Screening of Amazonian plants from the Adolpho Ducke forest reserve, Manaus, state of Amazonas, Brazil, for antimicrobial activity

Detalhes bibliográficos
Autor(a) principal: Carneiro, Ana Lúcia Basílio
Data de Publicação: 2008
Outros Autores: Teixeira, Maria Francisca Simas, Oliveira, Viviana Maria Araújo de, Fernandes, Ormezinda Celeste Cristo, Cauper, Gláucia Socorro de Barros, Pohlit, Adrian Martin
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/1917
Resumo: Universidade Federal do Amazonas. Instituto de Ciências Biológicas. Manaus, AM, Brasil.
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spelling Carneiro, Ana Lúcia BasílioTeixeira, Maria Francisca SimasOliveira, Viviana Maria Araújo deFernandes, Ormezinda Celeste CristoCauper, Gláucia Socorro de BarrosPohlit, Adrian Martin2011-04-15T13:03:01Z2011-04-15T13:03:01Z2008CARNEIRO, Ana Lúcia Basílio et al. Screening of Amazonian plants from the Adolpho Ducke forest reserve, Manaus, state of Amazonas, Brazil, for antimicrobial activity. Memória do Instituto Oswaldo Cruz, Rio de Janeiro, v. 103, n. 1, p. 31-38, Feb. 2008.0074-0276https://www.arca.fiocruz.br/handle/icict/1917engScreening of Amazonian plants from the Adolpho Ducke forest reserve, Manaus, state of Amazonas, Brazil, for antimicrobial activityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Amazonas. Instituto de Ciências Biológicas. Manaus, AM, Brasil.Fundação de Hematologia e Hemoterapia do Amazonas. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa Leônidas e Maria Deane. Manaus, AM, Brasil.Instituto Nacional de Pesquisa da Amazônia. Coordenação de Pesquisa em Produtos Naturais. Laboratório de Princípios Ativos da Amazônia. Manaus, AM, Brasil.Instituto Nacional de Pesquisa da Amazônia. Coordenação de Pesquisa em Produtos Naturais. Laboratório de Princípios Ativos da Amazônia. Manaus, AM, Brasil.Tropical forests are species-rich reserves for the discovery and development of antimicrobial drugs. The aim of this work is to investigate the in vitro antimicrobial potential of Amazon plants found within the National Institute on Amazon Research’s Adolpho Ducke forest reserve, located in Manaus, state of Amazonas, Brazil. 75 methanol, chloroform and water extracts representing 12 plant species were tested for antimicrobial activity towards strains of Mycobacterium smegmatis, Escherichia coli, Streptococcus sanguis, Streptococcus oralis, Staphylococcus aureus and Candida albicans using the gel-diffusion method. Active extracts were further evaluated to establish minimum inhibitory concentrations (MIC) and antimicrobial profiles using bioautography on normal-phase thin-layer chromatography plates. Diclinanona calycina presented extracts with good antimicrobial activity and S. oralis and M. smegmatis were the most sensitive bacteria. D. calycina and Lacmellea gracilis presented extracts with the lowest MIC (48.8 μg/ml). D. calycina methanol and chloroform leaf extracts presented the best overall antimicrobial activity. All test organisms were sensitive to D. calycina branch chloroform extract in the bioautography assay. This is the first evaluation of the biological activity of these plant species and significant in vitro antimicrobial activity was detected in extracts and components from two species, D. calycina and L. gracilis.Plant extractAntibacterialAntifungalDiclinanona calycinaLacmellea gracilisBioautographyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALScreening of Amazonian plants.pdfScreening of Amazonian plants.pdfapplication/pdf408539https://www.arca.fiocruz.br/bitstream/icict/1917/1/Screening%20of%20Amazonian%20plants.pdf43cd495995f15dbd3acd0c86e2e71d91MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/1917/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTScreening of Amazonian plants.pdf.txtScreening of Amazonian plants.pdf.txtExtracted texttext/plain36371https://www.arca.fiocruz.br/bitstream/icict/1917/5/Screening%20of%20Amazonian%20plants.pdf.txtc49433c140288e3b23f0587ec5ec827fMD55THUMBNAILScreening of Amazonian plants.pdf.jpgScreening of Amazonian plants.pdf.jpgGenerated Thumbnailimage/jpeg2298https://www.arca.fiocruz.br/bitstream/icict/1917/4/Screening%20of%20Amazonian%20plants.pdf.jpg3c9f6d3ad3b8de6203f5244e8307f09cMD54icict/19172018-04-06 09:17:42.3oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-04-06T12:17:42Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Screening of Amazonian plants from the Adolpho Ducke forest reserve, Manaus, state of Amazonas, Brazil, for antimicrobial activity
title Screening of Amazonian plants from the Adolpho Ducke forest reserve, Manaus, state of Amazonas, Brazil, for antimicrobial activity
spellingShingle Screening of Amazonian plants from the Adolpho Ducke forest reserve, Manaus, state of Amazonas, Brazil, for antimicrobial activity
Carneiro, Ana Lúcia Basílio
Plant extract
Antibacterial
Antifungal
Diclinanona calycina
Lacmellea gracilis
Bioautography
title_short Screening of Amazonian plants from the Adolpho Ducke forest reserve, Manaus, state of Amazonas, Brazil, for antimicrobial activity
title_full Screening of Amazonian plants from the Adolpho Ducke forest reserve, Manaus, state of Amazonas, Brazil, for antimicrobial activity
title_fullStr Screening of Amazonian plants from the Adolpho Ducke forest reserve, Manaus, state of Amazonas, Brazil, for antimicrobial activity
title_full_unstemmed Screening of Amazonian plants from the Adolpho Ducke forest reserve, Manaus, state of Amazonas, Brazil, for antimicrobial activity
title_sort Screening of Amazonian plants from the Adolpho Ducke forest reserve, Manaus, state of Amazonas, Brazil, for antimicrobial activity
author Carneiro, Ana Lúcia Basílio
author_facet Carneiro, Ana Lúcia Basílio
Teixeira, Maria Francisca Simas
Oliveira, Viviana Maria Araújo de
Fernandes, Ormezinda Celeste Cristo
Cauper, Gláucia Socorro de Barros
Pohlit, Adrian Martin
author_role author
author2 Teixeira, Maria Francisca Simas
Oliveira, Viviana Maria Araújo de
Fernandes, Ormezinda Celeste Cristo
Cauper, Gláucia Socorro de Barros
Pohlit, Adrian Martin
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Carneiro, Ana Lúcia Basílio
Teixeira, Maria Francisca Simas
Oliveira, Viviana Maria Araújo de
Fernandes, Ormezinda Celeste Cristo
Cauper, Gláucia Socorro de Barros
Pohlit, Adrian Martin
dc.subject.en.pt_BR.fl_str_mv Plant extract
Antibacterial
Antifungal
Diclinanona calycina
Lacmellea gracilis
Bioautography
topic Plant extract
Antibacterial
Antifungal
Diclinanona calycina
Lacmellea gracilis
Bioautography
description Universidade Federal do Amazonas. Instituto de Ciências Biológicas. Manaus, AM, Brasil.
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2011-04-15T13:03:01Z
dc.date.available.fl_str_mv 2011-04-15T13:03:01Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv CARNEIRO, Ana Lúcia Basílio et al. Screening of Amazonian plants from the Adolpho Ducke forest reserve, Manaus, state of Amazonas, Brazil, for antimicrobial activity. Memória do Instituto Oswaldo Cruz, Rio de Janeiro, v. 103, n. 1, p. 31-38, Feb. 2008.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/1917
dc.identifier.issn.none.fl_str_mv 0074-0276
identifier_str_mv CARNEIRO, Ana Lúcia Basílio et al. Screening of Amazonian plants from the Adolpho Ducke forest reserve, Manaus, state of Amazonas, Brazil, for antimicrobial activity. Memória do Instituto Oswaldo Cruz, Rio de Janeiro, v. 103, n. 1, p. 31-38, Feb. 2008.
0074-0276
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