Screening of Amazonian plants from the Adolpho Ducke forest reserve, Manaus, state of Amazonas, Brazil, for antimicrobial activity
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/1917 |
Resumo: | Universidade Federal do Amazonas. Instituto de Ciências Biológicas. Manaus, AM, Brasil. |
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Carneiro, Ana Lúcia BasílioTeixeira, Maria Francisca SimasOliveira, Viviana Maria Araújo deFernandes, Ormezinda Celeste CristoCauper, Gláucia Socorro de BarrosPohlit, Adrian Martin2011-04-15T13:03:01Z2011-04-15T13:03:01Z2008CARNEIRO, Ana Lúcia Basílio et al. Screening of Amazonian plants from the Adolpho Ducke forest reserve, Manaus, state of Amazonas, Brazil, for antimicrobial activity. Memória do Instituto Oswaldo Cruz, Rio de Janeiro, v. 103, n. 1, p. 31-38, Feb. 2008.0074-0276https://www.arca.fiocruz.br/handle/icict/1917engScreening of Amazonian plants from the Adolpho Ducke forest reserve, Manaus, state of Amazonas, Brazil, for antimicrobial activityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Amazonas. Instituto de Ciências Biológicas. Manaus, AM, Brasil.Fundação de Hematologia e Hemoterapia do Amazonas. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa Leônidas e Maria Deane. Manaus, AM, Brasil.Instituto Nacional de Pesquisa da Amazônia. Coordenação de Pesquisa em Produtos Naturais. Laboratório de Princípios Ativos da Amazônia. Manaus, AM, Brasil.Instituto Nacional de Pesquisa da Amazônia. Coordenação de Pesquisa em Produtos Naturais. Laboratório de Princípios Ativos da Amazônia. Manaus, AM, Brasil.Tropical forests are species-rich reserves for the discovery and development of antimicrobial drugs. The aim of this work is to investigate the in vitro antimicrobial potential of Amazon plants found within the National Institute on Amazon Research’s Adolpho Ducke forest reserve, located in Manaus, state of Amazonas, Brazil. 75 methanol, chloroform and water extracts representing 12 plant species were tested for antimicrobial activity towards strains of Mycobacterium smegmatis, Escherichia coli, Streptococcus sanguis, Streptococcus oralis, Staphylococcus aureus and Candida albicans using the gel-diffusion method. Active extracts were further evaluated to establish minimum inhibitory concentrations (MIC) and antimicrobial profiles using bioautography on normal-phase thin-layer chromatography plates. Diclinanona calycina presented extracts with good antimicrobial activity and S. oralis and M. smegmatis were the most sensitive bacteria. D. calycina and Lacmellea gracilis presented extracts with the lowest MIC (48.8 μg/ml). D. calycina methanol and chloroform leaf extracts presented the best overall antimicrobial activity. All test organisms were sensitive to D. calycina branch chloroform extract in the bioautography assay. This is the first evaluation of the biological activity of these plant species and significant in vitro antimicrobial activity was detected in extracts and components from two species, D. calycina and L. gracilis.Plant extractAntibacterialAntifungalDiclinanona calycinaLacmellea gracilisBioautographyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALScreening of Amazonian plants.pdfScreening of Amazonian plants.pdfapplication/pdf408539https://www.arca.fiocruz.br/bitstream/icict/1917/1/Screening%20of%20Amazonian%20plants.pdf43cd495995f15dbd3acd0c86e2e71d91MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/1917/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTScreening of Amazonian plants.pdf.txtScreening of Amazonian plants.pdf.txtExtracted texttext/plain36371https://www.arca.fiocruz.br/bitstream/icict/1917/5/Screening%20of%20Amazonian%20plants.pdf.txtc49433c140288e3b23f0587ec5ec827fMD55THUMBNAILScreening of Amazonian plants.pdf.jpgScreening of Amazonian plants.pdf.jpgGenerated Thumbnailimage/jpeg2298https://www.arca.fiocruz.br/bitstream/icict/1917/4/Screening%20of%20Amazonian%20plants.pdf.jpg3c9f6d3ad3b8de6203f5244e8307f09cMD54icict/19172018-04-06 09:17:42.3oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-04-06T12:17:42Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Screening of Amazonian plants from the Adolpho Ducke forest reserve, Manaus, state of Amazonas, Brazil, for antimicrobial activity |
