Towards a standard protocol for antimony intralesional infiltration technique for cutaneous leishmaniasis treatment
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/25172 |
Resumo: | Fundação Oswaldo Cruz. Instituto René Rachou. Centro de Referência em Leishmanioses, Pesquisa Clínica e Políticas Públicas em Doenças Infecto-Parasitárias. Belo Horizonte, MG, Brasil. |
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Silva, Rosiana Estéfane daCarvalho, Janaína de PinaRamalho, Dario BrockSenna, Maria Camilo Ribeiro DeMoreira, Hugo Silva AssisRabello, Ana Lúcia TelesCota, ÉrikaCota, Gláucia Fernandes2018-03-07T17:17:25Z2018-03-07T17:17:25Z2018SILVA, Rosiana Estéfane da et al. Towards a standard protocol for antimony intralesional infiltration technique for cutaneous leishmaniasis treatment. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 113, n. 2, p. 71-79, 2018.0074-0276https://www.arca.fiocruz.br/handle/icict/2517210.1590/0074-027601700125engFundação Oswaldo CruzLeishmaniose CutâneaTerapiaAntimoniato de MegluminaInfiltração IntralesionalValidaçãoCutaneous leishmaniasisTherapyMeglumine antimoniateIntralesional infiltrationValidationTowards a standard protocol for antimony intralesional infiltration technique for cutaneous leishmaniasis treatmentinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto René Rachou. Centro de Referência em Leishmanioses, Pesquisa Clínica e Políticas Públicas em Doenças Infecto-Parasitárias. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Centro de Referência em Leishmanioses, Pesquisa Clínica e Políticas Públicas em Doenças Infecto-Parasitárias. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Centro de Referência em Leishmanioses, Pesquisa Clínica e Políticas Públicas em Doenças Infecto-Parasitárias. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Centro de Referência em Leishmanioses, Pesquisa Clínica e Políticas Públicas em Doenças Infecto-Parasitárias. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Centro de Referência em Leishmanioses, Pesquisa Clínica e Políticas Públicas em Doenças Infecto-Parasitárias. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Centro de Referência em Leishmanioses, Pesquisa Clínica e Políticas Públicas em Doenças Infecto-Parasitárias. Belo Horizonte, MG, Brasil.Universidade Federal do Rio Grande do Sul. Instituto de Informática. Porto Alegre, RS, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Centro de Referência em Leishmanioses, Pesquisa Clínica e Políticas Públicas em Doenças Infecto-Parasitárias. Belo Horizonte, MG, Brasil.BACKGROUND: Despite its recognised toxicity, antimonial therapy continues to be the first-line drug for cutaneous leishmaniasis (CL) treatment. Intralesional administration of meglumine antimoniate (MA) represents an alternative that could reduce the systemic absorption of the drug and its side effects. OBJECTIVES: This study aims to validate the standard operational procedure (SOP) for the intralesional infiltration of MA for CL therapy as the first step before the assessment of efficacy and safety related to the procedure. METHODS: The SOP was created based on 21 trials retrieved from the literature, direct monitoring of the procedure and consultation with experts. This script was submitted to a formal computer-aided inspection to identify readability, clarity, omission, redundancy and unnecessary information (content validation). For criterion and construct validations, the influence of critical condition changes (compliance with the instructions and professional experience) on outcome conformity (saturation status achievement), tolerability (pain referred) and safety (bleeding) were assessed. FINDINGS: The median procedure length was 12 minutes and in 72% of them, patients classified the pain as mild. The bleeding was also classified as mild in 96.6% of the procedures. Full compliance with the SOP was observed in 66% of infiltrations. Despite this, in 100% of the inspected procedures, lesion saturation was observed at the end of infiltration, which means that it tolerates some degree of modification in its execution (robustness) without prejudice to the result. CONCLUSIONS: The procedure is reproducible and can be used by professionals without previous training with high success and safety rates.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/25172/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALTowards a standard protocol for antimony.pdfTowards a standard protocol for antimony.pdfapplication/pdf584185https://www.arca.fiocruz.br/bitstream/icict/25172/2/Towards%20a%20standard%20protocol%20for%20antimony.pdfe7e3d5273b317b06a81d7dfbe9570228MD52TEXTTowards a standard protocol for antimony.pdf.txtTowards a standard protocol for antimony.pdf.txtExtracted texttext/plain50451https://www.arca.fiocruz.br/bitstream/icict/25172/3/Towards%20a%20standard%20protocol%20for%20antimony.pdf.txt0e3c068cc08994b56415643ce63bbd09MD53icict/251722019-12-23 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| dc.title.pt_BR.fl_str_mv |
