Clinical Presentation of Parvovirus B19 Infection in Adults Living with HIV/AIDS: A Case Series

Detalhes bibliográficos
Autor(a) principal: Almeida, Daniela P. Mendes de
Data de Publicação: 2023
Outros Autores: Bokel, Joanna Paes Barreto, Alves, Arthur Daniel Rocha, Vizzoni, Alexandre G., Tavares, Isabel Cristina Ferreira, Silva, Mayara Secco Torres, Barbosa Netto, Juliana dos Santos, Grinsztejn, Beatriz, Leon, Luciane Almeida Amado
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/58913
Resumo: Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Departamento de Hematologia. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Câncer. Centro de Pesquisa. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Bio-Manguinhos. Instituto de Tecnologia em Imunobiológicos. Departamento de Assuntos Médicos, Estudos Clínicos e Vigilância Pós-Registro (DEAME). Rio de Janeiro, RJ, Brasil.
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spelling Almeida, Daniela P. Mendes deBokel, Joanna Paes BarretoAlves, Arthur Daniel RochaVizzoni, Alexandre G.Tavares, Isabel Cristina FerreiraSilva, Mayara Secco TorresBarbosa Netto, Juliana dos SantosGrinsztejn, BeatrizLeon, Luciane Almeida Amado2023-06-03T10:54:19Z2023-06-03T10:54:19Z2023ALMEIDA, Daniela P. Mendes de et al. Clinical Presentation of Parvovirus B19 Infection in Adults Living with HIV/AIDS: A Case Series. Viruses, v. 15, 1124, p. 1 - 10, May 2023.1999-4915https://www.arca.fiocruz.br/handle/icict/5891310.3390/v15051124engMDPIParvovirus B19Infecção pelo HIVHemóliseEsferocitose hereditáriaParvovirus B19HIV infectionHemolysisHereditary spherocytosisClinical Presentation of Parvovirus B19 Infection in Adults Living with HIV/AIDS: A Case Seriesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Departamento de Hematologia. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Câncer. Centro de Pesquisa. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Bio-Manguinhos. Instituto de Tecnologia em Imunobiológicos. Departamento de Assuntos Médicos, Estudos Clínicos e Vigilância Pós-Registro (DEAME). Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Departamento de Hematologia. Rio de Janeiro, RJ, Brasil / Clínica São Vicente. Unidade de Onco-Hematologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Departamento de Hematologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil.Abstract: Parvovirus B19 (B19V) infection varies clinically depending on the host’s immune status. Due to red blood cell precursors tropism, B19V can cause chronic anemia and transient aplastic crisis in patients with immunosuppression or chronic hemolysis. We report three rare cases of Brazilian adults living with human immunodeficiency virus (HIV) with B19V infection. All cases presented severe anemia and required red blood cell transfusions. The first patient had low CD4+ counts and was treated with intravenous immunoglobulin (IVIG). As he remained poorly adherent to antiretroviral therapy (ART), B19V detection persisted. The second patient had sudden pancytopenia despite being on ART with an undetectable HIV viral load. He had historically low CD4+ counts, fully responded to IVIG, and had undiagnosed hereditary spherocytosis. The third individual was recently diagnosed with HIV and tuberculosis (TB). One month after ART initiation, he was hospitalized with anemia aggravation and cholestatic hepatitis. An analysis of his serum revealed B19V DNA and anti-B19V IgG, corroborating bone marrow findings and a persistent B19V infection. The symptoms resolved and B19V became undetectable. In all cases, real time PCR was essential for diagnosing B19V. Our findings showed that adherence to ART was crucial to B19V clearance in HIV-patients and highlighted the importance of the early recognition of B19V disease in unexplained cytopenias.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/58913/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALArturAlves_LucianeLeon_etal_IOC_2023.pdfArturAlves_LucianeLeon_etal_IOC_2023.pdfapplication/pdf3162212https://www.arca.fiocruz.br/bitstream/icict/58913/2/ArturAlves_LucianeLeon_etal_IOC_2023.pdfae1a3c5c598fa12034381241fc262c9aMD52icict/589132023-09-04 11:17:38.81oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-04T14:17:38Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Clinical Presentation of Parvovirus B19 Infection in Adults Living with HIV/AIDS: A Case Series
