Genetic evidence and host immune response in persons reinfected with SARS-CoV-2, Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/47755 |
Resumo: | Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil (N. Fintelman-Rodrigues, A.P.D. da Silva, M.C. dos Santos, F.B. Saraiva, M.A. Ferreira, J. Gesto, I.G. de Azevedo, V.C. Soares, C.Q. Sacramento, F.A. Bozza, C.M. Morel, P.T. Bozza, T.M.L. Souza); Universidade Federal do Rio de Janeiro, Rio de Janeiro (D.A.S. Rodrigues, A.M. Vale, V.C. Soares, D.A. Tschoeke); MGI Tech Co., Ltd., Shenzhen, China (H. Jiang, H. Tan); D’Or Institute for Research and Education (F.A. Bozza). |
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Fintelman-Rodrigues, NataliaSilva, Aline P. D. daSantos, Monique Cristina dosSaraiva, Felipe B.Ferreira, Marcelo A.Gesto, JoãoRodrigues, Danielle A. S.Vale, André M.Azevedo, Isaclaudia G. deSoares, Vinícius C.Jiang, HuiTan, HongdongTschoeke, Diogo A.Sacramento, Carolina Q.Bozza, Fernando A.Morel, Carlos M.Bozza, Patrícia T.Souza, Thiago Moreno L.2021-06-18T11:53:19Z2021-06-18T11:53:19Z2021FINTELMAN-RODRIGUES, Natalia et al. Genetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil. Emerging infectious diseases, v. 27, n. 5, p. 1446-1453, 20211080-6040https://www.arca.fiocruz.br/handle/icict/4775510.3201/eid2705.204912Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil (N. Fintelman-Rodrigues, A.P.D. da Silva, M.C. dos Santos, F.B. Saraiva, M.A. Ferreira, J. Gesto, I.G. de Azevedo, V.C. Soares, C.Q. Sacramento, F.A. Bozza, C.M. Morel, P.T. Bozza, T.M.L. Souza); Universidade Federal do Rio de Janeiro, Rio de Janeiro (D.A.S. Rodrigues, A.M. Vale, V.C. Soares, D.A. Tschoeke); MGI Tech Co., Ltd., Shenzhen, China (H. Jiang, H. Tan); D’Or Institute for Research and Education (F.A. Bozza).Múltipla - Ver em Notas.The dynamics underlying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection remain poorly understood. We identified a small cluster of patients in Brazil who experienced 2 episodes of coronavirus disease (COVID-19) in March and late May 2020. In the first episode, patients manifested an enhanced innate response compared with healthy persons, but neutralizing humoral immunity was not fully achieved. The second episode was associated with different SARS-CoV-2 strains, higher viral loads, and clinical symptoms. Our finding that persons with mild COVID-19 may have controlled SARS-CoV-2 replication without developing detectable humoral immunity suggests that reinfection is more frequent than supposed, but this hypothesis is not well documented.engCenters for Disease Control and PreventionGenetic evidence and host immune response in persons reinfected with SARS-CoV-2, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCOVID-19SARS-CoV-2Coronavirus diseaseHumoral responseNext-generation sequencingReinfectionRespiratory infectionsSevere acute respiratory syndrome coronavirus 2VirusesZoonosesBrazilinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
Genetic evidence and host immune response in persons reinfected with SARS-CoV-2, Brazil |
| title |
Genetic evidence and host immune response in persons reinfected with SARS-CoV-2, Brazil |
| spellingShingle |
Genetic evidence and host immune response in persons reinfected with SARS-CoV-2, Brazil Fintelman-Rodrigues, Natalia COVID-19 SARS-CoV-2 Coronavirus disease Humoral response Next-generation sequencing Reinfection Respiratory infections Severe acute respiratory syndrome coronavirus 2 Viruses Zoonoses Brazil |
| title_short |
Genetic evidence and host immune response in persons reinfected with SARS-CoV-2, Brazil |
| title_full |
Genetic evidence and host immune response in persons reinfected with SARS-CoV-2, Brazil |
| title_fullStr |
Genetic evidence and host immune response in persons reinfected with SARS-CoV-2, Brazil |
