MicroRNAs in type 2 diabetes mellitus: potential role of physical exercise

Detalhes bibliográficos
Autor(a) principal: Caria, Alex Cleber Improta
Data de Publicação: 2022
Outros Autores: Sousa, Ricardo Augusto Leoni de, Roever, Leonardo, Fernandes, Tiago, Oliveira, Edilamar Menezes de, Aras Júnior, Roque, Souza, Bruno Solano de Freitas
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.31083/j.rcm2301029
Texto Completo: https://www.arca.fiocruz.br/handle/icict/51523
Resumo: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES) – Financial Code 001
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spelling Caria, Alex Cleber ImprotaSousa, Ricardo Augusto Leoni deRoever, LeonardoFernandes, TiagoOliveira, Edilamar Menezes deAras Júnior, RoqueSouza, Bruno Solano de Freitas2022-03-03T17:19:07Z2022-03-03T17:19:07Z2022CARIA, Alex Cleber Improta et al. MicroRNAs in type 2 diabetes mellitus: potential role of physical exercise. Reviews in Cardiovascular Medicine, v. 23, n. 1, p. 1-16, 2022.1530-6550https://www.arca.fiocruz.br/handle/icict/5152310.31083/j.rcm23010292153-8174Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES) – Financial Code 001Fundação Oswaldo Cruz (FIOCRUZ)Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Programa de Pós-Graduação em Ciências da Saúde. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Sociedade Brasileira de Cardiologia. Departamento de Educação Física em Cardiologia. Salvador, BA, Brasil.Universidade Federal dos Vales do Jequitinhonha e Mucuri. Diamantina, MG, Brasil.Universidade Federal de Uberlândia. Uberlândia, MG, Brasil.Universidade de São Paulo. Escola de Educação Física e Esporte. Laboratório de Bioquímica e Biologia Molecular do Exercício. São Paulo, SP, Brasil.Universidade de São Paulo. Escola de Educação Física e Esporte. Laboratório de Bioquímica e Biologia Molecular do Exercício. São Paulo, SP, Brasil.Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil.Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Instituto D'Or de Ensino e Pesquisao. Salvador, BA, Brasil.Type 2 diabetes mellitus (T2DM) is a multifactorial metabolic disease, and its prevalence has grown worldwide. Several pathophysiological processes contribute to the development, progression and aggravating of the disease, for example, decreased insulin synthesis and secretion, insulin resistance, inflammation, and apoptosis, all these processes are regulated by various epigenetic factors, including microRNAs (miRNAs). MiRNAs are small non-coding RNAs, which are around 20 nucleotides in length and are regulators of gene expression at the post-transcriptional level, have a specific function of inhibiting or degrading a messenger RNA target. Thus, miRNAs modulate the expression of many associated genes with the pathophysiological processes in T2DM. On the other hand, miRNAs are also modulated through physical exercise (PE), which induces a change in their expression pattern during and after exercise. Some scientific evidence shows that PE modulates miRNAs beneficially and improves the signaling pathway of insulin resistance, however, little is known about the function of PE modulating miRNAs associated with the processes of insulin secretion, inflammation, and apoptosis. Thus, the objective of this review is to identify the miRNAs expression pattern in T2DM and compare it with the exercise-induced miRNAs expression pattern, identifying the signaling pathways that these miRNAs are regulating in the processes of insulin secretion, insulin resistance, inflammation, and apoptosis in T2DM, and how PE may have a potential role in modulating these signal transduction pathways, promoting benefits for patients with T2DM.engIMR PressMicroRNAs in type 2 diabetes mellitus: potential role of physical exerciseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleType 2 diabetesMicroRNAsPhysical exerciseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/51523/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALImprota-Caria, A. C. Micro-RNAs.pdfImprota-Caria, A. C. Micro-RNAs.pdfapplication/pdf1499345https://www.arca.fiocruz.br/bitstream/icict/51523/2/Improta-Caria%2c%20A.%20C.%20Micro-RNAs.pdfc2045981c606f6be18818a9ab197da67MD52icict/515232023-03-15 14:33:11.641oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:11Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv MicroRNAs in type 2 diabetes mellitus: potential role of physical exercise
title MicroRNAs in type 2 diabetes mellitus: potential role of physical exercise
spellingShingle MicroRNAs in type 2 diabetes mellitus: potential role of physical exercise
Caria, Alex Cleber Improta
Type 2 diabetes
MicroRNAs
Physical exercise
title_short MicroRNAs in type 2 diabetes mellitus: potential role of physical exercise
title_full MicroRNAs in type 2 diabetes mellitus: potential role of physical exercise
title_fullStr MicroRNAs in type 2 diabetes mellitus: potential role of physical exercise
title_full_unstemmed MicroRNAs in type 2 diabetes mellitus: potential role of physical exercise
title_sort MicroRNAs in type 2 diabetes mellitus: potential role of physical exercise
author Caria, Alex Cleber Improta
author_facet Caria, Alex Cleber Improta
Sousa, Ricardo Augusto Leoni de
Roever, Leonardo
Fernandes, Tiago
Oliveira, Edilamar Menezes de
Aras Júnior, Roque
Souza, Bruno Solano de Freitas
author_role author
author2 Sousa, Ricardo Augusto Leoni de
Roever, Leonardo
Fernandes, Tiago
Oliveira, Edilamar Menezes de
Aras Júnior, Roque
Souza, Bruno Solano de Freitas
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Caria, Alex Cleber Improta
Sousa, Ricardo Augusto Leoni de
Roever, Leonardo
Fernandes, Tiago
Oliveira, Edilamar Menezes de
Aras Júnior, Roque
Souza, Bruno Solano de Freitas
dc.subject.en.en_US.fl_str_mv Type 2 diabetes
MicroRNAs
topic Type 2 diabetes
MicroRNAs
Physical exercise
dc.subject.en.pt_BR.fl_str_mv Physical exercise
description Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES) – Financial Code 001
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-03-03T17:19:07Z
dc.date.available.fl_str_mv 2022-03-03T17:19:07Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CARIA, Alex Cleber Improta et al. MicroRNAs in type 2 diabetes mellitus: potential role of physical exercise. Reviews in Cardiovascular Medicine, v. 23, n. 1, p. 1-16, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/51523
dc.identifier.issn.pt_BR.fl_str_mv 1530-6550
dc.identifier.doi.none.fl_str_mv 10.31083/j.rcm2301029
dc.identifier.eissn.pt_BR.fl_str_mv 2153-8174
identifier_str_mv CARIA, Alex Cleber Improta et al. MicroRNAs in type 2 diabetes mellitus: potential role of physical exercise. Reviews in Cardiovascular Medicine, v. 23, n. 1, p. 1-16, 2022.
1530-6550
10.31083/j.rcm2301029
2153-8174
url https://www.arca.fiocruz.br/handle/icict/51523
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv IMR Press
publisher.none.fl_str_mv IMR Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/51523/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/51523/2/Improta-Caria%2c%20A.%20C.%20Micro-RNAs.pdf
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