Comparison of 68Ga-DOTATOC and 18F-FDG Thoracic Lymph Node and Pulmonary Lesion Uptake Using PET/CT in Postprimary Tuberculosis

Detalhes bibliográficos
Autor(a) principal: Rosado-de-Castro, Paulo Henrique
Data de Publicação: 2022
Outros Autores: Pereira-de-Carvalho, Thiago, Barreto, Miriam Menna, Kritski, Afranio Lineu, Souza, Rebecca de Oliveira, Almeida, Sergio Altino de, Rolla, Valeria Cavalcanti, Zin, Walter Araujo, Carvalho, Alysson Roncally Silva, Rodrigues, Rosana Souza
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/59800
Resumo: D'Or Institute for Research and Education. Department of Internal Medicine. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Department of Radiology. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Institute of Biomedical Sciences. Rio de Janeiro, RJ, Brazil.
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spelling Rosado-de-Castro, Paulo HenriquePereira-de-Carvalho, ThiagoBarreto, Miriam MennaKritski, Afranio LineuSouza, Rebecca de OliveiraAlmeida, Sergio Altino deRolla, Valeria CavalcantiZin, Walter AraujoCarvalho, Alysson Roncally SilvaRodrigues, Rosana Souza2023-07-27T02:50:06Z2023-07-27T02:50:06Z2022ROSADO-DE-CASTRO, Paulo Henrique et al. Comparison of 68Ga-DOTATOC and 18F-FDG Thoracic Lymph Node and Pulmonary Lesion Uptake Using PET/CT in Postprimary Tuberculosis. The American Journal of Tropical Medicine and Hygiene, v. 106, n. 5, p. 1340-1344, Apr. 2022.0002-9637https://www.arca.fiocruz.br/handle/icict/5980010.4269/ajtmh.21-04161476-1645engAmerican Society of Tropical Medicine and HygieneComparison of 68Ga-DOTATOC and 18F-FDG Thoracic Lymph Node and Pulmonary Lesion Uptake Using PET/CT in Postprimary Tuberculosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleD'Or Institute for Research and Education. Department of Internal Medicine. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Department of Radiology. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Institute of Biomedical Sciences. Rio de Janeiro, RJ, Brazil.Federal University of Rio de Janeiro. Department of Radiology. Rio de Janeiro, RJ, Brazil / Petropolis School of Medicine/Arthur Sá Earp Neto Faculty. Department of Internal Medicine. Petropolis, RJ, Brazil.Federal University of Rio de Janeiro. Department of Radiology. Rio de Janeiro, RJ, Brazil.Federal University of Rio de Janeiro. School of Medicine. Academic Tuberculosis Program. Rio de Janeiro, RJ, Brazil.Federal University of Rio de Janeiro. Department of Statistical Methods. Rio de Janeiro, RJ, Brazil.D'Or Institute for Research and Education. Department of Internal Medicine. