Warifteine, an alkaloid of Cissampelos sympodialis, modulates allergic profile in a chronic allergic rhinitis model
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/36906 |
Resumo: | Universidade Federal da Paraíba. Centro de Ciências da Saúde. Departamento de Morfologia. Laboratório de Imunofarmacologia. João Pessoa, PB, Brasil. |
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Vieira, Giciane C.Gadelha, Francisco A. A. F.Pereira, Raquel F.Ferreira, Laércia K. D. P.Barbosa Filho, José M.Bozza, PatriciaPiuvezam, Marcia R.2019-11-06T16:22:17Z2019-11-06T16:22:17Z2018VIEIRA, Giciane C. et al. Warifteine, an alkaloid of Cissampelos sympodialis, modulates allergic profile in a chronic allergic rhinitis model. Revista Brasileira de Farmacognosia, Curitiba, v. 28, n. 1, p. 50-56, 2018.0102-695Xhttps://www.arca.fiocruz.br/handle/icict/3690610.1016/j.bjp.2017.10.0091981-528XengUniversidade Federal do Paraná. Laboratório de FarmacognosiaRinite alérgicaTecidos nasaisMastócitosImunoglobulina EAllergic rhinitisEosinophilIgENasal tissuesMast cellsWarifteineImunoglobulina EWarifteine, an alkaloid of Cissampelos sympodialis, modulates allergic profile in a chronic allergic rhinitis modelinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Paraíba. Centro de Ciências da Saúde. Departamento de Morfologia. Laboratório de Imunofarmacologia. João Pessoa, PB, Brasil.Universidade Federal da Paraíba. Centro de Ciências da Saúde. Departamento de Fisiologia e Patologia. Laboratório de Imunofarmacologia. João Pessoa, PB, Brasil.Universidade Federal da Paraíba. Centro de Ciências da Saúde. Departamento de Morfologia. Laboratório de Imunofarmacologia. João Pessoa, PB, Brasil.Universidade Federal da Paraíba. Centro de Ciências da Saúde. Departamento de Fisiologia e Patologia. Laboratório de Imunofarmacologia. João Pessoa, PB, Brasil.Universidade Federal da Paraíba. Centro de Ciências da Saúde. Departamento de Ciências Farmacêuticas. Laboratório de Fitoquímica. João Pessoa, PB, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Universidade Federal da Paraíba. Centro de Ciências da Saúde. Departamento de Fisiologia e Patologia. Laboratório de Imunofarmacologia. João Pessoa, PB, Brasil.Cissampelos sympodialis Eichler, Menispermaceae, a Brazilian medicinal plant and its alkaloid warifteine present immunomodulatory activity on asthma experimental model by reducing antigen-specific IgE levels, eosinophil infiltration and lung hyperactivity. Allergic rhinitis is a chronic inflammatory disorder of the nasal tissue that affect the quality of life and it is a risk factor for asthma exacerbation. This study evaluated the effect of inhaled warifteine in an allergic ovalbumin rhinitis model. Inhaled warifteine (2 mg/ml) treatment of ovalbumin-sensitized BALB/c mice significant decreased total and differential number of cells on the nasal cavity and decreased ovalbumin-specific IgE serum levels. Hematoxylin & eosin staining of histological preparations of ovalbumin nasal tissues showed changes such as congestion and a massive cell infiltration in the perivascular and subepithelial regions characterizing the nasal inflammatory process. However, inhaled warifteine or dexamethasone treatment decreased cell infiltration into the perivascular regions and it was observed an intact nasal tissue. Periodic acidic staining of nasal epithelium of ovalbumin animals demonstrated high amount of mucus production by goblet cells and inhaled warifteine or dexamethasone treatment modulated the mucus production. In addition, toluidine blue staining of the nasal epithelium of ovalbumin animals demonstrated an increase of mast cells on the tissue and inhaled warifteine or dexamethasone treatment decreased in average of 1.4 times the number of these cells on the nasal epithelium. Taken these data together we postulate that warifteine, an immunomodulatory alkaloid, can be a medicinal molecule prototype to ameliorate the allergic rhinitis conditions.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/36906/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMarciaPiuvesam_PatriciaBozza_etal_IOC_2018.pdfMarciaPiuvesam_PatriciaBozza_etal_IOC_2018.pdfapplication/pdf1148753https://www.arca.fiocruz.br/bitstream/icict/36906/2/MarciaPiuvesam_PatriciaBozza_etal_IOC_2018.pdf91aebdc83a7aa85957ee5616babe7496MD52TEXTMarciaPiuvesam_PatriciaBozza_etal_IOC_2018.pdf.txtMarciaPiuvesam_PatriciaBozza_etal_IOC_2018.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv |
Warifteine, an alkaloid of Cissampelos sympodialis, modulates allergic profile in a chronic allergic rhinitis model |
title |
Warifteine, an alkaloid of Cissampelos sympodialis, modulates allergic profile in a chronic allergic rhinitis model |
spellingShingle |
Warifteine, an alkaloid of Cissampelos sympodialis, modulates allergic profile in a chronic allergic rhinitis model Vieira, Giciane C. Rinite alérgica Tecidos nasais Mastócitos Imunoglobulina E Allergic rhinitis Eosinophil IgE Nasal tissues Mast cells Warifteine Imunoglobulina E |
title_short |
Warifteine, an alkaloid of Cissampelos sympodialis, modulates allergic profile in a chronic allergic rhinitis model |
title_full |
Warifteine, an alkaloid of Cissampelos sympodialis, modulates allergic profile in a chronic allergic rhinitis model |
title_fullStr |
Warifteine, an alkaloid of Cissampelos sympodialis, modulates allergic profile in a chronic allergic rhinitis model |
title_full_unstemmed |
Warifteine, an alkaloid of Cissampelos sympodialis, modulates allergic profile in a chronic allergic rhinitis model |
title_sort |
Warifteine, an alkaloid of Cissampelos sympodialis, modulates allergic profile in a chronic allergic rhinitis model |
author |
Vieira, Giciane C. |
author_facet |
Vieira, Giciane C. Gadelha, Francisco A. A. F. Pereira, Raquel F. Ferreira, Laércia K. D. P. Barbosa Filho, José M. Bozza, Patricia Piuvezam, Marcia R. |
author_role |
author |
author2 |
Gadelha, Francisco A. A. F. Pereira, Raquel F. Ferreira, Laércia K. D. P. Barbosa Filho, José M. Bozza, Patricia Piuvezam, Marcia R. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Vieira, Giciane C. Gadelha, Francisco A. A. F. Pereira, Raquel F. Ferreira, Laércia K. D. P. Barbosa Filho, José M. Bozza, Patricia Piuvezam, Marcia R. |
dc.subject.other.pt_BR.fl_str_mv |
Rinite alérgica Tecidos nasais Mastócitos Imunoglobulina E |
topic |
Rinite alérgica Tecidos nasais Mastócitos Imunoglobulina E Allergic rhinitis Eosinophil IgE Nasal tissues Mast cells Warifteine Imunoglobulina E |
dc.subject.en.pt_BR.fl_str_mv |
Allergic rhinitis Eosinophil IgE Nasal tissues Mast cells Warifteine |
dc.subject.decs.pt_BR.fl_str_mv |
Imunoglobulina E |
description |
Universidade Federal da Paraíba. Centro de Ciências da Saúde. Departamento de Morfologia. Laboratório de Imunofarmacologia. João Pessoa, PB, Brasil. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2019-11-06T16:22:17Z |
dc.date.available.fl_str_mv |
2019-11-06T16:22:17Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
VIEIRA, Giciane C. et al. Warifteine, an alkaloid of Cissampelos sympodialis, modulates allergic profile in a chronic allergic rhinitis model. Revista Brasileira de Farmacognosia, Curitiba, v. 28, n. 1, p. 50-56, 2018. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/36906 |
dc.identifier.issn.pt_BR.fl_str_mv |
0102-695X |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.bjp.2017.10.009 |
dc.identifier.eissn.none.fl_str_mv |
1981-528X |
identifier_str_mv |
VIEIRA, Giciane C. et al. Warifteine, an alkaloid of Cissampelos sympodialis, modulates allergic profile in a chronic allergic rhinitis model. Revista Brasileira de Farmacognosia, Curitiba, v. 28, n. 1, p. 50-56, 2018. 0102-695X 10.1016/j.bjp.2017.10.009 1981-528X |
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https://www.arca.fiocruz.br/handle/icict/36906 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal do Paraná. Laboratório de Farmacognosia |
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Universidade Federal do Paraná. Laboratório de Farmacognosia |
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