Epidemiology of Shigella infections and diarrhea in the first two years of life using culture-independent diagnostics in 8 lowresource settings
| Autor(a) principal: | |
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| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/45674 |
Resumo: | Department of Public Health Sciences, University of Virginia. Charlottesville, Virginia, USA / Division of Infectious Diseases & International Health. University of Virginia. Charlottesville, Virginia, USA. |
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McQuade, Elizabeth T. RogawskiShaheen, FarihaKabir, FurqanRizvi, ArjumandPlatts-Mills, James A.Aziz, FatimaKalam, AdilQureshi, ShahidaElwood, SarahLiu, JieLima, Aldo A. M.Kang, GagandeepBessong, PascalSamie, AmidouHaque, RashidulMduma, Estomih R.Kosek, Margaret N.Shrestha, SanjayaLeite, José Paulo G.Bodhidatta, LadapornPage, NicolaKiwelu, IreenShakoor, SadiaTurab, AliSoofi, Sajid BashirAhmed, TahmeedHoupt, Eric R.Bhutta, ZulfiqarIqbal, Najeeha Talat2021-01-13T20:37:48Z2021-01-13T20:37:48Z2020MCQUADE, Elizabeth T. Rogawski et al. Epidemiology of Shigella infections and diarrhea in the first two years of life using culture-independent diagnostics in 8 lowresource settings. PLoS Neglected Tropical Diseases, v. 14, n. 8, e0008536, p. 1-17, Aug. 2020.1935-2727https://www.arca.fiocruz.br/handle/icict/4567410.1371/journal.pntd.00085361935-2735engPublic Library of ScienceEpídemiologiaDiarréia infantilInfecções por ShigellaDiagnósticoEpidemiologyShigella infectionsDiarrheaChildrenDiagnosticsEpidemiology of Shigella infections and diarrhea in the first two years of life using culture-independent diagnostics in 8 lowresource settingsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDepartment of Public Health Sciences, University of Virginia. Charlottesville, Virginia, USA / Division of Infectious Diseases & International Health. University of Virginia. Charlottesville, Virginia, USA.Department of Pediatrics and Child Health. Aga Khan University. Karachi, Pakistan.Department of Pediatrics and Child Health. Aga Khan University. Karachi, Pakistan.Department of Pediatrics and Child Health. Aga Khan University. Karachi, Pakistan.Division of Infectious Diseases & International Health. University of Virginia. Charlottesville, Virginia, USA.Department of Pediatrics and Child Health. Aga Khan University. Karachi, Pakistan.Department of Pediatrics and Child Health. Aga Khan University. Karachi, Pakistan.Department of Pediatrics and Child Health. Aga Khan University. Karachi, Pakistan.Division of Infectious Diseases & International Health. University of Virginia. Charlottesville, Virginia, USA.Division of Infectious Diseases & International Health. University of Virginia. Charlottesville, Virginia, USA.Universidade Federal do Ceará. Fortaleza, CE, Brasil.Christian Medical College. Vellore, India.University of Venda. Thohoyandou, South Africa.University of Venda. Thohoyandou, South Africa.International Centre for Diarrheal Disease Research. Bangladesh, Dhaka, Bangladesh.Haydom Global Health Research Centre. Haydom, Tanzania.Division of Infectious Diseases & International Health. University of Virginia. Charlottesville, Virginia, USA / Asociación Benéfica PRISMA. Iquitos, Peru.Walter Reed/AFRIMS Research Unit, Nepal. Kathmandu, Nepal.