarren, RobSampson, Samantha LGey van Pittius, Nicolaas CGlynn, Judith RCrampin, Amelia CAlves, AdrianaBessa, Theolis Costa BarbosaCampino, SusanaDheda, KeertanGrandjean, LouisHasan, RuminaHasan, ZahraMiranda, AnabelaMoore, DavidPanaiotov, StefanPerdigao, JoaoPortugal, IsabelSheen, PatriciaSousa, Erivelton de OliveiraStreicher, Elizabeth Mvan Helden, Paul DViveiros, MiguelHibberd, Martin LPain, ArnabMcNerney, RuthClark, Taane G2017-02-10T16:54:31Z2017-02-10T16:54:31Z2016PHELAN, J. E. et al. Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages. BMC Genomics, v. 17, p. 151, 2016.1471-2164https://www.arca.fiocruz.br/handle/icict/1778810.1186/s12864-016-2467-yBiotechnology and Biological Sciences Research CouncilLondon School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Diseases Department of Pathogen. Molecular Biology. KeppelLondon School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Diseases Department of Pathogen. Molecular Biology. KeppelRoyal Tropical Institute. KIT Biomedical Research. Amsterdam, NetherlandsRoyal Tropical Institute. KIT Biomedical Research. Amsterdam, NetherlandsStellenbosch University. Faculty of Medicine and Health Sciences. Department of Science and Technology and National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, and Medical Research Council Centre for Molecular and Cellular Biology. Division of Molecular Biology and Human Genetics. Tygerberg, South Africa.Stellenbosch University. Faculty of Medicine and Health Sciences. Department of Science and Technology and National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, and Medical Research Council Centre for Molecular and Cellular Biology. Division of Molecular Biology and Human Genetics. Tygerberg, South Africa.Stellenbosch University. Faculty of Medicine and Health Sciences. Department of Science and Technology and National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, and Medical Research Council Centre for Molecular and Cellular Biology. Division of Molecular Biology and Human Genetics. Tygerberg, South Africa.London School of Hygiene & Tropical Medicine. Faculty of Epidemiology and Population Health. London, UKLondon School of Hygiene & Tropical Medicine. Faculty of Epidemiology and Population Health. London, UK / Karonga Prevention Study. Lilongwe, Malawi.National Mycobacterium Reference Laboratory. Porto, PortugalFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilLondon School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Diseases Department of Pathogen. Molecular Biology. KeppelUniversity of Cape Town. Department of Medicine, Lung Infection and Immunity Unit. Division of Pulmonology & UCT Lung Institute. Cape Town, Western Cape, South Africa / University of Cape Town. Institute of Infectious Diseases and Molecular Medicine. Cape Town, Western Cape, South AfricaLondon School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Diseases Department of Pathogen. Molecular Biology. Keppel / Universidad Peruana Cayetano Heredia. Facultad de Ciencias y Filosofía. Laboratorio de Enfermedades Infecciosas. Laboratorios de Investigación y Desarrollo. Lima, PeruThe Aga Khan University, Stadium Road. Department of Pathology and Laboratory Medicine. Karachi, PakistanThe Aga Khan University, Stadium Road. Department of Pathology and Laboratory Medicine. Karachi, PakistanNational Mycobacterium Reference Laboratory. Porto, PortugalLondon School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Diseases Department of Pathogen. Molecular Biology. KeppelNational Center of Infectious and Parasitic Diseases. Sofia, BulgariaNational Center of Infectious and Parasitic Diseases. Sofia, BulgariaUniversidade de Lisboa. Lisbon, PortugalUniversidad Peruana Cayetano Heredia. Facultad de Ciencias y Filosofía. Laboratorio de Enfermedades Infecciosas. Laboratorios de Investigación y Desarrollo. Lima, PeruFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilLondon School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Diseases Department of Pathogen. Molecular Biology. KeppelLondon School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Diseases Department of Pathogen. Molecular Biology. Keppel / London School of Hygiene & Tropical Medicine. Faculty of Epidemiology and Population Health. London, UKApproximately 10% of the Mycobacterium tuberculosis genome is made up of two families of genes that are poorly characterized due to their high GC content and highly repetitive nature. The PE and PPE families are typified by their highly conserved N-terminal domains that incorporate proline-glutamate (PE) and proline-proline-glutamate (PPE) signature motifs. They are hypothesised to be important virulence factors