Towards a standard protocol for antimony intralesional infiltration technique for cutaneous leishmaniasis treatment |
| title |
Towards a standard protocol for antimony intralesional infiltration technique for cutaneous leishmaniasis treatment |
| spellingShingle |
Towards a standard protocol for antimony intralesional infiltration technique for cutaneous leishmaniasis treatment Silva, Rosiana Estéfane da Leishmaniose Cutânea Terapia Antimoniato de Meglumina Infiltração Intralesional Validação Cutaneous leishmaniasis Therapy Meglumine antimoniate Intralesional infiltration Validation |
| title_short |
Towards a standard protocol for antimony intralesional infiltration technique for cutaneous leishmaniasis treatment |
| title_full |
Towards a standard protocol for antimony intralesional infiltration technique for cutaneous leishmaniasis treatment |
| title_fullStr |
Towards a standard protocol for antimony intralesional infiltration technique for cutaneous leishmaniasis treatment |
| title_full_unstemmed |
Towards a standard protocol for antimony intralesional infiltration technique for cutaneous leishmaniasis treatment |
| title_sort |
Towards a standard protocol for antimony intralesional infiltration technique for cutaneous leishmaniasis treatment |
| author |
Silva, Rosiana Estéfane da |
| author_facet |
Silva, Rosiana Estéfane da Carvalho, Janaína de Pina Ramalho, Dario Brock Senna, Maria Camilo Ribeiro De Moreira, Hugo Silva Assis Rabello, Ana Lúcia Teles Cota, Érika Cota, Gláucia Fernandes |
| author_role |
author |
| author2 |
Carvalho, Janaína de Pina Ramalho, Dario Brock Senna, Maria Camilo Ribeiro De Moreira, Hugo Silva Assis Rabello, Ana Lúcia Teles Cota, Érika Cota, Gláucia Fernandes |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Silva, Rosiana Estéfane da Carvalho, Janaína de Pina Ramalho, Dario Brock Senna, Maria Camilo Ribeiro De Moreira, Hugo Silva Assis Rabello, Ana Lúcia Teles Cota, Érika Cota, Gláucia Fernandes |
| dc.subject.other.pt_BR.fl_str_mv |
Leishmaniose Cutânea Terapia Antimoniato de Meglumina Infiltração Intralesional Validação |
| topic |
Leishmaniose Cutânea Terapia Antimoniato de Meglumina Infiltração Intralesional Validação Cutaneous leishmaniasis Therapy Meglumine antimoniate Intralesional infiltration Validation |
| dc.subject.en.pt_BR.fl_str_mv |
Cutaneous leishmaniasis Therapy Meglumine antimoniate Intralesional infiltration Validation |
| description |
Fundação Oswaldo Cruz. Instituto René Rachou. Centro de Referência em Leishmanioses, Pesquisa Clínica e Políticas Públicas em Doenças Infecto-Parasitárias. Belo Horizonte, MG, Brasil. |
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2018 |
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2018-03-07T17:17:25Z |
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2018-03-07T17:17:25Z |
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2018 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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SILVA, Rosiana Estéfane da et al. Towards a standard protocol for antimony intralesional infiltration technique for cutaneous leishmaniasis treatment. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 113, n. 2, p. 71-79, 2018. |
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https://www.arca.fiocruz.br/handle/icict/25172 |
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0074-0276 |
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10.1590/0074-027601700125 |
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SILVA, Rosiana Estéfane da et al. Towards a standard protocol for antimony intralesional infiltration technique for cutaneous leishmaniasis treatment. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 113, n. 2, p. 71-79, 2018. 0074-0276 10.1590/0074-027601700125 |
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Fundação Oswaldo Cruz |
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