Emulating a trial of joint dynamic strategies: An application to monitoring and treatment of HIV-positive individuals

Caniglia, Ellen C.; Robins, James M.; Cain, Lauren E.; Sabin, Caroline; Logan, Roger; Abgrall, Sophie; Mugavero, Michael J.; Hernández-Díaz, Sonia; Meyer, Laurence; Seng, Remonie; Drozd, Daniel R.; Seage Iii, George R.; Bonnet, Fabrice; Le Marec, Fabien; Moore, Richard D.; Reiss, Peter; van Sighem, Ard; Mathews, William C.; Jarrín, Inma; Alejos, Belén; Deeks, Steven G.; Muga, Roberto; Boswell, Stephen L.; Ferrer, Elena; Eron, Joseph J.; Gill, John; Pacheco, Antonio; Grinsztejn, Beatriz; Napravnik, Sonia; Jose, Sophie; Phillips, Andrew; Justice, Amy; Tate, Janet; Bucher, Heiner C.; Egger, Matthias; Furrer, Hansjakob; Miro, Jose M.; Casabona, Jordi; Porter, Kholoud; Touloumi, Giota; Crane, Heidi; Costagliola, Dominique; Saag, Michael; Hernán, Miguel A.

Emulating a trial of joint dynamic strategies: An application to monitoring and treatment of HIV-positive individuals

Detalhes bibliográficos
Autor(a) principal:	Caniglia, Ellen C.
Data de Publicação:	2019
Outros Autores:	Robins, James M., Cain, Lauren E., Sabin, Caroline, Logan, Roger, Abgrall, Sophie, Mugavero, Michael J., Hernández-Díaz, Sonia, Meyer, Laurence, Seng, Remonie, Drozd, Daniel R., Seage Iii, George R., Bonnet, Fabrice, Le Marec, Fabien, Moore, Richard D., Reiss, Peter, van Sighem, Ard, Mathews, William C., Jarrín, Inma, Alejos, Belén, Deeks, Steven G., Muga, Roberto, Boswell, Stephen L., Ferrer, Elena, Eron, Joseph J., Gill, John, Pacheco, Antonio, Grinsztejn, Beatriz, Napravnik, Sonia, Jose, Sophie, Phillips, Andrew, Justice, Amy, Tate, Janet, Bucher, Heiner C., Egger, Matthias, Furrer, Hansjakob, Miro, Jose M., Casabona, Jordi, Porter, Kholoud, Touloumi, Giota, Crane, Heidi, Costagliola, Dominique, Saag, Michael, Hernán, Miguel A.
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/35578
Resumo:	Harvard T. H. Chan School of Public Health. Department of Epidemiology. Boston, Massachusetts, USA / New York University. School of Medicine. Department of Population Health. New York, USA.

