The nitroxyl donor, Angeli’s salt, inhibits inflammatory hyperalgesia in rats
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/16029 |
Resumo: | CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico), Fundação Araucária, FAPESP (Fundação de Amparo à Pesquisa do Estado de São Paulo), CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior), Decit/SCTIE/MS |
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Zarpelon, Ana CarlaSouza, Guilherme R.Cunha, Thiago M.Schivo, Ieda R.S.Marchesi, MarioCasagrande, RubiaPinge-Filho, PhilenoCunha, Fernando Q.Ferreira, Sergio H.Miranda, Katrina M.Verri Jr, Waldiceu Aparecido2016-09-30T19:38:48Z2016-09-30T19:38:48Z2013ZARPELON, Ana Carla et al. The nitroxyl donor, Angeli’s salt, inhibits inflammatory hyperalgesia in rats. Neuropharmacology, n. 71, p. 1-9, 2013.0028-3908https://www.arca.fiocruz.br/handle/icict/1602910.1016/j.neuropharm.2013.03.009CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico), Fundação Araucária, FAPESP (Fundação de Amparo à Pesquisa do Estado de São Paulo), CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior), Decit/SCTIE/MSUniversidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Patologia. Londrina, PR, Brasil.Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Farmacologia. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Farmacologia. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Farmacologia. Ribeirão Preto, SP, Brasil.Universidade Estadual de Londrina. Hospital Universitário (Centro de Ciências da Saúde). Departamento de Ciências Farmacêuticas. Londrina, PR, Brasil.Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Patologia. Londrina, PR, Brasil / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Farmacologia. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Farmacologia. Ribeirão Preto, SP, Brasil.Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Patologia. Londrina, PR, Brasil.University of Arizona. Department of Chemistry and Biochemistry. Tucson, Arizona, USA.University of Arizona. Department of Chemistry and Biochemistry. Tucson, Arizona, USA.Nitric oxide modulates pain development. However, there is no evidence on the effect of nitroxyl (HNO/NO⁻) in nociception. Therefore, we addressed whether nitroxyl inhibits inflammatory hyperalgesia and its mechanism using the nitroxyl donor Angeli's salt (AS; Na₂N₂O₃). Mechanical hyperalgesia was evaluated using a modified Randall and Selitto method in rats, cytokine production by ELISA and nitroxyl was determined by confocal microscopy in DAF (a cell permeable reagent that is converted into a fluorescent molecule by nitrogen oxides)-treated dorsal root ganglia neurons in culture. Local pre-treatment with AS (17-450 μg/paw, 30 min) inhibited the carrageenin-induced mechanical hyperalgesia in a dose- and time-dependent manner with maximum inhibition of 97%. AS also inhibited carrageenin-induced cytokine production. AS inhibited the hyperalgesia induced by other inflammatory stimuli including lipopolysaccharide, tumor necrosis factor-α, interleukin-1β and prostaglandin E2. Furthermore, the analgesic effect of AS was prevented by treatment with ODQ (a soluble guanylate cyclase inhibitor), KT5823 (a protein kinase G [PKG] inhibitor) or glybenclamide (an ATP-sensitive K⁺ channel blocker), but not with naloxone (an opioid receptor antagonist). AS induced concentration-dependent increase in fluorescence intensity of DAF-treated neurons in a l-cysteine (nitroxyl scavenger) sensitive manner. l-cysteine did not affect the NO⁺ donor S-Nitroso-N-acetyl-DL- penicillamine (SNAP)-induced anti-hyperalgesia or fluorescence of DAF-treated neurons. This is the first study to demonstrate that nitroxyl inhibits inflammatory hyperalgesia by reducing cytokine production and activating the cGMP/PKG/ATP-sensitive K⁺ channel signaling pathway in vivo.engBruno FrenguelliThe nitroxyl donor, Angeli’s salt, inhibits inflammatory hyperalgesia in ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleNitroxylAngeli’s saltNociceptionPainCytokineNitric oxideÓxido NítricoNociceptividadeDorCitocinasinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83074https://www.arca.fiocruz.br/bitstream/icict/16029/1/license.txt0271fb68963c017aa933c7aff60379f4MD51ORIGINALThe