Outcomes in patients with fungal endocarditis: A multicenter observational cohort study
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/33880 |
Resumo: | Cristiane Lamas. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. |
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Siciliano, Rinaldo FocacciaGualandro, Danielle MenosiSejas, Odeli Nicole EncinasIgnoto, Bruno GiulianoCaramelli, BrunoMansur, Alfredo JoseSampaio, Roney OrismarPierrotti, Ligia CameraBarbosa, GiovannaGolebiovski, WilmaWeksler, ClaraLamas, CristianeFortes, Natália Rodrigues QueridoFortes, Claudio QueridoTarasoutchi, FlavioStrabelli, Tania Mara Varejão2019-07-08T15:01:19Z2019-07-08T15:01:19Z2018SICILIANO, Rinaldo Focaccia et al. Outcomes in patients with fungal endocarditis: a multicenter observational cohort study. International Journal of Infectious Diseases, v. 77, p. 48-52, Dec. 2018.1201-9712https://www.arca.fiocruz.br/handle/icict/3388010.1016/j.ijid.2018.09.0161878-3511Cristiane Lamas. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.University of São Paulo. Medical School. Heart Institute. Infection Control Team. São Paulo, SP, Brazil.University of São Paulo. Medical School. Heart Institute. Cardiology Department. São Paulo, SP, Brazil.University of São Paulo. Medical School. Heart Institute. Infection Control Team. São Paulo, SP, Brazil.University of São Paulo. Medical School. Heart Institute. Infection Control Team. São Paulo, SP, Brazil.University of São Paulo. Medical School. Heart Institute. Cardiology Department. São Paulo, SP, Brazil.University of São Paulo. Medical School. Heart Institute. Cardiology Department. São Paulo, SP, Brazil.University of São Paulo. Medical School. Heart Institute. Cardiology Department. São Paulo, SP, Brazil.Instituto do Câncer do Estado de São Paulo. Infection Control Team. São Paulo, SP, Brazil.Instituto Nacional de Cardiologia do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Cardiologia do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Cardiologia do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Cardiologia do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil.University of São Paulo. Medical School. Heart Institute. Cardiology Department. São Paulo, SP, Brazil.University of São Paulo. Medical School. Heart Institute. Infection Control Team. São Paulo, SP, Brazil.Objective: To compare the clinical and epidemiological features, treatments, and outcomes of patients with isolated right-sided and left-sided fungal endocarditis and to determine the risk factors for in-hospital mortality in patients with Candida sp endocarditis. Methods: A retrospective review of all consecutive cases of fungal endocarditis from five hospitals was performed. Clinical features were compared between patients with isolated right-sided and left-sided endocarditis. In the subgroup of fungal endocarditis due to Candida species, binary logistic regression analysis was performed to determine variables related to in-hospital mortality. Results: Seventy-eight patients with fungal endocarditis were studied. Their median age was 50 years; 55% were male and 19 patients (24%) had isolated right-sided endocarditis. Overall, cardiac surgery was performed in 46 patients (59%), and in-hospital mortality was 54%. Compared to patients with left-side fungal endocarditis, patients with isolated right-sided endocarditis had lower mortality (32% vs. 61%; p = 0.025) and were less often submitted to cardiac surgery (37% vs. 66%; p = 0.024). The most frequent etiology was Candida spp (85%). In this subgroup, acute heart failure (odds ratio 5.0; p = 0.027) and exclusive medical treatment (odds ratio 11.1; p = 0.004) were independent predictors of in-hospital death, whereas isolated right-sided endocarditis was related to a lower risk of mortality (odds ratio 0.13; p = 0.023). Conclusions: Patients with isolated right-sided fungal endocarditis have particular clinical and epidemiological features. They were submitted to cardiac surgery less often and had better survival than patients with left-sided fungal endocarditis. Isolated right-sided endocarditis was also a marker of a less harmful illness in the subgroup of Candida sp endocarditis.engElsevierOutcomes in patients with fungal endocarditis: A multicenter observational cohort studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleEndocarditisFungiCandidainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/33880/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALve_Siciliano_Rinaldo_etal_INI_2018.pdfve_Siciliano_Rinaldo_etal_INI_2018.pdfapplication/pdf344773https://www.arca.fiocruz.br/bitstream/icict/33880/2/ve_Siciliano_Rinaldo_etal_INI_2018.pdf77547a8561da908ad81c690d5bce17b8MD52TEXTve_Siciliano_Rinaldo_etal_INI_2018.pdf.txtve_Siciliano_Rinaldo_etal_INI_2018.