Systems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complications

Detalhes bibliográficos
Autor(a) principal: Medina, Cesar Augusto Prada
Data de Publicação: 2017
Outros Autores: Fukutani, Kiyoshi Ferreira, Pavan Kumar, Nathella, Santana, Leonardo Gil, Babu, Subash, Lichtenstein, Flávio, West, Kim, Sivakumar, Shanmugam, Menon, Pradeep A, Viswanathan, Vijay, Andrade, Bruno de Bezerril, Nakaya, Helder Tkashi Imoto, Kornfeld, Hardy
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/21098
Resumo: grant #USB1-31149-XX-13 (to V. Viswanathan and H. Kornfeld) jointly sponsored by the Indian Department of Biotechnology, the Indian Council of Medical Research and the National Institute for Allergy and Infectious Diseases, National Institutes of Health, and administered by CRDF Global.; FAPESP grant # 2013/08216-2 (to H. Nakaya). H. Nakaya receives a CNPq research fellowship.
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spelling Medina, Cesar Augusto PradaFukutani, Kiyoshi FerreiraPavan Kumar, NathellaSantana, Leonardo GilBabu, SubashLichtenstein, FlávioWest, KimSivakumar, ShanmugamMenon, Pradeep AViswanathan, VijayAndrade, Bruno de BezerrilNakaya, Helder Tkashi ImotoKornfeld, Hardy2017-09-25T17:09:30Z2017-09-25T17:09:30Z2017MEDINA, C. A. P. et al. Systems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complications. Scientific Reports, v. 7, p. 1999, 2017.2045-2322https://www.arca.fiocruz.br/handle/icict/2109810.1038/s41598-017-01767-4grant #USB1-31149-XX-13 (to V. Viswanathan and H. Kornfeld) jointly sponsored by the Indian Department of Biotechnology, the Indian Council of Medical Research and the National Institute for Allergy and Infectious Diseases, National Institutes of Health, and administered by CRDF Global.; FAPESP grant # 2013/08216-2 (to H. Nakaya). H. Nakaya receives a CNPq research fellowship.University of São Paulo. School of Pharmaceutical Sciences. Department of Pathophysiology and Toxicology. São Paulo, SP, BrazilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Imunoparasitologia. Salvador, BA, BrasilNational Institutes of Health- NIRT. International Center for Excellence in Research. Chennai, IndiaFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunorregulação. Unidade de Medicina Investigativa. Salvador, BA, Brasil / Instituto Brasileiro para a Investigação da Tuberculose. Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brazil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, BrazilNational Institutes of Health- NIRT. International Center for Excellence in Research. Chennai, IndiaUniversity of São Paulo. School of Pharmaceutical Sciences. Department of Pathophysiology and Toxicology. São Paulo, SP, BrazilUniversity of Massachusetts Medical School. Department of Medicine. Worcester, Massachusetts. USANational Institute for Research in Tuberculosis. Chennai, IndiaNational Institute for Research in Tuberculosis. Chennai, IndiaProf. M. Viswanathan Diabetes Research Center. Chennai, IndiaFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunorregulação. Unidade de Medicina Investigativa. Salvador, BA, Brasil / Instituto Brasileiro para a Investigação da Tuberculose. Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brazil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brazil / Universidade Salvador. Laureate Universities. Salvador, BA, Brazil / Vanderbilt University School of Medicine. Division of Infectious Diseases. Department of Medicine Nashville. USAUniversity of São Paulo. School of Pharmaceutical Sciences. Department of Pathophysiology and Toxicology. São Paulo, SP, BrazilUniversity of Massachusetts Medical School. Department of Medicine. Worcester, Massachusetts, USAComorbid diabetes mellitus (DM) increases tuberculosis (TB) risk and adverse outcomes but the pathological interactions between DM and TB remain incompletely understood. We performed an integrative analysis of whole blood gene expression and plasma analytes, comparing South Indian TB patients with and without DM to diabetic and non-diabetic controls without TB. Luminex assay of plasma cytokines and growth factors delineated a distinct biosignature in comorbid TBDM in this cohort. Transcriptional profiling revealed elements in common with published TB signatures from cohorts that excluded DM. Neutrophil count correlated with the molecular degree of perturbation, especially