Transforming growth factor-beta in human cutaneous leishmaniasis

Barral, Aldina Maria Prado; Teixeira, Mariana; Reis, Patricia; Vinhas, Vera; Costa, Jackson Mauricio Lopes; Lessa, Helio; Bittencourt, Achilea Candida Lisboa; Reed, Steven G; Carvalho Filho, Edgar Marcelino; Barral Netto, Manoel

Transforming growth factor-beta in human cutaneous leishmaniasis

Detalhes bibliográficos
Autor(a) principal:	Barral, Aldina Maria Prado
Data de Publicação:	1995
Outros Autores:	Teixeira, Mariana, Reis, Patricia, Vinhas, Vera, Costa, Jackson Mauricio Lopes, Lessa, Helio, Bittencourt, Achilea Candida Lisboa, Reed, Steven G, Carvalho Filho, Edgar Marcelino, Barral Netto, Manoel
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/7459
Resumo:	Universidade Federal da Bahia.Faculdade de Medicina. Serviço de Imunologia e Serviço de Anatomia Patologica. Salvador, BA, Brasil

Metadados do item

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network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
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spelling	Barral, Aldina Maria PradoTeixeira, MarianaReis, PatriciaVinhas, VeraCosta, Jackson Mauricio LopesLessa, HelioBittencourt, Achilea Candida LisboaReed, Steven GCarvalho Filho, Edgar MarcelinoBarral Netto, Manoel2014-03-27T12:29:42Z2014-03-27T12:29:42Z1995BARRAL, A. et al. Transforming growth factor-beta in human cutaneous leishmaniasis. American Journal of Pathology, v. 147, n. 4, 947-953, 1995.0002-9440https://www.arca.fiocruz.br/handle/icict/7459engAmerican Societ for Investigative PathologyTransforming growth factor-beta in human cutaneous leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia.Faculdade de Medicina. Serviço de Imunologia e Serviço de Anatomia Patologica. Salvador, BA, BrasilUniversidade Federal da Bahia.Faculdade de Medicina. Serviço de Imunologia e Serviço de Anatomia Patologica. Salvador, BA, BrasilUniversidade Federal da Bahia.Faculdade de Medicina. Serviço de Imunologia e Serviço de Anatomia Patologica. Salvador, BA, BrasilUniversidade Federal da Bahia.Faculdade de Medicina. Serviço de Imunologia e Serviço de Anatomia Patologica. Salvador, BA, BrasilUniversidade Federal do Maranhão. Maranhão, SL, BrasilUniversidade Federal da Bahia.Faculdade de Medicina. Serviço de Imunologia e Serviço de Anatomia Patologica. Salvador, BA, BrasilUniversidade Federal da Bahia.Faculdade de Medicina. Serviço de Imunologia e Serviço de Anatomia Patologica. Salvador, BA, BrasilSeattle Biomedical Researcb Institute. Seattle, WashingtonUniversidade Federal da Bahia.Faculdade de Medicina. Serviço de Imunologia e Serviço de Anatomia Patologica. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunoregulação. Salvador, BA, BrasilTransforming growth factor (TGF)-beta has several downregulatory functions on the immune system: inhibition of interleukin-2 receptor induction, decrease of interferon-gamma-induced class II antigen expression, inhibition of macrophage activation, as well as cytotoxic and lymphokine-activated killer cell generation. TGF-beta has also been recognized as an important immunoregulator in murine leishmaniasis, for which it increases susceptibility to disease. In the present study we evaluate the involvement of TGF-beta in human leishmaniasis in vitro and in patients with cutaneous leishmaniasis. Human macrophages produce active TGF-beta after infection by Leishmania amazonensis (480 +/- 44.7 pg/ml; mean +/- SEM), L. donovani chagasi (295 +/- 7.6 pg/ml), or L. braziliensis (196 +/- 15.7 pg/ml). When TGF-beta was added to cultures of human macrophages infected with L. braziliensis it led to an increase of approximately 50% in parasite numbers as compared with untreated cultures. Exogenous TGF-beta added to macrophage cultures was able to reverse the effect of interferon-gamma in controlling Leishmania growth. Even at 100 IU/ml interferon-gamma the presence of TGF-beta increases the number of intracellular parasites. On the other hand, TNF-alpha at high concentration (100 IU/ml) totally blunts the suppressive effect of TGF-beta. Immunostaining for TGF-beta was observed in the dermis, produced by fibroblasts and occasionally by inflammatory cells in the biopsies from human leishmaniasis lesions, being present in most of the biopsies taken from patients with early cutaneous leishmaniasis (less than 2 months of ulcer development) and in cases of active mucosal leishmaniasis. Taken together these observations suggest an important role for TGF-beta in human leishmaniasis, with its production by infected macrophages being probably related to parasite establishment in the early stages of the disease.Leishmaniose Cutânea/metabolismoFator de Crescimento Transformador beta/metabolismoAnimaisCélulas CultivadasHumanosImuno-HistoquímicaInterferon gama/antagonistas & inibidoresInterferon gama/farmacologiaLeishmania braziliensis/fisiologiaLeishmaniose Cutânea/patologiaMacrófagos/efeitos de drogasMacrófagos/parasitologiaMacrófagos/fisiologiaFator de Crescimento Transformador beta/farmacologiaFator de Necrose Tumoral alfa/antagonistas & inibidoresFator de Necrose Tumoral alfa/farmacologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALBarral A Transforming growth factor beta in human....pdfBarral A Transforming growth factor beta in