involved with host-pathogen interactions, but their high genetic variability and complexity of analysis means they are typically disregarded in genome studies.engBioMed CentralMycobacterium tuberculosisGenoma, BacterianoGenomicaEvolução, MolecularDNA, BacterianaAnálise de Seqüência, DNAGenes, BacterianaMycobacterium tuberculosisGenome, BacterialGenomicsEvolution, MolecularDNA, BacterialSequence Analysis, DNAGenes, BacterianoRecombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineagesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/17788/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPhelan JE Recombination....pdfPhelan JE 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dc.title.pt_BR.fl_str_mv Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages
title Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages
spellingShingle Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages
Phelan, Jody E
Mycobacterium tuberculosis
Genoma, Bacteriano
Genomica
Evolução, Molecular
DNA, Bacteriana
Análise de Seqüência, DNA
Genes, Bacteriana
Mycobacterium tuberculosis
Genome, Bacterial
Genomics
Evolution, Molecular
DNA, Bacterial
Sequence Analysis, DNA
Genes, Bacteriano
title_short Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages
title_full Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages
title_fullStr Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages
title_full_unstemmed Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages
title_sort Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages
author Phelan, Jody E
author_facet Phelan, Jody E
Coll, Francesc
Bergval, Indra
Anthony, Richard M
Warren, Rob
Sampson, Samantha L
Gey van Pittius, Nicolaas C
Glynn, Judith R
Crampin, Amelia C
Alves, Adriana
Bessa, Theolis Costa Barbosa
Campino, Susana
Dheda, Keertan
Grandjean, Louis
Hasan, Rumina
Hasan, Zahra
Miranda, Anabela
Moore, David
Panaiotov, Stefan
Perdigao, Joao
Portugal, Isabel
Sheen, Patricia
Sousa, Erivelton de Oliveira
Streicher, Elizabeth M
van Helden, Paul D
Viveiros, Miguel
Hibberd, Martin L
Pain, Arnab
McNerney, Ruth
Clark, Taane G
author_role author
author2 Coll, Francesc
Bergval, Indra
Anthony, Richard M
Warren, Rob
Sampson, Samantha L
Gey van Pittius, Nicolaas C
Glynn, Judith R
Crampin, Amelia C
Alves, Adriana
Bessa, Theolis Costa Barbosa
Campino, Susana
Dheda, Keertan
Grandjean, Louis
Hasan, Rumina
Hasan, Zahra
Miranda, Anabela
Moore, David
Panaiotov, Stefan
Perdigao, Joao
Portugal, Isabel
Sheen, Patricia
Sousa, Erivelton de Oliveira
Streicher, Elizabeth M
van Helden, Paul D
Viveiros, Miguel
Hibberd, Martin L
Pain, Arnab
McNerney, Ruth
Clark, Taane G
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Phelan, Jody E
Coll, Francesc
Bergval, Indra
Anthony, Richard M
Warren, Rob
Sampson, Samantha L
Gey van Pittius, Nicolaas C
Glynn, Judith R
Crampin, Amelia C
Alves, Adriana
Bessa, Theolis Costa Barbosa
Campino, Susana
Dheda, Keertan
Grandjean, Louis
Hasan, Rumina
Hasan, Zahra
Miranda, Anabela
Moore, David
Panaiotov, Stefan
Perdigao, Joao
Portugal, Isabel
Sheen, Patricia
Sousa, Erivelton de Oliveira
Streicher, Elizabeth M
van Helden, Paul D
Viveiros, Miguel
Hibberd, Martin L
Pain, Arnab
McNerney, Ruth
Clark, Taane G
dc.subject.other.pt_BR.fl_str_mv Mycobacterium tuberculosis
Genoma, Bacteriano
Genomica
Evolução, Molecular
DNA, Bacteriana
Análise de Seqüência, DNA
Genes, Bacteriana
topic Mycobacterium tuberculosis
Genoma, Bacteriano
Genomica
Evolução, Molecular
DNA, Bacteriana
Análise de Seqüência, DNA
Genes, Bacteriana
Mycobacterium tuberculosis
Genome, Bacterial
Genomics
Evolution, Molecular
DNA, Bacterial
Sequence Analysis, DNA
Genes, Bacteriano
dc.subject.en.pt_BR.fl_str_mv Mycobacterium tuberculosis
Genome, Bacterial
Genomics
Evolution, Molecular
DNA, Bacterial
Sequence Analysis, DNA
Genes, Bacteriano
description Biotechnology and Biological Sciences Research Council
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2017-02-10T16:54:31Z
dc.date.available.fl_str_mv 2017-02-10T16:54:31Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv PHELAN, J. E. et al. Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages. BMC Genomics, v. 17, p. 151, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/17788
dc.identifier.issn.pt_BR.fl_str_mv 1471-2164
dc.identifier.doi.none.fl_str_mv 10.1186/s12864-016-2467-y
identifier_str_mv PHELAN, J. E. et al. Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages. BMC Genomics, v. 17, p. 151, 2016.
1471-2164
10.1186/s12864-016-2467-y
url https://www.arca.fiocruz.br/handle/icict/17788
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dc.publisher.none.fl_str_mv BioMed Central
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