title Clinical Presentation of Parvovirus B19 Infection in Adults Living with HIV/AIDS: A Case Series
spellingShingle Clinical Presentation of Parvovirus B19 Infection in Adults Living with HIV/AIDS: A Case Series
Almeida, Daniela P. Mendes de
Parvovirus B19
Infecção pelo HIV
Hemólise
Esferocitose hereditária
Parvovirus B19
HIV infection
Hemolysis
Hereditary spherocytosis
title_short Clinical Presentation of Parvovirus B19 Infection in Adults Living with HIV/AIDS: A Case Series
title_full Clinical Presentation of Parvovirus B19 Infection in Adults Living with HIV/AIDS: A Case Series
title_fullStr Clinical Presentation of Parvovirus B19 Infection in Adults Living with HIV/AIDS: A Case Series
title_full_unstemmed Clinical Presentation of Parvovirus B19 Infection in Adults Living with HIV/AIDS: A Case Series
title_sort Clinical Presentation of Parvovirus B19 Infection in Adults Living with HIV/AIDS: A Case Series
author Almeida, Daniela P. Mendes de
author_facet Almeida, Daniela P. Mendes de
Bokel, Joanna Paes Barreto
Alves, Arthur Daniel Rocha
Vizzoni, Alexandre G.
Tavares, Isabel Cristina Ferreira
Silva, Mayara Secco Torres
Barbosa Netto, Juliana dos Santos
Grinsztejn, Beatriz
Leon, Luciane Almeida Amado
author_role author
author2 Bokel, Joanna Paes Barreto
Alves, Arthur Daniel Rocha
Vizzoni, Alexandre G.
Tavares, Isabel Cristina Ferreira
Silva, Mayara Secco Torres
Barbosa Netto, Juliana dos Santos
Grinsztejn, Beatriz
Leon, Luciane Almeida Amado
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Almeida, Daniela P. Mendes de
Bokel, Joanna Paes Barreto
Alves, Arthur Daniel Rocha
Vizzoni, Alexandre G.
Tavares, Isabel Cristina Ferreira
Silva, Mayara Secco Torres
Barbosa Netto, Juliana dos Santos
Grinsztejn, Beatriz
Leon, Luciane Almeida Amado
dc.subject.other.en_US.fl_str_mv Parvovirus B19
Infecção pelo HIV
Hemólise
Esferocitose hereditária
topic Parvovirus B19
Infecção pelo HIV
Hemólise
Esferocitose hereditária
Parvovirus B19
HIV infection
Hemolysis
Hereditary spherocytosis
dc.subject.en.en_US.fl_str_mv Parvovirus B19
HIV infection
Hemolysis
Hereditary spherocytosis
description Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Departamento de Hematologia. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Câncer. Centro de Pesquisa. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Bio-Manguinhos. Instituto de Tecnologia em Imunobiológicos. Departamento de Assuntos Médicos, Estudos Clínicos e Vigilância Pós-Registro (DEAME). Rio de Janeiro, RJ, Brasil.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-06-03T10:54:19Z
dc.date.available.fl_str_mv 2023-06-03T10:54:19Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ALMEIDA, Daniela P. Mendes de et al. Clinical Presentation of Parvovirus B19 Infection in Adults Living with HIV/AIDS: A Case Series. Viruses, v. 15, 1124, p. 1 - 10, May 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/58913
dc.identifier.issn.en_US.fl_str_mv 1999-4915
dc.identifier.doi.none.fl_str_mv 10.3390/v15051124
identifier_str_mv ALMEIDA, Daniela P. Mendes de et al. Clinical Presentation of Parvovirus B19 Infection in Adults Living with HIV/AIDS: A Case Series. Viruses, v. 15, 1124, p. 1 - 10, May 2023.
1999-4915
10.3390/v15051124
url https://www.arca.fiocruz.br/handle/icict/58913
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/58913/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/58913/2/ArturAlves_LucianeLeon_etal_IOC_2023.pdf
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