| title_full_unstemmed |
Genetic evidence and host immune response in persons reinfected with SARS-CoV-2, Brazil |
| title_sort |
Genetic evidence and host immune response in persons reinfected with SARS-CoV-2, Brazil |
| author |
Fintelman-Rodrigues, Natalia |
| author_facet |
Fintelman-Rodrigues, Natalia Silva, Aline P. D. da Santos, Monique Cristina dos Saraiva, Felipe B. Ferreira, Marcelo A. Gesto, João Rodrigues, Danielle A. S. Vale, André M. Azevedo, Isaclaudia G. de Soares, Vinícius C. Jiang, Hui Tan, Hongdong Tschoeke, Diogo A. Sacramento, Carolina Q. Bozza, Fernando A. Morel, Carlos M. Bozza, Patrícia T. Souza, Thiago Moreno L. |
| author_role |
author |
| author2 |
Silva, Aline P. D. da Santos, Monique Cristina dos Saraiva, Felipe B. Ferreira, Marcelo A. Gesto, João Rodrigues, Danielle A. S. Vale, André M. Azevedo, Isaclaudia G. de Soares, Vinícius C. Jiang, Hui Tan, Hongdong Tschoeke, Diogo A. Sacramento, Carolina Q. Bozza, Fernando A. Morel, Carlos M. Bozza, Patrícia T. Souza, Thiago Moreno L. |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Fintelman-Rodrigues, Natalia Silva, Aline P. D. da Santos, Monique Cristina dos Saraiva, Felipe B. Ferreira, Marcelo A. Gesto, João Rodrigues, Danielle A. S. Vale, André M. Azevedo, Isaclaudia G. de Soares, Vinícius C. Jiang, Hui Tan, Hongdong Tschoeke, Diogo A. Sacramento, Carolina Q. Bozza, Fernando A. Morel, Carlos M. Bozza, Patrícia T. Souza, Thiago Moreno L. |
| dc.subject.en.pt_BR.fl_str_mv |
COVID-19 SARS-CoV-2 Coronavirus disease Humoral response Next-generation sequencing Reinfection Respiratory infections Severe acute respiratory syndrome coronavirus 2 Viruses Zoonoses Brazil |
| topic |
COVID-19 SARS-CoV-2 Coronavirus disease Humoral response Next-generation sequencing Reinfection Respiratory infections Severe acute respiratory syndrome coronavirus 2 Viruses Zoonoses Brazil |
| description |
Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil (N. Fintelman-Rodrigues, A.P.D. da Silva, M.C. dos Santos, F.B. Saraiva, M.A. Ferreira, J. Gesto, I.G. de Azevedo, V.C. Soares, C.Q. Sacramento, F.A. Bozza, C.M. Morel, P.T. Bozza, T.M.L. Souza); Universidade Federal do Rio de Janeiro, Rio de Janeiro (D.A.S. Rodrigues, A.M. Vale, V.C. Soares, D.A. Tschoeke); MGI Tech Co., Ltd., Shenzhen, China (H. Jiang, H. Tan); D’Or Institute for Research and Education (F.A. Bozza). |
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2021 |
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2021-06-18T11:53:19Z |
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2021-06-18T11:53:19Z |
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2021 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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FINTELMAN-RODRIGUES, Natalia et al. Genetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil. Emerging infectious diseases, v. 27, n. 5, p. 1446-1453, 2021 |
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https://www.arca.fiocruz.br/handle/icict/47755 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1080-6040 |
| dc.identifier.doi.none.fl_str_mv |
10.3201/eid2705.204912 |
| identifier_str_mv |
FINTELMAN-RODRIGUES, Natalia et al. Genetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil. Emerging infectious diseases, v. 27, n. 5, p. 1446-1453, 2021 1080-6040 10.3201/eid2705.204912 |
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https://www.arca.fiocruz.br/handle/icict/47755 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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Centers for Disease Control and Prevention |
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Centers for Disease Control and Prevention |
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