Warifteine, an alkaloid of Cissampelos sympodialis, modulates allergic profile in a chronic allergic rhinitis model

Detalhes bibliográficos
Autor(a) principal: Vieira, Giciane C.
Data de Publicação: 2018
Outros Autores: Gadelha, Francisco A. A. F., Pereira, Raquel F., Ferreira, Laércia K. D. P., Barbosa Filho, José M., Bozza, Patricia, Piuvezam, Marcia R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/36906
Resumo: Universidade Federal da Paraíba. Centro de Ciências da Saúde. Departamento de Morfologia. Laboratório de Imunofarmacologia. João Pessoa, PB, Brasil.
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spelling Vieira, Giciane C.Gadelha, Francisco A. A. F.Pereira, Raquel F.Ferreira, Laércia K. D. P.Barbosa Filho, José M.Bozza, PatriciaPiuvezam, Marcia R.2019-11-06T16:22:17Z2019-11-06T16:22:17Z2018VIEIRA, Giciane C. et al. Warifteine, an alkaloid of Cissampelos sympodialis, modulates allergic profile in a chronic allergic rhinitis model. Revista Brasileira de Farmacognosia, Curitiba, v. 28, n. 1, p. 50-56, 2018.0102-695Xhttps://www.arca.fiocruz.br/handle/icict/3690610.1016/j.bjp.2017.10.0091981-528XengUniversidade Federal do Paraná. Laboratório de FarmacognosiaRinite alérgicaTecidos nasaisMastócitosImunoglobulina EAllergic rhinitisEosinophilIgENasal tissuesMast cellsWarifteineImunoglobulina EWarifteine, an alkaloid of Cissampelos sympodialis, modulates allergic profile in a chronic allergic rhinitis modelinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Paraíba. Centro de Ciências da Saúde. Departamento de Morfologia. Laboratório de Imunofarmacologia. João Pessoa, PB, Brasil.Universidade Federal da Paraíba. Centro de Ciências da Saúde. Departamento de Fisiologia e Patologia. Laboratório de Imunofarmacologia. João Pessoa, PB, Brasil.Universidade Federal da Paraíba. Centro de Ciências da Saúde. Departamento de Morfologia. Laboratório de Imunofarmacologia. João Pessoa, PB, Brasil.Universidade Federal da Paraíba. Centro de Ciências da Saúde. Departamento de Fisiologia e Patologia. Laboratório de Imunofarmacologia. João Pessoa, PB, Brasil.Universidade Federal da Paraíba. Centro de Ciências da Saúde. Departamento de Ciências Farmacêuticas. Laboratório de Fitoquímica. João Pessoa, PB, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Universidade Federal da Paraíba. Centro de Ciências da Saúde. Departamento de Fisiologia e Patologia. Laboratório de Imunofarmacologia. João Pessoa, PB, Brasil.Cissampelos sympodialis Eichler, Menispermaceae, a Brazilian medicinal plant and its alkaloid warifteine present immunomodulatory activity on asthma experimental model by reducing antigen-specific IgE levels, eosinophil infiltration and lung hyperactivity. Allergic rhinitis is a chronic inflammatory disorder of the nasal tissue that affect the quality of life and it is a risk factor for asthma exacerbation. This study evaluated the effect of inhaled warifteine in an allergic ovalbumin rhinitis model. Inhaled warifteine (2 mg/ml) treatment of ovalbumin-sensitized BALB/c mice significant decreased total and differential number of cells on the nasal cavity and decreased ovalbumin-specific IgE serum levels. Hematoxylin & eosin staining of histological preparations of ovalbumin nasal tissues showed changes such as congestion and a massive cell infiltration in the perivascular and subepithelial regions characterizing the nasal inflammatory process. However, inhaled warifteine or dexamethasone treatment decreased cell infiltration into the perivascular regions and it was observed an intact nasal tissue. Periodic acidic staining of nasal epithelium of ovalbumin animals demonstrated high amount of mucus production by goblet cells and inhaled warifteine or dexamethasone treatment modulated the mucus production. In addition, toluidine blue staining of the nasal epithelium of ovalbumin animals demonstrated an increase of mast cells on the tissue and inhaled warifteine or dexamethasone treatment decreased in average of 1.4 times the number of these cells on the nasal epithelium. Taken these data together we postulate that warifteine, an immunomodulatory alkaloid, can be a medicinal molecule prototype to ameliorate the allergic rhinitis conditions.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/36906/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMarciaPiuvesam_PatriciaBozza_etal_IOC_2018.pdfMarciaPiuvesam_PatriciaBozza_etal_IOC_2018.pdfapplication/pdf1148753https://www.arca.fiocruz.br/bitstream/icict/36906/2/MarciaPiuvesam_PatriciaBozza_etal_IOC_2018.pdf91aebdc83a7aa85957ee5616babe7496MD52TEXTMarciaPiuvesam_PatriciaBozza_etal_IOC_2018.pdf.txtMarciaPiuvesam_PatriciaBozza_etal_IOC_2018.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Warifteine, an alkaloid of Cissampelos sympodialis, modulates allergic profile in a chronic allergic rhinitis model
title Warifteine, an alkaloid of Cissampelos sympodialis, modulates allergic profile in a chronic allergic rhinitis model
spellingShingle Warifteine, an alkaloid of Cissampelos sympodialis, modulates allergic profile in a chronic allergic rhinitis model
Vieira, Giciane C.