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Clinical Research Laboratory on Mycobacteria. Rio de Janeiro, RJ, Brazil.Federal University of Rio de Janeiro. Carlos Chagas Filho Institute of Biophysics. Laboratory of Respiration Physiology. Rio de Janeiro, RJ, Brazil.Federal University of Rio de Janeiro. Carlos Chagas Filho Institute of Biophysics. Laboratory of Respiration Physiology. Rio de Janeiro, RJ, Brazil / University of Porto. Faculty of Medicine. Department of Surgery and Physiology. Cardiovascular R&D Centre (UnIC). Porto, Portugal / Federal University of Rio de Janeiro. Alberto Luiz Coimbra Institute of Post-Graduation and Research in Engineering. Biomedical Engineering Program. Laboratory of Pulmonary Engineering. Rio de Janeiro, RJ, Brazil.D'Or Institute for Research and Education. Department of Internal Medicine. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Department of Radiology. Rio de Janeiro, RJ, Brazil.Tuberculosis (TB) remains one of the world's leading infectious cause of morbidity and mortality. Positron emission tomography (PET) associated with computed tomography (CT) allows a structural and metabolic evaluation of TB lesions, being an excellent noninvasive alternative for understanding its pathogenesis. DOTATOC labeled with gallium-68 (68Ga-DOTATOC) can bind to somatostatin receptors present in activated macrophages and lymphocytes, cells with a fundamental role in TB pathogenesis. We describe 68Ga-DOTATOC uptake distribution and patterns in thoracic lymph nodes (LN) and pulmonary lesions (PL) in immunocompetent patients with active postprimary TB, analyze the relative LN/PL uptake, and compare this two tracer's uptake. High uptake of both radiotracers in PL and LN was demonstrated, with higher LN/PL ratio on 68Ga-DOTATOC (P < 0.05). Considering that LN in immunocompetent patients are poorly studied, 68Ga-DOTATOC can contribute to the understanding of the complex immunopathogenesis of TB.TuberculosisComputed tomography (CT)Ga-DOTATOCThoracic Lymph NodePulmonary Lesioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/59800/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_Rosado-de-Castro_Paulo_etal_INI_2022.pdfve_Rosado-de-Castro_Paulo_etal_INI_2022.pdfapplication/pdf655788https://www.arca.fiocruz.br/bitstream/icict/59800/2/ve_Rosado-de-Castro_Paulo_etal_INI_2022.pdfd07df4bd1a2f3a41e33e0830393a5aefMD52icict/598002023-07-26 