Types of marriages, population structure and genetic disease

Detalhes bibliográficos
Autor(a) principal: Machado, Taisa Manuela Bonfim
Data de Publicação: 2013
Outros Autores: Bomfim, Thaís Ferreira, Souza, L. V., Soares, N., Santos, F. L., Acosta, Angelina Xavier, Abe Sandes, Kiyoko
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/13597
Resumo: p. 461–470
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spelling Machado, Taisa Manuela BonfimBomfim, Thaís FerreiraSouza, L. V.Soares, N.Santos, F. L.Acosta, Angelina XavierAbe Sandes, Kiyoko2013-11-08T18:29:17Z2013-11-08T18:29:17Z20130021-9320http://repositorio.ufba.br/ri/handle/ri/13597p. 461–470A high occurrence rate of consanguineous marriages may favour the onset and increased frequency of autosomal recessive diseases in a population. The population of Monte Santo, Bahia, Brazil, has a high frequency of rare genetic diseases such as mucopolysaccharidosis type VI, whose observed frequency in this population is 1:5000, while the incidence of this disease recorded in other regions of the world varies from 1:43,261 in Turkey to 1:1,505,160 in Switzerland. To verify the influence of consanguineous marriage on the increased frequency of observed genetic diseases in this population, the population structure and frequency of different types of marriage during different time periods were evaluated. A total of 9765 marriages were found in an analysis of parish marriage records from the city. Over three periods, 1860–1895, 1950–1961 and 1975–2010, the inbreeding rates were 37.1%, 13.2% and 4.2% respectively. Although there was a high rate of inbreeding, endogamic marriages were the dominant marriage type in all three periods. In the most recent period, there was an increase in the number of exogamous marriages and those among immigrants, but most of these occurred among individuals from cities that neighbour Monte Santo. The low rate of migration and high frequency of endogamic and consanguineous marriages show that growth of this population is predominantly internal and could explain the occurrence, and increase in frequency, of recessive genetic diseases in the city.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-10-29T18:30:59Z No. of bitstreams: 1 22222.pdf: 327991 bytes, checksum: 2034040204790d41f69575c6eeee012f (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-11-08T18:29:17Z (GMT) No. of bitstreams: 1 22222.pdf: 327991 bytes, checksum: 2034040204790d41f69575c6eeee012f (MD5)Made available in DSpace on 2013-11-08T18:29:17Z (GMT). No. of bitstreams: 1 22222.pdf: 327991 bytes, checksum: 2034040204790d41f69575c6eeee012f (MD5) Previous issue date: 2013SalvadorJournal of Biosocial ScienceBrasilhttp://journals.cambridge.org/abstract_S0021932012000673reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBATypes of marriages, population structure and genetic diseaseJournal of Biosocial Scienceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessengORIGINAL22222.pdf22222.pdfapplication/pdf327991https://repositorio.ufba.br/bitstream/ri/13597/1/22222.pdf2034040204790d41f69575c6eeee012fMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/13597/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXT22222.pdf.txt22222.pdf.txtExtracted texttext/plain29989https://repositorio.ufba.br/bitstream/ri/13597/3/22222.pdf.txta295028b3d25e30f196942db896f39c4MD53ri/135972022-03-09 20:29:14.429oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-03-09T23:29:14Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Types of marriages, population structure and genetic disease
dc.title.alternative.pt_BR.fl_str_mv Journal of Biosocial Science
title Types of marriages, population structure and genetic disease
spellingShingle Types of marriages, population structure and genetic disease
Machado, Taisa Manuela Bonfim
title_short Types of marriages, population structure and genetic disease
title_full Types of marriages, population structure and genetic disease
title_fullStr Types of marriages, population structure and genetic disease
title_full_unstemmed Types of marriages, population structure and genetic disease
title_sort Types of marriages, population structure and genetic disease
author Machado, Taisa Manuela Bonfim
author_facet Machado, Taisa Manuela Bonfim
Bomfim, Thaís Ferreira
Souza, L. V.
Soares, N.
Santos, F. L.
Acosta, Angelina Xavier
Abe Sandes, Kiyoko
author_role author
author2 Bomfim, Thaís Ferreira
Souza, L. V.
Soares, N.
Santos, F. L.
Acosta, Angelina Xavier
Abe Sandes, Kiyoko
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Machado, Taisa Manuela Bonfim
Bomfim, Thaís Ferreira
Souza, L. V.
Soares, N.
Santos, F. L.
Acosta, Angelina Xavier
Abe Sandes, Kiyoko
description p. 461–470
publishDate 2013
dc.date.accessioned.fl_str_mv 2013-11-08T18:29:17Z
dc.date.available.fl_str_mv 2013-11-08T18:29:17Z
dc.date.issued.fl_str_mv 2013
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dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/13597
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dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Journal of Biosocial Science
dc.publisher.country.fl_str_mv Brasil
publisher.none.fl_str_mv Journal of Biosocial Science
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