Hydroxylation of 1,8-cineole by Mucor ramannianusand Aspergillus niger
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/47471 |
Resumo: | Fundação Oswaldo Cruz. Instituto de Tecnologia em fármacos. Rio de Janeiro, RJ, Brasil. |
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Ramos, Aline de SouzaRibeiro, Joyce BenzaquemTeixeira, Bruna GomesFerreira, José Luiz PintoSilva, Jefferson Rocha de AndrareFerreira, Alexandre do AmaralSouza, Rodrigo Octavio Mendonça Alves deAmaral, Ana Claudia Fernandes2021-06-01T12:16:45Z2021-06-01T12:16:45Z2015RAMOS, Aline de Souza et al. Hydroxylation of 1,8-cineole by Mucor ramannianus and Aspergillus niger. Brazilian Journal of Microbiology, v. 46, n. 1, p. 261-264, 2015.1678-4405https://www.arca.fiocruz.br/handle/icict/4747110.1590/S1517-838246120131020porHydroxylation of 1,8-cineole by Mucor ramannianusand Aspergillus nigerinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto de Tecnologia em fármacos. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Química. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em fármacos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em fármacos. Rio de Janeiro, RJ, Brasil / Universidade Federal Fluminense. Faculdade de Farmácia. Niterói, RJ, Brasil.Universidade Federal do Amazonas. Departamento de Química. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em fármacos. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Química. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em fármacos. Rio de Janeiro, RJ, Brasil.The monoterpenoid 1,8-cineole is obtained from the leaves of Eucalyptus globulus and it has important biological activities. It is a cheap natural substrate because it is a by-product of the Eucalyptus cultivation for wood and pulp production. In this study, it was evaluated the potential of three filamentous fungi in the biotransformation of 1,8-cineole. The study was divided in two steps: first, reactions were carried out with 1,8-cineole at 1 g/L for 24 h; afterwards, reactions were carried out with substrate at 5 g/L for 5 days. The substrate was hydroxylated into 2-exo-hydroxy-1,8-cineole and 3-exo-hydroxy-1,8-cineole by fungi Mucor ramannianus and Aspergillus niger with high stereoselectivity. Trichoderma harzianum was also tested but no transformation was detected. M. ramannianus led to higher than 99% of conversion within 24 h with a starting high substrate concentration (1 g/L). When substrate was added at 5 g/L, only M. ramannianus was able to catalyze the reaction, but the conversion level was 21.7% after 5 days. Both products have defined stereochemistry and could be used as chiral synthons. Furthermore, biological activity has been described for 3-exo-hydroxy-1,8-cineol. To the best of our knowledge, this is the first report on the use of M. ramannianus in this reaction.BiotransformationMonoterpene1,8-cineoleMucor RamannianusAspergillus Nigerinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83093https://www.arca.fiocruz.br/bitstream/icict/47471/1/license.txt34529d73b0c3f33b39c969c511d590fbMD51ORIGINAL1517-8382-bjm-46-01-0261.pdf1517-8382-bjm-46-01-0261.pdfapplication/pdf494953https://www.arca.fiocruz.br/bitstream/icict/47471/2/1517-8382-bjm-46-01-0261.pdfce1b9738fc12c28f0d95956fccbda7b1MD52TEXT1517-8382-bjm-46-01-0261.pdf.txt1517-8382-bjm-46-01-0261.pdf.txtExtracted texttext/plain17853https://www.arca.fiocruz.br/bitstream/icict/47471/3/1517-8382-bjm-46-01-0261.pdf.txt217c029dd4ce5448268bfc52da6f3de5MD53icict/474712021-06-09 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| dc.title.pt_BR.fl_str_mv |
Hydroxylation of 1,8-cineole by Mucor ramannianusand Aspergillus niger |
| title |
Hydroxylation of 1,8-cineole by Mucor ramannianusand Aspergillus niger |
| spellingShingle |
Hydroxylation of 1,8-cineole by Mucor ramannianusand Aspergillus niger Ramos, Aline de Souza Biotransformation Monoterpene 1,8-cineole Mucor Ramannianus Aspergillus Niger |
| title_short |
Hydroxylation of 1,8-cineole by Mucor ramannianusand Aspergillus niger |
| title_full |
Hydroxylation of 1,8-cineole by Mucor ramannianusand Aspergillus niger |
| title_fullStr |
Hydroxylation of 1,8-cineole by Mucor ramannianusand Aspergillus niger |
| title_full_unstemmed |
Hydroxylation of 1,8-cineole by Mucor ramannianusand Aspergillus niger |
| title_sort |
Hydroxylation of 1,8-cineole by Mucor ramannianusand Aspergillus niger |
| author |
Ramos, Aline de Souza |
| author_facet |
Ramos, Aline de Souza Ribeiro, Joyce Benzaquem Teixeira, Bruna Gomes Ferreira, José Luiz Pinto Silva, Jefferson Rocha de Andrare Ferreira, Alexandre do Amaral Souza, Rodrigo Octavio Mendonça Alves de Amaral, Ana Claudia Fernandes |
| author_role |
author |
| author2 |
Ribeiro, Joyce Benzaquem Teixeira, Bruna Gomes Ferreira, José Luiz Pinto Silva, Jefferson Rocha de Andrare Ferreira, Alexandre do Amaral Souza, Rodrigo Octavio Mendonça Alves de Amaral, Ana Claudia Fernandes |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Ramos, Aline de Souza Ribeiro, Joyce Benzaquem Teixeira, Bruna Gomes Ferreira, José Luiz Pinto Silva, Jefferson Rocha de Andrare Ferreira, Alexandre do Amaral Souza, Rodrigo Octavio Mendonça Alves de Amaral, Ana Claudia Fernandes |
| dc.subject.en.pt_BR.fl_str_mv |
Biotransformation Monoterpene 1,8-cineole Mucor Ramannianus Aspergillus Niger |
| topic |
Biotransformation Monoterpene 1,8-cineole Mucor Ramannianus Aspergillus Niger |
| description |
Fundação Oswaldo Cruz. Instituto de Tecnologia em fármacos. Rio de Janeiro, RJ, Brasil. |
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2015 |
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2015 |
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2021-06-01T12:16:45Z |
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2021-06-01T12:16:45Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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RAMOS, Aline de Souza et al. Hydroxylation of 1,8-cineole by Mucor ramannianus and Aspergillus niger. Brazilian Journal of Microbiology, v. 46, n. 1, p. 261-264, 2015. |
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https://www.arca.fiocruz.br/handle/icict/47471 |
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1678-4405 |
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10.1590/S1517-838246120131020 |
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RAMOS, Aline de Souza et al. Hydroxylation of 1,8-cineole by Mucor ramannianus and Aspergillus niger. Brazilian Journal of Microbiology, v. 46, n. 1, p. 261-264, 2015. 1678-4405 10.1590/S1517-838246120131020 |
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