23:50:07.309oai:www.arca.fiocruz.br:icict/59800Q0VTU8ODTyBOw4NPIEVYQ0xVU0lWQSBERSBESVJFSVRPUyBBVVRPUkFJUwoKQW8gYWNlaXRhciBvcyBURVJNT1MgZSBDT05EScOHw5VFUyBkZXN0YSBDRVNTw4NPLCBvIEFVVE9SIGUvb3UgVElUVUxBUiBkZSBkaXJlaXRvcwphdXRvcmFpcyBzb2JyZSBhIE9CUkEgZGUgcXVlIHRyYXRhIGVzdGUgZG9jdW1lbnRvOgoKKDEpIENFREUgZSBUUkFOU0ZFUkUsIHRvdGFsIGUgZ3JhdHVpdGFtZW50ZSwgw6AgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaLCBlbQpjYXLDoXRlciBwZXJtYW5lbnRlLCBpcnJldm9nw6F2ZWwgZSBOw4NPIEVYQ0xVU0lWTywgdG9kb3Mgb3MgZGlyZWl0b3MgcGF0cmltb25pYWlzIE7Dg08KQ09NRVJDSUFJUyBkZSB1dGlsaXphw6fDo28gZGEgT0JSQSBhcnTDrXN0aWNhIGUvb3UgY2llbnTDrWZpY2EgaW5kaWNhZGEgYWNpbWEsIGluY2x1c2l2ZSBvcyBkaXJlaXRvcwpkZSB2b3ogZSBpbWFnZW0gdmluY3VsYWRvcyDDoCBPQlJBLCBkdXJhbnRlIHRvZG8gbyBwcmF6byBkZSBkdXJhw6fDo28gZG9zIGRpcmVpdG9zIGF1dG9yYWlzLCBlbQpxdWFscXVlciBpZGlvbWEgZSBlbSB0b2RvcyBvcyBwYcOtc2VzOwoKKDIpIEFDRUlUQSBxdWUgYSBjZXNzw6NvIHRvdGFsIG7Do28gZXhjbHVzaXZhLCBwZXJtYW5lbnRlIGUgaXJyZXZvZ8OhdmVsIGRvcyBkaXJlaXRvcyBhdXRvcmFpcwpwYXRyaW1vbmlhaXMgbsOjbyBjb21lcmNpYWlzIGRlIHV0aWxpemHDp8OjbyBkZSBxdWUgdHJhdGEgZXN0ZSBkb2N1bWVudG8gaW5jbHVpLCBleGVtcGxpZmljYXRpdmFtZW50ZSwKb3MgZGlyZWl0b3MgZGUgZGlzcG9uaWJpbGl6YcOnw6NvIGUgY29tdW5pY2HDp8OjbyBww7pibGljYSBkYSBPQlJBLCBlbSBxdWFscXVlciBtZWlvIG91IHZlw61jdWxvLAppbmNsdXNpdmUgZW0gUmVwb3NpdMOzcmlvcyBEaWdpdGFpcywgYmVtIGNvbW8gb3MgZGlyZWl0b3MgZGUgcmVwcm9kdcOnw6NvLCBleGliacOnw6NvLCBleGVjdcOnw6NvLApkZWNsYW1hw6fDo28sIHJlY2l0YcOnw6NvLCBleHBvc2nDp8OjbywgYXJxdWl2YW1lbnRvLCBpbmNsdXPDo28gZW0gYmFuY28gZGUgZGFkb3MsIHByZXNlcnZhw6fDo28sIGRpZnVzw6NvLApkaXN0cmlidWnDp8OjbywgZGl2dWxnYcOnw6NvLCBlbXByw6lzdGltbywgdHJhZHXDp8OjbywgZHVibGFnZW0sIGxlZ2VuZGFnZW0sIGluY2x1c8OjbyBlbSBub3ZhcyBvYnJhcyBvdQpjb2xldMOibmVhcywgcmV1dGlsaXphw6fDo28sIGVkacOnw6NvLCBwcm9kdcOnw6NvIGRlIG1hdGVyaWFsIGRpZMOhdGljbyBlIGN1cnNvcyBvdSBxdWFscXVlciBmb3JtYSBkZQp1dGlsaXphw6fDo28gbsOjbyBjb21lcmNpYWw7CgooMykgUkVDT05IRUNFIHF1ZSBhIGNlc3PDo28gYXF1aSBlc3BlY2lmaWNhZGEgY29uY2VkZSDDoCBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPCkNSVVogbyBkaXJlaXRvIGRlIGF1dG9yaXphciBxdWFscXVlciBwZXNzb2Eg4oCTIGbDrXNpY2Egb3UganVyw61kaWNhLCBww7pibGljYSBvdSBwcml2YWRhLCBuYWNpb25hbCBvdQplc3RyYW5nZWlyYSDigJMgYSBhY2Vzc2FyIGUgdXRpbGl6YXIgYW1wbGFtZW50ZSBhIE9CUkEsIHNlbSBleGNsdXNpdmlkYWRlLCBwYXJhIHF1YWlzcXVlcgpmaW5hbGlkYWRlcyBuw6NvIGNvbWVyY2lhaXM7CgooNCkgREVDTEFSQSBxdWUgYSBvYnJhIMOpIGNyaWHDp8OjbyBvcmlnaW5hbCBlIHF1ZSDDqSBvIHRpdHVsYXIgZG9zIGRpcmVpdG9zIGFxdWkgY2VkaWRvcyBlIGF1dG9yaXphZG9zLApyZXNwb25zYWJpbGl6YW5kby1zZSBpbnRlZ3JhbG1lbnRlIHBlbG8gY29udGXDumRvIGUgb3V0cm9zIGVsZW1lbnRvcyBxdWUgZmF6ZW0gcGFydGUgZGEgT0JSQSwKaW5jbHVzaXZlIG9zIGRpcmVpdG9zIGRlIHZveiBlIGltYWdlbSB2aW5jdWxhZG9zIMOgIE9CUkEsIG9icmlnYW5kby1zZSBhIGluZGVuaXphciB0ZXJjZWlyb3MgcG9yCmRhbm9zLCBiZW0gY29tbyBpbmRlbml6YXIgZSByZXNzYXJjaXIgYSBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVogZGUKZXZlbnR1YWlzIGRlc3Blc2FzIHF1ZSB2aWVyZW0gYSBzdXBvcnRhciwgZW0gcmF6w6NvIGRlIHF1YWxxdWVyIG9mZW5zYSBhIGRpcmVpdG9zIGF1dG9yYWlzIG91CmRpcmVpdG9zIGRlIHZveiBvdSBpbWFnZW0sIHByaW5jaXBhbG1lbnRlIG5vIHF1ZSBkaXogcmVzcGVpdG8gYSBwbMOhZ2lvIGUgdmlvbGHDp8O1ZXMgZGUgZGlyZWl0b3M7CgooNSkgQUZJUk1BIHF1ZSBjb25oZWNlIGEgUG9sw610aWNhIEluc3RpdHVjaW9uYWwgZGUgQWNlc3NvIEFiZXJ0byBkYSBGSU9DUlVaIC0gRlVOREHDh8ODTwpPU1dBTERPIENSVVogZSBhcyBkaXJldHJpemVzIHBhcmEgbyBmdW5jaW9uYW1lbnRvIGRvIHJlcG9zaXTDs3JpbyBpbnN0aXR1Y2lvbmFsIEFSQ0EuCgpBIFBvbMOtdGljYSBJbnN0aXR1Y2lvbmFsIGRlIEFjZXNzbyBBYmVydG8gZGEgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaIHJlc2VydmEKZXhjbHVzaXZhbWVudGUgYW8gQVVUT1Igb3MgZGlyZWl0b3MgbW9yYWlzIGUgb3MgdXNvcyBjb21lcmNpYWlzIHNvYnJlIGFzIG9icmFzIGRlIHN1YSBhdXRvcmlhCmUvb3UgdGl0dWxhcmlkYWRlLCBzZW5kbyBvcyB0ZXJjZWlyb3MgdXN1w6FyaW9zIHJlc3BvbnPDoXZlaXMgcGVsYSBhdHJpYnVpw6fDo28gZGUgYXV0b3JpYSBlIG1hbnV0ZW7Dp8OjbwpkYSBpbnRlZ3JpZGFkZSBkYSBPQlJBIGVtIHF1YWxxdWVyIHV0aWxpemHDp8Ojby4KCkEgUG9sw610aWNhIEluc3RpdHVjaW9uYWwgZGUgQWNlc3NvIEFiZXJ0byBkYSBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVoKcmVzcGVpdGEgb3MgY29udHJhdG9zIGUgYWNvcmRvcyBwcmVleGlzdGVudGVzIGRvcyBBdXRvcmVzIGNvbSB0ZXJjZWlyb3MsIGNhYmVuZG8gYW9zIEF1dG9yZXMKaW5mb3JtYXIgw6AgSW5zdGl0dWnDp8OjbyBhcyBjb25kacOnw7VlcyBlIG91dHJhcyByZXN0cmnDp8O1ZXMgaW1wb3N0YXMgcG9yIGVzdGVzIGluc3RydW1lbnRvcy4KRepositório 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dc.title.en_US.fl_str_mv Comparison of 68Ga-DOTATOC and 18F-FDG Thoracic Lymph Node and Pulmonary Lesion Uptake Using PET/CT in Postprimary Tuberculosis
title Comparison of 68Ga-DOTATOC and 18F-FDG Thoracic Lymph Node and Pulmonary Lesion Uptake Using PET/CT in Postprimary Tuberculosis
spellingShingle Comparison of 68Ga-DOTATOC and 18F-FDG Thoracic Lymph Node and Pulmonary Lesion Uptake Using PET/CT in Postprimary Tuberculosis
Rosado-de-Castro, Paulo Henrique
Tuberculosis
Computed tomography (CT)
Ga-DOTATOC
Thoracic Lymph Node
Pulmonary Lesion
title_short Comparison of 68Ga-DOTATOC and 18F-FDG Thoracic Lymph Node and Pulmonary Lesion Uptake Using PET/CT in Postprimary Tuberculosis
title_full Comparison of 68Ga-DOTATOC and 18F-FDG Thoracic Lymph Node and Pulmonary Lesion Uptake Using PET/CT in Postprimary Tuberculosis
title_fullStr Comparison of 68Ga-DOTATOC and 18F-FDG Thoracic Lymph Node and Pulmonary Lesion Uptake Using PET/CT in Postprimary Tuberculosis
title_full_unstemmed Comparison of 68Ga-DOTATOC and 18F-FDG Thoracic Lymph Node and Pulmonary Lesion Uptake Using PET/CT in Postprimary Tuberculosis
title_sort Comparison of 68Ga-DOTATOC and 18F-FDG Thoracic Lymph Node and Pulmonary Lesion Uptake Using PET/CT in Postprimary Tuberculosis