in TBDM patients. Body mass index and HDL cholesterol were negatively correlated with molecular degree of perturbation. Diabetic complication pathways including several pathways linked to epigenetic reprogramming were activated in TBDM above levels observed with DM alone. Our data provide a rationale for trials of host-directed therapies in TBDM, targeting neutrophilic inflammation and diabetic complication pathways to address the greater morbidity and mortality associated with this increasingly prevalent dual burden of communicable and non-communicable diseases.engNature Publishing GroupDiabetes MellitusTuberculoseSaúde públicaDoenças transmissíveisDiabetes MellitusTuberculosisPublic healthcommunicable diseasesSystems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complicationsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/21098/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMedina CAP Systems immunology....pdfMedina CAP Systems 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dc.title.pt_BR.fl_str_mv Systems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complications
title Systems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complications
spellingShingle Systems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complications
Medina, Cesar Augusto Prada
Diabetes Mellitus
Tuberculose
Saúde pública
Doenças transmissíveis
Diabetes Mellitus
Tuberculosis
Public health
communicable diseases
title_short Systems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complications
title_full Systems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complications
title_fullStr Systems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complications
title_full_unstemmed Systems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complications
title_sort Systems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complications
author Medina, Cesar Augusto Prada
author_facet Medina, Cesar Augusto Prada
Fukutani, Kiyoshi Ferreira
Pavan Kumar, Nathella
Santana, Leonardo Gil
Babu, Subash
Lichtenstein, Flávio
West, Kim
Sivakumar, Shanmugam
Menon, Pradeep A
Viswanathan, Vijay
Andrade, Bruno de Bezerril
Nakaya, Helder Tkashi Imoto
Kornfeld, Hardy
author_role author
author2 Fukutani, Kiyoshi Ferreira
Pavan Kumar, Nathella
Santana, Leonardo Gil
Babu, Subash
Lichtenstein, Flávio
West, Kim
Sivakumar, Shanmugam
Menon, Pradeep A
Viswanathan, Vijay
Andrade, Bruno de Bezerril
Nakaya, Helder Tkashi Imoto
Kornfeld, Hardy
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Medina, Cesar Augusto Prada
Fukutani, Kiyoshi Ferreira
Pavan Kumar, Nathella
Santana, Leonardo Gil
Babu, Subash
Lichtenstein, Flávio
West, Kim
Sivakumar, Shanmugam
Menon, Pradeep A
Viswanathan, Vijay
Andrade, Bruno de Bezerril
Nakaya, Helder Tkashi Imoto
Kornfeld, Hardy
dc.subject.other.pt_BR.fl_str_mv Diabetes Mellitus
Tuberculose
Saúde pública
Doenças transmissíveis
topic Diabetes Mellitus
Tuberculose
Saúde pública
Doenças transmissíveis
Diabetes Mellitus
Tuberculosis
Public health
communicable diseases
dc.subject.en.pt_BR.fl_str_mv Diabetes Mellitus
Tuberculosis
Public health
communicable diseases
description grant #USB1-31149-XX-13 (to V. Viswanathan and H. Kornfeld) jointly sponsored by the Indian Department of Biotechnology, the Indian Council of Medical Research and the National Institute for Allergy and Infectious Diseases, National Institutes of Health, and administered by CRDF Global.; FAPESP grant # 2013/08216-2 (to H. Nakaya). H. Nakaya receives a CNPq research fellowship.
publishDate 2017
dc.date.accessioned.fl_str_mv 2017-09-25T17:09:30Z
dc.date.available.fl_str_mv 2017-09-25T17:09:30Z
dc.date.issued.fl_str_mv 2017
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MEDINA, C. A. P. et al. Systems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complications. Scientific Reports, v. 7, p. 1999, 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/21098
dc.identifier.issn.pt_BR.fl_str_mv 2045-2322
dc.identifier.doi.none.fl_str_mv 10.1038/s41598-017-01767-4
identifier_str_mv MEDINA, C. A. P. et al. Systems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complications. Scientific Reports, v. 7, p. 1999, 2017.
2045-2322
10.1038/s41598-017-01767-4
url https://www.arca.fiocruz.br/handle/icict/21098
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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