Rinite alérgica
Tecidos nasais
Mastócitos
Imunoglobulina E
Allergic rhinitis
Eosinophil
IgE
Nasal tissues
Mast cells
Warifteine
Imunoglobulina E
title_short Warifteine, an alkaloid of Cissampelos sympodialis, modulates allergic profile in a chronic allergic rhinitis model
title_full Warifteine, an alkaloid of Cissampelos sympodialis, modulates allergic profile in a chronic allergic rhinitis model
title_fullStr Warifteine, an alkaloid of Cissampelos sympodialis, modulates allergic profile in a chronic allergic rhinitis model
title_full_unstemmed Warifteine, an alkaloid of Cissampelos sympodialis, modulates allergic profile in a chronic allergic rhinitis model
title_sort Warifteine, an alkaloid of Cissampelos sympodialis, modulates allergic profile in a chronic allergic rhinitis model
author Vieira, Giciane C.
author_facet Vieira, Giciane C.
Gadelha, Francisco A. A. F.
Pereira, Raquel F.
Ferreira, Laércia K. D. P.
Barbosa Filho, José M.
Bozza, Patricia
Piuvezam, Marcia R.
author_role author
author2 Gadelha, Francisco A. A. F.
Pereira, Raquel F.
Ferreira, Laércia K. D. P.
Barbosa Filho, José M.
Bozza, Patricia
Piuvezam, Marcia R.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Vieira, Giciane C.
Gadelha, Francisco A. A. F.
Pereira, Raquel F.
Ferreira, Laércia K. D. P.
Barbosa Filho, José M.
Bozza, Patricia
Piuvezam, Marcia R.
dc.subject.other.pt_BR.fl_str_mv Rinite alérgica
Tecidos nasais
Mastócitos
Imunoglobulina E
topic Rinite alérgica
Tecidos nasais
Mastócitos
Imunoglobulina E
Allergic rhinitis
Eosinophil
IgE
Nasal tissues
Mast cells
Warifteine
Imunoglobulina E
dc.subject.en.pt_BR.fl_str_mv Allergic rhinitis
Eosinophil
IgE
Nasal tissues
Mast cells
Warifteine
dc.subject.decs.pt_BR.fl_str_mv Imunoglobulina E
description Universidade Federal da Paraíba. Centro de Ciências da Saúde. Departamento de Morfologia. Laboratório de Imunofarmacologia. João Pessoa, PB, Brasil.
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-11-06T16:22:17Z
dc.date.available.fl_str_mv 2019-11-06T16:22:17Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv VIEIRA, Giciane C. et al. Warifteine, an alkaloid of Cissampelos sympodialis, modulates allergic profile in a chronic allergic rhinitis model. Revista Brasileira de Farmacognosia, Curitiba, v. 28, n. 1, p. 50-56, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/36906
dc.identifier.issn.pt_BR.fl_str_mv 0102-695X
dc.identifier.doi.none.fl_str_mv 10.1016/j.bjp.2017.10.009
dc.identifier.eissn.none.fl_str_mv 1981-528X
identifier_str_mv VIEIRA, Giciane C. et al. Warifteine, an alkaloid of Cissampelos sympodialis, modulates allergic profile in a chronic allergic rhinitis model. Revista Brasileira de Farmacognosia, Curitiba, v. 28, n. 1, p. 50-56, 2018.
0102-695X
10.1016/j.bjp.2017.10.009
1981-528X
url https://www.arca.fiocruz.br/handle/icict/36906
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Universidade Federal do Paraná. Laboratório de Farmacognosia
publisher.none.fl_str_mv Universidade Federal do Paraná. Laboratório de Farmacognosia
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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instacron:FIOCRUZ
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