title |
Screening of Amazonian plants from the Adolpho Ducke forest reserve, Manaus, state of Amazonas, Brazil, for antimicrobial activity |
spellingShingle |
Screening of Amazonian plants from the Adolpho Ducke forest reserve, Manaus, state of Amazonas, Brazil, for antimicrobial activity Carneiro, Ana Lúcia Basílio Plant extract Antibacterial Antifungal Diclinanona calycina Lacmellea gracilis Bioautography |
title_short |
Screening of Amazonian plants from the Adolpho Ducke forest reserve, Manaus, state of Amazonas, Brazil, for antimicrobial activity |
title_full |
Screening of Amazonian plants from the Adolpho Ducke forest reserve, Manaus, state of Amazonas, Brazil, for antimicrobial activity |
title_fullStr |
Screening of Amazonian plants from the Adolpho Ducke forest reserve, Manaus, state of Amazonas, Brazil, for antimicrobial activity |
title_full_unstemmed |
Screening of Amazonian plants from the Adolpho Ducke forest reserve, Manaus, state of Amazonas, Brazil, for antimicrobial activity |
title_sort |
Screening of Amazonian plants from the Adolpho Ducke forest reserve, Manaus, state of Amazonas, Brazil, for antimicrobial activity |
author |
Carneiro, Ana Lúcia Basílio |
author_facet |
Carneiro, Ana Lúcia Basílio Teixeira, Maria Francisca Simas Oliveira, Viviana Maria Araújo de Fernandes, Ormezinda Celeste Cristo Cauper, Gláucia Socorro de Barros Pohlit, Adrian Martin |
author_role |
author |
author2 |
Teixeira, Maria Francisca Simas Oliveira, Viviana Maria Araújo de Fernandes, Ormezinda Celeste Cristo Cauper, Gláucia Socorro de Barros Pohlit, Adrian Martin |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Carneiro, Ana Lúcia Basílio Teixeira, Maria Francisca Simas Oliveira, Viviana Maria Araújo de Fernandes, Ormezinda Celeste Cristo Cauper, Gláucia Socorro de Barros Pohlit, Adrian Martin |
dc.subject.en.pt_BR.fl_str_mv |
Plant extract Antibacterial Antifungal Diclinanona calycina Lacmellea gracilis Bioautography |
topic |
Plant extract Antibacterial Antifungal Diclinanona calycina Lacmellea gracilis Bioautography |
description |
Universidade Federal do Amazonas. Instituto de Ciências Biológicas. Manaus, AM, Brasil. |
publishDate |
2008 |
dc.date.issued.fl_str_mv |
2008 |
dc.date.accessioned.fl_str_mv |
2011-04-15T13:03:01Z |
dc.date.available.fl_str_mv |
2011-04-15T13:03:01Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
CARNEIRO, Ana Lúcia Basílio et al. Screening of Amazonian plants from the Adolpho Ducke forest reserve, Manaus, state of Amazonas, Brazil, for antimicrobial activity. Memória do Instituto Oswaldo Cruz, Rio de Janeiro, v. 103, n. 1, p. 31-38, Feb. 2008. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/1917 |
dc.identifier.issn.none.fl_str_mv |
0074-0276 |
identifier_str_mv |
CARNEIRO, Ana Lúcia Basílio et al. Screening of Amazonian plants from the Adolpho Ducke forest reserve, Manaus, state of Amazonas, Brazil, for antimicrobial activity. Memória do Instituto Oswaldo Cruz, Rio de Janeiro, v. 103, n. 1, p. 31-38, Feb. 2008. 0074-0276 |
url |
https://www.arca.fiocruz.br/handle/icict/1917 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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