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Armed Forces Research Institute of Medical Sciences (AFRIMS. Bangkok, Thailand.National Institute for Communicable Diseases. Johannesburg, South Africa.Kilimanjaro Clinical Research Institute. Moshi, Tanzania.Department of Pathology and Laboratory Medicine. Aga Khan University. Karachi, Pakistan.Department of Pediatrics and Child Health. Aga Khan University. Karachi, Pakistan.International Centre for Diarrheal Disease Research. Bangladesh, Dhaka, Bangladesh.Division of Infectious Diseases & International Health. University of Virginia. Charlottesville, Virginia, USA.Department of Pediatrics and Child Health. Aga Khan University. Karachi, Pakistan.Department of Pediatrics and Child Health and Biological & Biomedical Sciences. Aga Khan University. Karachi, Pakistan.Culture-independent diagnostics have revealed a larger burden of Shigella among children in low-resource settings than previously recognized. We further characterized the epidemiology of Shigella in the first two years of life in a multisite birth cohort. We tested 41,405 diarrheal and monthly non-diarrheal stools from 1,715 children for Shigella by quantitative PCR. To assess risk factors, clinical factors related to age and culture positivity, and associations with inflammatory biomarkers, we used log-binomial regression with generalized estimating equations. The prevalence of Shigella varied from 4.9%-17.8% in non-diarrheal stools across sites, and the incidence of Shigella-attributable diarrhea was 31.8 cases (95% CI: 29.6, 34.2) per 100 child-years. The sensitivity of culture compared to qPCR was 6.6% and increased to 27.8% in Shigella-attributable dysentery. Shigella diarrhea episodes were more likely to be severe and less likely to be culture positive in younger children. Older age (RR: 1.75, 95% CI: 1.70, 1.81 per 6-month increase in age), unimproved sanitation (RR: 1.15, 95% CI: 1.03, 1.29), low maternal education (<10 years, RR: 1.14, 95% CI: 1.03, 1.26), initiating complementary foods before 3 months (RR: 1.10, 95% CI: 1.01, 1.20), and malnutrition (RR: 0.91, 95% CI: 0.88, 0.95 per unit increase in weight-for-age z-score) were risk factors for Shigella. There was a linear dose-response between Shigella quantity and myeloperoxidase concentrations. The burden of Shigella varied widely across sites, but uniformly increased through the second year of life and was associated with intestinal inflammation. Culture missed most clinically relevant cases of severe diarrhea and dysentery.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/45674/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALJosePauloLeite_ElizabethMcQuade_etal_IOC_2020.pdfJosePauloLeite_ElizabethMcQuade_etal_IOC_2020.pdfapplication/pdf1471187https://www.arca.fiocruz.br/bitstream/icict/45674/2/JosePauloLeite_ElizabethMcQuade_etal_IOC_2020.pdf191daea00f2726c84e0bf70ccc31071cMD52TEXTJosePauloLeite_ElizabethMcQuade_etal_IOC_2020.pdf.txtJosePauloLeite_ElizabethMcQuade_etal_IOC_2020.pdf.txtExtracted texttext/plain59341https://www.arca.fiocruz.br/bitstream/icict/45674/3/JosePauloLeite_ElizabethMcQuade_etal_IOC_2020.pdf.txt7a41b00b0ed503e36ec0a6a122260269MD53icict/456742021-03-13 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Epidemiology of Shigella infections and diarrhea in the first two years of life using culture-independent diagnostics in 8 lowresource settings |
| title |
Epidemiology of Shigella infections and diarrhea in the first two years of life using culture-independent diagnostics in 8 lowresource settings |
| spellingShingle |
Epidemiology of Shigella infections and diarrhea in the first two years of life using culture-independent diagnostics in 8 lowresource settings McQuade, Elizabeth T. Rogawski Epídemiologia Diarréia infantil Infecções por Shigella Diagnóstico Epidemiology Shigella infections Diarrhea Children Diagnostics |
| title_short |
Epidemiology of Shigella infections and diarrhea in the first two years of life using culture-independent diagnostics in 8 lowresource settings |
| title_full |
Epidemiology of Shigella infections and diarrhea in the first two years of life using culture-independent diagnostics in 8 lowresource settings |
| title_fullStr |
Epidemiology of Shigella infections and diarrhea in the first two years of life using culture-independent diagnostics in 8 lowresource settings |
| title_full_unstemmed |