nitroxyl donor, Angeli’s salt, inhibits inflammatory hyperalgesia in rats.pdfThe nitroxyl donor, Angeli’s salt, inhibits inflammatory hyperalgesia in rats.pdfapplication/pdf3177919https://www.arca.fiocruz.br/bitstream/icict/16029/2/The%20nitroxyl%20donor%2c%20Angeli%e2%80%99s%20salt%2c%20inhibits%20inflammatory%20hyperalgesia%20in%20rats.pdf6027b5849134737ba5280c4c4dd7ab29MD52TEXTThe nitroxyl donor, Angeli’s salt, inhibits inflammatory hyperalgesia in rats.pdf.txtThe nitroxyl donor, Angeli’s salt, inhibits inflammatory hyperalgesia in rats.pdf.txtExtracted texttext/plain55838https://www.arca.fiocruz.br/bitstream/icict/16029/3/The%20nitroxyl%20donor%2c%20Angeli%e2%80%99s%20salt%2c%20inhibits%20inflammatory%20hyperalgesia%20in%20rats.pdf.txt8907da6320a65b37bec74d25195d7bd0MD53icict/160292019-12-15 22:16:03.377oai:www.arca.fiocruz.br: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Repositório 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dc.title.pt_BR.fl_str_mv |
The nitroxyl donor, Angeli’s salt, inhibits inflammatory hyperalgesia in rats |
title |
The nitroxyl donor, Angeli’s salt, inhibits inflammatory hyperalgesia in rats |
spellingShingle |
The nitroxyl donor, Angeli’s salt, inhibits inflammatory hyperalgesia in rats Zarpelon, Ana Carla Nitroxyl Angeli’s salt Nociception Pain Cytokine Nitric oxide Óxido Nítrico Nociceptividade Dor Citocinas |
title_short |
The nitroxyl donor, Angeli’s salt, inhibits inflammatory hyperalgesia in rats |
title_full |
The nitroxyl donor, Angeli’s salt, inhibits inflammatory hyperalgesia in rats |
title_fullStr |
The nitroxyl donor, Angeli’s salt, inhibits inflammatory hyperalgesia in rats |
title_full_unstemmed |
The nitroxyl donor, Angeli’s salt, inhibits inflammatory hyperalgesia in rats |
title_sort |
The nitroxyl donor, Angeli’s salt, inhibits inflammatory hyperalgesia in rats |
author |
Zarpelon, Ana Carla |
author_facet |
Zarpelon, Ana Carla Souza, Guilherme R. Cunha, Thiago M. Schivo, Ieda R.S. Marchesi, Mario Casagrande, Rubia Pinge-Filho, Phileno Cunha, Fernando Q. Ferreira, Sergio H. Miranda, Katrina M. Verri Jr, Waldiceu Aparecido |
author_role |
author |
author2 |
Souza, Guilherme R. Cunha, Thiago M. Schivo, Ieda R.S. Marchesi, Mario Casagrande, Rubia Pinge-Filho, Phileno Cunha, Fernando Q. Ferreira, Sergio H. Miranda, Katrina M. Verri Jr, Waldiceu Aparecido |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Zarpelon, Ana Carla Souza, Guilherme R. Cunha, Thiago M. Schivo, Ieda R.S. Marchesi, Mario Casagrande, Rubia Pinge-Filho, Phileno Cunha, Fernando Q. Ferreira, Sergio H. Miranda, Katrina M. Verri Jr, Waldiceu Aparecido |
dc.subject.en.pt_BR.fl_str_mv |
Nitroxyl Angeli’s salt Nociception Pain Cytokine Nitric oxide |
topic |
Nitroxyl Angeli’s salt Nociception Pain Cytokine Nitric oxide Óxido Nítrico Nociceptividade Dor Citocinas |
dc.subject.decs.pt_BR.fl_str_mv |
Óxido Nítrico Nociceptividade Dor Citocinas |
description |
CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico), Fundação Araucária, FAPESP (Fundação de Amparo à Pesquisa do Estado de São Paulo), CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior), Decit/SCTIE/MS |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013 |
dc.date.accessioned.fl_str_mv |
2016-09-30T19:38:48Z |
dc.date.available.fl_str_mv |
2016-09-30T19:38:48Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ZARPELON, Ana Carla et al. The nitroxyl donor, Angeli’s salt, inhibits inflammatory hyperalgesia in rats. Neuropharmacology, n. 71, p. 1-9, 2013. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/16029 |
dc.identifier.issn.pt_BR.fl_str_mv |
0028-3908 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.1016/j.neuropharm.2013.03.009 |
identifier_str_mv |
ZARPELON, Ana Carla et al. The nitroxyl donor, Angeli’s salt, inhibits inflammatory hyperalgesia in rats. Neuropharmacology, n. 71, p. 1-9, 2013. 0028-3908 10.1016/j.neuropharm.2013.03.009 |
url |
https://www.arca.fiocruz.br/handle/icict/16029 |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Bruno Frenguelli |
publisher.none.fl_str_mv |
Bruno Frenguelli |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
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