Persistent inflammation during anti-tuberculosis treatment with diabetes comorbidity

Detalhes bibliográficos
Autor(a) principal: Kumar, Nathella Pavan
Data de Publicação: 2019
Outros Autores: Fukutani, Kiyoshi Ferreira, Shruthi, Basavaradhya S., Alves, Thabata, Mattos, Paulo Sérgio de Morais da Silveira, Rocha, Michael Santos, West, Kim, Natarajan, Mohan, Viswanathan, Vijay, Babu, Subash, Andrade, Bruno de Bezerril, Kornfeld, Hardy
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/34746
Resumo: Ethics Committee of the Prof. M. Viswanathan Diabetes Research Centre (ECR/51/INST/TN/2013/MVDRC/01). The Brazilian cohort study was approved by the Ethics Committee of the Maternidade Climério de Oliveira, Federal University of Bahia (CAAE: 0115.0.054.000-09).
id CRUZ_a2c9fbc6dc55fbb4a90558f841f478bf
oai_identifier_str oai:www.arca.fiocruz.br:icict/34746
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Kumar, Nathella PavanFukutani, Kiyoshi FerreiraShruthi, Basavaradhya S.Alves, ThabataMattos, Paulo Sérgio de Morais da SilveiraRocha, Michael SantosWest, KimNatarajan, MohanViswanathan, VijayBabu, SubashAndrade, Bruno de BezerrilKornfeld, Hardy2019-08-12T18:10:13Z2019-08-12T18:10:13Z2019KUMAR, Nathella Pavan et al. Persistent inflammation during anti-tuberculosis treatment with diabetes comorbidity. eLife, v. 8, p. 1-19, 2019.2050-084Xhttps://www.arca.fiocruz.br/handle/icict/3474610.7554/eLife.46477Ethics Committee of the Prof. M. Viswanathan Diabetes Research Centre (ECR/51/INST/TN/2013/MVDRC/01). The Brazilian cohort study was approved by the Ethics Committee of the Maternidade Climério de Oliveira, Federal University of Bahia (CAAE: 0115.0.054.000-09).National Institutes of Health. National Institute for Research in Tuberculosis. International Center for Excellence in Research. Chennai, India.Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brazil / Faculdade de Tecnologia e Ciências. Salvador, BA, Brazil.Prof. M. Viswanathan Diabetes Research Center. Chennai, India.Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brazil / Universidade Salvador. Laureate Universities. Salvador, BA, Brasil.Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brazil / Faculdade de Tecnologia e Ciências. Salvador, BA, Brazil.Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brazil.University of Massachusetts Medical School. Worcester, United States.National Institute for Research in Tuberculosis. Chennai, India.Prof. M. Viswanathan Diabetes Research Center. Chennai, India.National Institutes of Health. National Institute for Research in Tuberculosis. International Center for Excellence in Research. Chennai, India.Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brazil / Faculdade de Tecnologia e Ciências. Salvador, BA, Brazil / Universidade Salvador. Laureate Universities. Salvador, BA, Brasil.University of Massachusetts Medical School. Worcester, United States.Diabetes mellitus (DM) increases risk for pulmonary tuberculosis (TB) and adverse treatment outcomes. Systemic hyper-inflammation is characteristic in people with TB and concurrent DM (TBDM) at baseline, but the impact of TB treatment on this pattern has not been determined. We measured 17 plasma cytokines and growth factors in longitudinal cohorts of Indian and Brazilian pulmonary TB patients with or without DM. Principal component analysis revealed virtually complete separation of TBDM from TB individuals in both cohorts at baseline, with hyper-inflammation in TBDM that continued through treatment completion at six months. By one year after treatment completion, there was substantial convergence of mediator levels between groups within the India cohort. Non-resolving systemic inflammation in TBDM comorbidity could reflect delayed lesion sterilization or non-resolving sterile inflammation. Either mechanism portends unfavorable long-term outcomes including risk for recurrent TB and for damaging immune pathology.engeLife Sciences PublicationsCitocinasDiabetes mellitusHumanoImunologiaDoença infecciosaInflamaçãoMicrobiologiaTuberculoseCytokinesDiabetes mellitusHumanImmunologyInfectious diseaseInflammationMicrobiologyTuberculosisPersistent inflammation during anti-tuberculosis treatment with diabetes comorbidityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/34746/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALKumar, P. N. Persistent inflammation.pdfKumar, P. N. Persistent inflammation.pdfapplication/pdf2995177https://www.arca.fiocruz.br/bitstream/icict/34746/2/Kumar%2c%20P.%20N.%20Persistent%20inflammation.pdf4768d795e0eef3adcae0c8e8e11dd985MD52TEXTKumar, P. N. Persistent inflammation.pdf.txtKumar, P. N. Persistent inflammation.pdf.txtExtracted texttext/plain64604https://www.arca.fiocruz.br/bitstream/icict/34746/3/Kumar%2c%20P.%20N.%20Persistent%20inflammation.pdf.txt3de56fff869278d829499dc6ace37d73MD53icict/347462023-03-15 14:34:18.654oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:18Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Persistent inflammation during anti-tuberculosis treatment with diabetes comorbidity