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Outcomes in patients with fungal endocarditis: A multicenter observational cohort study |
| title |
Outcomes in patients with fungal endocarditis: A multicenter observational cohort study |
| spellingShingle |
Outcomes in patients with fungal endocarditis: A multicenter observational cohort study Siciliano, Rinaldo Focaccia Endocarditis Fungi Candida |
| title_short |
Outcomes in patients with fungal endocarditis: A multicenter observational cohort study |
| title_full |
Outcomes in patients with fungal endocarditis: A multicenter observational cohort study |
| title_fullStr |
Outcomes in patients with fungal endocarditis: A multicenter observational cohort study |
| title_full_unstemmed |
Outcomes in patients with fungal endocarditis: A multicenter observational cohort study |
| title_sort |
Outcomes in patients with fungal endocarditis: A multicenter observational cohort study |
| author |
Siciliano, Rinaldo Focaccia |
| author_facet |
Siciliano, Rinaldo Focaccia Gualandro, Danielle Menosi Sejas, Odeli Nicole Encinas Ignoto, Bruno Giuliano Caramelli, Bruno Mansur, Alfredo Jose Sampaio, Roney Orismar Pierrotti, Ligia Camera Barbosa, Giovanna Golebiovski, Wilma Weksler, Clara Lamas, Cristiane Fortes, Natália Rodrigues Querido Fortes, Claudio Querido Tarasoutchi, Flavio Strabelli, Tania Mara Varejão |
| author_role |
author |
| author2 |
Gualandro, Danielle Menosi Sejas, Odeli Nicole Encinas Ignoto, Bruno Giuliano Caramelli, Bruno Mansur, Alfredo Jose Sampaio, Roney Orismar Pierrotti, Ligia Camera Barbosa, Giovanna Golebiovski, Wilma Weksler, Clara Lamas, Cristiane Fortes, Natália Rodrigues Querido Fortes, Claudio Querido Tarasoutchi, Flavio Strabelli, Tania Mara Varejão |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Siciliano, Rinaldo Focaccia Gualandro, Danielle Menosi Sejas, Odeli Nicole Encinas Ignoto, Bruno Giuliano Caramelli, Bruno Mansur, Alfredo Jose Sampaio, Roney Orismar Pierrotti, Ligia Camera Barbosa, Giovanna Golebiovski, Wilma Weksler, Clara Lamas, Cristiane Fortes, Natália Rodrigues Querido Fortes, Claudio Querido Tarasoutchi, Flavio Strabelli, Tania Mara Varejão |
| dc.subject.en.pt_BR.fl_str_mv |
Endocarditis Fungi Candida |
| topic |
Endocarditis Fungi Candida |
| description |
Cristiane Lamas. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. |
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2018 |
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2018 |
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2019-07-08T15:01:19Z |
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2019-07-08T15:01:19Z |
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SICILIANO, Rinaldo Focaccia et al. Outcomes in patients with fungal endocarditis: a multicenter observational cohort study. International Journal of Infectious Diseases, v. 77, p. 48-52, Dec. 2018. |
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https://www.arca.fiocruz.br/handle/icict/33880 |
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1201-9712 |
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10.1016/j.ijid.2018.09.016 |
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1878-3511 |
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SICILIANO, Rinaldo Focaccia et al. Outcomes in patients with fungal endocarditis: a multicenter observational cohort study. International Journal of Infectious Diseases, v. 77, p. 48-52, Dec. 2018. 1201-9712 10.1016/j.ijid.2018.09.016 1878-3511 |
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Elsevier |
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Elsevier |
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