Cutaneous Leishmaniasis Vaccination: A Matter of Quality
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/16479 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. |
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Luca, Paula Mello deMacedo, Amanda Beatriz Barreto2016-12-08T11:06:50Z2016-12-08T11:06:50Z2016LUCA, Paula Mello De; MACEDO, Amanda Beatriz Barreto. Cutaneous Leishmaniasis vaccination: A Matter of Quality. Frontiers in Immunology, v.7, Article 151, 8p, Apr. 2016.1664-3224https://www.arca.fiocruz.br/handle/icict/1647910.3389/fimmu.2016.00151engFrontiers MediaVacinasMultifuncionalidadeLeishmania amazonensisLeishmania braziliensisResposta das células TvaccinemultifunctionalityT cell responseLeishmania amazonensisLeishmania braziliensisCutaneous Leishmaniasis Vaccination: A Matter of Qualityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.University of Utah School of Medicine. Division of Microbiology and Immunology. Department of Pathology. Salt Lake City, UT, USA.There have been exhaustive efforts to develop an efficient vaccine against leishmaniasis. Factors like host and parasite genetic characteristics, virulence, epidemiological scenarios, and, mainly, diverse immune responses triggered by Leishmania species make the achievement of this aim a complex task. It is already clear that the induction of a Th1, pro-inflammatory response, is important in the protection against Leishmania infection. However, many questions must still be answered to fully understand Leishmania immunopathology, especially regarding Leishmania-specific Th1 response induction, regulation, and persistence. A large number of Leishmania antigens able to induce pro-inflammatory response have been selected so far, but none of them demonstrated efficiency in protection assays. A possible explanation is that CD4 T cells display marked heterogeneity at a single-cell level especially regarding the production of Th1-defining cytokines and multifunctionality. It has been established in the literature that Th1 cells undergo a differentiation process, which can generate cells with diverse phenotypes and survival capabilities. Despite that, only a few studies evaluate this heterogenic response and the amount of multifunctional CD4 T cells induced by Leishmania vaccine candidates, missing what can be a crucial point in defining a correlate of protection after vaccination. Moreover, most of the knowledge involving the development of cutaneous leishmaniasis (CL) vaccines comes from the mouse model of infection with Leishmania major, which cannot be fully applied to New World Leishmaniasis. For this reason, the immune response triggered by infection with New World Leishmania species, as well as vaccine candidates, need further studies. In this review, we will reinforce the importance of evaluating the quality of immune response against Leishmania, using a multiparametric analysis in order to understand better this complex host-parasite interaction, discussing the differences in the responses triggered by different New World Leishmania species, as well as the impact on the development of an effective vaccine against CL.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/16479/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALpaula_luccaeamanda_IOC_2016.pdfpaula_luccaeamanda_IOC_2016.pdfapplication/pdf310404https://www.arca.fiocruz.br/bitstream/icict/16479/2/paula_luccaeamanda_IOC_2016.pdf81d5ff61c49aa2cbfac54ba19098402aMD52TEXTpaula_luccaeamanda_IOC_2016.pdf.txtpaula_luccaeamanda_IOC_2016.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Cutaneous Leishmaniasis Vaccination: A Matter of Quality |
| title |
Cutaneous Leishmaniasis Vaccination: A Matter of Quality |
| spellingShingle |
Cutaneous Leishmaniasis Vaccination: A Matter of Quality Luca, Paula Mello de Vacinas Multifuncionalidade Leishmania amazonensis Leishmania braziliensis Resposta das células T vaccine multifunctionality T cell response Leishmania amazonensis Leishmania braziliensis |
| title_short |
Cutaneous Leishmaniasis Vaccination: A Matter of Quality |
| title_full |
Cutaneous Leishmaniasis Vaccination: A Matter of Quality |
| title_fullStr |
Cutaneous Leishmaniasis Vaccination: A Matter of Quality |
| title_full_unstemmed |
Cutaneous Leishmaniasis Vaccination: A Matter of Quality |
| title_sort |
Cutaneous Leishmaniasis Vaccination: A Matter of Quality |
| author |
Luca, Paula Mello de |
| author_facet |
Luca, Paula Mello de Macedo, Amanda Beatriz Barreto |
| author_role |
author |
| author2 |
Macedo, Amanda Beatriz Barreto |
| author2_role |
author |
| dc.contributor.author.fl_str_mv |
Luca, Paula Mello de Macedo, Amanda Beatriz Barreto |
| dc.subject.other.pt_BR.fl_str_mv |
Vacinas Multifuncionalidade Leishmania amazonensis Leishmania braziliensis Resposta das células T |
| topic |
Vacinas Multifuncionalidade Leishmania amazonensis Leishmania braziliensis Resposta das células T vaccine multifunctionality T cell response Leishmania amazonensis Leishmania braziliensis |
| dc.subject.en.pt_BR.fl_str_mv |
vaccine multifunctionality T cell response Leishmania amazonensis Leishmania braziliensis |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. |
| publishDate |
2016 |
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2016-12-08T11:06:50Z |
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2016-12-08T11:06:50Z |
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2016 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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LUCA, Paula Mello De; MACEDO, Amanda Beatriz Barreto. Cutaneous Leishmaniasis vaccination: A Matter of Quality. Frontiers in Immunology, v.7, Article 151, 8p, Apr. 2016. |
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https://www.arca.fiocruz.br/handle/icict/16479 |
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1664-3224 |
| dc.identifier.doi.none.fl_str_mv |
10.3389/fimmu.2016.00151 |
| identifier_str_mv |
LUCA, Paula Mello De; MACEDO, Amanda Beatriz Barreto. Cutaneous Leishmaniasis vaccination: A Matter of Quality. Frontiers in Immunology, v.7, Article 151, 8p, Apr. 2016. 1664-3224 10.3389/fimmu.2016.00151 |
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Frontiers Media |
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Frontiers Media |
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