human....pdfapplication/pdf1613587https://www.arca.fiocruz.br/bitstream/icict/7459/1/Barral%20A%20Transforming%20growth%20factor%20beta%20in%20human....pdfaad1c6fa132a1219d56451a1603b5a2bMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7459/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTBarral A Transforming growth factor beta in human....pdf.txtBarral A Transforming growth factor beta in human....pdf.txtExtracted texttext/plain32252https://www.arca.fiocruz.br/bitstream/icict/7459/5/Barral%20A%20Transforming%20growth%20factor%20beta%20in%20human....pdf.txt636e3f2e11caf58d522b89ad2d36ecc4MD55THUMBNAILBarral A Transforming growth factor beta in human....pdf.jpgBarral A Transforming growth factor beta in human....pdf.jpgGenerated Thumbnailimage/jpeg2398https://www.arca.fiocruz.br/bitstream/icict/7459/4/Barral%20A%20Transforming%20growth%20factor%20beta%20in%20human....pdf.jpg7a11196e6a6f72f50543a805e7ba6911MD54icict/74592023-03-15 14:33:22.953oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:22Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv	Transforming growth factor-beta in human cutaneous leishmaniasis
title	Transforming growth factor-beta in human cutaneous leishmaniasis
spellingShingle	Transforming growth factor-beta in human cutaneous leishmaniasis Barral, Aldina Maria Prado Leishmaniose Cutânea/metabolismo Fator de Crescimento Transformador beta/metabolismo Animais Células Cultivadas Humanos Imuno-Histoquímica Interferon gama/antagonistas & inibidores Interferon gama/farmacologia Leishmania braziliensis/fisiologia Leishmaniose Cutânea/patologia Macrófagos/efeitos de drogas Macrófagos/parasitologia Macrófagos/fisiologia Fator de Crescimento Transformador beta/farmacologia Fator de Necrose Tumoral alfa/antagonistas & inibidores Fator de Necrose Tumoral alfa/farmacologia
title_short	Transforming growth factor-beta in human cutaneous leishmaniasis
title_full	Transforming growth factor-beta in human cutaneous leishmaniasis
title_fullStr	Transforming growth factor-beta in human cutaneous leishmaniasis
title_full_unstemmed	Transforming growth factor-beta in human cutaneous leishmaniasis
title_sort	Transforming growth factor-beta in human cutaneous leishmaniasis
author	Barral, Aldina Maria Prado
author_facet	Barral, Aldina Maria Prado Teixeira, Mariana Reis, Patricia Vinhas, Vera Costa, Jackson Mauricio Lopes Lessa, Helio Bittencourt, Achilea Candida Lisboa Reed, Steven G Carvalho Filho, Edgar Marcelino Barral Netto, Manoel
author_role	author
author2	Teixeira, Mariana Reis, Patricia Vinhas, Vera Costa, Jackson Mauricio Lopes Lessa, Helio Bittencourt, Achilea Candida Lisboa Reed, Steven G Carvalho Filho, Edgar Marcelino Barral Netto, Manoel
author2_role	author author author author author author author author author
dc.contributor.author.fl_str_mv	Barral, Aldina Maria Prado Teixeira, Mariana Reis, Patricia Vinhas, Vera Costa, Jackson Mauricio Lopes Lessa, Helio Bittencourt, Achilea Candida Lisboa Reed, Steven G Carvalho Filho, Edgar Marcelino Barral Netto, Manoel
dc.subject.decs.pt_BR.fl_str_mv	Leishmaniose Cutânea/metabolismo Fator de Crescimento Transformador beta/metabolismo Animais Células Cultivadas Humanos Imuno-Histoquímica Interferon gama/antagonistas & inibidores Interferon gama/farmacologia Leishmania braziliensis/fisiologia Leishmaniose Cutânea/patologia Macrófagos/efeitos de drogas Macrófagos/parasitologia Macrófagos/fisiologia Fator de Crescimento Transformador beta/farmacologia Fator de Necrose Tumoral alfa/antagonistas & inibidores Fator de Necrose Tumoral alfa/farmacologia
topic	Leishmaniose Cutânea/metabolismo Fator de Crescimento Transformador beta/metabolismo Animais Células Cultivadas Humanos Imuno-Histoquímica Interferon gama/antagonistas & inibidores Interferon gama/farmacologia Leishmania braziliensis/fisiologia Leishmaniose Cutânea/patologia Macrófagos/efeitos de drogas Macrófagos/parasitologia Macrófagos/fisiologia Fator de Crescimento Transformador beta/farmacologia Fator de Necrose Tumoral alfa/antagonistas & inibidores Fator de Necrose Tumoral alfa/farmacologia
description	Universidade Federal da Bahia.Faculdade de Medicina. Serviço de Imunologia e Serviço de Anatomia Patologica. Salvador, BA, Brasil
publishDate	1995
dc.date.issued.fl_str_mv	1995
dc.date.accessioned.fl_str_mv	2014-03-27T12:29:42Z
dc.date.available.fl_str_mv	2014-03-27T12:29:42Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	BARRAL, A. et al. Transforming growth factor-beta in human cutaneous leishmaniasis. American Journal of Pathology, v. 147, n. 4, 947-953, 1995.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/7459
dc.identifier.issn.none.fl_str_mv	0002-9440
identifier_str_mv	BARRAL, A. et al. Transforming growth factor-beta in human cutaneous leishmaniasis. American Journal of Pathology, v. 147, n. 4, 947-953, 1995. 0002-9440
url	https://www.arca.fiocruz.br/handle/icict/7459
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	American Societ for Investigative Pathology
publisher.none.fl_str_mv	American Societ for Investigative Pathology
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
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Transforming growth factor-beta in human cutaneous leishmaniasis

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