Intranasal Vaccination with Leishmanial Antigens Protects Golden Hamsters (Mesocricetus auratus) Against Leishmania (Viannia) braziliensis Infection
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/13733 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil. |
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Couto, Luzinei da SilvaRomão, Raquel Peralva RibeiroSaavedra, Andrea FrancoSouza, Beatriz Lilian da Silva CostaMoreira, Otacilio CruzSilva, Adriano GomesBergmann, Bartira RossiCruz, Alda Maria daPinto, Eduardo Fonseca2016-04-12T16:55:26Z2016-04-12T16:55:26Z2015COUTO, Luzinei da Silva et al. Intranasal Vaccination with Leishmanial Antigens Protects Golden Hamsters (Mesocricetus auratus) Against Leishmania (Viannia) braziliensis Infection. Plos One, v. 9, n. 1, p. 1-7, Jan. 2015.1932-6203https://www.arca.fiocruz.br/handle/icict/1373310.1371/journal.pntd.0003439engPublic Library of ScienceIntranasal Vaccination with Leishmanial Antigens Protects Golden Hamsters (Mesocricetus auratus) Against Leishmania (Viannia) braziliensis Infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho (IBCCF). Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho (IBCCF). Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.Background: Previous results have shown that oral and intranasal administration of particulate Leishmania (Leishmania) amazonensis antigens (LaAg) partially protects mice against L. amazonensis infection. However, vaccination studies on species of the subgenus Viannia, the main causative agent of cutaneous and mucosal leishmaniasis in the Americas, have been hampered by the lack of easy-to-handle bio-models that accurately mimic the human disease. Recently, we demonstrated that the golden hamster is an appropriate model for studying the immunopathogenesis of cutaneous leishmaniasis caused by L. (Viannia) braziliensis. Using the golden hamster model, our current study investigated whether the protective effect of intranasal immunisation with LaAg can be extended to L. braziliensis infection. Methodology/Principal Findings: Golden hamsters vaccinated with either two intranasal (IN) doses of LaAg (10 mg) or two intramuscular doses of LaAg (20 mg) were challenged 2 weeks post-vaccination with L. braziliensis. The results showed that IN immunisation with LaAg significantly reduced lesion growth and parasitic load as well as serum IgG and IgG2 levels. At the experimental endpoint on day 114 post-infection, IN-immunised hamsters that were considered protected expressed IFN-c and IL10 mRNA levels that returned to uninfected skin levels. In contrast to the nasal route, intramuscular (IM) immunisation failed to provide protection. Conclusions/Significance: These results demonstrate for the first time that the nasal route of immunisation can induce cross protection against L. braziliensis infection.Leishmania (Viannia) braziliensisInfectionImmunizationMesocricetusIntranasal VaccinationMesocricetusLeishmania braziliensisInfecçãoImunizaçãoVacinaçãoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/13733/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALeduardo_pinto_etal_IOC_2015.PDFeduardo_pinto_etal_IOC_2015.PDFapplication/pdf746965https://www.arca.fiocruz.br/bitstream/icict/13733/2/eduardo_pinto_etal_IOC_2015.PDF9ceff3f77203960eddb2c695ec746309MD52TEXTeduardo_pinto_etal_IOC_2015.PDF.txteduardo_pinto_etal_IOC_2015.PDF.txtExtracted 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dc.title.pt_BR.fl_str_mv |
Intranasal Vaccination with Leishmanial Antigens Protects Golden Hamsters (Mesocricetus auratus) Against Leishmania (Viannia) braziliensis Infection |
title |
Intranasal Vaccination with Leishmanial Antigens Protects Golden Hamsters (Mesocricetus auratus) Against Leishmania (Viannia) braziliensis Infection |
spellingShingle |
Intranasal Vaccination with Leishmanial Antigens Protects Golden Hamsters (Mesocricetus auratus) Against Leishmania (Viannia) braziliensis Infection Couto, Luzinei da Silva Leishmania (Viannia) braziliensis Infection Immunization Mesocricetus Intranasal Vaccination Mesocricetus Leishmania braziliensis Infecção Imunização Vacinação |
title_short |
Intranasal Vaccination with Leishmanial Antigens Protects Golden Hamsters (Mesocricetus auratus) Against Leishmania (Viannia) braziliensis Infection |
title_full |
Intranasal Vaccination with Leishmanial Antigens Protects Golden Hamsters (Mesocricetus auratus) Against Leishmania (Viannia) braziliensis Infection |
title_fullStr |
Intranasal Vaccination with Leishmanial Antigens Protects Golden Hamsters (Mesocricetus auratus) Against Leishmania (Viannia) braziliensis Infection |
title_full_unstemmed |
Intranasal Vaccination with Leishmanial Antigens Protects Golden Hamsters (Mesocricetus auratus) Against Leishmania (Viannia) braziliensis Infection |
title_sort |
Intranasal Vaccination with Leishmanial Antigens Protects Golden Hamsters (Mesocricetus auratus) Against Leishmania (Viannia) braziliensis Infection |
author |
Couto, Luzinei da Silva |
author_facet |
Couto, Luzinei da Silva Romão, Raquel Peralva Ribeiro Saavedra, Andrea Franco Souza, Beatriz Lilian da Silva Costa Moreira, Otacilio Cruz Silva, Adriano Gomes Bergmann, Bartira Rossi Cruz, Alda Maria da Pinto, Eduardo Fonseca |
author_role |
author |
author2 |
Romão, Raquel Peralva Ribeiro Saavedra, Andrea Franco Souza, Beatriz Lilian da Silva Costa Moreira, Otacilio Cruz Silva, Adriano Gomes Bergmann, Bartira Rossi Cruz, Alda Maria da Pinto, Eduardo Fonseca |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Couto, Luzinei da Silva Romão, Raquel Peralva Ribeiro Saavedra, Andrea Franco Souza, Beatriz Lilian da Silva Costa Moreira, Otacilio Cruz Silva, Adriano Gomes Bergmann, Bartira Rossi Cruz, Alda Maria da Pinto, Eduardo Fonseca |
dc.subject.en.pt_BR.fl_str_mv |
Leishmania (Viannia) braziliensis Infection Immunization Mesocricetus Intranasal Vaccination |
topic |
Leishmania (Viannia) braziliensis Infection Immunization Mesocricetus Intranasal Vaccination Mesocricetus Leishmania braziliensis Infecção Imunização Vacinação |
dc.subject.decs.pt_BR.fl_str_mv |
Mesocricetus Leishmania braziliensis Infecção Imunização Vacinação |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015 |
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2016-04-12T16:55:26Z |
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2016-04-12T16:55:26Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
COUTO, Luzinei da Silva et al. Intranasal Vaccination with Leishmanial Antigens Protects Golden Hamsters (Mesocricetus auratus) Against Leishmania (Viannia) braziliensis Infection. Plos One, v. 9, n. 1, p. 1-7, Jan. 2015. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/13733 |
dc.identifier.issn.none.fl_str_mv |
1932-6203 |
dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pntd.0003439 |
identifier_str_mv |
COUTO, Luzinei da Silva et al. Intranasal Vaccination with Leishmanial Antigens Protects Golden Hamsters (Mesocricetus auratus) Against Leishmania (Viannia) braziliensis Infection. Plos One, v. 9, n. 1, p. 1-7, Jan. 2015. 1932-6203 10.1371/journal.pntd.0003439 |
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https://www.arca.fiocruz.br/handle/icict/13733 |
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Public Library of Science |
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Public Library of Science |
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