Specific antigen serologic tests in leprosy: implications for epidemiological surveillance of leprosy cases and household contacts

Detalhes bibliográficos
Autor(a) principal: Carvalho, Ana Paula Mendes
Data de Publicação: 2017
Outros Autores: Coelho, Angélica da Conceição Oliveira, Oliveira, Rodrigo Correa de, Lana, Francisco Carlos Félix
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/29293
Resumo: Universidade Federal de Minas Gerais. Escola de Enfermagem. Programa de Pós-Graduação em Enfermagem. Belo Horizonte, MG, Brasil.
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spelling Carvalho, Ana Paula MendesCoelho, Angélica da Conceição OliveiraOliveira, Rodrigo Correa deLana, Francisco Carlos Félix2018-10-03T16:36:28Z2018-10-03T16:36:28Z2017CARVALHO, Ana Paula Mendes et al. Specific antigen serologic tests in leprosy: implications for epidemiological surveillance of leprosy cases and household contacts. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 112, n. 9, p. 609-616, Sept. 2017.0074-0276https://www.arca.fiocruz.br/handle/icict/2929310.1590/0074-02760160505engFundação Oswaldo CruzLepraMonitoramento epidemiológicoTestes sorológicosMycobacterium lepraeLeprosyEpidemiological monitoringSerologic testsMycobacterium lepraeSpecific antigen serologic tests in leprosy: implications for epidemiological surveillance of leprosy cases and household contactsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Escola de Enfermagem. Programa de Pós-Graduação em Enfermagem. Belo Horizonte, MG, Brasil.Universidade Federal de Juiz de Fora. Faculdade de Enfermagem. Departamento de Enfermagem Básica. Juiz de Fora, MG, Brasil.Universidade Federal de Minas Gerais. Escola de Enfermagem. Programa de Pós-Graduação em Enfermagem. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Escola de Enfermagem. Departamento de Enfermagem Materno-Infantil e Saúde Pública. Programa de Pós-Graduação em Enfermagem. Belo Horizonte, MG, Brasil.BACKGROUND: There is a lack of straightforward tests for field application and known biomarkers for predicting leprosy progression in infected individuals. OBJECTIVE: The aim was to analyse the response to infection by Mycobacterium leprae based on the reactivity of specific antigens: natural disaccharide linked to human serum albumin via an octyl (NDOHSA), a semisynthetic phenolic glycolipid-I (PGL-I); Leprosy Infectious Disease Research Institute Diagnostic-1 (LID-1) and natural disaccharide octyl - Leprosy Infectious Disease Research Institute Diagnostic-1 (NDOLID). METHODS: The study population consisted of 130 leprosy cases diagnosed between 2010 and 2015 and 277 household contacts. An enzyme-linked immunosorbent assay (ELISA) was used to analyse the reactivity of antibodies against NDOHSA, LID-1 and NDOLID. The samples and controls were tested in duplicate, and the antibody titer was expressed as an ELISA index. Data collection was made by home visits with application of questionnaire and dermatological evaluation of all household contacts to identify signs and symptoms of leprosy. FINDINGS: Significant differences in the median ELISA results were observed among leprosy cases in treatment, leprosy cases that had completed treatment and household contacts. Higher proportions of seropositivity were observed in leprosy cases in treatment. Seropositivity was also higher in multibacillary in relation to paucibacillary, with the difference reaching statistical significance. Lower titers were observed among cases with a longer treatment time or discharge. For household contacts, the differences according to the clinical characteristics of the leprosy index case were less pronounced than expected. Other factors, such as the endemicity of leprosy, exposure outside the residence and genetic characteristics, appeared to have a greater influence on the seropositivity. MAIN CONCLUSIONS: Serologic tests could be used as auxiliary tools for determining the operational classification, in addition to identifying infected individuals and as a strategy for surveillance of household contacts.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/29293/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALSpecific antigen serologic tests in leprosy.pdfSpecific antigen serologic tests in leprosy.pdfapplication/pdf1148323https://www.arca.fiocruz.br/bitstream/icict/29293/2/Specific%20antigen%20serologic%20tests%20in%20leprosy.pdf2133eccd063cd36f9b4abb3ddd79401cMD52TEXTSpecific antigen serologic tests in leprosy.pdf.txtSpecific antigen serologic tests in leprosy.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Specific antigen serologic tests in leprosy: implications for epidemiological surveillance of leprosy cases and household contacts
title Specific antigen serologic tests in leprosy: implications for epidemiological surveillance of leprosy cases and household contacts
spellingShingle Specific antigen serologic tests in leprosy: implications for epidemiological surveillance of leprosy cases and household contacts
Carvalho, Ana Paula Mendes
Lepra
Monitoramento epidemiológico
Testes sorológicos
Mycobacterium leprae
Leprosy
Epidemiological monitoring
Serologic tests
Mycobacterium leprae
title_short Specific antigen serologic tests in leprosy: implications for epidemiological surveillance of leprosy cases and household contacts
title_full Specific antigen serologic tests in leprosy: implications for epidemiological surveillance of leprosy cases and household contacts
title_fullStr Specific antigen serologic tests in leprosy: implications for epidemiological surveillance of leprosy cases and household contacts
title_full_unstemmed Specific antigen serologic tests in leprosy: implications for epidemiological surveillance of leprosy cases and household contacts
title_sort Specific antigen serologic tests in leprosy: implications for epidemiological surveillance of leprosy cases and household contacts
author Carvalho, Ana Paula Mendes
author_facet Carvalho, Ana Paula Mendes
Coelho, Angélica da Conceição Oliveira
Oliveira, Rodrigo Correa de
Lana, Francisco Carlos Félix
author_role author
author2 Coelho, Angélica da Conceição Oliveira
Oliveira, Rodrigo Correa de
Lana, Francisco Carlos Félix
author2_role author
author
author
dc.contributor.author.fl_str_mv Carvalho, Ana Paula Mendes
Coelho, Angélica da Conceição Oliveira
Oliveira, Rodrigo Correa de
Lana, Francisco Carlos Félix
dc.subject.other.pt_BR.fl_str_mv Lepra
Monitoramento epidemiológico
Testes sorológicos
Mycobacterium leprae
topic Lepra
Monitoramento epidemiológico
Testes sorológicos
Mycobacterium leprae
Leprosy
Epidemiological monitoring
Serologic tests
Mycobacterium leprae
dc.subject.en.pt_BR.fl_str_mv Leprosy
Epidemiological monitoring
Serologic tests
Mycobacterium leprae
description Universidade Federal de Minas Gerais. Escola de Enfermagem. Programa de Pós-Graduação em Enfermagem. Belo Horizonte, MG, Brasil.
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2018-10-03T16:36:28Z
dc.date.available.fl_str_mv 2018-10-03T16:36:28Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CARVALHO, Ana Paula Mendes et al. Specific antigen serologic tests in leprosy: implications for epidemiological surveillance of leprosy cases and household contacts. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 112, n. 9, p. 609-616, Sept. 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/29293
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/0074-02760160505
identifier_str_mv CARVALHO, Ana Paula Mendes et al. Specific antigen serologic tests in leprosy: implications for epidemiological surveillance of leprosy cases and household contacts. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 112, n. 9, p. 609-616, Sept. 2017.
0074-0276
10.1590/0074-02760160505
url https://www.arca.fiocruz.br/handle/icict/29293
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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