Metadados do item

id	CRUZ_a40d5ac7c4551af3c61b977e7e13b2ab
oai_identifier_str	oai:www.arca.fiocruz.br:icict/35578
network_acronym_str	CRUZ
network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str	2135
spelling	Caniglia, Ellen C.Robins, James M.Cain, Lauren E.Sabin, CarolineLogan, RogerAbgrall, SophieMugavero, Michael J.Hernández-Díaz, SoniaMeyer, LaurenceSeng, RemonieDrozd, Daniel R.Seage Iii, George R.Bonnet, FabriceLe Marec, FabienMoore, Richard D.Reiss, Petervan Sighem, ArdMathews, William C.Jarrín, InmaAlejos, BelénDeeks, Steven G.Muga, RobertoBoswell, Stephen L.Ferrer, ElenaEron, Joseph J.Gill, JohnPacheco, AntonioGrinsztejn, BeatrizNapravnik, SoniaJose, SophiePhillips, AndrewJustice, AmyTate, JanetBucher, Heiner C.Egger, MatthiasFurrer, HansjakobMiro, Jose M.Casabona, JordiPorter, KholoudTouloumi, GiotaCrane, HeidiCostagliola, DominiqueSaag, MichaelHernán, Miguel A.2019-09-13T16:08:07Z2019-09-13T16:08:07Z2019CANIGLIA, Ellen C. et al. Emulating a trial of joint dynamic strategies: An application to monitoring and treatment of HIV-positive individuals. Statistics in Medicine, v. 38, p. 2428-2446, Jan. 2019.0277-6715https://www.arca.fiocruz.br/handle/icict/3557810.1002/sim.8120Emulating a trial of joint dynamic strategies: An application to monitoring and treatment of HIV-positive individualsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHarvard T. H. Chan School of Public Health. Department of Epidemiology. Boston, Massachusetts, USA / New York University. School of Medicine. Department of Population Health. New York, USA.Harvard T. H. Chan School of Public Health. Department of Epidemiology. Boston, Massachusetts, USA / Harvard T.H. Chan School of Public Health. Department of Biostatistics. Boston, Massachusetts, USA.Harvard T. H. Chan School of Public Health. Department of Epidemiology. Boston, Massachusetts, USA.University College London. London, UK.Harvard T. H. Chan School of Public Health. Department of Epidemiology. Boston, Massachusetts, USA.APHP Hôpital Avicenne. Bobigny, France.University of Alabama at Birmingham. School of Medicine. Birmingham, Alabama, USA..Harvard T. H. Chan School of Public Health. Department of Epidemiology. Boston, Massachusetts, USA.Inserm, Université Paris Sud. Orsay, France.Inserm, Université Paris Sud. Orsay, France.University of Washington. Seattle, Washington, USA.Harvard T. H. Chan School of Public Health. Department of Epidemiology. Boston, Massachusetts, USA.Centre Hospitalier Universitaire de Bordeaux. Bordeaux, France.Centre Hospitalier Universitaire de Bordeaux. Bordeaux, France.The Johns Hopkins University. School of Medicine. Baltimore, Maryland, USA.Academisch Medisch Centrum Geneeskunde. Amsterdam, The Netherlands.Academisch Medisch Centrum Geneeskunde. Amsterdam, The Netherlands.University of California San Diego Health. Department of Medicine. San Diego, California, USA.Instituto de Salud Carlos III. National Center of Epidemiology. Madrid, Spain.Instituto de Salud Carlos III. National Center of Epidemiology. Madrid, Spain.University of California. School of Medicine. San Francisco, California, USA.Germans Trias Hospital. Barcelona, Spain.Fenway Health. Boston, Massachusetts, USA.Hospital Universitari de Bellvitge. Barcelona, Spain.University of North Carolina at Chapel Hill. School of Medicine. Department of Medicine. Chapel Hill, North Carolina, USA..Southern Alberta HIV Program. Calgary, Canada.Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brazil.University of North Carolina at Chapel Hill. School of Medicine. Department of Medicine. Chapel Hill, North Carolina, USA.University College London. London, UK.University College London. London, UK.Yale University. School of Public Health. New Haven, Connecticut, USA.Yale University. School of Public Health. New Haven, Connecticut, USA.Universitätsspital Basel. Basel, Switzerland.University of Bern. Institute of Social and Preventive Medicine. Bern, Switzerland.University of Bern. Bern University Hospital. Division of Infectious Diseases. Bern, Switzerland.University of Barcelona. Barcelona, Spain.Institut Català d'Oncologia. Barcelona, Spain.University College London. London, UK.Athens University Medical School. Department of Hygiene, Epidemiology and Medical Statistics. Athens, Greece.University of Washington. Seattle, Washington, USA.University Pierre and Marie Curie. Paris, France.University of Alabama at Birmingham. Birmingham, Alabama, USA.Harvard T. H. Chan