Epidemiology of Shigella infections and diarrhea in the first two years of life using culture-independent diagnostics in 8 lowresource settings |
| title_sort |
Epidemiology of Shigella infections and diarrhea in the first two years of life using culture-independent diagnostics in 8 lowresource settings |
| author |
McQuade, Elizabeth T. Rogawski |
| author_facet |
McQuade, Elizabeth T. Rogawski Shaheen, Fariha Kabir, Furqan Rizvi, Arjumand Platts-Mills, James A. Aziz, Fatima Kalam, Adil Qureshi, Shahida Elwood, Sarah Liu, Jie Lima, Aldo A. M. Kang, Gagandeep Bessong, Pascal Samie, Amidou Haque, Rashidul Mduma, Estomih R. Kosek, Margaret N. Shrestha, Sanjaya Leite, José Paulo G. Bodhidatta, Ladaporn Page, Nicola Kiwelu, Ireen Shakoor, Sadia Turab, Ali Soofi, Sajid Bashir Ahmed, Tahmeed Houpt, Eric R. Bhutta, Zulfiqar Iqbal, Najeeha Talat |
| author_role |
author |
| author2 |
Shaheen, Fariha Kabir, Furqan Rizvi, Arjumand Platts-Mills, James A. Aziz, Fatima Kalam, Adil Qureshi, Shahida Elwood, Sarah Liu, Jie Lima, Aldo A. M. Kang, Gagandeep Bessong, Pascal Samie, Amidou Haque, Rashidul Mduma, Estomih R. Kosek, Margaret N. Shrestha, Sanjaya Leite, José Paulo G. Bodhidatta, Ladaporn Page, Nicola Kiwelu, Ireen Shakoor, Sadia Turab, Ali Soofi, Sajid Bashir Ahmed, Tahmeed Houpt, Eric R. Bhutta, Zulfiqar Iqbal, Najeeha Talat |
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author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
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McQuade, Elizabeth T. Rogawski Shaheen, Fariha Kabir, Furqan Rizvi, Arjumand Platts-Mills, James A. Aziz, Fatima Kalam, Adil Qureshi, Shahida Elwood, Sarah Liu, Jie Lima, Aldo A. M. Kang, Gagandeep Bessong, Pascal Samie, Amidou Haque, Rashidul Mduma, Estomih R. Kosek, Margaret N. Shrestha, Sanjaya Leite, José Paulo G. Bodhidatta, Ladaporn Page, Nicola Kiwelu, Ireen Shakoor, Sadia Turab, Ali Soofi, Sajid Bashir Ahmed, Tahmeed Houpt, Eric R. Bhutta, Zulfiqar Iqbal, Najeeha Talat |
| dc.subject.other.pt_BR.fl_str_mv |
Epídemiologia Diarréia infantil Infecções por Shigella Diagnóstico |
| topic |
Epídemiologia Diarréia infantil Infecções por Shigella Diagnóstico Epidemiology Shigella infections Diarrhea Children Diagnostics |
| dc.subject.en.pt_BR.fl_str_mv |
Epidemiology Shigella infections Diarrhea Children Diagnostics |
| description |
Department of Public Health Sciences, University of Virginia. Charlottesville, Virginia, USA / Division of Infectious Diseases & International Health. University of Virginia. Charlottesville, Virginia, USA. |
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2020 |
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2020 |
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2021-01-13T20:37:48Z |
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2021-01-13T20:37:48Z |
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MCQUADE, Elizabeth T. Rogawski et al. Epidemiology of Shigella infections and diarrhea in the first two years of life using culture-independent diagnostics in 8 lowresource settings. PLoS Neglected Tropical Diseases, v. 14, n. 8, e0008536, p. 1-17, Aug. 2020. |
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https://www.arca.fiocruz.br/handle/icict/45674 |
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1935-2727 |
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10.1371/journal.pntd.0008536 |
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1935-2735 |
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MCQUADE, Elizabeth T. Rogawski et al. Epidemiology of Shigella infections and diarrhea in the first two years of life using culture-independent diagnostics in 8 lowresource settings. PLoS Neglected Tropical Diseases, v. 14, n. 8, e0008536, p. 1-17, Aug. 2020. 1935-2727 10.1371/journal.pntd.0008536 1935-2735 |
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