Types of marriages, population structure and genetic disease

Detalhes bibliográficos
Autor(a) principal: Machado, Taisa Manuela Bonfim
Data de Publicação: 2013
Outros Autores: Bomfim, Thais Ferreira, Souza, L. V, Soares, Neci Matos, Santos, F. L, Acosta, Angelina Xavier, Sandes, Kiyoko Abe
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7233
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Institute of Health Science. Laboratory of Immunology and Molecular Biology. Salvador, BA, Brasil.
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spelling Machado, Taisa Manuela BonfimBomfim, Thais FerreiraSouza, L. VSoares, Neci MatosSantos, F. LAcosta, Angelina XavierSandes, Kiyoko Abe2013-11-13T17:58:52Z2013-11-13T17:58:52Z2013MACHADO, T. M. B. et al. Types of marriages, population structure and genetic disease. Journal of Biosocial Science, v. 45, p. 461-470, 2013.0021-9320https://www.arca.fiocruz.br/handle/icict/723310.1017/S0021932012000673engCambridge University PressGenéticaPopulaçãoCasamentoGenéticaPopulaçãoCasamentoEndogamia humanaMigração humanaTypes of marriages, population structure and genetic diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Institute of Health Science. Laboratory of Immunology and Molecular Biology. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Institute of Health Science. Laboratory of Immunology and Molecular Biology. Salvador, BA, Brasil.Federal Institute of Education. Science and Technology of Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil.Federal University of Bahia Reconcavo. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. School of Medicine of Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / State University of Bahia. Salvador, Bahia, Brasil / Federal University of Bahia Reconcavo. Salvador, BA, Brasil.A high occurrence rate of consanguineous marriages may favour the onset and increased frequency of autosomal recessive diseases in a population. The population of Monte Santo, Bahia, Brazil, has a high frequency of rare genetic diseases such as mucopolysaccharidosis type VI, whose observed frequency in this population is 1:5000, while the incidence of this disease recorded in other regions of the world varies from 1:43,261 in Turkey to 1:1,505,160 in Switzerland. To verify the influence of consanguineous marriage on the increased frequency of observed genetic diseases in this population, the population structure and frequency of different types of marriage during different time periods were evaluated. A total of 9765 marriages were found in an analysis of parish marriage records from the city. Over three periods, 1860–1895, 1950–1961 and 1975–2010, the inbreeding rates were 37.1%, 13.2% and 4.2% respectively. Although there was a high rate of inbreeding, endogamic marriages were the dominant marriage type in all three periods. In the most recent period, there was an increase in the number of exogamous marriages and those among immigrants, but most of these occurred among individuals from cities that neighbour Monte Santo. The low rate of migration and high frequency of endogamic and consanguineous marriages show that growth of this population is predominantly internal and could explain the occurrence, and increase in frequency, of recessive genetic diseases in the city.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALMachado TM Types of marriages....pdfMachado TM Types of marriages....pdfapplication/pdf327895https://www.arca.fiocruz.br/bitstream/icict/7233/1/Machado%20TM%20Types%20of%20marriages....pdf00be59a3aada841466756fea690959a9MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7233/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTMachado TM Types of marriages....pdf.txtMachado TM Types of marriages....pdf.txtExtracted texttext/plain30217https://www.arca.fiocruz.br/bitstream/icict/7233/5/Machado%20TM%20Types%20of%20marriages....pdf.txt15a09e60352555b60b16bc1df7fe6bd1MD55THUMBNAILMachado TM Types of marriages....pdf.jpgMachado TM Types of marriages....pdf.jpgGenerated Thumbnailimage/jpeg1882https://www.arca.fiocruz.br/bitstream/icict/7233/4/Machado%20TM%20Types%20of%20marriages....pdf.jpg8967a0d9d34376e9cf24af3f0c5a4605MD54icict/72332023-03-15 14:33:24.307oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:24Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Types of marriages, population structure and genetic disease
title Types of marriages, population structure and genetic disease
spellingShingle Types of marriages, population structure and genetic disease
Machado, Taisa Manuela Bonfim
Genética
População
Casamento
Genética
População
Casamento
Endogamia humana
Migração humana
title_short Types of marriages, population structure and genetic disease
title_full Types of marriages, population structure and genetic disease
title_fullStr Types of marriages, population structure and genetic disease
title_full_unstemmed Types of marriages, population structure and genetic disease
title_sort Types of marriages, population structure and genetic disease
author Machado, Taisa Manuela Bonfim
author_facet Machado, Taisa Manuela Bonfim
Bomfim, Thais Ferreira
Souza, L. V
Soares, Neci Matos
Santos, F. L
Acosta, Angelina Xavier
Sandes, Kiyoko Abe
author_role author
author2 Bomfim, Thais Ferreira
Souza, L. V
Soares, Neci Matos
Santos, F. L
Acosta, Angelina Xavier
Sandes, Kiyoko Abe
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Machado, Taisa Manuela Bonfim
Bomfim, Thais Ferreira
Souza, L. V
Soares, Neci Matos
Santos, F. L
Acosta, Angelina Xavier
Sandes, Kiyoko Abe
dc.subject.other.pt_BR.fl_str_mv Genética
População
Casamento
topic Genética
População
Casamento
Genética
População
Casamento
Endogamia humana
Migração humana
dc.subject.decs.pt_BR.fl_str_mv Genética
População
Casamento
Endogamia humana
Migração humana
description Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Institute of Health Science. Laboratory of Immunology and Molecular Biology. Salvador, BA, Brasil.
publishDate 2013
dc.date.accessioned.fl_str_mv 2013-11-13T17:58:52Z
dc.date.available.fl_str_mv 2013-11-13T17:58:52Z
dc.date.issued.fl_str_mv 2013
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MACHADO, T. M. B. et al. Types of marriages, population structure and genetic disease. Journal of Biosocial Science, v. 45, p. 461-470, 2013.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7233
dc.identifier.issn.none.fl_str_mv 0021-9320
dc.identifier.doi.none.fl_str_mv 10.1017/S0021932012000673
identifier_str_mv MACHADO, T. M. B. et al. Types of marriages, population structure and genetic disease. Journal of Biosocial Science, v. 45, p. 461-470, 2013.
0021-9320
10.1017/S0021932012000673
url https://www.arca.fiocruz.br/handle/icict/7233
dc.language.iso.fl_str_mv eng
language eng
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dc.publisher.none.fl_str_mv Cambridge University Press
publisher.none.fl_str_mv Cambridge University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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