School of Public Health. Department of Epidemiology. Boston, Massachusetts, USA / Harvard T.H. Chan School of Public Health. Department of Biostatistics. Boston, Massachusetts, USA / Harvard-MIT Division of Health Sciences and Technology. Boston, Massachusetts, USA.Decisions about when to start or switch a therapy often depend on the frequency with which individuals are monitored or tested. For example, the optimal time to switch antiretroviral therapy depends on the frequency with which HIV-positive individuals have HIV RNA measured. This paper describes an approach to use observational data for the comparison of joint monitoring and treatment strategies and applies the method to a clinically relevant question in HIV research: when can monitoring frequency be decreased and when should individuals switch from a first-line treatment regimen to a new regimen? We outline the target trial that would compare the dynamic strategies of interest and then describe how to emulate it using data from HIV-positive individuals included in the HIV-CAUSAL Collaboration and the Centers for AIDS Research Network of Integrated Clinical Systems. When, as in our example, few individuals follow the dynamic strategies of interest over long periods of follow-up, we describe how to leverage an additional assumption: no direct effect of monitoring on the outcome of interest. We compare our results with and without the "no direct effect" assumption. We found little differences on survival and AIDS-free survival between strategies where monitoring frequency was decreased at a CD4 threshold of 350 cells/μl compared with 500 cells/μl and where treatment was switched at an HIV-RNA threshold of 1000 copies/ml compared with 200 copies/ml. The "no direct effect" assumption resulted in efficiency improvements for the risk difference estimates ranging from an 7- to 53-fold increase in the effective sample size.Causal inferenceDynamic regimeJoint treatment strategiesMarginal structural modelNo direct effectinfo:eu-repo/semantics/openAccessengreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/35578/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALEmulating a trial of joint dynamic strategies- An application to monitoring and treatment of HIV-positive individuals.pdfEmulating a trial of joint dynamic strategies- An application to monitoring and treatment of HIV-positive individuals.pdfapplication/pdf992666https://www.arca.fiocruz.br/bitstream/icict/35578/2/Emulating%20a%20trial%20of%20joint%20dynamic%20strategies-%20An%20application%20to%20monitoring%20and%20treatment%20of%20HIV-positive%20individuals.pdf4f381b4aff1ba47d7ebe1d3a180ea425MD52TEXTEmulating a trial of joint dynamic strategies- An application to monitoring and treatment of HIV-positive individuals.pdf.txtEmulating a trial of joint dynamic strategies- An application to monitoring and treatment of HIV-positive individuals.pdf.txtExtracted texttext/plain70855https://www.arca.fiocruz.br/bitstream/icict/35578/3/Emulating%20a%20trial%20of%20joint%20dynamic%20strategies-%20An%20application%20to%20monitoring%20and%20treatment%20of%20HIV-positive%20individuals.pdf.txt60c569e9c0ae856c7b37b252ac0d7546MD53icict/355782022-01-13 21:25:09.494oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-01-14T00:25:09Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv	Emulating a trial of joint dynamic strategies: An application to monitoring and treatment of HIV-positive individuals
title	Emulating a trial of joint dynamic strategies: An application to monitoring and treatment of HIV-positive individuals
spellingShingle	Emulating a trial of joint dynamic strategies: An application to monitoring and treatment of HIV-positive individuals Caniglia, Ellen C. Causal inference Dynamic regime Joint treatment strategies Marginal structural model No direct effect
title_short	Emulating a trial of joint dynamic strategies: An application to monitoring and treatment of HIV-positive individuals
title_full	Emulating a trial of joint dynamic strategies: An application to monitoring and treatment of HIV-positive individuals
title_fullStr	Emulating a trial of joint dynamic strategies: An application to monitoring and treatment of HIV-positive individuals
title_full_unstemmed	Emulating a trial of joint dynamic strategies: An application to monitoring and treatment of HIV-positive individuals
title_sort	Emulating a trial of joint dynamic strategies: An application to monitoring and treatment of HIV-positive individuals