title Persistent inflammation during anti-tuberculosis treatment with diabetes comorbidity
spellingShingle Persistent inflammation during anti-tuberculosis treatment with diabetes comorbidity
Kumar, Nathella Pavan
Citocinas
Diabetes mellitus
Humano
Imunologia
Doença infecciosa
Inflamação
Microbiologia
Tuberculose
Cytokines
Diabetes mellitus
Human
Immunology
Infectious disease
Inflammation
Microbiology
Tuberculosis
title_short Persistent inflammation during anti-tuberculosis treatment with diabetes comorbidity
title_full Persistent inflammation during anti-tuberculosis treatment with diabetes comorbidity
title_fullStr Persistent inflammation during anti-tuberculosis treatment with diabetes comorbidity
title_full_unstemmed Persistent inflammation during anti-tuberculosis treatment with diabetes comorbidity
title_sort Persistent inflammation during anti-tuberculosis treatment with diabetes comorbidity
author Kumar, Nathella Pavan
author_facet Kumar, Nathella Pavan
Fukutani, Kiyoshi Ferreira
Shruthi, Basavaradhya S.
Alves, Thabata
Mattos, Paulo Sérgio de Morais da Silveira
Rocha, Michael Santos
West, Kim
Natarajan, Mohan
Viswanathan, Vijay
Babu, Subash
Andrade, Bruno de Bezerril
Kornfeld, Hardy
author_role author
author2 Fukutani, Kiyoshi Ferreira
Shruthi, Basavaradhya S.
Alves, Thabata
Mattos, Paulo Sérgio de Morais da Silveira
Rocha, Michael Santos
West, Kim
Natarajan, Mohan
Viswanathan, Vijay
Babu, Subash
Andrade, Bruno de Bezerril
Kornfeld, Hardy
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Kumar, Nathella Pavan
Fukutani, Kiyoshi Ferreira
Shruthi, Basavaradhya S.
Alves, Thabata
Mattos, Paulo Sérgio de Morais da Silveira
Rocha, Michael Santos
West, Kim
Natarajan, Mohan
Viswanathan, Vijay
Babu, Subash
Andrade, Bruno de Bezerril
Kornfeld, Hardy
dc.subject.other.pt_BR.fl_str_mv Citocinas
Diabetes mellitus
Humano
Imunologia
Doença infecciosa
Inflamação
Microbiologia
Tuberculose
topic Citocinas
Diabetes mellitus
Humano
Imunologia
Doença infecciosa
Inflamação
Microbiologia
Tuberculose
Cytokines
Diabetes mellitus
Human
Immunology
Infectious disease
Inflammation
Microbiology
Tuberculosis
dc.subject.en.pt_BR.fl_str_mv Cytokines
Diabetes mellitus
Human
Immunology
Infectious disease
Inflammation
Microbiology
Tuberculosis
description Ethics Committee of the Prof. M. Viswanathan Diabetes Research Centre (ECR/51/INST/TN/2013/MVDRC/01). The Brazilian cohort study was approved by the Ethics Committee of the Maternidade Climério de Oliveira, Federal University of Bahia (CAAE: 0115.0.054.000-09).
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-08-12T18:10:13Z
dc.date.available.fl_str_mv 2019-08-12T18:10:13Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv KUMAR, Nathella Pavan et al. Persistent inflammation during anti-tuberculosis treatment with diabetes comorbidity. eLife, v. 8, p. 1-19, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/34746
dc.identifier.issn.pt_BR.fl_str_mv 2050-084X
dc.identifier.doi.none.fl_str_mv 10.7554/eLife.46477
identifier_str_mv KUMAR, Nathella Pavan et al. Persistent inflammation during anti-tuberculosis treatment with diabetes comorbidity. eLife, v. 8, p. 1-19, 2019.
2050-084X
10.7554/eLife.46477
url https://www.arca.fiocruz.br/handle/icict/34746
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv eLife Sciences Publications
publisher.none.fl_str_mv eLife Sciences Publications
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/34746/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/34746/2/Kumar%2c%20P.%20N.%20Persistent%20inflammation.pdf
https://www.arca.fiocruz.br/bitstream/icict/34746/3/Kumar%2c%20P.%20N.%20Persistent%20inflammation.pdf.txt
bitstream.checksum.fl_str_mv 5a560609d32a3863062d77ff32785d58
4768d795e0eef3adcae0c8e8e11dd985
3de56fff869278d829499dc6ace37d73
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1798325058415886336

Registros relacionados