author Rosado-de-Castro, Paulo Henrique
author_facet Rosado-de-Castro, Paulo Henrique
Pereira-de-Carvalho, Thiago
Barreto, Miriam Menna
Kritski, Afranio Lineu
Souza, Rebecca de Oliveira
Almeida, Sergio Altino de
Rolla, Valeria Cavalcanti
Zin, Walter Araujo
Carvalho, Alysson Roncally Silva
Rodrigues, Rosana Souza
author_role author
author2 Pereira-de-Carvalho, Thiago
Barreto, Miriam Menna
Kritski, Afranio Lineu
Souza, Rebecca de Oliveira
Almeida, Sergio Altino de
Rolla, Valeria Cavalcanti
Zin, Walter Araujo
Carvalho, Alysson Roncally Silva
Rodrigues, Rosana Souza
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rosado-de-Castro, Paulo Henrique
Pereira-de-Carvalho, Thiago
Barreto, Miriam Menna
Kritski, Afranio Lineu
Souza, Rebecca de Oliveira
Almeida, Sergio Altino de
Rolla, Valeria Cavalcanti
Zin, Walter Araujo
Carvalho, Alysson Roncally Silva
Rodrigues, Rosana Souza
dc.subject.en.en_US.fl_str_mv Tuberculosis
Computed tomography (CT)
Ga-DOTATOC
Thoracic Lymph Node
Pulmonary Lesion
topic Tuberculosis
Computed tomography (CT)
Ga-DOTATOC
Thoracic Lymph Node
Pulmonary Lesion
description D'Or Institute for Research and Education. Department of Internal Medicine. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Department of Radiology. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Institute of Biomedical Sciences. Rio de Janeiro, RJ, Brazil.
publishDate 2022
dc.date.issued.fl_str_mv 2022
dc.date.accessioned.fl_str_mv 2023-07-27T02:50:06Z
dc.date.available.fl_str_mv 2023-07-27T02:50:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ROSADO-DE-CASTRO, Paulo Henrique et al. Comparison of 68Ga-DOTATOC and 18F-FDG Thoracic Lymph Node and Pulmonary Lesion Uptake Using PET/CT in Postprimary Tuberculosis. The American Journal of Tropical Medicine and Hygiene, v. 106, n. 5, p. 1340-1344, Apr. 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/59800
dc.identifier.issn.en_US.fl_str_mv 0002-9637
dc.identifier.doi.none.fl_str_mv 10.4269/ajtmh.21-0416
dc.identifier.eissn.none.fl_str_mv 1476-1645
identifier_str_mv ROSADO-DE-CASTRO, Paulo Henrique et al. Comparison of 68Ga-DOTATOC and 18F-FDG Thoracic Lymph Node and Pulmonary Lesion Uptake Using PET/CT in Postprimary Tuberculosis. The American Journal of Tropical Medicine and Hygiene, v. 106, n. 5, p. 1340-1344, Apr. 2022.
0002-9637
10.4269/ajtmh.21-0416
1476-1645
url https://www.arca.fiocruz.br/handle/icict/59800
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/59800/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/59800/2/ve_Rosado-de-Castro_Paulo_etal_INI_2022.pdf
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