author	Caniglia, Ellen C.
author_facet	Caniglia, Ellen C. Robins, James M. Cain, Lauren E. Sabin, Caroline Logan, Roger Abgrall, Sophie Mugavero, Michael J. Hernández-Díaz, Sonia Meyer, Laurence Seng, Remonie Drozd, Daniel R. Seage Iii, George R. Bonnet, Fabrice Le Marec, Fabien Moore, Richard D. Reiss, Peter van Sighem, Ard Mathews, William C. Jarrín, Inma Alejos, Belén Deeks, Steven G. Muga, Roberto Boswell, Stephen L. Ferrer, Elena Eron, Joseph J. Gill, John Pacheco, Antonio Grinsztejn, Beatriz Napravnik, Sonia Jose, Sophie Phillips, Andrew Justice, Amy Tate, Janet Bucher, Heiner C. Egger, Matthias Furrer, Hansjakob Miro, Jose M. Casabona, Jordi Porter, Kholoud Touloumi, Giota Crane, Heidi Costagliola, Dominique Saag, Michael Hernán, Miguel A.
author_role	author
author2	Robins, James M. Cain, Lauren E. Sabin, Caroline Logan, Roger Abgrall, Sophie Mugavero, Michael J. Hernández-Díaz, Sonia Meyer, Laurence Seng, Remonie Drozd, Daniel R. Seage Iii, George R. Bonnet, Fabrice Le Marec, Fabien Moore, Richard D. Reiss, Peter van Sighem, Ard Mathews, William C. Jarrín, Inma Alejos, Belén Deeks, Steven G. Muga, Roberto Boswell, Stephen L. Ferrer, Elena Eron, Joseph J. Gill, John Pacheco, Antonio Grinsztejn, Beatriz Napravnik, Sonia Jose, Sophie Phillips, Andrew Justice, Amy Tate, Janet Bucher, Heiner C. Egger, Matthias Furrer, Hansjakob Miro, Jose M. Casabona, Jordi Porter, Kholoud Touloumi, Giota Crane, Heidi Costagliola, Dominique Saag, Michael Hernán, Miguel A.
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Caniglia, Ellen C. Robins, James M. Cain, Lauren E. Sabin, Caroline Logan, Roger Abgrall, Sophie Mugavero, Michael J. Hernández-Díaz, Sonia Meyer, Laurence Seng, Remonie Drozd, Daniel R. Seage Iii, George R. Bonnet, Fabrice Le Marec, Fabien Moore, Richard D. Reiss, Peter van Sighem, Ard Mathews, William C. Jarrín, Inma Alejos, Belén Deeks, Steven G. Muga, Roberto Boswell, Stephen L. Ferrer, Elena Eron, Joseph J. Gill, John Pacheco, Antonio Grinsztejn, Beatriz Napravnik, Sonia Jose, Sophie Phillips, Andrew Justice, Amy Tate, Janet Bucher, Heiner C. Egger, Matthias Furrer, Hansjakob Miro, Jose M. Casabona, Jordi Porter, Kholoud Touloumi, Giota Crane, Heidi Costagliola, Dominique Saag, Michael Hernán, Miguel A.
dc.subject.en.pt_BR.fl_str_mv	Causal inference Dynamic regime Joint treatment strategies Marginal structural model No direct effect
topic	Causal inference Dynamic regime Joint treatment strategies Marginal structural model No direct effect
description	Harvard T. H. Chan School of Public Health. Department of Epidemiology. Boston, Massachusetts, USA / New York University. School of Medicine. Department of Population Health. New York, USA.
publishDate	2019
dc.date.accessioned.fl_str_mv	2019-09-13T16:08:07Z
dc.date.available.fl_str_mv	2019-09-13T16:08:07Z
dc.date.issued.fl_str_mv	2019
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	CANIGLIA, Ellen C. et al. Emulating a trial of joint dynamic strategies: An application to monitoring and treatment of HIV-positive individuals. Statistics in Medicine, v. 38, p. 2428-2446, Jan. 2019.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/35578
dc.identifier.issn.pt_BR.fl_str_mv	0277-6715
dc.identifier.doi.pt_BR.fl_str_mv	10.1002/sim.8120
identifier_str_mv	CANIGLIA, Ellen C. et al. Emulating a trial of joint dynamic strategies: An application to monitoring and treatment of HIV-positive individuals. Statistics in Medicine, v. 38, p. 2428-2446, Jan. 2019. 0277-6715 10.1002/sim.8120
url	https://www.arca.fiocruz.br/handle/icict/35578
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/35578/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/35578/2/Emulating%20a%20trial%20of%20joint%20dynamic%20strategies-%20An%20application%20to%20monitoring%20and%20treatment%20of%20HIV-positive%20individuals.pdf https://www.arca.fiocruz.br/bitstream/icict/35578/3/Emulating%20a%20trial%20of%20joint%20dynamic%20strategies-%20An%20application%20to%20monitoring%20and%20treatment%20of%20HIV-positive%20individuals.pdf.txt
bitstream.checksum.fl_str_mv	5a560609d32a3863062d77ff32785d58 4f381b4aff1ba47d7ebe1d3a180ea425 60c569e9c0ae856c7b37b252ac0d7546
bitstream.checksumAlgorithm.fl_str_mv	MD5 MD5 MD5
repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
_version_	1813009081152045056

Emulating a trial of joint dynamic strategies: An application to monitoring and treatment of HIV-positive individuals

Registros relacionados